Widen NomoGram for multinomial logistic regression: an application to staging liver fibrosis in chronic hepatitis C patients

2014 ◽  
Vol 26 (2) ◽  
pp. 823-838 ◽  
Author(s):  
Ilaria Ardoino ◽  
Monica Lanzoni ◽  
Giuseppe Marano ◽  
Patrizia Boracchi ◽  
Elisabetta Sagrini ◽  
...  

The interpretation of regression models results can often benefit from the generation of nomograms, ‘user friendly’ graphical devices especially useful for assisting the decision-making processes. However, in the case of multinomial regression models, whenever categorical responses with more than two classes are involved, nomograms cannot be drawn in the conventional way. Such a difficulty in managing and interpreting the outcome could often result in a limitation of the use of multinomial regression in decision-making support. In the present paper, we illustrate the derivation of a non-conventional nomogram for multinomial regression models, intended to overcome this issue. Although it may appear less straightforward at first sight, the proposed methodology allows an easy interpretation of the results of multinomial regression models and makes them more accessible for clinicians and general practitioners too. Development of prediction model based on multinomial logistic regression and of the pertinent graphical tool is illustrated by means of an example involving the prediction of the extent of liver fibrosis in hepatitis C patients by routinely available markers.

Objective: While the use of intraoperative laser angiography (SPY) is increasing in mastectomy patients, its impact in the operating room to change the type of reconstruction performed has not been well described. The purpose of this study is to investigate whether SPY angiography influences post-mastectomy reconstruction decisions and outcomes. Methods and materials: A retrospective analysis of mastectomy patients with reconstruction at a single institution was performed from 2015-2017.All patients underwent intraoperative SPY after mastectomy but prior to reconstruction. SPY results were defined as ‘good’, ‘questionable’, ‘bad’, or ‘had skin excised’. Complications within 60 days of surgery were compared between those whose SPY results did not change the type of reconstruction done versus those who did. Preoperative and intraoperative variables were entered into multivariable logistic regression models if significant at the univariate level. A p-value <0.05 was considered significant. Results: 267 mastectomies were identified, 42 underwent a change in the type of planned reconstruction due to intraoperative SPY results. Of the 42 breasts that underwent a change in reconstruction, 6 had a ‘good’ SPY result, 10 ‘questionable’, 25 ‘bad’, and 2 ‘had areas excised’ (p<0.01). After multivariable analysis, predictors of skin necrosis included patients with ‘questionable’ SPY results (p<0.01, OR: 8.1, 95%CI: 2.06 – 32.2) and smokers (p<0.01, OR:5.7, 95%CI: 1.5 – 21.2). Predictors of any complication included a change in reconstruction (p<0.05, OR:4.5, 95%CI: 1.4-14.9) and ‘questionable’ SPY result (p<0.01, OR: 4.4, 95%CI: 1.6-14.9). Conclusion: SPY angiography results strongly influence intraoperative surgical decisions regarding the type of reconstruction performed. Patients most at risk for flap necrosis and complication post-mastectomy are those with questionable SPY results.


2021 ◽  
Vol 10 (2) ◽  
pp. 50
Author(s):  
Naomi Biegel ◽  
Karel Neels ◽  
Layla Van den Berg

Grandparents constitute an important source of childcare to many parents. Focusing on the Belgian context, this paper improves our understanding of childcare decision-making by investigating how formal childcare availability and availability of grandparents affect childcare arrangements. By means of multinomial regression models we simultaneously model uptake of formal and informal childcare by parents. Combining linked microdata from the Belgian censuses with contextual data on childcare at the level of municipalities, we consider formal childcare availability at a local level, while including a wide array of characteristics which may affect grandparental availability. Results indicate that increasing formal care crowds-out informal care as the sole care arrangement, whereas combined use of formal and informal care becomes more prevalent. Characteristics indicating a lack of grandmaternal availability increase uptake of formal care and inhibit to a lesser extent the uptake of combined formal and informal care. While increasing formal care substitutes informal care use, the lack of availability of informal care by grandparents may be problematic, particularly for those families most prone to use informal care.


2016 ◽  
Vol 31 (3) ◽  
pp. 402-415 ◽  
Author(s):  
Rémi Boivin ◽  
Chloé Leclerc

This article analyzes reported incidents of domestic violence according to the source of the complaint and whether the victim initially supported judicial action against the offender. Almost three quarters of incidents studied were reported by the victim (72%), and a little more than half of victims initially wanted to press charges (55%). Using multinomial logistic regression models, situational and individual factors are used to distinguish 4 incident profiles. Incidents in which the victim made the initial report to the police and wished to press charges are the most distinct and involve partners who were already separated at the time of the incident or had a history of domestic violence. The other profiles also show important differences.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Maassen ◽  
C Sostongs

Abstract In 2019, members of the EuroHealthNet Partnership established the first Thematic Working Group on Health Promotion and Disease Prevention Programme Registers with the intention of becoming 'the competence engine for Programme Registers in Europe.' The group's objectives include to exchange experience, to initiate joint projects, to identify and further develop common topics relevant to Programme Registers, and to share findings in scientific papers and international conferences. Through such activities, the group builds the foundation for a more systematic and scientific European approach to translating evidence into practice and provides a forum for liaison and exchange between EU Member States, the European Commission, and international partners. Programme registers are only as relevant as they are influential in professionals' and policy makers' decision-making around intervention selection. Facilitating uptake of best practices requires an understanding of incentives, disincentives and decision-making processes, as well as how to make the programme registers more prominent and user-friendly. Outcomes from the 2020 Working Group meeting in Cologne will be presented, including case studies from across Europe, as well as recommendations to improve the uptake of best practices, tailored to portals at different stages of development.


Author(s):  
Karen Zwanch ◽  
Jesse L. M. Wilkins

Abstract Constructing multiplicative reasoning is critical for students’ learning of mathematics, particularly throughout the middle grades and beyond. Tzur, Xin, Si, Kenney, and Guebert [American Educational Research Association, ERIC No. ED510991, (2010)] conclude that an assimilatory composite unit is a conceptual spring to multiplicative reasoning. This study examines patterns in the percentages of students who construct multiplicative reasoning across the middle grades based on their fluency in operating with composite units. Multinomial logistic regression models indicate that students’ rate of constructing an assimilatory composite unit but not multiplicative reasoning in sixth and seventh grades is significantly greater than that in eighth and ninth grades. Furthermore, the proportion of students who have constructed multiplicative reasoning in sixth and seventh grades is significantly less than the proportion of those who have constructed multiplicative reasoning in eighth and ninth grades. One implication of this is the quantitative verification of Tzur, Xin, Si, Kenney, and Guebert’s (2010) conceptual spring. That is, students who construct assimilatory composite units early in the middle grades are likely to construct multiplicative reasoning; students who do not construct assimilatory composite units early in the middle grades likely do not construct multiplicative reasoning in the middle grades.


2017 ◽  
Vol 35 (3-4) ◽  
pp. 662-681 ◽  
Author(s):  
Myriam Forster ◽  
Amy L. Gower ◽  
Barbara J. McMorris ◽  
Iris W. Borowsky

Retrospective studies using adult self-report data have demonstrated that adverse childhood experiences (ACEs) increase risk of violence perpetration and victimization. However, research examining the associations between adolescent reports of ACE and school violence involvement is sparse. The present study examines the relationship between adolescent reported ACE and multiple types of on-campus violence (bringing a weapon to campus, being threatened with a weapon, bullying, fighting, vandalism) for boys and girls as well as the risk of membership in victim, perpetrator, and victim–perpetrator groups. The analytic sample was comprised of ninth graders who participated in the 2013 Minnesota Student Survey ( n ~ 37,000). Multinomial logistic regression models calculated the risk of membership for victim only, perpetrator only, and victim–perpetrator subgroups, relative to no violence involvement, for students with ACE as compared with those with no ACE. Separate logistic regression models assessed the association between cumulative ACE and school-based violence, adjusting for age, ethnicity, family structure, poverty status, internalizing symptoms, and school district size. Nearly 30% of students were exposed to at least one ACE. Students with ACE represent 19% of no violence, 38% of victim only, 40% of perpetrator only, and 63% of victim–perpetrator groups. There was a strong, graded relationship between ACE and the probability of school-based victimization: physical bullying for boys but not girls, being threatened with a weapon, and theft or property destruction ( ps < .001) and perpetration: bullying and bringing a weapon to campus ( ps < .001), with boys especially vulnerable to the negative effects of cumulative ACE. We recommend that schools systematically screen for ACE, particularly among younger adolescents involved in victimization and perpetration, and develop the infrastructure to increase access to trauma-informed intervention services. Future research priorities and implications are discussed.


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