Effect of Haloperidol on Dopamine-Induced Increase in Renal Blood Flow

1986 ◽  
Vol 20 (7-8) ◽  
pp. 543-546 ◽  
Author(s):  
Deborah K. Armstrong ◽  
Joseph F. Dasta ◽  
Thomas E. Reilley ◽  
Richard D. Tallman
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Stroke Volume ◽  
Renal Blood Flow ◽  
Urine Output ◽  
Low Dose ◽  
Simultaneous Administration ◽  
Dopaminergic Receptors ◽  
Stimulation Of

Increasing renal blood flow (RBF) by the administration of low-dose dopamine is one mechanism to increase urine output in oliguric patients. This response is mediated in part by stimulation of dopaminergic receptors in the kidney, which could be attenuated by the dopamine blocker haloperidol. We evaluated this interaction by administering both drugs in clinically used doses to six anesthetized mongrel dogs. A dopamine regimen of 2.5 μg/kg/min significantly increased RBF along with cardiac output and stroke volume. Simultaneous administration of haloperidol 50 μg/kg iv did not influence the ability of low-dose dopamine to increase RBF. Although haloperidol is an antagonist of dopaminergic receptors, the increase in RBF associated with low-dose dopamine is maintained when intravenous haloperidol is concurrently administered to dogs.

LOW DOSE L-NAME DECREASES CARDIAC OUTPUT AND RENAL BLOOD FLOW IN PIGLETS

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A231
Author(s):  
Abhijit Lohe ◽  
John Kuluz ◽  
Barry Gelman ◽  
Ricardo Prado ◽  
Charles Schleien
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Renal Blood Flow ◽  
Low Dose

Low-dose dopamine preserves renal blood flow in endotoxin shocked dogs treated with ibuprofen

1985 ◽  
Vol 38 (6) ◽  
pp. 582-591 ◽  
Author(s):  
Mitchell P. Fink ◽  
Ronald Nelson ◽  
Rudolph Roethel
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Low Dose

Cardiac Output Changes in Newborns With Hyperbilirubinemia Treated With Phototherapy

PEDIATRICS ◽  
1985 ◽  
Vol 76 (6) ◽  
pp. 918-921
Author(s):  
Frans J. Walther ◽  
Paul Y. K. Wu ◽  
Bijan Siassi
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Stroke Volume ◽  
Skin Blood Flow ◽  
Peripheral Blood ◽  
Cardiovascular Effects ◽  
Tissue Perfusion ◽  
Peripheral Blood Flow ◽  
Limb Blood Flow ◽  
Term Infants

Phototherapy is known to increase peripheral blood flow in neonates, but information on the associated cardiovascular effects is not available. Using pulsed Doppler echocardiography we evaluated cardiac output and stroke volume in 12 preterm and 13 term neonates during and after phototherapy. We concomitantly measured arterial limb blood flow by strain gauge plethysmography and skin blood flow by photoplethysmography. Cardiac output decreased by 6% due to reduced stroke volume during phototherapy, whereas total limb blood flow and skin blood flow increased by 38% and 41%, respectively. Peripheral blood flow increments tended to be higher in the preterm than in the term infants. The reduced stroke volume during phototherapy may be an expression of reduced activity of the newborn during phototherapy. For healthy neonates the reduction in cardiac output is minimal, but for sick infants with reduced cardiac output, this reduction may further aggravate the decrease in tissue perfusion.

Circulatory and renal control by prostaglandins and renin in low cardiac output in dogs

1989 ◽  
Vol 256 (4) ◽  
pp. H1079-H1086 ◽  
Author(s):  
G. A. Riegger ◽  
D. Elsner ◽  
E. P. Kromer
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Glomerular Filtration Rate ◽  
Renal Blood Flow ◽  
Plasma Levels ◽  
Filtration Rate ◽  
Sympathetic Nerve Activity ◽  
Peripheral Vascular ◽  
Nerve Activity ◽  
Low Cardiac Output

Changes of neurohumoral factors including vasodilatory prostaglandins (PGs) were investigated in an experimental model of moderate low-cardiac-output status induced by rapid right ventricular pacing (240 beats/min). After 7 days of pacing, we studied the response of renal, hormonal, and hemodynamic parameters to cyclooxygenase inhibition by indomethacin and the effects of the renin system by converting-enzyme blockade in addition to the inhibition of PG synthesis. Lowering cardiac output increased plasma levels of norepinephrine and atrial natriuretic peptide. Plasma renin concentration was suppressed, despite a fall in cardiac output and blood pressure and a stimulation of sympathetic nerve activity. Urinary excretion of PGE2 was increased (P less than 0.04); plasma levels of PGE2 and 6-keto-PGF1 alpha were unchanged as measured in blood from the renal vein, pulmonary artery, and aorta. During low cardiac output, we found a significant decrease of glomerular filtration rate, whereas renal blood flow and renal and peripheral vascular resistances were unchanged. Administration of indomethacin decreased plasma and urinary PGs significantly, markedly reduced renal blood flow, and increased renal vascular resistance without affecting peripheral vascular resistance. The additional blockade of the renin-angiotensin system by captopril showed mainly a vasodilator effect on peripheral arterial resistance vessels, resulting in an increase of cardiac output. Our results suggest that, in moderate low-cardiac-output status, renal blood flow is maintained by renal vasodilator PGs, which counterbalance vasoconstrictor mechanisms like the activated sympathetic nerve activity. We indirectly showed the importance of angiotensin II in preserving glomerular filtration rate, which declines when renin secretion is suppressed, as it may be the case in moderate heart failure.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Development of a Simple ImageJ-Based Method for Dynamic Blood Flow Tracking in Zebrafish Embryos and Its Application in Drug Toxicity Evaluation

Inventions ◽  
2019 ◽  
Vol 4 (4) ◽  
pp. 65 ◽  
Author(s):  
Fiorency Santoso ◽  
Bonifasius Putera Sampurna ◽  
Yu-Heng Lai ◽  
Sung-Tzu Liang ◽  
Erwei Hao ◽  
...  
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Cardiac Output ◽  
Blood Cell ◽  
Stroke Volume ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Video Recording ◽  
Cardiovascular Function ◽  
Zebrafish Embryos

This study aimed to develop a simple and cost-effective method to measure blood flow in zebrafish by using an image-based approach. Three days post fertilization (dpf) zebrafish embryos were mounted with methylcellulose and subjected to video recording for tracking blood flow under an inverted microscope equipped with a high-speed CCD camera. In addition, Hoffman lens was used to enhance the blood cell contrast. The red blood cell movement was tracked by using the TrackMate plug-in in the ImageJ image processing program. Moreover, Stack Difference and Time Series Analyzer plug-in were used to detect dynamic pixel changes over time to calculate the blood flow rate. In addition to blood flow velocity and heart rate, the effect of drug treatments on other cardiovascular function parameters, such as stroke volume and cardiac output remains to be explored. Therefore, by using this method, the potential side effects on the cardiovascular performance of ethyl 3-aminobenzoate methanesulfonate (MS222) and 3-isobutyl-1-methylxanthine (IBMX) were evaluated. MS222 is a common anesthetic, while IBMX is a naturally occurring methylxanthine. Compared to normal embryos, MS222- and IBMX-treated embryos had a reduced blood flow velocity by approximately 72% and 58%, respectively. This study showed that MS222 significantly decreased the heart rate, whereas IBMX increased the heart rate. Moreover, it also demonstrated that MS222 treatment reduced 50% of the stroke volume and cardiac output. While IBMX decreased the stroke volume only. The results are in line with previous studies that used expensive instruments and complicated software analysis to assess cardiovascular function. In conclusion, a simple and low-cost method can be used to study blood flow in zebrafish embryos for compound screening. Furthermore, it could provide a precise measurement of clinically relevant cardiac functions, specifically heart rate, stroke volume, and cardiac output.

A simple module for on-line computation of stroke volume and cardiac output

1975 ◽  
Vol 38 (5) ◽  
pp. 927-929 ◽  
Author(s):  
G. Pinardi ◽  
A. Sainz ◽  
E. Santiago
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Data Analysis ◽  
Stroke Volume ◽  
Simple Module ◽  
Cardiovascular Responses ◽  
Aortic Blood Flow ◽  
Aortic Blood ◽  
On Line ◽  
Aortic Blood Flow Velocity

An easily constructed, low-priced, simple, and reliable module to obtain stroke volume and cardiac output by analog integration of aortic blood flow velocity signals is described. Rapid data analysis of physiologic and pharmacologic cardiovascular responses in dogs is greatly facilitated by on line computation of these parameters.

scholarly journals The effect of mannitol infusion on cardiac output and renal blood flow after graded hemorrhage

1965 ◽  
Vol 50 (4) ◽  
pp. 561-566 ◽  
Author(s):  
Worthington G. Schenk ◽  
N. Anders Delin ◽  
Lawrence Pollock ◽  
Kjartan B. Kjartansson ◽  
John W. Boylan
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Renal Blood Flow

scholarly journals Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss

2019 ◽  
Vol 317 (5) ◽  
pp. E871-E878 ◽  
Author(s):  
Eleni Rebelos ◽  
Prince Dadson ◽  
Vesa Oikonen ◽  
Hidehiro Iida ◽  
Jarna C. Hannukainen ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Blood Flow ◽  
Cardiac Output ◽  
Fatty Acid ◽  
Renal Blood Flow ◽  
Renal Hemodynamics ◽  
Renal Volume ◽  
Obese Subjects ◽  
Total Renal Blood Flow

Human studies of renal hemodynamics and metabolism in obesity are insufficient. We hypothesized that renal perfusion and renal free fatty acid (FFA) uptake are higher in subjects with morbid obesity compared with lean subjects and that they both decrease after bariatric surgery. Cortical and medullary hemodynamics and metabolism were measured in 23 morbidly obese women and 15 age- and sex-matched nonobese controls by PET scanning of [15O]-H2O (perfusion) and 14( R,S)-[18F]fluoro-6-thia-heptadecanoate (FFA uptake). Kidney volume and radiodensity were measured by computed tomography, cardiac output by MRI. Obese subjects were re-studied 6 mo after bariatric surgery. Obese subjects had higher renal volume but lower radiodensity, suggesting accumulation of water and/or lipid. Both cardiac output and estimated glomerular filtration rate (eGFR) were increased by ~25% in the obese. Total renal blood flow was higher in the obese [885 (317) (expressed as median and interquartile range) vs. 749 (300) (expressed as means and SD) ml/min of controls, P = 0.049]. In both groups, regional blood perfusion was higher in the cortex than medulla; in either region, FFA uptake was ~50% higher in the obese as a consequence of higher circulating FFA levels. Following weight loss (26 ± 8 kg), total renal blood flow was reduced ( P = 0.006). Renal volume, eGFR, cortical and medullary FFA uptake were decreased but not fully normalized. Obesity is associated with renal structural, hemodynamic, and metabolic changes. Six months after bariatric surgery, the hemodynamic changes are reversed and the structural changes are improved. On the contrary, renal FFA uptake remains increased, driven by high substrate availability.

EFFECT OF MANNITOL ON RENAL BLOOD FLOW AND CARDIAC OUTPUT IN HEMORRHAGIC SHOCK

1966 ◽  
Vol 10 (3) ◽  
pp. 230???231
Author(s):  
R. C. CAMISHION ◽  
N. H. FISHMAN ◽  
Hebbel E. Hoff
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Hemorrhagic Shock ◽  
Renal Blood Flow
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