A Case Report of Mucoepidermoid Carcinoma With Extensive Keratinization in Parotid: Expanding the Morphologic Spectrum

2021 ◽  
pp. 106689692110604
Author(s):  
Mei Kong ◽  
Bo Wang ◽  
Xiaoxi Wang ◽  
Liming Xu
Keyword(s):  
Case Report ◽  
Mucoepidermoid Carcinoma ◽  
Gene Fusion ◽  
Squamous Metaplasia ◽  
Low Grade ◽  
Mucous Cells ◽  
Squamous Cells ◽  
Children And Young Adults ◽  
Intermediate Cells

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands in children and young adults. Typically, it is composed of squamoid, mucin-producing and intermediate-types cells. However, overt keratinization is rare. To the best of our knowledge, extensive keratinization or keratin pearls in MEC has never been reported. Keratinization or keratin pearls are regard “practically never seen in low-grade MEC”. Herein, we report a case of a 34-year-old woman who presented with a tumor in right parotid gland for 2 months. Microscopically, the tumor was composed of extensive squamous cells with overt keratin pearls, intermediate cells and few scattered mucous cells. MAML2 gene break-apart and CRTC1-MAML2 gene fusion were detected by fluorescence in situ hybridization. This is the first report to describe a MEC case with extensive squamous metaplasia and overt keratin pearls formation, which expands the morphologic spectrum of MEC.

Ichthyosis Uteri: A Case Report and Review of the Literature

2005 ◽  
Vol 129 (5) ◽  
pp. e124-e125
Author(s):  
Chhanda Bewtra ◽  
Qing M. Xie ◽  
William J. Hunter ◽  
William Jurgensen
Keyword(s):  
Case Report ◽  
Squamous Metaplasia ◽  
Endometrial Adenocarcinoma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Squamous Cells ◽  
First Case

Abstract Squamous metaplasia of endometrium is mostly manifested by morules or nodules of benign nonkeratinizing squamous cells intimately mixed with benign or malignant endometrial glands. It has been described with low-grade adenocarcinoma of the endometrium, as well as with various benign conditions, including hyperplasia, chronic endometritis, and endometrial polyps. However, extensive plaquelike, keratinizing squamous change is distinctly uncommon. To our knowledge, we describe the first case of extensive benign squamous keratinization with underlying endometrial adenocarcinoma.

scholarly journals Pleomorphic adenoma with squamous and appendageal metaplasia mimicking mucoepidermoid carcinoma on cytology

CytoJournal ◽  
2008 ◽  
Vol 6 ◽  
pp. 5 ◽  
Author(s):  
Meenakshi Batrani ◽  
Manju Kaushal ◽  
A. K. Sen ◽  
Rajbala Yadav ◽  
N. K. Chaturvedi
Keyword(s):  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Squamous Metaplasia ◽  
Salivary Gland Tumor ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Case Presentation ◽  
Squamous Cells ◽  
Foreign Body Giant Cells ◽  
Needle Aspiration Cytology

Background: Histological diversity is the hallmark of pleomorphic adenoma, the most common salivary gland tumor. It may cause difficulty in cytological interpretation, due to limited and selective sampling. Case presentation: A 16-year-old female patient presented with right cheek swelling. Fine needle aspiration cytology showed squamous cells, basaloid cells, and foamy cells, along with extracellular keratin and foreign body giant cells. Characteristic metachromatic fibrillary chondromyxoid stroma, which is usually seen in pleomorphic adenoma, was not seen in the aspirate. A diagnosis of mucoepidermoid carcinoma was given on cytology. Subsequent resection revealed an encapsulated pleomorphic adenoma, with extensive squamous metaplasia and appendageal differentiation on histology. Conclusion: This case illustrates that pleomorphic adenoma with squamous metaplasia presents a potential for misinterpretation as mucoepidermoid carcinoma on cytology. We discuss the various pitfalls and the features that are helpful in distinguishing these two lesions.

scholarly journals Central Mucoepidermoid Carcinoma, A Case Report with Molecular Analysis of the TORC1/MAML2 Gene Fusion

2010 ◽  
Vol 4 (3) ◽  
pp. 261-264 ◽  
Author(s):  
Haseeb Ahmed Khan ◽  
Asif Loya ◽  
Rafay Azhar ◽  
Nasir Ud Din ◽  
Diana Bell
Keyword(s):  
Case Report ◽  
Molecular Analysis ◽  
Mucoepidermoid Carcinoma ◽  
Gene Fusion ◽  
Central Mucoepidermoid Carcinoma

scholarly journals A rare case of mucoepidermoid carcinoma of the skin: A case report and a literature review

2021 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Marcello Filotico ◽  
Francesca Mazzeo
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Salivary Glands ◽  
Scoring System ◽  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Epidemiological Data ◽  
Low Grade ◽  
Morphological Picture

This report presents the case of primary Mucoepidermoid Carcinoma of the skin on the leg of a 74-year-old man. The epidemiological data of the neoplasm are examined, and the morphological picture and immunophenotypic profile are compared with those of the homologous tumor of the salivary glands. According to the scoring system of this type of tumor, our case is classified as low-grade.

scholarly journals Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion

2011 ◽  
Vol 2011 ◽  
pp. 1-9
Author(s):  
Katsunari Ishida ◽  
Makoto Nagasaki ◽  
Masayuki Kobayashi ◽  
Tatsushi Nakagawa ◽  
Toru Nabika ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Routine Testing ◽  
Squamous Cells ◽  
Intraepithelial Lesion ◽  
Liquid Based Cytology ◽  
Undetermined Significance

To examine the diagnostic utility for squamous intraepithelial lesion (SIL) by cytological in situ hybridization (c-ISH) for the human papillomavirus using liquid-based cytology specimens, we investigated c-ISH signal patterns in the cases of low-grade SIL (LSIL), atypical squamous cells of undetermined significance (ASC-US), and high-grade SIL (HSIL). Episomal (E) and/or integrated (I) signals were observed. Two signal patterns (E≧I or I>E) were obtained by counting the number of E+ or I+ cells. E≧I was specific to LSIL and ASC-US (10/12); I>E, to HSIL (9/11) (P<0.01, χ2 test), suggesting significant utility of c-ISH in diagnosing SIL. In the cell fraction, E≧I in large cells was dominant in LSIL. Two cases of I>E in large cells of LSIL showed HPV persistence and/or progression during follow-up. Thus, c-ISH is useful in routine testing for diagnosing cervical dysplastic lesions, especially for detecting LSIL suspected for progression.

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