Trends in Invasive Cutaneous Melanoma in Saskatchewan 1970–1999

2003 ◽  
Vol 7 (6) ◽  
pp. 433-442 ◽  
Author(s):  
Marcie J. Ulmer ◽  
Jon M. Tonita ◽  
Peter R. Hull
Keyword(s):  
Prognostic Factors ◽  
Cutaneous Melanoma ◽  
Excess Mortality ◽  
Tumor Thickness ◽  
Tumor Characteristics ◽  
Anatomic Site ◽  
Clark Level ◽  
Melanoma Incidence ◽  
Number Of Patients ◽  
And Gender

Background: Melanoma incidence rates have increased dramatically in white populations worldwide during the past several decades. A more modest increase has been observed for melanoma-related mortality. Cause-specific and disease-free survivals are related to tumor characteristics, gender, age, and possibly anatomic site. It is difficult to accurately assess these trends without information on tumor thickness that is often unavailable. Objective: This study determines trends in melanoma incidence, mortality, and survival in Saskatchewan for a 30-year period, incorporating analysis of tumor thickness. Methods: Information about cases of primary cutaneous melanoma for the 30-year period 1970–1999 was obtained from the population-based Saskatchewan Cancer Registry. A 50% random sample of charts was reviewed to collect information about Breslow depth, Clark level, and other demographic data not available from the Registry. Multivariate regression analysis was used to determine the significance of prognostic factors on incidence and five-year relative survival rates. Results: The number of patients registered increased dramatically during the study period. The increase was greatest for thin lesions in all age groups. Anatomic site varied by gender. Head and neck tumors showed continual increase in risk with increasing age. Mortality rates in females have been stable over time but increased for males in the 1990s. The prognostic factors that predicted excess mortality at five years were tumor thickness, Clark level, and gender. Conclusion: The observed increase in melanoma appears to be real and not the result of increased surveillance or screening. Tumor characteristics (Breslow depth, Clark level) and gender were significant prognostic indicators of five-year excess mortality.

scholarly journals Does morphology have real impact on local and distant recurrences in head and neck cutaneous melanoma?

2020 ◽  
Vol 10 (3) ◽  
pp. 55-64
Author(s):  
A. M. Mudunov ◽  
M. B. Pak ◽  
L. V. Demidov ◽  
K. A. Baryshnikov
Keyword(s):  
Prognostic Factors ◽  
Surgical Treatment ◽  
Local Recurrence ◽  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Primary Tumor ◽  
Resection Margin ◽  
Tumor Thickness ◽  
Treatment Results ◽  
Level Of Invasion

Introduction. The term “local recurrence” is usually understood as regrowth of a tumor after surgical treatment. The regrowth appears within 3–5 cm from postoperative cicatrix. The causes for such prolonged tumor growth or recurrence of patients with cutaneous melanoma are nonradical surgical treatment as well as satellite or transit metastases that were not removed in-block with primary tumor. A great number of clinical researches, aimed at examination of melanoma, its patterns, anatomical criteria and features of clinical course, gave an opportunity to separate satellite or transit metastases into an independent group. Such metastases are realized inside or subdermally, up to 2 cm or more than 2 cm from the primary tumor, yet, not reaching the location of the first regional barrier.The aim of the study is to define influence of the main prognostic factors such as tumor thickness according to Breslow, the level of invasion according to Clark and the presence of ulceration on the frequency of local recurrence with cutaneous melanoma of head and neck.Materials and methods. The research involved 174 patients with cutaneous melanoma of head and neck (1995–2014). According to our index of contraction of a skin flap (median 30 %) the true borders of resection were clearly defined within all the patients. Thereby, 3 groups were identified with the following resection margin: 1.0 cm, where followed-up treatment results were analyzed.Results. Progression-free survival didn’t correlate with the size of surgical resection margins. The survival rates were the best with the lowest resection margin under 0.5 cm (77.3 %) and the worst with the highest resection margin more then 1.0 cm (38.7 %). That means that the treatment results don’t depend on the width increase of tumor resection margin.Conclusions. We consider that clear surgical margins for any thickness of cutaneous melanoma of head and neck should be as follows: 4 mm – 0.72 mm (p = 0.016). In our work, the influence of the main prognostic factors, such as tumor thickness according to Breslow, level of invasion according to Clark and ulceration on the frequency of head and neck cutaneous melanoma local recurrences had no impact.

scholarly journals Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966–2007

2010 ◽  
Vol 101 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Emanuela Cicarma ◽  
Asta Juzeniene ◽  
Alina C. Porojnicu ◽  
Øyvind S. Bruland ◽  
Johan Moan
Keyword(s):  
Anatomic Site ◽  
Melanoma Incidence ◽  
And Gender

Sex and Gender Differences in Rilpivirine based ART - Data from the HIVCENTER Frankfurt

2019 ◽  
Vol 17 (5) ◽  
pp. 368-374
Author(s):  
G. Schüttfort ◽  
K. Philipp ◽  
P. de Leuw ◽  
E. Herrmann ◽  
G. Kann ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Virologic Failure ◽  
Response Rates ◽  
Virologic Response ◽  
Close Monitoring ◽  
Sex And Gender ◽  
Overall Response ◽  
Number Of Patients ◽  
And Gender ◽  
Gender Specific

Objectives: While Rilpivirine has shown high overall response rates in treatment-naïve patients without sex and gender specific differences in clinical trials, Sex and gender specific data in treatment experienced patients receiving rilpivirine are still limited. We conducted a 48 week efficacy and safety analysis in naïve and treatment experienced men and women using retrospective data from the HIVCENTER Frankfurt. Materials and methods: In this retrospective observational study data of all patients who received a rilpivirine based regimen at the HIVCENTER between March 2011 and December 2015 were analyzed. Primary endpoint was the proportion of patients with any discontinuation until week 48. Virologic response rates (FDA snapshot analysis; HIV-1 RNA <50 copies/mL) were assessed at week 48. Results: 194 patients (34% female) were included in the analysis. 74% were treatment-experienced and 26% naïve, respectively. Discontinuations were observed in 31 (15.9%) patients. Regarding sex differences, the proportion of discontinuations was significantly higher in women than in men (24.2% vs. 11.7%; p=0.024; ODDS-Ratio = 2.41; CI 1.12 – 5.18). Virologic failure occurred in 8 PLWHIV (4.1%). Conclusions: While virologic overall response rates to rilpivirine based ART were high for both treatment-experienced and -naïve patients the proportion of discontinuations was significantly higher in women (24.2% vs. 11.7%; p = 0.024; ODDS-Ratio = 2.41; CI 1.12 – 5.18). Although the total number of patients with virologic failure was low (4.1%), the higher rate of ART discontinuations in female patients receiving RPV require close monitoring in the first months of treatment addressing special needs of women living with HIV.

scholarly journals Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 324
Author(s):  
Ho-Seok Oh ◽  
Sung-Kyu Kim ◽  
Hyoung-Yeon Seo
Keyword(s):  
Health Insurance ◽  
Age Groups ◽  
Osteoporotic Fractures ◽  
Prescription Data ◽  
Diagnostic Codes ◽  
Number Of Patients ◽  
Upper And Lower Extremities ◽  
Fractures Of The Spine ◽  
And Gender ◽  
Age Range

To investigate the incidence and characteristics of osteoporosis and osteoporotic fractures in Korea, we used the Health Insurance Review and Assessment Service (HIRA) database. Patients over 50 years old, who were diagnosed or treated for osteoporosis and osteoporotic fractures in all hospitals and clinics, were analyzed between 1 January 2009 and 31 December 2017 by using the HIRA database that contains prescription data and diagnostic codes. These data were retrospectively analyzed by decade and age-specific and gender-specific incidents in each year. We also evaluated other characteristics of patients including medication state of osteoporosis, primary used medical institution, regional-specific incidence of osteoporosis, and incidence of site-specific osteoporotic fractures. The number of osteoporosis patients over 50 years old, as diagnosed by a doctor, steadily increased from 2009 to 2017. The number of osteoporosis patients was notably greatest in the 60′s and 70′s age groups in every study period. Patients undergoing treatment for osteoporosis increased significantly (96%) from 2009 to 2017. Among the patients diagnosed with osteoporosis, the proportion who experienced osteoporotic fracture increased gradually (60%) from 2009 to 2017. The number of patients with osteoporotic fractures of the spine and hip was highest in the 70 to 90 age range, and the number of patients with osteoporotic fractures in the upper and lower extremities was highest in the 50 to 70 age range. Understanding the trends of osteoporosis in Korea will contribute to manage the increased number of patients with osteoporosis and osteoporotic fractures.

scholarly journals Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors

2013 ◽  
Vol 11 (1) ◽  
pp. 36 ◽  
Author(s):  
Nicola Mozzillo ◽  
Corrado Caracò ◽  
Ugo Marone ◽  
Gianluca Di Monta ◽  
Anna Crispo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Clinical Outcome ◽  
Lymph Node Dissection ◽  
Cutaneous Melanoma ◽  
Stage Iii ◽  
Node Dissection

Seasonal variation in cutaneous melanoma incidence, link with recent UV levels

2016 ◽  
Vol 26 (2) ◽  
pp. 195-201
Author(s):  
Kristine Rommens ◽  
David Jegou ◽  
Hugo De Backer ◽  
Joost Weyler
Keyword(s):  
Seasonal Variation ◽  
Cutaneous Melanoma ◽  
Melanoma Incidence

Analysis of the structure of ophthalmological pathology of outpatients in the treatment and diagnostic department

2021 ◽  
pp. 30-33
Author(s):  
A.V. Romanova ◽  
◽  
R.A. Burya ◽  
A.D. Pilipenko ◽  
E.L. Sorokin ◽  
...  
Keyword(s):  
Vascular Diseases ◽  
State Institution ◽  
Clinical Analysis ◽  
Diagnostic Methods ◽  
Federal State ◽  
Similar Data ◽  
High Turnover ◽  
Continuous Sampling ◽  
Number Of Patients ◽  
And Gender

Purpose. Clinical analysis of the nosological structure of ophthalmologic pathology in patients who applied to the treatment and diagnostic department (TDD) in 2020. Material and methods. The article provides an analysis of the number of patients who applied to the TDD of the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution for the period from the beginning of January to the end of December 2020 (continuous sampling method). An assessment of their age and gender composition is given, an analysis of the nosological structure of ophthalmopathology in the patients who have applied, its stage, is carried out, a comparison is made with similar data from five years ago. Results. In the structure of ophthalmic pathology, there was a high turnover rate of patients with the presence of various types of ametropia, as well as for the purpose of its surgical correction. A large number of patients with socially significant types of pathologies: cataracts, glaucoma, acquired diseases of the macular region, vascular diseases of the retina, requiring highly specialized surgical and conservative treatment. The analysis of the results of the work of the TDD showed a high percentage of detection of eye diseases, as well as for the first time detected serious pathology, achieved with the help of complex modern diagnostic methods. Conclusion. In 2020 8 851 patients with various ophthalmic pathologies were examined. In comparison with the five-year data, the volume of applications to LDOs increased significantly by 42%. Key words: ophthalmopathology, refractive error, cataract, glaucoma, medical and diagnostic department.

scholarly journals What is the prevalence of dyslipidemia in patients with idiopathic tinnitus?

2020 ◽  
Vol 8 (8) ◽  
pp. 2983
Author(s):  
Suleyman Erdogdu
Keyword(s):  
Blood Lipid ◽  
Control Group ◽  
Test Results ◽  
Cochlear Blood Flow ◽  
Number Of Patients ◽  
Significant Difference ◽  
Low Hdl ◽  
Training And Research ◽  
Male Patients ◽  
And Gender

Background: Dyslipidemia is a metabolic disorder that results from imbalanced and overfeeding as well as sedentary life. Elevated blood lipid levels can affect cochlear blood flow and fluidity, leading to decreased hearing and tinnitus. We aimed to determine whether there is a relationship between tinnitus and dyslipidemia by investigating the blood lipoprotein values of patients with tinnitus.Methods: The lipid profiles of the patients with idiopathic tinnitus who were selected among the patients who applied to Istanbul Haydarpaşa Numune Training and Research Hospital with the complaint of tinnitus between January 2019 and May 2020 were examined. The test results and age and gender distributions were compared with control groups without tinnitus complaints and statistical evaluation was performed.Results: Hypercholesterolemia in 42% of 6472 patients with idiopathic tinnitus, 18% low HDL, 50% high LDL, Hyperlipidemia was detected in 21%. 1942 (30%) of these patients were male; 4530 (70%) are women. The number of patients in the control group without tinnitus was 6470. Hypercholesterolemia in 49% of this group; 21% low HDL, 42% high LDL, 16% hyperlipidemia was detected. In this control group, 1950 (30%) of the patients were male and 4520 (70%) were female. Cholesterol of male and female patients with tinnutus. When the cholesterol, LDL and triglyceride values of HDL and LDL values and female and male patients in the control group were examined, a statistically significant difference was found (p <0.005). No statistically significant difference was found between HDL values of female and male patients with tinnutus and HDL values of female and male patients in the control group (P> 0.05).Conclusions: There is a statistically relationship between tinnitus and dyslipidemia. The presence of dyslipidemia is vital due to atherosclerosis caused by dyslipidemia, especially coronary artery involvement. Therefore, dyslipidemia should be treated as it causes many diseases.

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