A new measure to quantify sedentary behavior using accelerometer data: Application to the Hispanic Community Health Study/Study of Latinos

Availability of accelerometer data has made it possible to objectively and continuously monitor sedentary behavior. Various summaries of the extensive accelerometer data have been used to understand the relationship between sedentary behavior and health. However, the widely used summary measures on sedentary bouts, average bout length or its derivatives, fail to reveal patterns of accumulated sedentary behavior over time. Studies have suggested that prolonged uninterrupted sedentary behavior can be an important metric that is related to health states. Yet existing measures to capture the prolonged sedentary patterns either rely on parametric assumptions on the underlying distribution of sedentary bout length or have to categorize sedentary bout length into somewhat arbitrary categories. Gini index was also used; however, it only measures the variability in bout lengths but not the actual length. To overcome these limitations, we proposed a non-parametric weighted survival function to characterize uninterrupted sedentary behavior over time in a continuous fashion and used the area under the survival curve as a new summary measure to quantify sedentary behavior. We showed that this measure is a weighted average of bout length and contains the information on both the mean and variability of bout lengths. We demonstrated in the simulation studies that the proposed measure could better identify prolonged uninterrupted sedentary behavior and predict health outcomes. We applied this new measure and existing sedentary measures to data from the Hispanic Community Health Study/Study of Latinos to examine the association between sedentary behavior and overweight/obesity.

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The Role of Stress in Understanding Differences in Sedentary Behavior in Hispanic/Latino Adults: Results From the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0608 ◽

2016 ◽

Vol 13 (3) ◽

pp. 310-317 ◽

Cited By ~ 9

Author(s):

Elizabeth Vásquez ◽

Garrett Strizich ◽

Linda Gallo ◽

Simon J. Marshall ◽

Gina C. Merchant ◽

...

Keyword(s):

Community Health ◽

Sedentary Behavior ◽

Stress Reduction ◽

Self Report ◽

Health Study ◽

Sedentary Behaviors ◽

Ancillary Study ◽

Hispanic Community ◽

Latino Adults ◽

Sedentary Activities

Background:Chronic stress and/or lifetime traumatic stress can create a self-reinforcing cycle of unhealthy behaviors, such as overeating and sedentary behavior, that can lead to further increases in stress. This study examined the relationship between stress and sedentary behavior in a sample of Hispanic/Latino adults (N = 4244) from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.Methods:Stress was measured as the number of ongoing difficulties lasting 6 months or more and as lifetime exposure to traumatic events. Sedentary behavior was measured by self-report and with accelerometer. Multivariable regression models examined associations of stress measures with time spent in sedentary behaviors adjusting by potential confounders.Results:Those who reported more than one chronic stressor spent, on average, 8 to 10 additional minutes per day in objectively measured sedentary activities (P < .05), whereas those with more than one lifetime traumatic stressor spent (after we adjusted for confounders) 10 to 14 additional minutes in sedentary activities (P < .01) compared with those who did not report any stressors. Statistical interactions between the 2 stress measures and age or sex were not significant.Conclusion:Interventions aimed at reducing sedentary behaviors might consider incorporating stress reduction into their approaches.

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Cross-sectional and prospective associations between sleep regularity and metabolic health in the Hispanic Community Health Study/Study of Latinos

SLEEP ◽

10.1093/sleep/zsaa218 ◽

2020 ◽

Author(s):

Josef Fritz ◽

Andrew J K Phillips ◽

Larissa C Hunt ◽

Akram Imam ◽

Kathryn J Reid ◽

...

Keyword(s):

Community Health ◽

Cell Function ◽

Diabetes Risk ◽

Health Study ◽

Diabetes Incidence ◽

Antidiabetic Medication ◽

Cross Sectional ◽

Hispanic Community ◽

Changes Over Time ◽

Over Time

Abstract Study Objectives Sleep is an emergent, multi-dimensional risk factor for diabetes. Sleep duration, timing, quality, and insomnia have been associated with diabetes risk and glycemic biomarkers, but the role of sleep regularity in the development of metabolic disorders is less clear. Methods We analyzed data from 2107 adults, aged 19–64 years, from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos, followed over a mean of 5.7 years. Multivariable-adjusted complex survey regression methods were used to model cross-sectional and prospective associations between the sleep regularity index (SRI) in quartiles (Q1-least regular, Q4-most regular) and diabetes (either laboratory-confirmed or self-reported antidiabetic medication use), baseline levels of insulin resistance (HOMA-IR), beta-cell function (HOMA-β), hemoglobin A1c (HbA1c), and their changes over time. Results Cross-sectionally, lower SRI was associated with higher odds of diabetes (odds ratio [OR]Q1 vs. Q4 = 1.64, 95% CI: 0.98–2.74, ORQ2 vs. Q4 = 1.12, 95% CI: 0.70–1.81, ORQ3 vs. Q4 = 1.00, 95% CI: 0.62–1.62, ptrend = 0.023). The SRI effect was more pronounced in older (aged ≥ 45 years) adults (ORQ1 vs. Q4 = 1.88, 95% CI: 1.14–3.12, pinteraction = 0.060) compared to younger ones. No statistically significant associations were found between SRI and diabetes incidence, as well as baseline HOMA-IR, HOMA-β, and HbA1c values, or their changes over time among adults not taking antidiabetic medication. Conclusions Our results suggest that sleep regularity represents another sleep dimension relevant for diabetes risk. Further research is needed to elucidate the relative contribution of sleep regularity to metabolic dysregulation and pathophysiology.

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Isotemporal Analysis of the Association of Objectively Measured Physical Activity With Depressive Symptoms: Results From Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Journal of Physical Activity and Health ◽

10.1123/jpah.2016-0648 ◽

2017 ◽

Vol 14 (9) ◽

pp. 733-739 ◽

Cited By ~ 9

Author(s):

Chad D. Rethorst ◽

Ashley E. Moncrieft ◽

Marc D. Gellman ◽

Elva M. Arredondo ◽

Christina Buelna ◽

...

Keyword(s):

Physical Activity ◽

Depressive Symptoms ◽

Community Health ◽

Sedentary Behavior ◽

Health Study ◽

Hispanic Community ◽

Hispanic Latinos ◽

Objectively Measured ◽

Relationship Of ◽

The Relationship

Background:The burden of depression among Hispanics/Latinos indicates the need to identify factors related to depressive symptoms. This paper examines the relationship of physical activity (PA) and sedentary behavior (SB) with depressive symptoms in Hispanic/Latinos.Methods:The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a population-based, cohort study of Hispanic/Latinos in 4 United States metropolitan areas. Objectively measured PA was coded into: sedentary behavior (SB), light-intensity (LPA), moderate-intensity (MPA), and vigorous-intensity (VPA); and the Center for Epidemiological Studies Depression Scale-10 assessed depressive symptoms. Multiple regression analysis utilizing isotemporal substitution, adjusted for relevant covariates, examined PA as predictors of depressive symptoms.Results:Substitution of 1 hour of SB with VPA resulted in a significant decrease in depressive symptoms (β = –1.215, P = .021). Similar decreases were observed when VPA replaced LPA (β = –1.212, P = .021) and MPA (β = –1.50 P = .034). MPA and LPA were not associated with lower depressive symptoms.Conclusions:Previous research has focused on the relationship of MVPA on depressive symptoms. Our results suggest these constructs should be examined separately as they may have unique relationships with depressive symptoms. The association of SB with greater depressive symptoms confirms previous reports.

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Is there a relationship between accelerometer-assessed physical activity and sedentary behavior and cognitive function in US Hispanic/Latino adults? The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Preventive Medicine ◽

10.1016/j.ypmed.2017.07.024 ◽

2017 ◽

Vol 103 ◽

pp. 43-48 ◽

Cited By ~ 9

Author(s):

Elizabeth Vásquez ◽

Garrett Strizich ◽

Carmen R. Isasi ◽

Sandra E. Echeverria ◽

Daniela Sotres-Alvarez ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Function ◽

Community Health ◽

Sedentary Behavior ◽

Health Study ◽

Hispanic Community ◽

Latino Adults

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Objectively Measured Physical Activity, Sedentary Behavior, and Genetic Predisposition to Obesity in U.S. Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Diabetes ◽

10.2337/db17-0573 ◽

2017 ◽

Vol 66 (12) ◽

pp. 3001-3012 ◽

Cited By ~ 11

Author(s):

Jee-Young Moon ◽

Tao Wang ◽

Tamar Sofer ◽

Kari E. North ◽

Carmen R. Isasi ◽

...

Keyword(s):

Physical Activity ◽

Community Health ◽

Sedentary Behavior ◽

Genetic Predisposition ◽

Health Study ◽

Hispanic Community ◽

Objectively Measured ◽

Objectively Measured Physical Activity

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The association of acculturation with accelerometer-assessed and self-reported physical activity and sedentary behavior: The Hispanic Community Health Study/Study of Latinos

Preventive Medicine Reports ◽

10.1016/j.pmedr.2020.101050 ◽

2020 ◽

Vol 17 ◽

pp. 101050

Author(s):

Ricky Camplain ◽

Daniela Sotres-Alvarez ◽

Carolina Alvarez ◽

Rebbecca Wilson ◽

Krista M. Perreira ◽

...

Keyword(s):

Physical Activity ◽

Community Health ◽

Sedentary Behavior ◽

Health Study ◽

Hispanic Community

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Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Kidney360 ◽

10.34067/kid.0006202020 ◽

2020 ◽

pp. 10.34067/KID.0006202020

Author(s):

Mary Hannan ◽

Ana C. Ricardo ◽

Jianwen Cai ◽

Nora Franceschini ◽

Robert Kaplan ◽

...

Keyword(s):

Community Health ◽

Sedentary Behavior ◽

Kidney Function ◽

Sedentary Time ◽

Multivariable Analysis ◽

Health Study ◽

Hispanic Community ◽

The Impact ◽

Egfr Decline

Background: There is accumulating evidence linking prolonged sedentary time to adverse health outcomes. The impact of sedentary behavior on kidney function has not been evaluated in U.S. Hispanics/Latinos, a population disproportionately affected by chronic kidney disease (CKD). Methods: We evaluated the association between accelerometer measured (one week) sedentary time at baseline and kidney function among 7,134 adults without CKD at entry in the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL), who completed a baseline visit with accelerometry (2008-2011) and a follow-up visit (2014-2017). Outcomes included: 1) change in kidney function (estimated glomerular filtration rate [eGFR] and urine albumin-to-creatinine ratio [ACR]), 2) incident low eGFR (eGFR <60 ml/min/1.73m2 and eGFR decline ≥1 mL/min/year), and 3) incident albuminuria (ACR ≥17 mg/g in men or ≥25 mg/g in women). Linear regression using survey procedures was used to evaluate change in kidney function (eGFR and ACR), and Poisson regression with robust variance was used to evaluate incident low eGFR and albuminuria. Results: The median sedentary time was 12 hours/day. Over a median follow-up of 6.1 years, the mean relative change in eGFR was -0.50% per year, and there were 167 incident low eGFR events. On multivariable analysis, each one hour increase in sedentary time was associated with a longitudinal decline in eGFR (-0.06% per year [95% CI, -0.10 to -0.02]). There was a significant interaction with sex, and on stratified analyses, higher sedentary time was associated with eGFR decline in women but not men. There was no association between sedentary time and the other outcomes. Conclusion: Sedentary time was associated with a small longitudinal decline in eGFR, which could have important implications in a population that experiences a disproportionate burden of CKD but further investigation is needed.

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Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

BMC Public Health ◽

10.1186/s12889-020-09497-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Yasmin Mossavar-Rahmani ◽

Simin Hua ◽

Qibin Qi ◽

Garrett Strizich ◽

Daniela Sotres-Alvarez ◽

...

Keyword(s):

Physical Activity ◽

Community Health ◽

Sedentary Behavior ◽

Cardiometabolic Risk ◽

Ldl Cholesterol ◽

Vigorous Physical Activity ◽

Health Benefits ◽

Health Study ◽

Cardiometabolic Disease ◽

Hispanic Community

Abstract Background Whether physical activity can reduce cardiometabolic risk particularly in understudied populations such as US Hispanics/Latinos is of public health interest. We prospectively examined the association of physical activity and cardiometabolic biomarkers in n = 8049 participants of the Hispanic Community Health Study/Study of Latinos, a community-based cohort study of 16,415 adults aged 18–74 yr who self-identified as Hispanic/Latino from four US urban centers. Methods We assessed physical activity using accelerometry in 2008–2011 at visit 1. We assessed cardiometabolic biomarkers twice: once at visit 1 and collected a second measure in 2014–2017 at visit 2. We used survey linear regression models with changes in cardiometabolic markers as the dependent variables and quartiles of sedentary behavior or whether adults met guidelines for moderate-to-vigorous physical activity as the independent variables. Results In normoglycemic adults without cardiovascular disease, but not in adults with evidence of cardiometabolic disease, those who were in the lowest quartile for sedentary behavior (< 10.08 h/day) had a significant decline in mean LDL-cholesterol of − 3.94 mg/dL (95% CI: − 6.37, − 1.52) compared to adults in the highest quartile (≥13.0 h/day) who exhibited a significant increase in LDL-cholesterol of 0.14 mg/dL (95% CI, − 2.15,2.42) over the six year period (P < 0.02 in fully adjusted models.) There was also a trend toward lower mean increase in HbA1c comparing the lowest with the highest quartile of sedentary behavior. Overall regardless of glycemic level or evidence of cardiometabolic disease, adults who met guidelines for moderate-to-vigorous physical activity at visit 1, had significantly lower mean increases in level of fasting glucose compared to adults not meeting guidelines in fully adjusted models. Conclusions In this cohort of Hispanics/Latinos, being free of cardiometabolic disease and having low levels of sedentary behavior were associated with health benefits. Among all adults regardless of cardiometabolic disease, meeting guidelines for moderate-to-vigorous physical activity was associated with health benefits. Overall these data suggest that an active lifestyle may blunt the association of advancing age with worsening cardiometabolic risk factors.

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Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Genome Biology ◽

10.1186/s13059-019-1831-z ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 14

Author(s):

Robert C. Kaplan ◽

Zheng Wang ◽

Mykhaylo Usyk ◽

Daniela Sotres-Alvarez ◽

Martha L. Daviglus ◽

...

Keyword(s):

Community Health ◽

Gut Microbiome ◽

Alpha Diversity ◽

Amplicon Sequencing ◽

Shannon Index ◽

Health Study ◽

Rrna Gene ◽

Cross Sectional ◽

Hispanic Community ◽

The Usa

Abstract Background Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

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