The Sinewy Swirls- Angioleiomyoma

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Anubha Bajaj ◽  
Keyword(s):  
Smooth Muscle ◽  
Ganglion Cyst ◽  
Smooth Muscle Actin ◽  
Fibrous Tissue ◽  
Surgical Excision ◽  
Glomus Tumour ◽  
Tissue Cell ◽  
Muscle Fibres ◽  
Cavernous Haemangioma ◽  
Traumatic Neuroma

Angioleiomyoma is an exceptional, benign, solitary neoplasm originating from tunica media of vascular smooth muscle. The neoplasm commonly represents as a uniform, well defined, solitary, soft, nodular, gradually progressive, bluish or purple lesion commonly beneath <2 centimetres magnitude with an absence of accompanying inflammation. Tumefaction is composed of thickened smooth muscle fibres and vascular channels with circumscribing attenuated fibrous tissue capsule. Additionally, the lesion may denominate organizing thrombus, mature adipose tissue cell aggregates and lymphocytic infiltrate. The neoplasm is immune reactive to desmin, myosin, α-smooth muscle actin, HHF35, calponin and h-caldesmon. Angioleiomyoma necessitates a segregation from angiomyolipoma, leiomyoma with bizarre nuclei, glioblastoma multiforme, arteriovenous malformation, cavernous haemangioma, angiofibroma, primary intracranial myopericytoma, glomus tumour, traumatic neuroma, eccrine spiradenoma, angiolipoma, ganglion cyst, neuroma, fibroma, lipoma, neurofibroma, neurilemmoma, salivary gland neoplasms as mucocoele, pleomorphic adenoma, vascular neoplasms as lymphangioma, haemangioma, pyogenic granuloma or dermoid cyst. Comprehensive surgical excision of the lesion with a tumour -free perimeter is an optimal treatment strategy.

scholarly journals Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review

2021 ◽  
pp. 104063872199206
Author(s):  
Niora J. Fabian ◽  
Michael Y. Esmail ◽  
Lauren Richey ◽  
Sureshkumar Muthupalani ◽  
Jennifer L. Haupt ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Columba Livia ◽  
Avian Species ◽  
Doppler Imaging ◽  
Mesenchymal Tumors ◽  
Tissue Mass ◽  
Color Flow ◽  
Visceral Metastases

Cutaneous leiomyosarcomas are malignant mesenchymal tumors of smooth muscle origin and are reported occasionally in avian species. A 14-y-old male laboratory White Carneau pigeon ( Columba livia) was presented for surgical excision of a cervical soft tissue mass. Ultrasonography with color flow Doppler imaging revealed multiple cavitations of mixed echogenicity within the mass and vascularization. Histologically, the dermis and subcutis were expanded by a densely cellular multinodular mass comprised of fusiform cells forming haphazardly arranged broad streams and short interwoven bundles, often surrounding blood vessels and variably sized cavitations. Neoplastic cells were strongly immunopositive for desmin and α–smooth muscle actin, and negative for pancytokeratin, S100, and von Willebrand factor. Based on histopathology and IHC findings, the cutaneous mass was diagnosed as leiomyosarcoma (LMS). The pigeon died 312 d post-operatively. Postmortem examination revealed masses infiltrating the left and right pulmonary airways and one hepatic nodule, but no regrowth at the surgical site. Histologic and IHC evaluation of the pulmonary and hepatic masses were consistent with LMS, representing metastatic foci from the primary cutaneous LMS. Our case highlights the malignant behavior and histomorphologic features of cutaneous LMS in an avian species.

Piloleiomyosarcoma in Seven Ferrets

2001 ◽  
Vol 38 (6) ◽  
pp. 710-711 ◽  
Author(s):  
B. H. Rickman ◽  
L. E. Craig ◽  
M. H. Goldschmidt
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Muscle Actin ◽  
Mustela Putorius ◽  
Nuclear Pleomorphism ◽  
Complete Surgical Excision

In each of seven ferrets ( Mustela putorius furo) with leiomyosarcoma, a single dermal mass was identified and biopsied. Each mass consisted of a well-demarcated but nonencapsulated proliferation of large spindle- to strap-shaped cells arranged in interwoven bundles. The cells resembled the smooth muscle cells of the adjacent arrector pili muscles, but with marked nuclear pleomorphism. Immunohistochemical staining for smooth muscle actin, desmin, and vimentin was positive and staining for myoglobin and cytokeratin was negative. Follow-up on three of the ferrets indicates that the prognosis is good following complete surgical excision.

An Angiomyomatous Hamartoma With Features of Vascular Transformation of Sinuses in the Mediastinal Lymph Node of a Beagle Dog

2020 ◽  
Vol 48 (8) ◽  
pp. 1017-1024
Author(s):  
Sophie Nelissen ◽  
Ronnie Chamanza
Keyword(s):  
Smooth Muscle ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Blood Vessels ◽  
Mediastinal Lymph Node ◽  
Smooth Muscle Actin ◽  
Fibrous Tissue ◽  
Vascular Lesions ◽  
Positive Staining ◽  
Beagle Dog

Two similar benign, nonneoplastic vascular lesions have been described in the lymph nodes of humans and animals: angiomyomatous hamartoma (AMH), which is characterized by the replacement of lymphoid tissue by blood vessels, smooth muscle, and fibrous tissue, and vascular transformation of sinuses (VTS), which is considered a reactive transformation of lymph node sinuses into capillary-like vascular channels. We hereby report a lesion with features common to both lesions in the mediastinal lymph nodes of a 1-year-old beagle dog in a 1-month toxicity study. Grossly, enlargement and red discoloration were observed, while microscopically, the lesion was characterized by effacement of the lymph node parenchyma with replacement by mature blood vessels, smooth muscle, and fibrous tissue, associated with lymphoid atrophy, which is consistent with AMH. However, multifocal areas of anastomosing or plexiform capillary-like channels lined by normal to slightly plump endothelium, similar to those described for VTS, were also present. Immunohistochemistry analysis revealed abundant positive staining for smooth muscle actin and endothelial cells (von Willebrand factor/factor VIII) and the absence of proliferation (Ki67). In conclusion, these lesions most likely represent a mixture of both AMH and VTS.

Primary Leiomyosarcoma of the Pancreas

2001 ◽  
Vol 125 (1) ◽  
pp. 152-155
Author(s):  
Gabriella Nesi ◽  
Desiree Pantalone ◽  
Ilaria Ragionieri ◽  
Andrea Amorosi
Keyword(s):  
Smooth Muscle ◽  
World Literature ◽  
Soft Tissues ◽  
Malignant Tumors ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
High Rate ◽  
Complete Surgical Excision ◽  
Membrane Components ◽  
Primary Leiomyosarcoma

Abstract Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, α-smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.

scholarly journals An oncological curiosity of a male patient with a huge leiomyoma of the terminal ileum

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Syaza Zainudin ◽  
Saravana Kumar Rajanthran ◽  
Nornazirah Azizan ◽  
Firdaus Hayati ◽  
Joriana Ginawoi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Terminal Ileum ◽  
Smooth Muscle Actin ◽  
Iliac Fossa ◽  
Gastrointestinal Stromal Tumour ◽  
Right Hemicolectomy ◽  
The Body ◽  
Muscle Fibres ◽  
Smooth Muscle Tumour ◽  
The Right

Abstract Leiomyoma is a smooth muscle tumour that can arise in any part of the body especially the uterus. Even though it is traditionally linked with hormonal influence, it can also develop in extrauterine organs with a slight female predominance. It is indistinguishable with gastrointestinal stromal tumour (GIST) histologically. We report a case of a 30-year-old gentleman who presented with a huge painful mass in the right iliac fossa. Computed tomography revealed a 10 × 10 cm homogeneous mass arising from the terminal ileum; he subsequently underwent an open right hemicolectomy. Histology showed a well-circumscribed lesion composed of interlacing bundles of smooth muscle fibres of the submucosa with positive smooth muscle actin and H-Caldesmon stains but negative for DOG-1 and CD117 (c-kit) stains which were consistent with leiomyoma. Despite its rarity, this hormone-related tumour needs to be considered regardless of gender. Immunohistochemistry is paramount as it is histologically identical to GIST.

scholarly journals Glomangiomyoma of Uncertain Malignant Potential in the Urinary Bladder: A Case Report

2021 ◽  
Vol 59 (239) ◽  
Author(s):  
Sanat Chalise ◽  
Abhimanyu Jha ◽  
Prakash Raj Neupane
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Subcutaneous Tissue ◽  
Smooth Muscle Actin ◽  
Bladder Tumour ◽  
Malignant Potential ◽  
Glomus Tumour ◽  
Uncertain Malignant Potential ◽  
Ki 67 ◽  
Unusual Variant

Glomus tumour typically occurs in subcutaneous tissue but rarely in the visceral organs. Most glomus tumours are benign but few atypical glomus tumours have been reported. Herein, we report a case of a 44-year-old male who presented with hematuria. Transurethral resection of bladder tumour was done. Microscopic examination showed nests and sheets of tumor around the blood vessels. Spindle cells resembling smooth muscle were also observed. An increase in mitosis was observed. These tumour cells show diffuse and strong cytoplasmic positivity for smooth muscle actin and negative for Pancytokeratin, Desmin, Synaptophysin, Chromogranin, S100, and Cluster of Differentiation 34. Ki-67 index was approximately 5%. To our knowledge, this is the first report of Glomangiomyoma of uncertain malignant potential in the urinary bladder which is considered as an unusual variant of atypical glomus tumor. This case emphasizes the importance of broad differential diagnosis which has to be considered in the urinary bladder mass.

Dacryops (Lacrimal Cyst) in Three Young Labrador Retrievers

2009 ◽  
Vol 45 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Juri Ota ◽  
Jacqueline W. Pearce ◽  
Michael J. Finn ◽  
Gayle C. Johnson ◽  
Elizabeth A. Giuliano
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Case Series ◽  
Surgical Excision ◽  
Cystic Mass ◽  
Muscle Actin ◽  
Aspiration Cytology ◽  
History Of ◽  
The Masses ◽  
Labrador Retrievers

This case series constitutes a report of dacryops in multiple Labrador retrievers and the use of smooth-muscle actin immunostaining to confirm the lacrimal duct origins of the cyst wall. Three Labrador retrievers were presented with a history of a slowly enlarging mass adjacent to the left medial canthus. Ultrasonography of the masses revealed they were each spherical, thin-walled cystic structures. Aspiration cytology was performed in two cases revealing mixed inflammation and absence of detectable microorganisms. Dacryocystorhinography of the left nasolacrimal system performed in two cases revealed a normal nasolacrimal system that was closely associated, but not communicating with, the cystic mass in both cases. Surgical excision of all cysts was curative. Histopathology and positive immunohistochemical staining for smooth-muscle actin confirmed a diagnosis of dacryops in all cases.

Evaluation of the efficacy of foam sclerosant after addition of glycerine on human great saphenous vein: histological and immunohistochemical study

2021 ◽  
Author(s):  
A Sawaby ◽  
S Maklad ◽  
I Atta ◽  
A El Abd ◽  
MM Mady ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Varicose Vein ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Treatment Modalities ◽  
Muscle Fibres ◽  
Vein Wall ◽  
Saphenous Veins ◽  
The Media

Introduction Several treatment modalities have been postulated to improve the efficacy of varicose vein treatment. Addition of glycerine to the sclerosing material has been documented to increase its viscosity and subsequently prolong the duration of stability, in addition to the direct sclerosing effect of glycerine. This histological and immunohistochemical study investigated the efficacy of addition of glycerine 72% to sclerotherapy on the human varicose vein. Methods After surgical stripping of great saphenous veins, three equal segments were resected between two clamps. Specimen 1 was injected with saline only, specimen 2 was exposed to foam sclerosant 2%, and specimen 3 was exposed to a mixture of foam sclerosant 2% and glycerine 72%. All segments were left for 5min. Vein segments were then processed for histological and immunohistochemical study. Results Microscopically, haematoxylin and eosin-stained specimen 1 showed endothelial swelling, cytoplasmic eosinophilia and pyknotic nuclei. The media showed sarcoplasm vacuolisation and necrosis. Specimen 3 showed hypereosinophilic sarcoplasm of the smooth muscle fibres. Oedema was less evident, with a relative decrease in the thickness of the wall compared with specimen 2. Immunohistochemically, the expression of smooth muscle actin was weak in specimen 3 compared with specimens 1 and 2. Expression of CD31 antibody was much reduced in specimen 2 which showed conserved islands of endothelial cells. By contrast, there was a complete loss of endothelial cells in specimen 3. Conclusion Addition of glycerine 72% to foam sclerosant has a more damaging effect on human vein wall.

scholarly journals Piloleiomyosarcoma in cats: Histological and immunohistochemical features

2021 ◽  
pp. 030098582110425
Author(s):  
Francisco Rodríguez Guisado ◽  
Pedro Luis Castro
Keyword(s):  
Smooth Muscle ◽  
Subcutaneous Tissue ◽  
Smooth Muscle Actin ◽  
Neuron Specific Enolase ◽  
Surgical Excision ◽  
Giant Cells ◽  
Hair Follicles ◽  
Muscle Actin ◽  
Neoplastic Cells ◽  
S 100

This study describes the histomorphology and immunohistochemical profile of 9 cases of feline piloleiomyosarcoma. Cats ranged in age from 7 to 16 years (mean 10), and tumors were 7 to 24 mm in diameter (mean 15). Tumors were composed of fusiform cells that were haphazardly arranged or in variably sized interwoven bundles. Neoplastic cells had eosinophilic and fibrillar cytoplasm, and elongated blunt-ended nuclei. Entrapment of hair follicles and absence of vascular components support an origin from the smooth muscle cells of the arrector pili. Additional findings included bizarre nuclei and giant cells (7/9 cases), atypical mitoses (7/9 cases), ulceration (3/9 cases), and intratumoral necrosis (6/9 cases). Neoplastic cells expressed calponin, desmin, α-smooth muscle actin, and vimentin, but not CD18, CD31, cytokeratins, glial fibrillary acidic protein, neuron-specific enolase, Melan A, p63, or S-100 protein. Surgical excision was curative in 6/9 cases, with local recurrence in 2/9 cases and metastasis to local lymph nodes in 1/9 case. Clinical outcome was influenced by mitotic count, infiltration of subcutaneous tissue, and intensity of nuclear immunolabeling for p53.

scholarly journals Myofibroblastic Dermatofibroma: An Unusual Variant / Miofibroblastni Dermatofibrom: Neuobičajena Varijacija

2009 ◽  
Vol 1 (1) ◽  
pp. 34-37
Author(s):  
Cynthia Okoduwa ◽  
Robyn D. Siperstein ◽  
Wen Chen ◽  
Rajit Malliah ◽  
Valerie Fitzhugh ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Fibrous Tissue ◽  
Factor Xiiia ◽  
Muscle Actin ◽  
Fixed Tissue ◽  
S 100 ◽  
Unusual Variant ◽  
Tissue Specimens ◽  
Myofibroblastic Differentiation

Abstract Myofibroblastic dermatofibroma (MFD) is an unusual neoplasm characterized by a predominance of myofibroblastic differentiation. It is extremely rare and it is not well described. Expressions of smooth muscle actin, CD34, S-100, desmin, CD31, and Factor XIIIa were evaluated along with hematoxylin-eosin and trichrome staining of fixed tissue specimens from a fibrohistiocytic neoplasm. The neoplasm demonstrated a storiform pattern characteristic of fibrohistiocytic origin. It was strongly and diffusely positive for smooth muscle actin and vimentin, and negative for all other stains performed. A trichrome stain showed the entire tumor to be blue, demonstrating the collagenous and fibrous tissue to a marked degree. MFD is a distinct variant of dermatofibroma characterized by a predominance of myofibroblastic differentiation.

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