Three-Dimensional Printing of Prenatal Ultrasonographic Diagnosis of Cleft Lip and Palate: Presenting the Needed “Know-How” and Discussing Its Use in Parental Education

2020 ◽  
Vol 57 (8) ◽  
pp. 1041-1044
Author(s):  
Matthias Schlund ◽  
Jean-Marc Levaillant ◽  
Romain Nicot
Keyword(s):  
Parental Education ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
3D Models ◽  
Prenatal Counseling ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
3D Information ◽  
Dimensional Printing

Parental prenatal counseling is of paramount significance since parents often experience an emotional crisis with feelings of disappointment and helplessness. Three-dimensional (3D) printed model of the unborn child’s face presenting with cleft lip and palate, based on ultrasonographic information, could be used to provide visual 3D information, further enhancing the prospective parent’s comprehension of their unborn child’s pathology and morphology, helping them to be psychologically prepared and improving the communication with the caretaking team. Prospective parents appreciate if prenatal counseling is available with the most detailed information as well as additional resources. The technique necessary to create 3D models after ultrasonographic information is explained, and the related costs are evaluated. The use of such models in parental education is then discussed.

3D-Printed Models of Cleft Lip and Palate for Surgical Training and Patient Education

2017 ◽  
Vol 55 (3) ◽  
pp. 323-327 ◽  
Author(s):  
Pang-Yun Chou ◽  
Rami R. Hallac ◽  
Ellen Shih ◽  
Jenny Trieu ◽  
Anjani Penumatcha ◽  
...  
Keyword(s):  
Patient Education ◽  
Cleft Palate ◽  
Parental Education ◽  
Cleft Lip ◽  
Soft Tissues ◽  
Cleft Lip And Palate ◽  
3D Models ◽  
Physical Models ◽  
3D Printed ◽  
Manufacturing Techniques

Background: Sculpted physical models and castings of the anatomy of cleft lip and palate are used for parent, patient, and trainee education of cleft lip and palate conditions. In this study, we designed a suite of digital 3-dimensional (3D) models of cleft lip and palate anatomy with additive manufacturing techniques for patient education. Methods: CT scans of subjects with isolated cleft palate, unilateral and bilateral cleft lip and palate, and a control were obtained. Soft tissue and bony structures were segmented and reconstructed into digital 3D models. The oral soft tissues overlying the cleft palate were manually molded with silicone putty and scanned using CT to create digital 3D models. These were then combined with the original model to integrate with segmentable soft tissues. Bone and soft tissues were 3D printed in different materials to mimic the rigidity/softness of the relevant anatomy. These models were presented to the parents/patients at our craniofacial clinic. Visual analog scale (VAS) surveys were obtained pertaining to the particular use of the models, to ascertain their value in parental education. Results: A total of 30 parents of children with cleft conditions completed VAS evaluations. The models provided the parents with a better understanding of their child’s condition with an overall evaluation score of 9.35 ± 0.5. Conclusions: We introduce a suite of 3D-printed models of cleft conditions that has a useful role in patient, parental, and allied health education with highly positive feedback.

scholarly journals Three-dimensional Printing of Models of Cleft Lip and Palate

2016 ◽  
Vol 4 (4) ◽  
pp. e689 ◽  
Author(s):  
Wenceslao M. Calonge ◽  
Ahmad B. AlAli ◽  
Michelle Griffin ◽  
Peter E. Butler
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Dimensional Printing

scholarly journals 3D printing technologies in the treatment of patients with injuries and diseases of the forearm and hand

2020 ◽  
Vol 22 (1) ◽  
pp. 113-118
Author(s):  
V V Khominets ◽  
S A Peleshok ◽  
D A Volov ◽  
M V Titova ◽  
M I Eliseeva ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Swelling Pressure ◽  
3D Models ◽  
3D Scanner ◽  
Three Dimensional Printing ◽  
The Past ◽  
3D Printed ◽  
The Individual ◽  
Dimensional Printing

In the last decade, the range of applications of three-dimensional printing (3D printing) in surgery has been expanding. In traumatology, orthopedics and rehabilitation of injuries of the upper limbs, there is growing interest in creating splints and orthoses that can take into account the individual anatomical features of the human body. Traditional orthoses and splints are not always convenient and can lead to undesirable consequences such as pain, swelling, pressure, or even lack of therapeutic effect. The prospects of 3D printing technology in medicine from the beginning of its mass introduction, the features of modeling, manufacturing and application of means for immobilization of injuries and diseases of the upper extremities according to domestic and foreign publications over the past 5 years are considered. The data on the functionality of 3D-printed tire structures and orthoses used to immobilize the upper limb are analyzed in comparison with traditional methods of fixation. Three-dimensional images of patients with injuries obtained using computed tomography, magnetic resonance imaging or using a 3D scanner can be used to create virtual 3D models of the forearm, wrist, fingers of the patient, and 3D printing with these anatomical models allows you to create personalized tires and orthoses. Thanks to an individual approach and the use of various solutions, three-dimensional printing can be widely used in traumatology and orthopedics. As a result of this approach, it becomes possible to implement and effectively use a variety of solutions that will find support in healthcare.

scholarly journals Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution

2021 ◽  
Vol 5 (1) ◽  
pp. 15
Author(s):  
Nuno Venâncio ◽  
Gabriela G. Pereira ◽  
João F. Pinto ◽  
Ana I. Fernandes
Keyword(s):  
Three Dimensional ◽  
Drug Dissolution ◽  
Fused Deposition Modelling ◽  
Three Dimensional Printing ◽  
Preliminary Results ◽  
Fused Deposition ◽  
3D Printed ◽  
Dimensional Printing ◽  
Hot Melt ◽  
Patient Centric

Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect of infill geometry (cross, star, grid) on drug content and release are reported.

3D-Printed Conductive Filaments Based on Carbon Nanostructures Embedded in a Polymer Matrix

2021 ◽  
pp. 1725-1742
Author(s):  
Diogo José Horst ◽  
Pedro Paulo Andrade Junior
Keyword(s):  
Polymer Matrix ◽  
Carbon Nanostructures ◽  
Three Dimensional ◽  
Full Potential ◽  
Electrically Conductive ◽  
Three Dimensional Printing ◽  
Current State ◽  
3D Printed ◽  
The Subject ◽  
Dimensional Printing

Conductive and magnetic filaments are revolutionizing three-dimensional printing (3DP) to a new level. This review study presents the current state of the art on the subject, summarizing recent high impact studies about main advances regarding the application of 3DP filaments based on carbon nanostructures such as graphene, carbon fibers, nanotubes, and conductive carbon black embedded in a polymer matrix, by reviewing its main characteristics and showing the main producers and also the products available on the market. The availability of inexpensive, reliable, and electrically conductive material will be indispensable for the fabrication of circuits and sensors before the full potential of 3DP for customized products incorporating electrical elements can be fully explored.

scholarly journals 3D-Printed Soft Structure of Polyurethane and Magnetorheological Fluid: A Proof-of-Concept Investigation of its Stiffness Tunability

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 655 ◽  
Author(s):  
Seong-Woo Hong ◽  
Ji-Young Yoon ◽  
Seong-Hwan Kim ◽  
Sun-Kon Lee ◽  
Yong-Rae Kim ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Permanent Magnets ◽  
Thermoplastic Polyurethane ◽  
Three Dimensional ◽  
Magnetorheological Fluid ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Dimensional Printing

In this study, a soft structure with its stiffness tunable by an external field is proposed. The proposed soft beam structure consists of a skin structure with channels filled with a magnetorheological fluid (MRF). Two specimens of the soft structure are fabricated by three-dimensional printing and fused deposition modeling. In the fabrication, a nozzle is used to obtain channels in the skin of the thermoplastic polyurethane, while another nozzle is used to fill MRF in the channels. The specimens are tested by using a universal tensile machine to evaluate the relationships between the load and deflection under two different conditions, without and with permanent magnets. It is empirically shown that the stiffness of the proposed soft structure can be altered by activating the magnetic field.

3D-Printed Conductive Filaments Based on Carbon Nanostructures Embedded in a Polymer Matrix

2019 ◽  
Vol 4 (1) ◽  
pp. 26-40 ◽  
Author(s):  
Diogo José Horst ◽  
Pedro Paulo Andrade Junior
Keyword(s):  
Polymer Matrix ◽  
Carbon Nanostructures ◽  
Three Dimensional ◽  
Full Potential ◽  
Electrically Conductive ◽  
Three Dimensional Printing ◽  
Current State ◽  
3D Printed ◽  
The Subject ◽  
Dimensional Printing

Conductive and magnetic filaments are revolutionizing three-dimensional printing (3DP) to a new level. This review study presents the current state of the art on the subject, summarizing recent high impact studies about main advances regarding the application of 3DP filaments based on carbon nanostructures such as graphene, carbon fibers, nanotubes, and conductive carbon black embedded in a polymer matrix, by reviewing its main characteristics and showing the main producers and also the products available on the market. The availability of inexpensive, reliable, and electrically conductive material will be indispensable for the fabrication of circuits and sensors before the full potential of 3DP for customized products incorporating electrical elements can be fully explored.

scholarly journals Utility of Three-Dimensional Printing for Preoperative Assessment of Children with Extra-Cranial Solid Tumors: A Systematic Review

2022 ◽  
Vol 14 (1) ◽  
pp. 32-39
Author(s):  
Sachit Anand ◽  
Nellai Krishnan ◽  
Prabudh Goel ◽  
Anjan Kumar Dhua ◽  
Vishesh Jain ◽  
...  
Keyword(s):  
Systematic Review ◽  
3D Printing ◽  
Solid Tumors ◽  
Surgical Planning ◽  
Three Dimensional ◽  
Current Evidence ◽  
Printing Technology ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Dimensional Printing

Background: In cases with solid tumors, preoperative radiological investigations provide valuable information on the anatomy of the tumor and the adjoining structures, thus helping in operative planning. However, due to a two-dimensional view in these investigations, a detailed spatial relationship is difficult to decipher. In contrast, three-dimensional (3D) printing technology provides a precise topographic view to perform safe surgical resections of these tumors. This systematic review aimed to summarize and analyze current evidence on the utility of 3D printing in pediatric extra-cranial solid tumors. Methods: The present study was registered on PROSPERO—international prospective register of systematic reviews (registration number: CRD42020206022). PubMed, Embase, SCOPUS, and Google Scholar databases were explored with appropriate search criteria to select the relevant studies. Data were extracted to study the bibliographic information of each article, the number of patients in each study, age of the patient(s), type of tumor, organ of involvement, application of 3D printing (surgical planning, training, and/or parental education). The details of 3D printing, such as type of imaging used, software details, printing technique, printing material, and cost were also synthesized. Results: Eight studies were finally included in the systematic review. Three-dimensional printing technology was used in thirty children with Wilms tumor (n = 13), neuroblastoma (n = 7), hepatic tumors (n = 8), retroperitoneal tumor (n = 1), and synovial sarcoma (n = 1). Among the included studies, the technology was utilized for preoperative surgical planning (five studies), improved understanding of the surgical anatomy of solid organs (two studies), and improving the parental understanding of the tumor and its management (one study). Computed tomography and magnetic resonance imaging were either performed alone or in combination for radiological evaluation in these children. Different types of printers and printing materials were used in the included studies. The cost of the 3D printed models and time involved (range 10 h to 4–5 days) were reported by two studies each. Conclusions: 3D printed models can be of great assistance to pediatric surgeons in understanding the spatial relationships of tumors with the adjacent anatomic structures. They also facilitate the understanding of families, improving doctor–patient communication.

scholarly journals Metabolism Control in 3D Printed Living Materials

2021 ◽  
Author(s):  
Tobias Butelmann ◽  
Hans Priks ◽  
Zoel Parent ◽  
Trevor G. Johnston ◽  
Tarmo Tamm ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Terminal Electron Acceptor ◽  
Three Dimensional Printing ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Brewing Process ◽  
3D Printed ◽  
Dimensional Printing ◽  
Living Materials

AbstractThe three-dimensional printing of cells offers an attractive opportunity to design and develop innovative biotechnological applications, such as the fabrication of biosensors or modular bioreactors. Living materials (LMs) are cross-linked polymeric hydrogel matrices containing cells, and recently, one of the most deployed LMs consists of F127-bis-urethane methacrylate (F127-BUM). The material properties of F127-BUM allow reproducible 3D printing and stability of LMs in physiological environments. These materials are permissible for small molecules like glucose and ethanol. However, no information is available for oxygen, which is essential— for example, towards the development of aerobic bioprocesses using microbial cell factories. To address this challenge, we investigated the role of oxygen as a terminal electron acceptor in the budding yeast’s respiratory chain and determined its permissibility in LMs. We quantified the ability of cell-retaining LMs to utilize oxygen and compared it with cells in suspension culture. We found that the cells’ ability to consume oxygen was heavily impaired inside LMs, indicating that the metabolism mostly relied on fermentation instead of respiration. To demonstrate an application of these 3D printed LMs, we evaluated a comparative brewing process. The analysis showed a significantly higher (3.7%) ethanol production using 3D printed LMs than traditional brewing, indicating an efficient control of the metabolism. Towards molecular and systems biology studies using LMs, we developed a highly reliable method to isolate cells from LMs for flow cytometry and further purified macromolecules (proteins, RNA, and DNA). Our results show the application of F127-BUM-based LMs for microaerobic processes and envision the development of diverse bioprocesses using versatile LMs in the future.

scholarly journals Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration: A Literature Review

2020 ◽  
Vol 9 (12) ◽  
pp. 4008
Author(s):  
Simon Raveau ◽  
Fabienne Jordana
Keyword(s):  
Selective Laser Sintering ◽  
Periodontal Regeneration ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Natural Polymers ◽  
Three Dimensional Printing ◽  
Computer Assisted Design ◽  
New Ideas ◽  
3D Printed ◽  
Dimensional Printing

The three-dimensional printing of scaffolds is an interesting alternative to the traditional techniques of periodontal regeneration. This technique uses computer assisted design and manufacturing after CT scan. After 3D modelling, individualized scaffolds are printed by extrusion, selective laser sintering, stereolithography, or powder bed inkjet printing. These scaffolds can be made of one or several materials such as natural polymers, synthetic polymers, or bioceramics. They can be monophasic or multiphasic and tend to recreate the architectural structure of the periodontal tissue. In order to enhance the bioactivity and have a higher regeneration, the scaffolds can be embedded with stem cells and/or growth factors. This new technique could enhance a complete periodontal regeneration. This review summarizes the application of 3D printed scaffolds in periodontal regeneration. The process, the materials and designs, the key advantages and prospects of 3D bioprinting are highlighted, providing new ideas for tissue regeneration.

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