Evaluating the Effect of Low Power Diode Laser 806 nm on the Healing of Unilateral Cleft Lip Scar: An Open-Label Comparative Study

Objective To investigate the effect of laser bio-modulation irradiation therapy on the scar after surgical correction of unilateral cleft lip. Design a comparative, open-label study. Setting we conducted the study in a university based tertiary hospital that recruited early wound healers of unilateral cleft lip correction. Patients Eighty patients were divided into two groups: In study's group, patients undergo laser bio-modulation irradiation (n = 60); in the control group, patients were followed-up without intervention (n = 20). Intervention In the study's group, patients underwent low-power diode Laser with wavelength of 806 nm and power of 100 mw. Main outcome The change in the scar of cleft lip patients, which was assessed by clinical examination and ultrasound. Results The median pigmentation score was significantly lower in the laser group (median = 1; IQR = 1–2) than the control group (median 2; IQR 1–3), with p-value of <0.001. Likewise, the median height score was significantly lower in the laser group (median = 1; IQR = 1–1) than the control group (median 1.5; IQR 1.5–2), with p-value of 0.001. The median pliability score was significantly lower in the laser group (median = 1; IQR = 1–1) than the control group (median 2.5; IQR 1–3), with p-value of <0.001. Finally, the median vascularity score was significantly lower in the laser group (median = 1; IQR = 1–1) than the control group (median 1.5; IQR 1–2), with p-value of <0.001. Conclusion laser bio-modulation irradiation therapy demonstrates a potential efficacy in managing the hypertrophic scars after surgical repair of unilateral cleft lip.

Download Full-text

High-power diode laser for second-stage implant surgery: a randomized pilot clinical trial

Research Society and Development ◽

10.33448/rsd-v9i7.4122 ◽

2020 ◽

Vol 9 (7) ◽

pp. e128974122

Author(s):

Geise da Silva Grigio ◽

Ricardo Yudi Tateno ◽

Luiz Felipe Palma ◽

Caleb Shitsuka ◽

Wilson Roberto Sendyk ◽

...

Keyword(s):

Diode Laser ◽

High Power ◽

Control Group ◽

Surgical Time ◽

Implant Surgery ◽

Second Stage ◽

Bone Level ◽

Laser Group ◽

Power Diode ◽

High Power Diode Laser

The present study aimed to compare the conventional scalpel technique and the use of a high-power diode laser for second-stage implant surgery. For that, fifteen patients were randomly assigned to receive either the conventional scalpel technique (Control Group, n = 7) or a diode laser-assisted technique (Laser Group, n = 8) for second-stage surgery of submerged dental implants placed at bone level. The local anesthetic amount required, and the total surgical time was determined just after surgery. Local pain, peri-implant mucosa status, and bleeding were assessed at the end of the surgery and after 7 and 15 days. Information on the need for postoperative pain medication on the first day and during the next two weeks was also gathered. The surgical time was significantly shorter in the Laser Group (P = 0.001) and only the Control Group presented bleeding at the end of surgery and on the seventh day (P = <0.001, P = 0.026). The other evaluations did not show differences between the groups. Within the limitations of the present pilot study and in comparison to clinical outcomes of the conventional scalpel technique, the use of a high-power diode laser seems to be slightly advantageous for the second-stage implant surgery.

Download Full-text

Effect of conversion from calcineurin inhibitors to everolimus on hepatitis C viremia in adult kidney transplant recipients

Brazilian Journal of Nephrology ◽

10.1590/2175-8239-jbn-3860 ◽

2018 ◽

Vol 40 (2) ◽

pp. 143-150 ◽

Cited By ~ 1

Author(s):

Larissa Sgaria Pacheco ◽

Valter Duro Garcia ◽

Ronivan Luis Dal Prá ◽

Bruna Doleys Cardoso ◽

Mariana Ferras Rodrigues ◽

...

Keyword(s):

Hepatitis C ◽

Controlled Trial ◽

Calcineurin Inhibitors ◽

Control Group ◽

P Value ◽

Kidney Transplant Recipients ◽

Positive Serology ◽

Open Label ◽

Adult Kidney ◽

Group 1

ABSTRACT Introduction: Currently, there is no specific immunosuppressive protocol for hepatitis C (HCV)-positive renal transplants recipients. Thus, the aim of this study was to evaluate the conversion effect to everolimus (EVR) on HCV in adult kidney recipients. Method: This is an exploratory single-center, prospective, randomized, open label controlled trial with renal allograft recipients with HCV-positive serology. Participants were randomized for conversion to EVR or maintenance of calcineurin inhibitors. Results: Thirty patients were randomized and 28 were followed-up for 12 months (conversion group, Group 1 =15 and control group, Group 2 =13). RT-PCR HCV levels reported in log values were comparable in both groups and among patients in the same group. The statistical analysis showed no interaction effect between time and group (p value G*M= 0.852), overtime intra-groups (p-value M=0.889) and between group (p-value G=0.286). Group 1 showed a higher incidence of dyslipidemia (p=0.03) and proteinuria events (p=0.01), while no difference was observed in the incidence of anemia (p=0.17), new onset of post-transplant diabetes mellitus (p=1.00) or urinary tract infection (p=0.60). The mean eGFR was similar in both groups. Conclusion: Our study did not show viral load decrease after conversion to EVR with maintenance of antiproliferative therapy.

Download Full-text

A CLINICAL STUDY TO ASSESS THE EFFICACY OF SHWASAHARA DASHEMANI GHANAVATI IN CARDIAC ASTHMA W.S.R L.V.F

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj04p6012021 ◽

2021 ◽

Vol p6 (1) ◽

pp. 3179-3185

Author(s):

Roopa M.R ◽

Vasudev A Chate ◽

Shreevathsa Shreevathsa ◽

Mohan Kumar G

Keyword(s):

Standard Treatment ◽

Intervention Group ◽

Simple Random Sampling ◽

Control Group ◽

P Value ◽

Common Symptom ◽

Open Label ◽

Post Test ◽

Clinically Significant ◽

Cardiac Asthma

Introduction: Shwasa is said as Shigrapranahara Roga. It occurs as the main disease and also a symptom in various diseases. Shwasakruchrata is a common symptom that occurs in Hrudroga. Acharya Charaka mentioned the unique classification of drugs based on their action. Shwasahara Dashemani is one among them. It is containing 10 herbal drugs which are specially indicated in Shwasa Roga. Hence to evaluate the efficacy of Shwasahara Dashemani in Lakshana Roopi Shwasa in L.V.F (Cardiac Asthma) has taken for the study. Aim and Objective: The objective is to assess the efficacy of Shwasahara Dashemani in L.V.F with dyspnea (Cardiac Asthma). Method: The present study is a controlled comparative, open-label, clinical trial with pre and post-test design. A total of 40 subjects of a diagnosed case of L.V.F with dyspnea (Cardiac Asthma) were selected by using a simple random sampling method. Control group subjects were intervened with standard treatment of L.V.F and intervention group subjects were intervened with standard treatment of L.V.F along with Shwasahara Dashemani Ghana Vati, for the duration of 30 days. Its efficacy was assessed before treatment (0th day) and after treatment (31st day) by using BDI (Baseline Dyspnea Index Scale). Results: The P-value of dyspnea of the control group is 1.000 and the P-value of dyspnea of the intervention group is 0.105. This shows that the results of both groups are statistically not significant. But as compared to the control group, the intervention group is clinically significant because after the intervention 35% of subjects had shown improvement in the intervention group. Conclusion: As compared to the control group, in the intervention group Shwasahara Dashemani Ghanavati is clinically significant in relieving cardiac asthma when used with standard treatment of L.V.F. Keyword: Shwasahara Dashemani. Cardiac Asthma, L.V.F, Dyspnea

Download Full-text

A prospective, open label, randomized-controlled study to evaluate the efficacy and safety of Herbovir syrup in mildly symptomatic COVID-19 patients

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20205548 ◽

2020 ◽

Vol 10 (1) ◽

pp. 106

Author(s):

A. Gopal Rao ◽

Shankar Achar Somashekar ◽

Poorna Prasad ◽

Manjunath Reddy Lekkala ◽

Sreenivasa Hanumanthaiah ◽

...

Keyword(s):

Clinical Symptoms ◽

Standard Of Care ◽

Pulmonary Complications ◽

Controlled Study ◽

Control Group ◽

P Value ◽

Immune Markers ◽

Open Label ◽

Early Recovery ◽

D Dimer

Background: COVID-19 patients experience cytokine storm which cause pulmonary and extra-pulmonary complications. Effective antiviral and immune boosters are need of hour to treat COVID-19 as well as post COVID complications.Methods: In this study involving mild COVID-19 we randomized 40 patients to receive a Herbovir syrup along with standard of care (SOC) or SOC alone in 1:1 ratio. We evaluated the benefits of Herbovir syrup by assessing clinical outcomes and improvement in immune markers (LDH, CRP, D-dimer).Results: At the end of the study the immune markers in Herbovir group improved significant compared to control group. In patients who received Herbovir, LDH decreased from 334 U/l at baseline to 254 U/l at the end of treatment (p value <0.009), CRP decreased from 7.4 mg/l to 3.1 mg/l (p value=0.0171) and D-dimer decreased from 0.610 mg/l at baseline to 318 mg/l at the end of study (p value=0.001). TLC values did not go below normal range in Herbovir group whereas 8 patients in control group had low TLC at the end of study. Early recovery from COVID 19 symptoms was observed in >75% patients in Herbovir treated group.Conclusions: Herbovir accelerated recovery of COVID-19 patients by early improvement in clinical symptoms and immune markers in this study and results clearly indicates that Herbovir syrup has antiviral, immune booster activity and has definitive role in the management of mild COVID-19 patients along with standard of care. (Funded by Venkat pharma. CTRI no. CTRI/2020/08/027041).

Download Full-text

COMPARATIVE EVALUATION OF EFFICACY OF SCALING AND ROOT PLANING WITH AND WITHOUT CHLORHEXIDINE CHIP AND DIODE LASER IN CHRONIC PERIODONTITIS PATIENTS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i11.2287 ◽

2021 ◽

Vol 5 (11) ◽

Author(s):

Reya Shree ◽

Varun Dahiya ◽

Pradeep Shukla ◽

Prerna Kataria ◽

Mona Dagar

Keyword(s):

Diode Laser ◽

Chronic Periodontitis ◽

Control Group ◽

Clinical Parameters ◽

Scaling And Root Planing ◽

Pocket Depth ◽

Probing Pocket Depth ◽

Root Planing ◽

Before And After ◽

Laser Group

Introduction: The motive of the present study is to comparatively measure the competence and effectiveness of diode laser and chlorhexidine chip as adjuncts to the scaling and root planing procedure, in patients with chronic periodontitis. Aim: To evaluate the efficacy of diode laser and chlorhexidine chip before and after scaling and root planing in the management of chronic periodontitis. The objective is to compare the efficacy of chlorhexidine chip and diode laser before and after scaling and root planning on clinical parameters. Study and design: Randomized clinical trial with split mouth design done in the Department of Periodontics and Implantology. Materials and methods: Twenty chronic periodontitis patients having a probing pocket depth of 5mm-7mm on at least one interproximal site in each quadrant of the mouth were selected in the study. After initial treatment, four sites in each patient were randomly subjected to scaling and root planing (control), chlorhexidine chip application (CHX chip group), diode laser (810 nm) decontamination (Diode laser group) or combination of both (Diode laser and chip group). All subjects received a clinical periodontal examination by single examiner who recorded all the variables by manual procedure. Clinical parameters namely Plaque index (PI), Gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, one month and three months. Results were statistically analysed using one-way ANOVA followed by Post Hoc Analysis. Results: The differences in PPD reduction and CAL gain between control group and CHX chip and combination groups were statistically significant (p<0.05) at three months, whereas, the diode laser group did not show any significant difference from the control group. Conclusion: Within the limitations in the present study, the following conclusions were derived, i.e., chlorhexidine local delivery alone or in combination with diode laser decontamination is effective in improving oral hygiene, reducing gingival inflammation, reducing probing pocket depth and improving clinical attachment levels when used as adjuncts to scaling and root planing in non-surgical periodontal therapy of patients with chronic periodontitis. Keywords: Diode laser decontamination, Local drug delivery, Scaling and root planing.

Download Full-text

Evaluation of the Effects of 660-nm and 810-nm Low-Level Diode Lasers on the Treatment of Dentin Hypersensitivity

Journal of lasers in medical sciences ◽

10.34172/jlms.2020.22 ◽

2020 ◽

Vol 11 (2) ◽

pp. 126-134

Author(s):

Narges Naghsh ◽

Mahdi Kachuie ◽

Marzie Kachuie ◽

Reza Birang

Keyword(s):

Diode Laser ◽

Repeated Measures ◽

Diode Lasers ◽

Tooth Surface ◽

Control Group ◽

Dentin Hypersensitivity ◽

Double Blind ◽

Group I ◽

Significant Difference ◽

Laser Group

Introduction: Dentin hypersensitivity is a common oral problem that occurs as a short and sharp pain. There are many techniques to treat this condition, the latest of which is laser treatment. The aim of this study was to evaluate the effect of two types of low-power diode lasers (660 nm and 810 nm) on dentin hypersensitivity in order to achieve an acceptable clinical application by adjusting the effective parameters. Methods: In this randomized, double-blind clinical trial, sensitive teeth of 7 patients were divided into three groups with a randomized matching method: group I, treated with 660-nm diode laser irradiation, group II, treated with diode laser 810-nm, and group III, the control group. Irradiation parameters for 660-nm and 810-nm diode lasers were the power of 30 mW and 100 mW respectively, in contact and continuous modes, perpendicular to the tooth surface with a sweeping motion. Treatments were carried out in four sessions at weekly intervals. The data obtained were analyzed with SPSS 22, using one-way repeated measures ANOVA and the LSD (least significant difference) test. The significance level was considered as P≤0.05. Results: There were no significant differences in visual analogue scale (VAS) score changes between the two laser groups after the intervention in the first, second and third weeks compared to the baseline (P>0.05). These changes in the fourth week were significantly higher in the 810-nm laser group compared to the 660-nm laser group (P=0.04), and in the 660-nm laser group, they were more than the control group (P=0.02). The mean VAS scores at 1-week, 1-month and 2-month postoperative intervals were significantly lower in the 810-nm laser group than in the 660-nm laser group, and in the 660-nm laser group, they were less than the control group (P<0.001). Conclusion: The use of 660-nm and 810-nm diode lasers with the power of 30 and 100 mW respectively for 120 seconds was effective in reducing pain in patients with dentin hypersensitivity. However, the effect of the 810-nm laser on reducing the dentin hypersensitivity was more long-lasting than that of the 660-nm laser.

Download Full-text

The effects of photobiomodulation therapy for the treatment of dentin hypersensitivity

Clinical and Laboratorial Research in Dentistry ◽

10.11606/issn.2357-8041.clrd.2020.162971 ◽

2020 ◽

Author(s):

Erika Michele dos Santos Araújo ◽

Bárbara Fávero Araújo Lima ◽

Júlia Gomes Lúcio de Araújo ◽

Fernanda Cristina Nogueira Rodrigues ◽

Stella Ferreira do Amaral ◽

...

Keyword(s):

Case Report ◽

Visual Analogue Scale ◽

Low Power ◽

Diode Laser ◽

Male Patient ◽

Analogue Scale ◽

Dentin Hypersensitivity ◽

Cervical Lesions ◽

Patient Reported ◽

Power Diode

Objective: This case report proposes a treatment for dentin hypersensitivity (DH) using photobiomodulation (PBT) with low power diode laser. Methods and Results: Male patient, 28 years old, reporting “dental sensitivity,” diagnosed by anamnesis and intraoral examination, with non-carious cervical lesions (NCCL) and DH on teeth 15 to 25, with different pain intensities, measured with visual analogue scale (VAS). For DH treatment, a PBT was proposed, with 808nm, 100mW, 20s and 2J of energy, applied during 3 sessions, with one-week interval and reevaluation after 30 days. After the first session, the patient reported improvement of sensitivity in all teeth, except for 15, that remained sensitive even during the reevaluation. Conclusion: PBT was effective in DH treatment, with desensitization being observed for 30 days in 90% of treated teeth.

Download Full-text

Activation of C-fiber nociceptors by low-power diode laser

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160018 ◽

2016 ◽

Vol 74 (3) ◽

pp. 223-227 ◽

Cited By ~ 2

Author(s):

Eduardo Azevedo ◽

Andressa Silva ◽

Raquel Martins ◽

Monica L. Andersen ◽

Sergio Tufik ◽

...

Keyword(s):

Low Power ◽

Evoked Potentials ◽

Diode Laser ◽

Laser Evoked Potentials ◽

Non Invasive ◽

C Fibers ◽

C Fiber ◽

The Mean ◽

Young Subjects ◽

Power Diode

ABSTRACT Objective The evaluation of selective activation of C-fibers to record evoked potentials using the association of low-power diode laser (810 nm), tiny-area stimulation and skin-blackening. Method Laser-evoked potentials (LEPs) were obtained from 20 healthy young subjects. An aluminum plate with one thin hole was attached to the laser probe to provide tiny-area stimulation of the hand dorsum and the stimulated area was covered with black ink. Results The mean intensity used for eliciting the ultra-late laser-evoked potential (ULEP) was 70 ± 32 mW. All subjects showed a clear biphasic potential that comprised a negative peak (806 ± 61 ms) and a positive deflection (1033 ± 60 ms), corresponding to the ULEP related to C-fiber activation. Conclusion C-fiber-evoked responses can be obtained using a very low-power diode laser when stimulation is applied to tiny areas of darkened skin. This strategy offers a non-invasive and easy methodology that minimizes damage to the tissue.

Download Full-text