scholarly journals Erratum

2011 ◽  
Vol 16 (5) ◽  
pp. 560-560
Keyword(s):  
Transcription Factors ◽  
Nuclear Export ◽  
Forkhead Transcription Factors ◽  
Article Figure

Bouck DC, Shu P, Cui J, Shelat A, Chen T. A High-Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors. J. Biomol. Screen. 2011, 16, 394-404. (Original 10.1177/1087057110397889) In the April issue of the Journal of Biomolecular Screening, in the above-mentioned article, Figure 1 contained incorrect axis labels; Figure 3a contained an unintended artifact. Corrected figures have been posted online at http://jbx.sagepub.com/content/16/4/394/suppl/DC1.

Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors

2003 ◽  
Vol 31 (1) ◽  
pp. 292-297 ◽  
Author(s):  
K.U. Birkenkamp ◽  
P.J. Coffer
Keyword(s):  
Transcription Factors ◽  
Cell Survival ◽  
Cell Fate ◽  
Nuclear Export ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Acute Lymphocytic Leukaemia ◽  
Cell Fate Decisions ◽  
Forkhead Transcription Factors ◽  
Forkhead Box

Recently, the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors has been identified as direct targets of phosphoinositide 3-kinase-mediated signal transduction. The AFX (acute-lymphocytic-leukaemia-1 fused gene from chromosome X), FKHR (Forkhead in rhabdomyosarcoma) and FKHR-L1 (FKHR-like 1) transcription factors are directly phosphorylated by protein kinase B, resulting in nuclear export and inhibition of transcription. This signalling pathway was first identified in the nematode worm Caenorhabditis elegans, where it has a role in regulation of the life span of the organism. Studies have shown that this evolutionarily conserved signalling module has a role in regulation of both cell-cycle progression and cell survival in higher eukaryotes. These effects are co-ordinated by FOXO-mediated induction of a variety of specific target genes that are only now beginning to be identified. Interestingly, FOXO transcription factors appear to be able to regulate transcription through both DNA-binding-dependent and -independent mechanisms. Our understanding of the regulation of FOXO activity, and defining specific transcriptional targets, may provide clues to the molecular mechanisms controlling cell fate decisions to divide, differentiate or die.

scholarly journals A High-Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors

2011 ◽  
Vol 16 (4) ◽  
pp. 394-404 ◽  
Author(s):  
David C. Bouck ◽  
Peter Shu ◽  
Jimmy Cui ◽  
Anang Shelat ◽  
Taosheng Chen
Keyword(s):  
Transcription Factors ◽  
Nuclear Export ◽  
Cell Cycle Progression ◽  
Akt Signaling Pathway ◽  
Cycle Progression ◽  
Forkhead Transcription Factors ◽  
Forkhead Box ◽  
Therapeutic Value ◽  
Isoform Specificity ◽  
Foxo Transcription Factors

Class O forkhead box (FOXO) transcription factors are downstream targets of the PI3K/AKT signaling pathway, which is upregulated in many tumors. AKT phosphorylates and inactivates FOXO1 by relocating it to the cytoplasm. Because FOXO1 functions as a tumor suppressor by negatively regulating cell cycle progression and cell survival, compounds that promote FOXO1 localization to the nucleus might have therapeutic value in oncology. Here the authors describe the identification of such compounds by using an image-based, high-content screen. Compounds that were active in retaining FOXO1 in the nucleus were tested to determine their pathway specificity and isoform specificity by using high-content assays for Rev and FOXO3, respectively.

scholarly journals Understanding the perspectives of forkhead transcription factors in delayed wound healing

2018 ◽  
Vol 13 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Naresh Kumar Rajendran ◽  
Sathish Sundar Dhilip Kumar ◽  
Nicolette Nadene Houreld ◽  
Heidi Abrahamse
Keyword(s):  
Wound Healing ◽  
Transcription Factors ◽  
Delayed Wound Healing ◽  
Forkhead Transcription Factors

scholarly journals In control of biology: of mice, men and Foxes

2006 ◽  
Vol 397 (2) ◽  
pp. 233-246 ◽  
Author(s):  
Patrick J. E. C. Wijchers ◽  
J. Peter H. Burbach ◽  
Marten P. Smidt
Keyword(s):  
Transcription Factors ◽  
Current Knowledge ◽  
Treatment Strategies ◽  
Model Organisms ◽  
Functional Protein ◽  
Comprehensive Overview ◽  
Developmental Defects ◽  
Forkhead Transcription Factors ◽  
Human Pathology ◽  
Forkhead Gene

Forkhead proteins comprise a highly conserved family of transcription factors, named after the original forkhead gene in Drosophila. To date, over 100 forkhead genes have been identified in a large variety of species, all sharing the evolutionary conserved ‘forkhead’ DNA-binding domain, and the cloning and characterization of forkhead genes have continued in recent years. Forkhead transcription factors regulate the expression of countless genes downstream of important signalling pathways in most, if not all, tissues and cell types. Recent work has provided novel insights into the mechanisms that contribute to their functional diversity, including functional protein domains and interactions of forkheads with other transcription factors. Studies using loss- and gain-of-function models have elucidated the role of forkhead factors in developmental biology and cellular functions such as metabolism, cell division and cell survival. The importance of forkhead transcription factors is underlined by the developmental defects observed in mutant model organisms, and multiple human disorders and cancers which can be attributed to mutations within members of the forkhead gene family. This review provides a comprehensive overview of current knowledge on forkhead transcription factors, from structural organization and regulatory mechanisms to cellular and developmental functions in mice and humans. Finally, we will discuss how novel insights gained from involvement of ‘Foxes’ in the mechanisms underlying human pathology may create new opportunities for treatment strategies.

scholarly journals Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

Cell ◽  
2008 ◽  
Vol 135 (6) ◽  
pp. 1053-1064 ◽  
Author(s):  
Sarah De Val ◽  
Neil C. Chi ◽  
Stryder M. Meadows ◽  
Simon Minovitsky ◽  
Joshua P. Anderson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Combinatorial Regulation ◽  
Forkhead Transcription Factors ◽  
Endothelial Gene Expression
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