scholarly journals Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review

2021 ◽  
pp. 104063872199206
Author(s):  
Niora J. Fabian ◽  
Michael Y. Esmail ◽  
Lauren Richey ◽  
Sureshkumar Muthupalani ◽  
Jennifer L. Haupt ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Columba Livia ◽  
Avian Species ◽  
Doppler Imaging ◽  
Mesenchymal Tumors ◽  
Tissue Mass ◽  
Color Flow ◽  
Visceral Metastases

Cutaneous leiomyosarcomas are malignant mesenchymal tumors of smooth muscle origin and are reported occasionally in avian species. A 14-y-old male laboratory White Carneau pigeon ( Columba livia) was presented for surgical excision of a cervical soft tissue mass. Ultrasonography with color flow Doppler imaging revealed multiple cavitations of mixed echogenicity within the mass and vascularization. Histologically, the dermis and subcutis were expanded by a densely cellular multinodular mass comprised of fusiform cells forming haphazardly arranged broad streams and short interwoven bundles, often surrounding blood vessels and variably sized cavitations. Neoplastic cells were strongly immunopositive for desmin and α–smooth muscle actin, and negative for pancytokeratin, S100, and von Willebrand factor. Based on histopathology and IHC findings, the cutaneous mass was diagnosed as leiomyosarcoma (LMS). The pigeon died 312 d post-operatively. Postmortem examination revealed masses infiltrating the left and right pulmonary airways and one hepatic nodule, but no regrowth at the surgical site. Histologic and IHC evaluation of the pulmonary and hepatic masses were consistent with LMS, representing metastatic foci from the primary cutaneous LMS. Our case highlights the malignant behavior and histomorphologic features of cutaneous LMS in an avian species.

scholarly journals Non-metastatic ileal leiomyosarcoma in an aged pouter pigeon (Columba livia)

2018 ◽  
Vol 68 (4) ◽  
pp. 675
Author(s):  
CD GORNATTI CHURRIA ◽  
P LOUKOPOULOS
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Columba Livia ◽  
Avian Species ◽  
Intestinal Smooth Muscle ◽  
Muscle Actin ◽  
First Report ◽  
Spindle Cells ◽  
Tunica Muscularis ◽  
Antiparasitic Treatment

Intestinal smooth muscle neoplasms are rarely reported in avian species. An aged male pouter pigeon (Columba livia) had anorexia, somnolence, progressive emaciation and yellowish diarrhea of four days’ duration and died despite antibiotic and antiparasitic treatment. At necropsy, the ileum bore a whitish, nodular, 0.8 cm in diameter mass severely narrowing the lumen. Histopathologically, the ileal mass was a well-demarcated, expansile neoplasm severely expanding the tunica muscularis and invading the mucosa. The neoplasm was composed of densely packed spindle cells with elongated nuclei arranged in broad interlacing bundles, and showing mild anisocytosis and anisokaryosis. Immunohistochemically, the neoplasm was positive for desmin and smooth muscle actin, and negative for cytokeratin, and c-kit. The gross, histopathologic and immunohistochemical findings provided the diagnosis of ileal leiomyosarcoma. This is the first report of an ileal leiomyosarcoma in Columbiformes and one of few intestinal smooth muscle neoplasms described in birds.

Piloleiomyosarcoma in Seven Ferrets

2001 ◽  
Vol 38 (6) ◽  
pp. 710-711 ◽  
Author(s):  
B. H. Rickman ◽  
L. E. Craig ◽  
M. H. Goldschmidt
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Muscle Actin ◽  
Mustela Putorius ◽  
Nuclear Pleomorphism ◽  
Complete Surgical Excision

In each of seven ferrets ( Mustela putorius furo) with leiomyosarcoma, a single dermal mass was identified and biopsied. Each mass consisted of a well-demarcated but nonencapsulated proliferation of large spindle- to strap-shaped cells arranged in interwoven bundles. The cells resembled the smooth muscle cells of the adjacent arrector pili muscles, but with marked nuclear pleomorphism. Immunohistochemical staining for smooth muscle actin, desmin, and vimentin was positive and staining for myoglobin and cytokeratin was negative. Follow-up on three of the ferrets indicates that the prognosis is good following complete surgical excision.

Primary Leiomyosarcoma of the Pancreas

2001 ◽  
Vol 125 (1) ◽  
pp. 152-155
Author(s):  
Gabriella Nesi ◽  
Desiree Pantalone ◽  
Ilaria Ragionieri ◽  
Andrea Amorosi
Keyword(s):  
Smooth Muscle ◽  
World Literature ◽  
Soft Tissues ◽  
Malignant Tumors ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
High Rate ◽  
Complete Surgical Excision ◽  
Membrane Components ◽  
Primary Leiomyosarcoma

Abstract Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, α-smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.

Intraoperative color-flow Doppler imaging of AVM's and aneurysms

1988 ◽  
Vol 68 (4) ◽  
pp. 635-639 ◽  
Author(s):  
Keith L. Black ◽  
Jonathan M. Rubin ◽  
William F. Chandler ◽  
John E. McGillicuddy
Keyword(s):  
Arteriovenous Malformations ◽  
Doppler Sonography ◽  
Giant Aneurysm ◽  
Surgical Excision ◽  
Doppler Imaging ◽  
Vascular Lesions ◽  
Color Flow ◽  
Content Type ◽  
Color Flow Doppler Sonography ◽  
Spinal Arteriovenous Malformations

✓ The use of intraoperative color-flow Doppler sonography to image cerebral and spinal arteriovenous malformations (AVM's) and a giant aneurysm is reported in 10 patients. The technique is a useful adjunct in localizing vascular lesions, identifying feeding or draining vessels, and confirming intraoperative surgical excision of AVM's or ligation of giant aneurysms. Imaging of lesions deeper than 4 to 5 cm is, however, limited with the equipment design now commercially available.

Gastric smooth muscle hamartoma in a cat

2010 ◽  
Vol 12 (4) ◽  
pp. 334-337 ◽  
Author(s):  
Thomas J. Smith ◽  
Wendy I. Baltzer ◽  
Craig G. Ruaux ◽  
Jerry R. Heidel ◽  
Patrick Carney
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Clinical Signs ◽  
Surgical Excision ◽  
Endoscopic Examination ◽  
Tissue Mass ◽  
Gastric Smooth Muscle ◽  
Esophageal Sphincter

An 11-year-old cat presented for evaluation of intermittent vomiting, constipation and hyporexia of 3 weeks duration. Ultrasonographic and endoscopic examination revealed a soft tissue mass adjacent to the lower gastro-esophageal sphincter. Surgical excision of the mass was successfully performed resulting in a resolution of clinical signs. Histologically the mass was consistent with a smooth muscle hamartoma. At follow-up 7 months after surgery, the cat remained free from clinical signs.

scholarly journals Leiomyosarcoma of the colon

2015 ◽  
Vol 68 (11-12) ◽  
pp. 413-417 ◽  
Author(s):  
Vlado Janevski ◽  
Redzep Selmani ◽  
Vesna Janevska ◽  
Liljana Spasevska ◽  
Julija Zhivadinovik
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumors ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Neuron Specific Enolase ◽  
Muscle Actin ◽  
Ascending Colon ◽  
Mesenchymal Tumors ◽  
Stromal Tumors

Introduction. Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract. Leiomyosarcomas of the gastrointestinal tract are rare mesenchymal neoplasms which grossly and histologically resemble gastrointestinal stromal tumors. They may be differentiated from gastrointestinal stromal tumors by using immunohistochemistry and they are typically positive for ? smooth muscle actin and desmin and negative for c-kit, CD34 and DOG1.1. They often express calponin and h-caldesmon. Case Report. We present a case of a 59-year-old male with anemia, weight loss, intermittent abdominal pain and right abdominal mass. Colonoscopy revealed an exophytic ulcerated neoplastic mass in the ascending colon and abdominal computed tomography scan showed an ill-defined heterogeneous tumor mass which surrounded almost the whole ascending colon. The patient underwent right hemicolectomy and partial resection of ileum. Histopathological examination revealed a leiomyosarcoma composed of atypical spindle cells positive for ? smooth muscle actin, desmin and vimentin, and negative for c-kit, CD34, S100 and neuron specific enolase. The patient is alive 8 months after the operation, undergoing chemotherapy. Conclusion. We have concluded that the multimodal approach comprising chemotherapy and complete surgical resection controls the leiomyosarcomas.

Dacryops (Lacrimal Cyst) in Three Young Labrador Retrievers

2009 ◽  
Vol 45 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Juri Ota ◽  
Jacqueline W. Pearce ◽  
Michael J. Finn ◽  
Gayle C. Johnson ◽  
Elizabeth A. Giuliano
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Case Series ◽  
Surgical Excision ◽  
Cystic Mass ◽  
Muscle Actin ◽  
Aspiration Cytology ◽  
History Of ◽  
The Masses ◽  
Labrador Retrievers

This case series constitutes a report of dacryops in multiple Labrador retrievers and the use of smooth-muscle actin immunostaining to confirm the lacrimal duct origins of the cyst wall. Three Labrador retrievers were presented with a history of a slowly enlarging mass adjacent to the left medial canthus. Ultrasonography of the masses revealed they were each spherical, thin-walled cystic structures. Aspiration cytology was performed in two cases revealing mixed inflammation and absence of detectable microorganisms. Dacryocystorhinography of the left nasolacrimal system performed in two cases revealed a normal nasolacrimal system that was closely associated, but not communicating with, the cystic mass in both cases. Surgical excision of all cysts was curative. Histopathology and positive immunohistochemical staining for smooth-muscle actin confirmed a diagnosis of dacryops in all cases.

The Sinewy Swirls- Angioleiomyoma

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Anubha Bajaj ◽  
Keyword(s):  
Smooth Muscle ◽  
Ganglion Cyst ◽  
Smooth Muscle Actin ◽  
Fibrous Tissue ◽  
Surgical Excision ◽  
Glomus Tumour ◽  
Tissue Cell ◽  
Muscle Fibres ◽  
Cavernous Haemangioma ◽  
Traumatic Neuroma

Angioleiomyoma is an exceptional, benign, solitary neoplasm originating from tunica media of vascular smooth muscle. The neoplasm commonly represents as a uniform, well defined, solitary, soft, nodular, gradually progressive, bluish or purple lesion commonly beneath <2 centimetres magnitude with an absence of accompanying inflammation. Tumefaction is composed of thickened smooth muscle fibres and vascular channels with circumscribing attenuated fibrous tissue capsule. Additionally, the lesion may denominate organizing thrombus, mature adipose tissue cell aggregates and lymphocytic infiltrate. The neoplasm is immune reactive to desmin, myosin, α-smooth muscle actin, HHF35, calponin and h-caldesmon. Angioleiomyoma necessitates a segregation from angiomyolipoma, leiomyoma with bizarre nuclei, glioblastoma multiforme, arteriovenous malformation, cavernous haemangioma, angiofibroma, primary intracranial myopericytoma, glomus tumour, traumatic neuroma, eccrine spiradenoma, angiolipoma, ganglion cyst, neuroma, fibroma, lipoma, neurofibroma, neurilemmoma, salivary gland neoplasms as mucocoele, pleomorphic adenoma, vascular neoplasms as lymphangioma, haemangioma, pyogenic granuloma or dermoid cyst. Comprehensive surgical excision of the lesion with a tumour -free perimeter is an optimal treatment strategy.

scholarly journals Piloleiomyosarcoma in cats: Histological and immunohistochemical features

2021 ◽  
pp. 030098582110425
Author(s):  
Francisco Rodríguez Guisado ◽  
Pedro Luis Castro
Keyword(s):  
Smooth Muscle ◽  
Subcutaneous Tissue ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Surgical Excision ◽  
Giant Cells ◽  
Hair Follicles ◽  
Muscle Actin ◽  
Neoplastic Cells ◽  
S 100

This study describes the histomorphology and immunohistochemical profile of 9 cases of feline piloleiomyosarcoma. Cats ranged in age from 7 to 16 years (mean 10), and tumors were 7 to 24 mm in diameter (mean 15). Tumors were composed of fusiform cells that were haphazardly arranged or in variably sized interwoven bundles. Neoplastic cells had eosinophilic and fibrillar cytoplasm, and elongated blunt-ended nuclei. Entrapment of hair follicles and absence of vascular components support an origin from the smooth muscle cells of the arrector pili. Additional findings included bizarre nuclei and giant cells (7/9 cases), atypical mitoses (7/9 cases), ulceration (3/9 cases), and intratumoral necrosis (6/9 cases). Neoplastic cells expressed calponin, desmin, α-smooth muscle actin, and vimentin, but not CD18, CD31, cytokeratins, glial fibrillary acidic protein, neuron-specific enolase, Melan A, p63, or S-100 protein. Surgical excision was curative in 6/9 cases, with local recurrence in 2/9 cases and metastasis to local lymph nodes in 1/9 case. Clinical outcome was influenced by mitotic count, infiltration of subcutaneous tissue, and intensity of nuclear immunolabeling for p53.

scholarly journals Color Flow Doppler Echocardiography in Healthy Racing Pigeons (Columba livia f. domestica) and the Evidence of Physiological Blood Flow Vortex Formations

2020 ◽  
Vol 7 (2) ◽  
pp. 60
Author(s):  
Marko Legler ◽  
Lajos Koy ◽  
Norbert Kummerfeld ◽  
Michael Fehr
Keyword(s):  
Blood Flow ◽  
Pulse Repetition Frequency ◽  
Color Doppler ◽  
Columba Livia ◽  
Doppler Imaging ◽  
Color Flow ◽  
Chamber View ◽  
Flow Vortex ◽  
The Right ◽  
Ventricular Filling

In avian medicine, Doppler sonographic techniques are used to visualize and estimate blood flow in the heart. In the literature there is a lack of standardized studies of the use of color Doppler flow on healthy avian species. For this purpose, we examined blood flow in the heart in the four-chamber view of clinically healthy awake racing pigeons (n = 43) by color flow Doppler sonography. With this technique the diastolic and systolic blood flow in the heart chambers and the heart valve regions were well visualized. However, the pulse repetition frequency must be adapted to the specific blood flow velocities of the heart region to be measured to reduce aliasing in higher velocities and to visualize blood flow of lower velocities. With the help of color Doppler imaging in the four-chamber view, typical physiological atrial and ventricular blood flow vortex formations were visualized in the avian heart for the first time. In the left ventricle an asymmetric vortex ring in the passive and active ventricular filling, in the right ventricle a great counter-clockwise blood vortex in the active ventricular filling, in the left atrium a vortex clockwise, and in the right atrium counter-clockwise were observed. The knowledge of these physiological blood flow vortices is important to identify pathological blood flow.

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