Myoclonus Due to Chlorambucil in Two Adults with Lymphoma

1997 ◽  
Vol 31 (2) ◽  
pp. 171-174 ◽  
Author(s):  
Andrew Rj Wyllie ◽  
Charles D Bayliff ◽  
Michael J Kovacs
Keyword(s):  
Nephrotic Syndrome ◽  
Science Citation Index ◽  
Low Dose ◽  
Citation Index ◽  
Science Citation ◽  
Data Sources ◽  
High Dose ◽  
Drug Induced ◽  
Neurologic Status ◽  
Subsequent Decrease

Objective To report myoclonus due to chlorambucil therapy in two adults with lymphoma, and to review the literature of chlorambucil neurotoxicity in adults. Case Summaries Case 1: An 81-year-old man with lymphoma being treated with chlorambucil developed jerking movements and stiffness that persisted for 3 days and intensified at night. The dosage of chlorambucil was decreased with a subsequent decrease in symptomatology. Resolution of the myoclonus occurred with discontinuation of the chlorambucil. Rechallenge evoked a return of tremors the next day that later became constant and again resolved on discontinuation of chlorambucil. Case 2: A 75-year-old woman with lymphoma being treated with chlorambucil developed jerking movements in her limbs, particularly in her arms and right hip. The symptoms were so severe they prevented the patient from leaving her house. All symptoms resolved within 2–3 days after the cycle was completed and did not return. She was diagnosed as having had chlorambucil-induced myoclonus. Data Sources Searches were performed on MEDLINE, CancerLit, and Science Citation Index Review to identify reports and articles discussing chlorambucil-induced neurotoxicity, particularly myoclonus. Discussion Chlorambucil-induced myoclonus has been described in overdose situations and in the treatment of nephrotic syndrome in children. Three cases of reversible myoclonic activity associated with high-dose chlorambucil in adults have also been described. In each case, the myoclonus resolved following discontinuation of the drug. Only one other conclusive case of low-dose chlorambucil-induced myoclonus in an adult has been described. The two cases presented here are unique in that the myoclonus occurred in adults receiving low-dose chlorambucil who had no myoclonus before or after treatment with the drug. Conclusions From the cases reviewed, it appears that chlorambucil may induce myoclonus in adults receiving therapeutic dosages of chlorambucil. The neurologic status of patients receiving chlorambucil should be followed closely during treatment. If myoclonus develops, drug-induced myoclonus should be considered, as well as discontinuation of the drug.

Scientometric Parameters of Russian Economic Science:General State and the Evaluation of Thesis boards

2013 ◽  
pp. 129-146 ◽  
Author(s):  
N. Kurakova ◽  
L. Tsvetkova ◽  
O. Eremchenko
Keyword(s):  
Science Citation Index ◽  
Web Of Science ◽  
Citation Index ◽  
Science Citation ◽  
Russian Science ◽  
Russian Science Citation Index

The paper analyses the publications of Russian authors in various fields of economics indexed in Web of Science and Russian Science Citation Index. The authors claim that the scientometric parameters are only in a limited way applicable in evaluating the performance of expert and thesis boards in economics in Russia. The authors also put forward the approaches in order to improve Russia’s positions in the international citations indexes in economics.

scholarly journals Nodding syndrome: bridging the gap—a scoping review protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e035269
Author(s):  
Ana Cristina De Castro ◽  
Ivan Ortega-Deballon
Keyword(s):  
Social Science ◽  
Scoping Review ◽  
Science Citation Index ◽  
Citation Index ◽  
Grey Literature ◽  
Social Science Citation Index ◽  
Science Citation ◽  
Cochrane Library ◽  
Future Research ◽  
Nodding Syndrome

IntroductionNodding syndrome (NS) is an encephalopathy of unknown origin that affects children aged between 3 and 15 years old. Cases have been reported since the 1950 in Tanzania and South Sudan, the most heavily affected population is the Acholi community in Uganda. In response to the high incidence of the disease, the Ugandan Government has developed a management algorithm, but access to such measures in affected communities is limited. There is little funding for research on the disease, consequently, few studies have been conducted to date. Nevertheless, the number of scientific publications on NS has increased since 2013, reporting several aetiological hypotheses, management algorithms and cases of stigmatisation; however, none has obtained conclusive results.This document describes a protocol for a scoping review of NS to date aimed at obtaining a broad overview of the disease. The results will identify gaps in knowledge in order to better guide future research, intervention strategies, health policies in areas at risk and cooperation and development programmes.Methods and analysisTo identify the relevant data, we will conduct a literature search using the electronic databases PubMed/Medline, Embase, Social Science Citation Index Scopus, Scientific Electronic Library Online (SciELO), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS), Social Science Citation Index Expanded and The Cochrane Library. We will also include grey literature. The search strategy will be designed by a librarian.Two members of the team will work independently to identify studies for inclusion and perform data extraction. The search results will be assessed by two independent reviewers and data from the included studies will be charted and summarised in duplicate. The data will be summarised in tables and figures to present the research landscape and describe and map gaps.Ethics and disseminationEthical approval is not required. The scoping review will adhere to the Preferred Reporting Items for Systematic Reviews andMeta-Analyses-ScR guidelines. The results will be disseminated at scientific congresses and meetings.

Application of photo and video recording in dentistry. Review

2021 ◽  
pp. 28-32
Author(s):  
E.Yu. Leontyeva ◽  
A.V. Dmitrieva ◽  
P.S. Kravchenko ◽  
G.S. Leontyev
Keyword(s):  
Oral Cavity ◽  
Science Citation Index ◽  
Web Of Science ◽  
Citation Index ◽  
Video Recording ◽  
The State ◽  
Dental Status ◽  
Science Citation ◽  
Russian Science ◽  
Russian Science Citation Index

The review conducted research of the Russian and foreign literature of recent years on the methods of using photo and video recording in dentistry in the databases of the Russian Science Citation Index, SCOPUS, Web of Science, Pubmed and others. The data of the possibilities of using the method of registration of the dental status and the state of the tissues of the oral cavity using photo and video fixation in the diagnosis, treatment and observation of patients are presented.

scholarly journals Visibilidade da produção científica de grupos de pesquisa em serviço social do estado do Rio de Janeiro

2011 ◽  
Vol 23 (3) ◽  
pp. 185-194
Author(s):  
Tânia Chalhub ◽  
Claudia Guerra
Keyword(s):  
Science Citation Index ◽  
Rio De Janeiro ◽  
Citation Index ◽  
Science Citation

Pesquisa descritiva quantitativa de grupos de pesquisa em Serviço Social de universidades do Estado do Rio de Janeiro cadastrados no Conselho Nacional de Desenvolvimento Científico e Tecnológico que têm por objetivo analisar visibilidade da produção científica dos líderes desses grupos. A visibilidade dos resultados de pesquisas em Serviço Social viabilizaria a ampliação da cidadania. Foi realizado levantamento da produção na plataforma Lattes e analisado o período de 2003 a 2010. Dentre os periódicos mais utilizados por esses grupos, que representam boa parte da produção científica em Serviço Social no país, a maioria está veiculada pela forma tradicional de comunicação, publicação impressa, até 2009. Desses periódicos alguns são reconhecidos por sua abrangência nacional, porém os que apresentam maior número de artigos publicados pelo grupo estudado têm sua visibilidade comprometida por serem impressos ou por não estarem indexados em bases de dados de acesso via web. O padrão de comunicação científica corrobora o de outras áreas das Ciências Sociais, contudo não apresenta boa visibilidade como outras áreas que dispõem de número expressivo de periódicos de acesso livre e indexação em bases de dados (Science Citation Index), diretórios (Latindex) e redes cooperativas (Redalyc).

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