scholarly journals Video chat technology to remotely quantify dietary, supplement and medication adherence in clinical trials

2016 ◽  
Vol 116 (9) ◽  
pp. 1646-1655 ◽  
Author(s):  
Courtney M. Peterson ◽  
John W. Apolzan ◽  
Courtney Wright ◽  
Corby K. Martin
Keyword(s):  
Medication Adherence ◽  
Online Survey ◽  
Self Report ◽  
Rater Agreement ◽  
Monitoring Methods ◽  
Video Chat ◽  
Pill Counts ◽  
Survey Results ◽  
Adherence Monitoring ◽  
Study Participants

AbstractWe conducted two studies to test the validity, reliability, feasibility and acceptability of using video chat technology to quantify dietary and pill-taking (i.e. supplement and medication) adherence. In study 1, we investigated whether video chat technology can accurately quantify adherence to dietary and pill-taking interventions. Mock study participants ate food items and swallowed pills, while performing randomised scripted ‘cheating’ behaviours to mimic non-adherence. Monitoring was conducted in a cross-over design, with two monitors watching in-person and two watching remotely by Skype on a smartphone. For study 2, a twenty-two-item online survey was sent to a listserv with more than 20 000 unique email addresses of past and present study participants to assess the feasibility and acceptability of the technology. For the dietary adherence tests, monitors detected 86 % of non-adherent events (sensitivity) in-person v. 78 % of events via video chat monitoring (P=0·12), with comparable inter-rater agreement (0·88 v. 0·85; P=0·62). However, for pill-taking, non-adherence trended towards being more easily detected in-person than by video chat (77 v. 60 %; P=0·08), with non-significantly higher inter-rater agreement (0·85 v. 0·69; P=0·21). Survey results from study 2 (n 1076 respondents; ≥5 % response rate) indicated that 86·4 % of study participants had video chatting hardware, 73·3 % were comfortable using the technology and 79·8 % were willing to use it for clinical research. Given the capability of video chat technology to reduce participant burden and outperform other adherence monitoring methods such as dietary self-report and pill counts, video chatting is a novel and promising platform to quantify dietary and pill-taking adherence.

scholarly journals The Time is Now for Disruptive Innovation in Pre-Exposure Prophylaxis Adherence Monitoring

2020 ◽  
Vol 7 (1) ◽  
pp. 5-9
Author(s):  
Giffin Daughtridge ◽  
◽  
Elijah Kahn-Woods ◽  
Casper Enghuus ◽  
Shane Hebel ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Disruptive Innovation ◽  
Self Report ◽  
Monitoring Methods ◽  
Adherence Support ◽  
Immunodeficiency Virus ◽  
The Us ◽  
Hiv Acquisition ◽  
Adherence Monitoring ◽  
Exposure Prophylaxis

Monitoring adherence to pre-exposure prophylaxis is a critical component of reaching ending the human immunodeficiency virus infection (HIV) epidemic goals in the US. Currently, providers still depend on “self-report” pre-exposure prophylaxis (PrEP) adherence, whereby providers ask their patients about their recent pill taking habits. There appears to be growing consensus across the HIV prevention community that “self-report” is an inadequate method of identifying that is in-need of additional adherence support services. In a recent survey, 97% of providers report utilizing self-reported adherence because it is convenient, but only 10% of these providers believe it is accurate. While “self-report” is convenient, evidence and testimonials from diverse stakeholders across the HIV prevention landscape indicate that there is a desire for more accurate, effective adherence monitoring methods. In this mini-review, we will briefly synthesize the emerging evidence and propose a solution to ensure all patients receive the support needed to protect them from HIV acquisition.

scholarly journals Testing the Confluence Model Theory of Sexual Aggression

2020 ◽  
Author(s):  
Taylor Kohut ◽  
William Fisher
Keyword(s):  
Young Adult ◽  
Sexual Aggression ◽  
Online Survey ◽  
Self Report ◽  
Causal Explanations ◽  
Post Secondary ◽  
Confluence Model ◽  
Pornography Consumption ◽  
Pornography Use ◽  
Survey Results

The connection between pornography use and sexual violence remains an ongoing concern within and outside academia. The current research sought to test Confluence Model reasoning that pornography use will be most strongly related to sexual aggression among men who are high in the predisposing risk factors of hostile masculinity and impersonal sexuality. To this end, a sample of young adult (18-24 years of age) males from Mechanical Turk (N = 1,528) and two national samples of young adult Canadian males who were currently enrolled (N = 1,049) or not currently enrolled (N = 905) in post-secondary education completed self-report measures of pornography use, hostile masculinity, impersonal sexuality, and sexual aggression in an online survey. Results supported some aspects of Confluence Model theorizing but challenged others. When pornography use was operationalized with a contemporary approach that assessed use of all forms of pornography, the results did not confirm a positive relationship between pornography use and sexual aggression among men with high levels of hostile masculinity and impersonal sexuality. When operationalized as the use of pornographic magazines, a relatively uncommon contemporary form of pornography consumption, pornography use was found to be correlated with sexual aggression, and the magnitude of this association was larger among men who were high in either hostile masculinity or impersonal sexuality, depending on the sample. These discrepant findings serve as a challenge to causal explanations for previously published correlations of pornography use and sexual aggression and a warning about the non-equivalence of pornography use measures.

scholarly journals Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study

10.2196/21023 ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. e21023
Author(s):  
Jianqiao Li ◽  
Margaret A Hojlo ◽  
Sampath Chennuri ◽  
Nitin Gujral ◽  
Heather L Paterson ◽  
...  
Keyword(s):  
Online Survey ◽  
Phenotypic Variability ◽  
Genetic Disorders ◽  
Self Report ◽  
Rare Disorders ◽  
Survey Tool ◽  
Affected Person ◽  
Number Variation ◽  
Survey Results ◽  
Variable Presentation

Background 16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental and physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use a patient “self-phenotyping” survey to collect data directly from patients to further characterize the phenotypes of 16p13.11 microduplication syndrome. Objective This study aimed to (1) discover self-identified phenotypes in 16p13.11 microduplication syndrome that have been underrepresented in the scientific literature and (2) demonstrate that self-phenotyping tools are valuable sources of data for the medical and scientific communities. Methods As part of a large study to compare and evaluate patient self-phenotyping surveys, an online survey tool, Phenotypr, was developed for patients with rare disorders to self-report phenotypes. Participants with 16p13.11 microduplication syndrome were recruited through the Boston Children's Hospital 16p13.11 Registry. Either the caregiver, parent, or legal guardian of an affected child or the affected person (if aged 18 years or above) completed the survey. Results were securely transferred to a Research Electronic Data Capture database and aggregated for analysis. Results A total of 19 participants enrolled in the study. Notably, among the 19 participants, aggression and anxiety were mentioned by 3 (16%) and 4 (21%) participants, respectively, which is an increase over the numbers in previously published literature. Additionally, among the 19 participants, 3 (16%) had asthma and 2 (11%) had other immunological disorders, both of which have not been previously described in the syndrome. Conclusions Several phenotypes might be underrepresented in the previous 16p13.11 microduplication literature, and new possible phenotypes have been identified. Whenever possible, patients should continue to be referenced as a source of complete phenotyping data on their condition. Self-phenotyping may lead to a better understanding of the prevalence of phenotypes in genetic disorders and may identify previously unreported phenotypes.

scholarly journals The Association of Oral Stimulant Medication Adherence with Work Productivity among Adults with ADHD

2021 ◽  
pp. 108705472110201
Author(s):  
William Spalding ◽  
Sepehr Farahbakhshian ◽  
Martine C. Maculaitis ◽  
Eugenia Y. Peck ◽  
Amir Goren
Keyword(s):  
Medication Adherence ◽  
Online Survey ◽  
Adult Adhd ◽  
Stimulant Medication ◽  
General Health Questionnaire ◽  
Work Productivity ◽  
Indirect Costs ◽  
Self Report ◽  
Activity Impairment ◽  
Scale Total Score

Objective: Examine associations between oral psychostimulant pharmacotherapy adherence, work productivity, and related indirect costs among US adults with ADHD. Methods: Medication adherence (Medication Adherence Reasons Scale [MAR-Scale]), work productivity and activity impairment (Work Productivity and Activity Impairment–General Health questionnaire), and ADHD symptom level (Adult ADHD Self-Report Scale version 1.1 Symptom Checklist) were assessed in this noninterventional online survey of adults who self-reported having an ADHD diagnosis and were currently receiving oral psychostimulant treatment for ≥3 months. Results: Of 602 respondents, 395 had low/medium adherence (LMA: MAR-Scale total score ≥1) and 207 had high adherence (HA: MAR-Scale total score 0). After adjusting for covariates, the LMA group had significantly greater levels of absenteeism, absenteeism-related indirect costs, and total indirect costs (all p < .01) than the HA group. Conclusion: In adults with ADHD using oral psychostimulants, lower medication adherence was associated with greater absenteeism and indirect costs.

Adherence to oral tamoxifen: a comparison of patient self-report, pill counts, and microelectronic monitoring.

1993 ◽  
Vol 11 (6) ◽  
pp. 1189-1197 ◽  
Author(s):  
D M Waterhouse ◽  
K A Calzone ◽  
C Mele ◽  
D E Brenner
Keyword(s):  
Patient Adherence ◽  
Tamoxifen Therapy ◽  
Self Report ◽  
Adherence Behavior ◽  
Event Monitoring ◽  
Dosing Interval ◽  
Drug Packaging ◽  
Continuous Record ◽  
Pill Counts ◽  
Adherence Monitoring

PURPOSE Recent innovations allow the integration of microelectronics into drug packaging, providing a continuous record of the interactions of the patient with the drug package. We hypothesized that adherence to oral tamoxifen, as measured by a pressure-activated microelectronic monitoring device, would be significantly discrepant from traditional measures of patient adherence, ie, patient self-report (SR) and pill counts (PCs). PATIENTS AND METHODS Twenty-six patients receiving oral tamoxifen therapy were assessed by patient SR, PCs, and Medication Event Monitoring System (MEMS; Aprex Corp, Fremont, CA) microelectronic monitoring. A microprocessor in the MEMS cap recorded each opening as a presumptive dose, listing the date, time, and duration of opening for later retrieval on a microcomputer. Patients were not informed that their adherence was to be monitored electronically or that PCs would be performed. RESULTS A total of 2,102 days (70.1 months) of tamoxifen therapy were monitored; patients were monitored for a mean of 2.92 months of tamoxifen therapy. SR adherence to oral tamoxifen was significantly higher than that suggested by either PCs (SR missed doses only v PC, P = .008) or MEMS adherence monitoring (SR missed doses only v MEMS missed doses only, P = .005; SR dosing-interval errors only v MEMS dosing-interval errors only, P < .0001; SR all dosing errors v MEMS all dosing errors, P < .0005). PC data also suggested significantly higher adherence rates than MEMS monitoring. CONCLUSION Microelectronic adherence monitoring provides both confirmatory and complimentary data regarding adherence behavior, while also allowing for the evaluation of patterns of nonadherence. Patient SRs and PCs likely overestimate the degree to which patients adhere to their tamoxifen regimen.

scholarly journals Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study (Preprint)

2020 ◽  
Author(s):  
Jianqiao Li ◽  
Margaret A Hojlo ◽  
Sampath Chennuri ◽  
Nitin Gujral ◽  
Heather L Paterson ◽  
...  
Keyword(s):  
Online Survey ◽  
Phenotypic Variability ◽  
Genetic Disorders ◽  
Self Report ◽  
Rare Disorders ◽  
Survey Tool ◽  
Affected Person ◽  
Number Variation ◽  
Survey Results ◽  
Variable Presentation

BACKGROUND 16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental and physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use a patient “self-phenotyping” survey to collect data directly from patients to further characterize the phenotypes of 16p13.11 microduplication syndrome. OBJECTIVE This study aimed to (1) discover self-identified phenotypes in 16p13.11 microduplication syndrome that have been underrepresented in the scientific literature and (2) demonstrate that self-phenotyping tools are valuable sources of data for the medical and scientific communities. METHODS As part of a large study to compare and evaluate patient self-phenotyping surveys, an online survey tool, Phenotypr, was developed for patients with rare disorders to self-report phenotypes. Participants with 16p13.11 microduplication syndrome were recruited through the Boston Children's Hospital 16p13.11 Registry. Either the caregiver, parent, or legal guardian of an affected child or the affected person (if aged 18 years or above) completed the survey. Results were securely transferred to a Research Electronic Data Capture database and aggregated for analysis. RESULTS A total of 19 participants enrolled in the study. Notably, among the 19 participants, aggression and anxiety were mentioned by 3 (16%) and 4 (21%) participants, respectively, which is an increase over the numbers in previously published literature. Additionally, among the 19 participants, 3 (16%) had asthma and 2 (11%) had other immunological disorders, both of which have not been previously described in the syndrome. CONCLUSIONS Several phenotypes might be underrepresented in the previous 16p13.11 microduplication literature, and new possible phenotypes have been identified. Whenever possible, patients should continue to be referenced as a source of complete phenotyping data on their condition. Self-phenotyping may lead to a better understanding of the prevalence of phenotypes in genetic disorders and may identify previously unreported phenotypes.

The Stereotype Threat Effect

2018 ◽  
Vol 29 (4) ◽  
pp. 249-258 ◽  
Author(s):  
Steffen Moritz ◽  
Insa Happach ◽  
Karla Spirandelli ◽  
Tania M. Lincoln ◽  
Fabrice Berna
Keyword(s):  
Stereotype Threat ◽  
Self Report ◽  
Neuropsychological Performance ◽  
Neurocognitive Deficits ◽  
Online Study ◽  
Memory And Attention ◽  
Threat Effect ◽  
Efficacy Expectations ◽  
Study Participants ◽  
The Impact

Abstract. Neurocognitive deficits in patients with mental disorders are partially due to secondary influences. “Stereotype threat” denotes the phenomenon that performance is compromised when a participant is confronted with a devaluing stereotype. The present study examined the impact of stereotype threat on neuropsychological performance in schizophrenia. Seventy-seven participants with a self-reported diagnosis of schizophrenia were randomly assigned to either an experimental condition involving stereotype threat activation or a control condition in an online study. Participants completed memory and attention tests as well as questionnaires on motivation, self-efficacy expectations, cognitive complaints, and self-stigmatization. Contrary to our prediction, the two groups showed no significant differences regarding neuropsychological performance and self-report measures. Limitations, such as a possibly too weak threat cue, are discussed and recommendations for future studies are outlined.

Does Dispositional Mindfulness Predict the Development of Grit?

2018 ◽  
Vol 39 (2) ◽  
pp. 76-87 ◽  
Author(s):  
Buaphrao Raphiphatthana ◽  
Paul Jose ◽  
Karen Salmon
Keyword(s):  
Undergraduate Students ◽  
Online Survey ◽  
Cross Sectional Study ◽  
Self Report ◽  
Dispositional Mindfulness ◽  
Cross Sectional ◽  
Report Data ◽  
Self Report Data ◽  
Acting With Awareness ◽  
Mindfulness Facets

Abstract. Grit, that is, perseverance and passion for long-term goals, is a novel construct that has gained attention in recent years ( Duckworth, Peterson, Matthews, & Kelly, 2007 ). To date, little research has been performed with the goal of identifying the antecedents of grit. Thus, in order to fill this gap in the literature, self-report data were collected to examine whether mindfulness, a mindset of being-in-the-present in a nonjudgmental way, plays a role in fostering grittiness. Three hundred and forty-three undergraduate students completed an online survey once in a cross-sectional study, and of these, 74 students completed the survey again 4.5 months later. Although the cross-sectional analyses identified a number of positive associations between mindfulness and grit, the longitudinal analysis revealed that the mindfulness facets of acting with awareness and non-judging were the most important positive predictors of grit 4.5 months later. This set of findings offers implications for future grit interventions.

Examining User Perception and Usage of Voice Search

2020 ◽  
Vol 5 (1) ◽  
pp. 40-47
Author(s):  
Ning Sa ◽  
Xiaojun (Jenny) Yuan
Keyword(s):  
Success Rate ◽  
Mobile Devices ◽  
Online Survey ◽  
Search Behavior ◽  
Mobile Technologies ◽  
User Perception ◽  
Daily Lives ◽  
Survey Results ◽  
Search Systems

AbstractWith the development of mobile technologies, voice search is becoming increasingly important in our daily lives. By investigating the general usage of voice search and user perception about voice search systems, this research aims to understand users’ voice search behavior. We are particularly interested in how users perform voice search, their topics of interest, and their preference toward voice search. We elicit users’ opinions by asking them to fill out an online survey. Results indicated that participants liked voice search because it was convenient. However, voice search was used much less frequently than keyboard search. The success rate of voice search was low, and the participants usually gave up voice search or switched to keyboard search. They tended to perform voice search when they were driving or walking. Moreover, the participants mainly used voice search for simple tasks on mobile devices. The main reasons why participants disliked voice search are attributed to the system mistakes and the fact that they were unable to modify the queries.

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