Vaccines as a trigger for myopathies

Lupus ◽  
2009 ◽  
Vol 18 (13) ◽  
pp. 1213-1216 ◽  
Author(s):  
H. Orbach ◽  
A. Tanay
Keyword(s):  
Quality Of Life ◽  
Environmental Factors ◽  
Vaccination Campaign ◽  
Bacillus Calmette Guerin ◽  
Inflammatory Myopathies ◽  
Multicenter Studies ◽  
Flu Vaccination ◽  
B Virus ◽  
Macrophagic Myofasciitis

Vaccines are considered to be among the greatest medical discoveries, credited with the virtual eradication of some diseases and the consequent improved survival and quality of life of the at-risk population. With that, vaccines are among the environmental factors implicated as triggers for the development of inflammatory myopathies. The sporadic reports on vaccineinduced inflammatory myopathies include cases of hepatitis B virus, bacillus Calmette—Guérin, tetanus, influenza, smallpox, polio, diphtheria, diphtheria—pertussis—tetanus, combination of diphtheria with scarlet fever and diphtheria—pertussis—tetanus with polio vaccines. However, a significant increase in the incidence of dermatomyositis or polymyositis after any massive vaccination campaign has not been reported in the literature. In study patients with inflammatory myopathies, no recent immunization was recorded in any of the patients. Moreover, after the 1976 mass flu vaccination, no increase in the incidence of inflammatory myopathies was observed. Although rare, macrophagic myofasciitis has been reported following vaccination and is attributed to the aluminium hydroxide used as an adjuvant in some vaccines. Prospective multicenter studies are needed to identify potential environmental factors, including vaccines, as potential triggers for inflammatory myopathies. Lupus (2009) 18, 1213—1216.

scholarly journals Personalized, Predictive, Participatory, Precision, and Preventive (P5) Medicine in Rotator Cuff Tears

2021 ◽  
Vol 11 (4) ◽  
pp. 255
Author(s):  
Umile Giuseppe Longo ◽  
Arianna Carnevale ◽  
Carlo Massaroni ◽  
Daniela Lo Presti ◽  
Alessandra Berton ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rotator Cuff ◽  
Environmental Factors ◽  
Multidisciplinary Approach ◽  
Musculoskeletal Disorder ◽  
Scientific Evidence ◽  
Rotator Cuff Tears ◽  
Diagnosis And Therapy

Rotator cuff (RC) disease is a common musculoskeletal disorder of the shoulder entailing pain, with reduced functionality and quality of life. The main objective of this study was to present a perspective of the current scientific evidence about personalized, predictive, participatory, precision, and preventive approaches in the management of RC diseases. The personalized, predictive, participatory, precision and preventive (P5) medicine model is an interdisciplinary and multidisciplinary approach that will provide researchers and clinicians with a comprehensive patrimony of knowledge in the management of RC diseases. The ability to define genetic predispositions in conjunction with the evaluation of lifestyle and environmental factors may boost the tailoring of diagnosis and therapy in patients suffering from RC diseases.

The Quality of Life During Intravesical Bacillus Calmette-Guerin Therapy

1996 ◽  
Vol 155 (4) ◽  
pp. 1221-1226 ◽  
Author(s):  
Andreas Bohle ◽  
Friedrich Balck ◽  
Jorn Von Wietersheim ◽  
Dieter Jocham
Keyword(s):  
Quality Of Life ◽  
Bacillus Calmette Guerin

scholarly journals The risk of fracture and prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies: data from a single Hungarian center

2020 ◽  
Author(s):  
Anett Vincze ◽  
Levente Bodoki ◽  
Katalin Szabó ◽  
Melinda Nagy-Vincze ◽  
Orsolya Szalmás ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Fracture Risk ◽  
Physical Function ◽  
Inflammatory Myopathies ◽  
Mineral Density ◽  
Fracture Prevalence ◽  
Prevalence Of Osteoporosis

Abstract Background: The prevalence of osteoporosis and risk of fractures is elevated in rheumatoid arthritis, but we have little information about the bone mineral density and fracture risk in patients with inflammatory myopathies. We intended to ascertain and compare fracture risk, bone mineral density (BMD) and the prevalence of vertebral fractures in patients with inflammatory myositis and rheumatoid arthritis (RA) and to assess the effect of prevalent fractures on the quality of life and functional capacity. Methods: Fifty-two patients with myositis and 43 patients with rheumatoid arthritis were included in the study. Fracture Risk was determined using FRAX® Calculation Tool developed by the University of Sheffield. Dual energy X-ray absorptiometry and bidirectional thoracolumbar radiographs were performed to assess BMD and vertebral fractures. Quality of life was measured with Short Form-36 (SF-36) and physical function assessment was performed using Health Assessment Questionnaire (HAQ). Results: We found a significantly elevated fracture risk in RA compared to myositis patients if the risk assessment was performed without the application of the BMD results. If BMD results and glucocorticoid dose adjustment were taken into account, the differences in fracture risk were no longer significant. The prevalence of osteoporosis was found to be significantly higher in the myositis group (7% vs. 13.5%, p: 0,045), but the fracture prevalence was similar in the two groups (75% vs. 68%). The fractures rates were associated with age in both groups, but not with cumulative dose of steroid and BMD results correlated with fracture prevalence only in the RA patients. The number of prevalent fractures was significantly correlated to poorer physical function in both groups, and poorer health status in the myositis group, but not in the RA group. Conclusions: Our findings suggest that inflammatory myopathies carry significantly elevated risk for osteoporosis and fractures. This higher risk is comparable to one detected with RA in studies and strongly affects the physical function and quality of life of patients. Therefore further efforts are required to make the fracture risk assessment reliable and to facilitate the use early preventive treatments.

scholarly journals Impact of Periodontal Disease on the Quality of Life of Older People in Indonesia: A Qualitative Study

2021 ◽  
pp. 238008442110419
Author(s):  
M. Hijryana ◽  
M. MacDougall ◽  
N. Ariani ◽  
L.S. Kusdhany ◽  
A.W.G. Walls
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Environmental Factors ◽  
Periodontal Disease ◽  
Older People ◽  
Structured Interviews ◽  
Research Perspective ◽  
The Impact ◽  
People’S Perceptions

Introduction: The impact of periodontal disease on oral health–related quality of life (OHRQoL) has often been investigated from a quantitative research perspective, which is based on clinical findings and an OHRQoL questionnaire. Very few studies have examined the issue from the view of qualitative research. To our knowledge, there have been no previous qualitative studies focusing the effect of periodontal disease on OHRQoL in Indonesian older people. Objectives: To explore and understand the impact of periodontal disease on the OHRQoL of older people as a subjective reflection in relation to periodontal disease experiences. Methods: Semi-structured interviews were conducted in a sample of 31 older people with generalized chronic periodontitis. Thematic analysis was used to identify the key issues in participants’ accounts. The analysis was undertaken by 2 independent coders to ensure reliability. To achieve thematic saturation, successive interviews were undertaken until 5 sequential interviews did not bring new themes. Results: Participants reported the negative effects likely related to periodontal disease. The impacts of periodontal disease were described by these older people as affecting more than pain, physical discomfort, and physical function restrictions. Periodontal disease also affected their psychological and social aspects of daily living. In addition, this study identified themes related to individual and environmental factors that may modify and personalize periodontal disease experiences. Furthermore, this study identified a misleading belief that problems related to periodontal disease were a normal part of aging, which might influence individuals’ expectations toward oral health. Relatedly, participants frequently reported that the progression of tooth mobility to tooth loss was an inevitable part of the aging process. Conclusions: Periodontal disease negatively affected participants’ OHRQoL. It is fundamental to understand older people’s perceptions toward their periodontal disease as well as individual and environmental factors that may have an influence on their periodontal disease experiences. Knowledge Transfer Statement: This study is a reflection of Indonesian older people’s subjective periodontal disease experiences. Therefore, the present study can be used to understand older people’s perceptions, attitudes, behaviors, and experiences toward periodontal disease and how this disease may affect their quality of life. This study also highlights a widespread and misleading belief that oral problems related to periodontal disease are an inevitable part of aging in this study population.

Behavioural and psychological symptoms of dementia

2020 ◽  
pp. 247-258
Author(s):  
Rianne van der Linde ◽  
Tom Dening
Keyword(s):  
Quality Of Life ◽  
Environmental Factors ◽  
Psychological Symptoms ◽  
Symptom Clusters ◽  
Psychotic Symptoms ◽  
Mixed Group ◽  
People With Dementia ◽  
Affective Symptoms ◽  
Behavioural And Psychological Symptoms

The term: ‘behavioural and psychological symptoms of dementia’ (BPSD) refers to a mixed group of phenomena. BPSD are the non-cognitive features of dementia and include depression, anxiety, psychotic symptoms, apathy, irritability, aggression, and sleep and eating problems. They occur in around 80% of people with dementia at some stage, several of them becoming more frequent as dementia progresses. Some BPSD, notably apathy, are very persistent. BPSD often limit the person’s quality of life and can be stressful for carers. Causes of BPSD include biological, psychological, social, and environmental factors. This chapter explores how they are assessed and measured, and how they may usefully grouped together in symptom clusters. Usually four symptom groups are found: affective symptoms, psychosis, hyperactivity, and euphoria. However, these are not always consistent and in particular apathy does not consistently belong in one group. Approaches to management of BPSD are outlined.

Psychosocial Treatments for Schizophrenia

2007 ◽  
pp. 243-270
Author(s):  
Alex Kopelowicz ◽  
Robert Paul Liberman ◽  
Roberto Zaratem
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Environmental Factors ◽  
Protective Factors ◽  
Psychiatric Treatment ◽  
Psychosocial Treatments ◽  
Level Of Functioning ◽  
Stress Vulnerability ◽  
Persons With Schizophrenia

Data from hundreds of intervention research studies validate a biopsychosocial view of treatment for schizophrenia that combines pharmacotherapy with psychosocial treatments and social support. Based on the stress-vulnerability-protective factors model, these treatments work by strengthening biological, personal, and environmental factors that protect against relapse while mitigating the stressors that adversely affect the course of schizophrenia. Psychiatric treatment and rehabilitation must be integrated in a seamless approach aimed at restoring persons with schizophrenia to their best possible level of functioning and quality of life.

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