scholarly journals The Association of Oral Stimulant Medication Adherence with Work Productivity among Adults with ADHD

2021 ◽  
pp. 108705472110201
Author(s):  
William Spalding ◽  
Sepehr Farahbakhshian ◽  
Martine C. Maculaitis ◽  
Eugenia Y. Peck ◽  
Amir Goren
Keyword(s):  
Medication Adherence ◽  
Online Survey ◽  
Adult Adhd ◽  
Stimulant Medication ◽  
General Health Questionnaire ◽  
Work Productivity ◽  
Indirect Costs ◽  
Self Report ◽  
Activity Impairment ◽  
Scale Total Score

Objective: Examine associations between oral psychostimulant pharmacotherapy adherence, work productivity, and related indirect costs among US adults with ADHD. Methods: Medication adherence (Medication Adherence Reasons Scale [MAR-Scale]), work productivity and activity impairment (Work Productivity and Activity Impairment–General Health questionnaire), and ADHD symptom level (Adult ADHD Self-Report Scale version 1.1 Symptom Checklist) were assessed in this noninterventional online survey of adults who self-reported having an ADHD diagnosis and were currently receiving oral psychostimulant treatment for ≥3 months. Results: Of 602 respondents, 395 had low/medium adherence (LMA: MAR-Scale total score ≥1) and 207 had high adherence (HA: MAR-Scale total score 0). After adjusting for covariates, the LMA group had significantly greater levels of absenteeism, absenteeism-related indirect costs, and total indirect costs (all p < .01) than the HA group. Conclusion: In adults with ADHD using oral psychostimulants, lower medication adherence was associated with greater absenteeism and indirect costs.

Work participation in spondyloarthritis across countries: analysis from the ASAS-COMOSPA study

2018 ◽  
Vol 77 (9) ◽  
pp. 1303-1310 ◽  
Author(s):  
Santiago Rodrigues Manica ◽  
Alexandre Sepriano ◽  
Sofia Ramiro ◽  
Fernando Pimentel Santos ◽  
Polina Putrik ◽  
...  
Keyword(s):  
Higher Education ◽  
Disease Activity ◽  
General Health Questionnaire ◽  
Random Effect ◽  
Work Productivity ◽  
Activity Impairment ◽  
Individual Level ◽  
Country Level ◽  
Asas Classification Criteria ◽  
Per Capita

ObjectivesTo explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide.MethodsPatients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General Health questionnaire. Three multivariable models were built (one per outcome) using mixed-effects binomial (for work status) or ordinal regressions (for absenteeism and presenteeism), with country as random effect. The contribution of SE factors at the individual-level (eg, gender, education, marital status) and country-level (healthcare expenditure (HCE) per capita, Human Development Index (HDI) and gross domestic product per capita) SE factors, independent of clinical factors, was assessed.ResultsIn total, 3114 patients with SpA were included of which 1943 (62%) were employed. Physical function and comorbidities were related to all work outcomes in expected directions and disease activity also with absenteeism and presenteeism. Higher education (OR 4.2 (95% CI 3.1 to 5.6)) or living in a country with higher HCE (OR 2.3 (1.5 to 3.6)) or HDI (OR 1.9 (1.2 to 3.3)) was positively associated with being employed. Higher disease activity was associated with higher odds for absenteeism (OR 1.5 (1.3 to 1.7)) and presenteeism (OR 2.1 (1.8 to 2.4)). No significant association between individual-level and country-level SE factors and absenteeism or presenteeism was found.ConclusionsHigher education level and higher country SE welfare are associated with a higher likelihood of keeping patients with SpA employed. Absenteeism and presenteeism are only associated with clinical but not with individual-level or country-level SE factors.

Impact of constipation on opioid therapy management among long-term opioid users, based on a patient survey

2015 ◽  
Vol 11 (4) ◽  
pp. 325 ◽  
Author(s):  
Shaloo Gupta, MS ◽  
Haridarshan Patel, PharmD ◽  
Justin Scopel, MD, MBA ◽  
Reema R. Mody, MBA, PhD
Keyword(s):  
Quality Of Life ◽  
Medication Adherence ◽  
Treatment Satisfaction ◽  
Linear Models ◽  
Productivity Loss ◽  
Work Productivity ◽  
Opioid Therapy ◽  
Activity Impairment ◽  
Cross Sectional

Objective: The authors sought to characterize health-related quality of life (HRQoL), medication adherence, productivity losses, and treatment satisfaction associated with modifications to opioid therapy due to opioid-induced constipation (OIC).Design: A cross-sectional, between-subjects design was used to examine health outcomes among US noncancer participants currently taking opioids.Patients, participants: Participants were adults in the 2012 US National Health and Wellness Survey, who reported currently using opioids (>30 days) and experiencing constipation. Respondents were categorized as making modifications to opioid therapy due to OIC (modifiers, n = 244) or making no modifications (nonmodifiers, n = 247).Main outcome measures: Patient Assessment of Constipation Quality of Life (PAC-QoL) and Symptoms (PAC-Sym), Morisky Medication Adherence Scale (MMAS-4), Work Productivity and Activity Impairment, and the Treatment Satisfaction Questionnaire for Medication (TSQM II) for OIC treatment were administered. Generalized linear models were adjusted to control for baseline characteristics (age, gender, comorbidities, opioid strength, etc). Results: Modifiers reported poorer HRQoL (PAC-QoL total: 1.74 vs 1.44, p < 0.001), worse constipation (PAC-Sym total: 1.56 vs 1.35, p = 0.003), more pain-related resource use (surgery: odds ratio (OR) = 3.72, p = 0.002; emergency room visits: OR = 1.88, p = 0.049; hospitalizations: OR = 2.47, p = 0.033), and lower adherence (MMAS-4 pain: OR = 0.12, p < 0.001; MMAS-4 OIC: OR = 0.39, p < 0.001) than nonmodifiers. Modifiers reported greater presenteeism (49.75 percent vs 38.28 percent, p = 0.038), but no significant differences were found for activity impairment or OIC treatment satisfaction.Conclusions: Treating OIC effectively may help prevent inadequate pain management secondary to opioid therapy modification, help increase HRQoL, lessen OIC symptoms, decrease productivity loss, and improve adherence to opioid and OIC treatments.

scholarly journals Video chat technology to remotely quantify dietary, supplement and medication adherence in clinical trials

2016 ◽  
Vol 116 (9) ◽  
pp. 1646-1655 ◽  
Author(s):  
Courtney M. Peterson ◽  
John W. Apolzan ◽  
Courtney Wright ◽  
Corby K. Martin
Keyword(s):  
Medication Adherence ◽  
Online Survey ◽  
Self Report ◽  
Rater Agreement ◽  
Monitoring Methods ◽  
Video Chat ◽  
Pill Counts ◽  
Survey Results ◽  
Adherence Monitoring ◽  
Study Participants

AbstractWe conducted two studies to test the validity, reliability, feasibility and acceptability of using video chat technology to quantify dietary and pill-taking (i.e. supplement and medication) adherence. In study 1, we investigated whether video chat technology can accurately quantify adherence to dietary and pill-taking interventions. Mock study participants ate food items and swallowed pills, while performing randomised scripted ‘cheating’ behaviours to mimic non-adherence. Monitoring was conducted in a cross-over design, with two monitors watching in-person and two watching remotely by Skype on a smartphone. For study 2, a twenty-two-item online survey was sent to a listserv with more than 20 000 unique email addresses of past and present study participants to assess the feasibility and acceptability of the technology. For the dietary adherence tests, monitors detected 86 % of non-adherent events (sensitivity) in-person v. 78 % of events via video chat monitoring (P=0·12), with comparable inter-rater agreement (0·88 v. 0·85; P=0·62). However, for pill-taking, non-adherence trended towards being more easily detected in-person than by video chat (77 v. 60 %; P=0·08), with non-significantly higher inter-rater agreement (0·85 v. 0·69; P=0·21). Survey results from study 2 (n 1076 respondents; ≥5 % response rate) indicated that 86·4 % of study participants had video chatting hardware, 73·3 % were comfortable using the technology and 79·8 % were willing to use it for clinical research. Given the capability of video chat technology to reduce participant burden and outperform other adherence monitoring methods such as dietary self-report and pill counts, video chatting is a novel and promising platform to quantify dietary and pill-taking adherence.

scholarly journals Smartphone Addiction and Associated Factors among Postgraduate Students in an Arabic Sample: A Cross-sectional Study.

2021 ◽  
Author(s):  
Asem Alageel ◽  
Rayyan Alyahya ◽  
Yasser Bahatheq ◽  
Norah Alzunaydi ◽  
Raed Alghamdi ◽  
...  
Keyword(s):  
Mental Health ◽  
Associated Factors ◽  
Online Survey ◽  
Adult Adhd ◽  
Significant Risk ◽  
Self Report ◽  
Smartphone Addiction ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Postgraduate Students

Abstract Background:Smartphone addiction and other behavioral addictions have been established to accompany social, physical, and mental health issues. In this article, we will be investigating the prevalence of smartphone addiction among postgraduate students as well as assessing its relationship to social demographics, depression, ADHD, and nicotine dependence.Objectives:· The prevalence of smartphone addiction among middle eastern postgraduate students.· Ascertain the associated factors of smartphone addiction.· Measure the incidence of MDD, ADHD, insomnia, and nicotine addiction among postgraduate students with smartphone addiction.Methods:A Cross-sectional online survey, a self-questionnaire is divided into six sections; Socio-demographics, the Smartphone Addiction Scale (SAS) Patient Health Questionnaire for Depression (PHQ9). Athens Insomnia Scale (AIS) the Fagerstrom Test for Cigarette Dependence Questionnaire (FTCd) and the Adult ADHD Self-Report Scale (ASRS-v1.1)Results:51.0% of the participants had smartphone addiction. There’s a significant association between high smartphone use and MDD (p=0.001). 41.5% of smokers are addicted to smartphones (p=0.039). Smartphone addicts have about two times the risk of developing insomnia (OR= 2.113) (P= 0.013). Smartphone addicts had a significant risk of developing ADHD symptoms (OR =2.712) (P <0.001). Conclusion:Confirming several studies, we found a positive association between Insomnia, Depression, Adult ADHD, and Smartphone addiction. Therefore, we encourage the scientific community to study the impacts of smartphone addiction and the mental health of post-graduate students.

scholarly journals Use of healthcare REsources and associated COsts in controlled versus uncontrolled carcinoid SYndrome in patients with neuroendocrine tumours: the RECOSY study

2021 ◽  
Author(s):  
A. Custodio ◽  
P. Jimenez-Fonseca ◽  
A. Carmona-Bayonas ◽  
M. J. Gomez ◽  
M. I. Del Olmo-García ◽  
...  
Keyword(s):  
Resource Use ◽  
Carcinoid Syndrome ◽  
Neuroendocrine Tumours ◽  
Healthcare Resource ◽  
General Health Questionnaire ◽  
Work Productivity ◽  
Healthcare Resource Use ◽  
University Hospitals ◽  
Activity Impairment ◽  
Cross Sectional

Abstract Purpose To report healthcare resource use and associated costs in controlled versus uncontrolled carcinoid syndrome (CS) in patients with neuroendocrine tumours. Methods A cross-sectional, non-interventional multicentre study was conducted with retrospective data analysis. Resource use was compared between two patient groups: those with controlled CS (> 12 months with no uncontrolled CS episodes) and uncontrolled CS (< 12 months since last uncontrolled episode). Patients were matched for age, sex, and origin and grade of tumour. When no matching patients were available, data from deceased patients were used. Information on healthcare resource use came from review of medical records, patient history and physician reports. Working capacity was assessed using the Work Productivity and Activity Impairment General Health questionnaire. Results Twenty-six university hospitals in Spain participated, between July 2017 and April 2018. 137 patients were enrolled; 104 were analysed (2 groups of 52). Patients with uncontrolled CS had 10 times more emergency department (ED) visits (mean 1.0 vs 0.10 visits; P = 0.0167), were more likely to have a hospital admission (40.4% vs 19.2%; P = 0.0116) and had longer hospital stays (mean 7.87 vs 2.10 days; P = 0.0178) than those with controlled CS. This corresponded to higher annual hospitalisation costs (mean €5511.59 vs €1457.22; P = 0.028) and ED costs (€161.25 vs €14.85; P = 0.0236). The mean annual total healthcare costs were 60.0% higher in patients with uncontrolled than controlled CS (P = NS). Conclusion This study quantifies higher health resource use, and higher hospitalisation and ED costs in patients with uncontrolled CS. Better control of CS may result 3in lower medical costs.

scholarly journals High Disease Burden Drives Indirect Costs in Employed Inflammatory Bowel Disease Patients: The WORK-IBD Study

2020 ◽  
Author(s):  
Sara van Gennep ◽  
Sanne W Evers ◽  
Svend T Rietdijk ◽  
Marieke E Gielen ◽  
Nanne K H de Boer ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Disease Activity ◽  
Bowel Disease ◽  
Disease Burden ◽  
Productivity Loss ◽  
Work Productivity ◽  
Indirect Costs ◽  
Mean Difference ◽  
Activity Impairment ◽  
Inflammatory Bowel

Abstract Background Work productivity (WP) loss includes absence from work (absenteeism) and productivity loss while working (presenteeism), which leads to high indirect costs in inflammatory bowel disease (IBD). Prior health economic analyses predominantly focused on absenteeism. Here we focus on presenteeism and assess predictors of WP loss, fatigue, and reduced health-related quality of life (HRQL). Methods Employed IBD patients completed the following surveys: Work Productivity and Activity Impairment, Multidimensional Fatigue Inventory, and Short Inflammatory Bowel Disease Questionnaire. Predictors were assessed using uni- and multivariable regression analyses. Annual costs were calculated using percentages of WP loss, hourly wages, and contract hours. Results Out of 1590 invited patients, 768 (48%) responded and 510 (32%) were included. Absenteeism, presenteeism, and overall WP loss were reported by 94 (18%), 257 (50%), and 269 (53%) patients, respectively, resulting in mean (SD) annual costs of €1738 (5505), €5478 (8629), and €6597 (9987), respectively. Disease activity and active perianal disease were predictors of WP loss (odds ratio [OR] = 6.6; 95% confidence interval [CI], 3.6-12.1); OR = 3.7; 95% CI, 1.5-8.7). Disease activity and arthralgia were associated with fatigue (OR = 3.6; 95% CI, 1.9-6.8; OR = 1.8; 95% CI, 1.0-3.3)) and reduced HRQL (OR = 10.3; 95% CI, 5.9-17.9; OR = 2.3; 95 % CI, 1.4-3.8). Fatigue was the main reason for absenteeism (56%) and presenteeism (70%). Fatigue and reduced HRQL led to increased costs compared with absence of fatigue and normal HRQL (mean difference = €6630; 95% CI, €4977–€8283, P &lt; 0.01; mean difference = €9575; 95% CI, €7767–€11,384, P &lt; 0.01). Conclusions Disease activity and disease burden lead to WP loss in approximately half of the employed IBD population, driving indirect costs. Fatigue is the most important reason for WP loss.

scholarly journals Non-credible symptom report in the clinical evaluation of adult ADHD: development and initial validation of a new validity index embedded in the Conners’ adult ADHD rating scales

2021 ◽  
Author(s):  
Miriam Becke ◽  
Lara Tucha ◽  
Matthias Weisbrod ◽  
Steffen Aschenbrenner ◽  
Oliver Tucha ◽  
...  
Keyword(s):  
Classification Accuracy ◽  
Adult Adhd ◽  
Rating Scales ◽  
Stimulant Medication ◽  
Self Report ◽  
Symptom Report ◽  
Hyperactivity Disorder ◽  
Detection Strategies ◽  
Unusual Symptom ◽  
Adhd Rating Scales

AbstractAs attention-deficit/hyperactivity disorder (ADHD) is a feasible target for individuals aiming to procure stimulant medication or accommodations, there is a high clinical need for accurate assessment of adult ADHD. Proven falsifiability of commonly used diagnostic instruments is therefore of concern. The present study aimed to develop a new, ADHD-specific infrequency index to aid the detection of non-credible self-report. Disorder-specific adaptations of four detection strategies were embedded into the Conners’ Adult ADHD Rating Scales (CAARS) and tested for infrequency among credible neurotypical controls (n = 1001) and credible adults with ADHD (n = 100). The new index’ ability to detect instructed simulators (n = 242) and non-credible adults with ADHD (n = 22) was subsequently examined using ROC analyses. Applying a conservative cut-off score, the new index identified 30% of participants instructed to simulate ADHD while retaining a specificity of 98%. Items assessing supposed symptoms of ADHD proved most useful in distinguishing genuine patients with ADHD from simulators, whereas inquiries into unusual symptom combinations produced a small effect. The CAARS Infrequency Index (CII) outperformed the new infrequency index in terms of sensitivity (46%), but not overall classification accuracy as determined in ROC analyses. Neither the new infrequency index nor the CII detected non-credible adults diagnosed with ADHD with adequate accuracy. In contrast, both infrequency indices showed high classification accuracy when used to detect symptom over-report. Findings support the new indices’ utility as an adjunct measure in uncovering feigned ADHD, while underscoring the need to differentiate general over-reporting from specific forms of feigning.

scholarly journals Smartphone addiction and associated factors among postgraduate students in an Arabic sample: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Asem A. Alageel ◽  
Rayyan A. Alyahya ◽  
Yasser A. Bahatheq ◽  
Norah A. Alzunaydi ◽  
Raed A. Alghamdi ◽  
...  
Keyword(s):  
Mental Health ◽  
Online Survey ◽  
Adult Adhd ◽  
Middle Eastern ◽  
Positive Association ◽  
Self Report ◽  
Smartphone Addiction ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Postgraduate Students

Abstract Background Smartphone addiction, as with other behavioral addictions, is associated with social, physical, and mental health issues. In this article, we investigated the prevalence of smartphone addiction among postgraduate students and evaluated its correlation with social demographics, depression, attention-deficit/hyperactivity disorder (ADHD), and nicotine dependence. Objectives The objective of this study was to investigate the prevalence of smartphone addiction among Middle Eastern postgraduate students, determine the factors associated with smartphone addiction, and estimate the incidence rate of major depressive disorder (MDD), ADHD, insomnia, and nicotine addiction among postgraduate students with smartphone addiction. Methods As part of a cross-sectional online survey, participants were given a self-questionnaire divided into six sections: Socio-demographics, Smartphone Addiction Scale (SAS), Patient Health Questionnaire (PHQ9) for Depression, Athens Insomnia Scale (AIS), the Fagerström Test for Cigarette Dependence Questionnaire (FTCd), and the adult ADHD Self-Report Scale (ASRS-v1.1). Results Of the 506 patients, 51.0% of the participants demonstrated smartphone addiction. A significant association was also observed between extensive smartphone use and MDD (P = 0.001). Of the smokers in this study, 41.5% were addicted to smartphones (P = 0.039). Smartphone addicts had approximately two times the chance of having insomnia (OR = 2.113) (P = 0.013). In addition, they showcased more ADHD symptoms (OR = 2.712) (P < 0.001). Conclusions We found a positive association among insomnia, depression, adult ADHD, and smartphone addiction, which confirms the findings reported in the previous studies. Therefore, we encourage the scientific community to further study the impacts of smartphone addiction on the mental health of postgraduate students.

scholarly journals Burden of migraine among Japanese patients: a cross-sectional National Health and Wellness Survey

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Shoji Kikui ◽  
Yirong Chen ◽  
Hiroshi Todaka ◽  
Keiko Asao ◽  
Kenji Adachi ◽  
...  
Keyword(s):  
National Health ◽  
Healthcare Providers ◽  
Work Productivity ◽  
Indirect Costs ◽  
Japanese Patients ◽  
Total Activity ◽  
Health And Wellness ◽  
Activity Impairment ◽  
Cross Sectional ◽  
Factors Associated

Abstract Background Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National Health and Wellness Survey. Methods Migraine patients were defined by ICHD-3 like criteria with ≥4 monthly headache days (MHDs), and non-migraine respondents were selected using 1:4 propensity score matching. Multivariate analyses were conducted to compare Health-related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), healthcare resource utilization (HRU) and costs between the two groups, and to identify factors associated with these outcomes in migraine patients. Results In 30,001 respondents, 378 migraine patients were identified. Compared to matched controls (N = 1512), migraine patients had lower physical (45.17 vs. 49.89), mental (42.28 vs. 47.71) and role/social (37.91 vs. 44.19) component summary scores (p < 0.001). Migraine patients had higher absenteeism (6.4% vs. 2.2%), presenteeism (40.2% vs. 22.5%), total work productivity impairment (44.3% vs. 24.5%), total activity impairment (45.0% vs. 23.9%), indirect costs (1,492,520 JPY vs. 808,320 JPY) and more visits to healthcare providers in the past 6 months (7.23 vs. 3.96) (p < 0.001). More MHDs was associated with worse HRQoL, and higher HRU and indirect costs. Conclusions Japanese migraine patients experience an incremental burden. This demonstrates the unmet needs among Japanese migraine patients.

scholarly journals Health-Related Quality of Life and Work Productivity of Adults With ADHD: A U.K. Web-Based Cross-Sectional Survey

2018 ◽  
Vol 23 (13) ◽  
pp. 1610-1623 ◽  
Author(s):  
Alain Joseph ◽  
Charlotte E. Kosmas ◽  
Chloe Patel ◽  
Helen Doll ◽  
Philip Asherson
Keyword(s):  
Quality Of Life ◽  
Adult Adhd ◽  
Rating Scale ◽  
Work Productivity ◽  
Daily Activities ◽  
Health Related Quality ◽  
Activity Impairment ◽  
Related Quality ◽  
Health Related

Objective: The objective of this study was to assess health-related quality of life (HRQoL) in adult ADHD. Method: U.K. residents aged 18 to 55 years with ADHD and no major mental health comorbidities completed an online survey of disorder history, the EuroQoL 5-Dimensions 5-Level (EQ-5D-5L), and the Work Productivity and Activity Impairment Questionnaire: General Health (WPAI:GH). ADHD Rating Scale-IV (ADHD-RS-IV) score was assessed by telephone. Results: In total, 233 participants completed the study (mean age 32.6 years; 65.2% women). Mean ( SD) ADHD-RS-IV total score, EQ-5D utility, and visual analog scale (VAS) scores were 43.5 (7.88), 0.74 (.21), and 69.8 (17.76), respectively. Mean ( SD) WPAI:GH scores indicated that health problems caused 45.7% (29.9) overall work impairment and 45.8% (28.9) impairment in regular daily activities. Greater work and activity impairment were both significantly independently associated with lower utility after adjusting for age, gender, and somatic comorbidities. Conclusion: Adult ADHD impairs HRQoL, work productivity, and regular daily activities.

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