Pulmonary Mycobacterial Spindle Cell Pseudotumor: A Report of 3 Cases Including a Practical Approach to Histopathologic Recognition of This Unusual Entity

2018 ◽  
Vol 26 (7) ◽  
pp. 629-634 ◽  
Author(s):  
Katherine E. Boylan ◽  
Brandon T. Larsen ◽  
Brittany A. Young ◽  
Erinn Downs-Kelly ◽  
Tanmay S. Panchabhai ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Spindle Cell ◽  
Accurate Diagnosis ◽  
Practical Approach ◽  
Hiv Positive ◽  
Histopathological Diagnosis ◽  
Immunocompromised Patients ◽  
Clinical Context ◽  
Benign Condition ◽  
Spindle Cell Lesion

Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. The histopathological diagnosis of MSP in the lung lends itself to many challenges due to its rare incidence and its spindled tumor-like appearance. The differential diagnosis is broad and includes both benign and malignant entities. We highlight the importance of the clinical context in which these lesions typically present and the morphologic spectrum of features seen, and we offer a practical approach to the workup of pulmonary mycobacterial pseudotumor. Appropriate recognition of this entity should lead to an accurate diagnosis of a treatable benign condition despite the clinical presentation often favoring malignancy.

scholarly journals Atypical Spindle Cell Lesion of Larynx: A Rare Benign Condition mimicking Malignancy

2017 ◽  
Vol 7 (1) ◽  
pp. 31-35
Author(s):  
Sridhar R Dandala ◽  
Achyuth Panuganti ◽  
Pindicura Kumuda
Keyword(s):  
Spindle Cell ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Rare Condition ◽  
Definitive Treatment ◽  
Histopathological Diagnosis ◽  
Benign Condition ◽  
Spindle Cell Neoplasm ◽  
Spindle Cell Lesion ◽  
Well Differentiated

ABSTRACT Atypical spindle cell lesion of larynx is a very rare condition usually misdiagnosed as malignant spindle cell tumor, requiring immunohistochemical (IHC) studies for reaching a correct diagnosis. We present a case of a 75-year-old male patient, who presented to the ear, nose, and throat casualty in stridor, and was tracheostomized. Videolaryngoscopy revealed a huge irregular growth filling the supraglottis. Biopsy of the growth suggested a reactive fibroblastic proliferation with atypia. The patient was again subjected to biopsy and it revealed well-differentiated squamous cell carcinoma (SCC). Total laryngectomy was done. The specimen on histopathological examination revealed atypical spindle cell lesion, and on IHC revealed a benign inflammatory spindle cell neoplasm. Here, we discuss the difficulty in making a decision on definitive treatment for such a condition and the importance of histopathological diagnosis of this condition for better understanding of its management. How to cite this article Dandala SR, Panuganti A, Kumuda P. Atypical Spindle Cell Lesion of Larynx: A Rare Benign Condition mimicking Malignancy. Int J Phonosurg Laryngol 2017;7(1):31-35.

scholarly journals Hysteroscopic Findings Related with the Assessment and Treatment of Uterine Florid Cystic Endosalpingiosis: A Case Report and Review of All the Published Cases

2020 ◽  
Vol 33 (13) ◽  
Author(s):  
Catarina Peixinho ◽  
Raquel Machado-Neves ◽  
Pedro Tiago Silva ◽  
João Bernardes ◽  
Ana Catarina Silva ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Polypoid Lesion ◽  
Pelvic Mass ◽  
Rare Condition ◽  
Laparoscopic Hysterectomy ◽  
Histopathological Diagnosis ◽  
Benign Condition ◽  
First Case ◽  
Assessment And Treatment ◽  
One Year

Introduction: Endosalpingiosis is a rare benign condition characterized by the presence of tubal epithelium outside the Fallopian tube. The clinical presentation of endosalpingiosis is nonspecific, and the diagnosis is typically incidental in women undergoing surgery for pelvic pain, infertility, urinary symptoms, or a pelvic mass. It can only be confirmed with histopathological examination.Case Report: We report the first case of uterine florid cystic endosalpingiosis, with unusual hysteroscopic findings. We reviewed all the published cases of uterine florid cystic endosalpingiosis and their clinical presentation including hysteroscopic characteristics. It is a rare benign condition, with only 32 cases described in the literature. This is the first hysteroscopic description of this condition to be made.Discussion: The patient first underwent a hysteroscopy and a leiomyoma resection when she was 51 years old. At 55, she went through another hysteroscopy, and a polypoid lesion was excised. A third hysteroscopy, one year later, revealed a new polypoid lesion in a similar location. After the initial incisions, this polypoid lesion disappeared. By decreasing the intrauterine pressure, it became visible again, corresponding histologically to an endometrial polyp with tubal metaplasia. At last, she underwent a laparoscopic hysterectomy with a final histopathological diagnosis of uterine florid cystic endosalpingiosis.Conclusion: Florid cystic endosalpingiosis is a rare condition that may be associated with several bizarre hysteroscopic findings.

Spindle cell angiosarcoma of the oropharynx

2000 ◽  
Vol 114 (2) ◽  
pp. 160-162 ◽  
Author(s):  
A. Maheshwar ◽  
M. D. Barnes ◽  
A. G. Douglas-Jones ◽  
N. R. Nind ◽  
S. H. Burroughs
Keyword(s):  
Head And Neck ◽  
Vascular Endothelium ◽  
Rare Case ◽  
Clinical Presentation ◽  
Spindle Cell ◽  
Histopathological Diagnosis ◽  
Malignant Tumours

Angiosarcomas are uncommon malignant tumours of vascular endothelium. In the head and neck, the scalp is the commonest site of origin. A rare case of spindle-cell angiosarcoma of the oropharynx, treated by surgery and post-operative radiotherapy, is reported. We discuss the clinical presentation and histopathological diagnosis of this lesion.

scholarly journals Isolated Non-Resolving Vulvar Lesion as a Presentation of Disseminated Histoplasmosis in a Woman with HIV

2020 ◽  
Author(s):  
Moni Roy ◽  
Ashish Kumar Roy ◽  
Jan Nalinee Upalakalin ◽  
Sharjeel Ahmad
Keyword(s):  
Opportunistic Infection ◽  
Literature Search ◽  
Histoplasma Capsulatum ◽  
Clinical Presentation ◽  
Histopathological Diagnosis ◽  
Immunocompromised Patients ◽  
Cns Involvement ◽  
Delay In Diagnosis ◽  
Disseminated Histoplasmosis ◽  
Disseminated Disease

Disseminated histoplasmosis is most commonly caused by Histoplasma capsulatum and is a known opportunistic infection in immunocompromised patients. The clinical presentation of histoplasmosis varies from asymptomatic to a progressive disseminated form. Pulmonary and CNS involvement is common in disseminated histoplasmosis. Rarely, disseminated disease can present as vulvar lesion in the absence of pulmonary symptoms, causing a delay in diagnosis. As per our PubMed literature search, there have only been two reported cases where vulvar lesion was the only presenting symptom of disseminated disease. In our patient, a histopathological diagnosis was made with staining showing budding yeast forms of histoplasma.

scholarly journals Malignant Arrhythmic Mitral Valve Prolapse: A Continuum of Clinical Challenges from Diagnosis to Risk Stratification and Patient Management

2020 ◽  
Vol 8 (1) ◽  
pp. 2
Author(s):  
Idit Yedidya ◽  
Aniek L. van Wijngaarden ◽  
Nina Ajmone Marsan
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Ventricular Arrhythmias ◽  
Clinical Decision Making ◽  
Clinical Presentation ◽  
Clinical Decision ◽  
Benign Condition ◽  
Long Period ◽  
Patients Experience ◽  
Hospital Cardiac Arrest

Mitral valve prolapse (MVP) is a common valvular disease, which may remain a benign condition for a long period of time. However, some patients experience malignant ventricular arrhythmias and sudden cardiac death (SCD). It is still largely unknown how to risk-stratify these patients, and no specific recommendations have been proposed to help the clinical decision-making. We present the case of a young man whose first clinical presentation was an out-of-hospital cardiac arrest and was subsequently diagnosed with MVP. We highlighted the possible risk factors for SCD and the challenges in the clinical management of these patients.

scholarly journals Temporal gliosarcoma: case report and review of literature

2015 ◽  
Vol 22 (1) ◽  
pp. 112-116
Author(s):  
Amit Agrawal ◽  
Vissa Shanthi ◽  
Baddukonda Appala Ramakrishna ◽  
Kuppili Venkata Murali Mohan
Keyword(s):  
Case Report ◽  
Median Survival ◽  
Glial Cells ◽  
Primary Tumor ◽  
Clinical Presentation ◽  
Spindle Cell ◽  
Review Of Literature ◽  
Future Studies ◽  
Aggressive Tumor ◽  
The Brain

Abstract First characterized by Stroebe, the gliosarcomas are highly malignant and rare primary tumor of the brain composed of neoplastic glial cells in association with spindle cell sarcomatous elements (biphasic tissue patterns). In spite of being recognized as two different pathologies studies have not shown any significant differences between gliosarcoma and glioblastoma with regard to age, sex, size, clinical presentation, and median survival. In summary, gliosarcoma is an aggressive tumor with a propensity to recur and re-grow with poor outcome. Future studies are needed to understand the true pathology of these biphasic tumors.

scholarly journals Dendritic Myxofibrolipoma: Often Misdiagnosed as Sarcoma

2011 ◽  
Vol 4 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Awatif Y. Al-Maskery ◽  
Salem M. Al-Sidairy ◽  
Aisha S. Al-Hamadani
Keyword(s):  
Soft Tissue Tumor ◽  
Clinical Presentation ◽  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Complete Excision ◽  
Lower Lip ◽  
Benign Soft Tissue Tumor ◽  
Proper Diagnosis ◽  
Fibrous Tumor ◽  
Combined Feature

The author describes a benign soft tissue tumor that could be easily mistaken for sarcoma. It represents a combined feature of solitary fibrous tumor and spindle cell lipoma. The clinical presentation, diagnosis, and management of this lesion are discussed. It highlights the importance of proper diagnosis to prevent unnecessary and ineffective treatment by clinicians as the complete excision of this lesion is the treatment of choice and recurrence is very unlikely. It is believed that this case is the first reported case of dendritic myxofibrolipoma occurring in the lower lip mucosa in an Omani patient.

Atonic Seizures

1987 ◽  
Vol 9 (2) ◽  
pp. 43-49
Author(s):  
Michael S. Duchowny
Keyword(s):  
Clinical Presentation ◽  
Muscle Tone ◽  
Skull Fracture ◽  
Dental Trauma ◽  
Accurate Diagnosis ◽  
Correct Identification ◽  
Grand Mal ◽  
Important Challenge ◽  
Resting Tone ◽  
Atonic Seizures

Seizures consisting of rapidly arrested movement are relatively common and account for approximately 12% of all episodes. Atonic seizure is the preferred designation for this form of clinical presentation, although more descriptive terms such as "drop attack" and "epileptic fall" are also popular. Many clinicians still use the term "akinetic seizure," but this is inaccurate because attacks of behavioral immobility with preserved muscle tone and consciousness cannot be differentiated from absence seizures. Furthermore, it is unlikely that neurophysiologic mechanisms can arrest behavior without altering muscle tone or compromising consciousness. The accurate diagnosis and management of atonic seizures constitutes an important challenge for the practicing pediatrician. Whereas grand mal and petit mal seizures are well-known manifestations of epilepsy in childhood, seizures limited to the loss of muscle tone are more likely to go unrecognized. The large variety of nonepileptic conditions that mimic atonic seizures further adds to the difficulties of correct identification. DESCRIPTION Atonic seizures show considerable variation in presentation and severity. Typically, without warning, the voluntary muscles synchronously increase and then lose resting tone. No aura precedes these muscular changes. Both the myoclonic and atonic seizure components can cause the child to collapse limply to the ground. Massive myoclonus and loss of tone may even precipitate a violent fall from a sitting position (Fig 1), resulting in craniofacial injury, skull fracture, facial laceration, or dental trauma.

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