Verrucous Carcinoma due to Arsenic Ingestion in a Psoriasis Patient

2012 ◽  
Vol 16 (6) ◽  
pp. 445-447 ◽  
Author(s):  
Jian-Wei Zhu ◽  
Min Zheng
Keyword(s):  
Pulmonary Embolism ◽  
Male Patient ◽  
Acute Pulmonary Embolism ◽  
Verrucous Carcinoma ◽  
Psoriasis Patient ◽  
Large Tumor ◽  
Embolie Pulmonaire ◽  
Drug Ingestion ◽  
Arsenic Ingestion ◽  
The Right

Background and Objective: Verrucous carcinoma is a rare clinicopathologic entity caused by multifactorial influences. We report here a 64-year-old male patient presenting with a large exophytic mass in the right leg. Results and Conclusion: The patient had a 19-year duration of psoriasis and received various treatments. In his last year of life, he had been taking an illegally produced folk drug with the hope of controlling his psoriasis. However, 6 months after the drug ingestion, many papules appeared on his right leg, which eventually developed into a large tumor in the next few months. The patient died of acute pulmonary embolism only a week after hospitalization, when his tumor was pathologically confirmed as verrucous carcinoma. Later, the folk drug was analyzed and found to contain arsenic. The causative relevance of the tumor with his daily arsenic intake is discussed. Contexte et objectif: Le carcinome verruqueux est une entité clinicopathologique rare, causée par divers facteurs. Nous exposons ici le cas d'un homme de 64 ans, qui a consulté pour une grosse masse exophytique sur la jambe droite. Résultats et conclusions: Le patient souffrait de psoriasis depuis 19 ans et a été soumis à divers traitements. Au cours de sa dernière année de vie, il a pris un remède empirique traditionnel, illégal, dans l'espoir de soulager le psoriasis. Cependant, 6 mois après la consommation du remède, de nombreuses papules sont apparues sur la jambe droite, et ont fini par former une grosse tumeur au cours des mois suivants. Le patient est mort d'une embolie pulmonaire aiguë, une semaine seulement après son hospitalisation, lorsque l'examen histopathologique de la tumeur a révélé qu'il s'agissait d'un carcinome verruqueux. Le remède a été analysé plus tard, et il s'est avéré que celui-ci contenait de l'arsenic. Le lien de cause à effet entre la tumeur et la consommation quotidienne d'arsenic fera l'objet de discussion.

Multidisciplinary Approach of a Very Rare Infected Verrucous Carcinoma of the Scrotum

2019 ◽  
Vol 70 (4) ◽  
pp. 1476-1478
Author(s):  
Laura Raducu ◽  
Adelaida Avino ◽  
Cristina-Nicoleta Cozma ◽  
Sorin Nedelea ◽  
Andra-Elena Balcangiu-Stroescu ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Rare Disease ◽  
Chronic Inflammation ◽  
Male Patient ◽  
Multidisciplinary Approach ◽  
Verrucous Carcinoma ◽  
Surgical Excision ◽  
Diagnosis And Treatment ◽  
Wide Surgical Excision ◽  
The Right

Verrucous carcinoma of the scrotum is an extremely rare disease and most cases are thought to result from poor hygiene and chronic inflammation. Currently, it has not been well characterized, the etiology, diagnosis and treatment remaining poorly understood. We present the case of a 50-year-old male patient diagnosed with verrucous carcinoma of the right hemiscrotum. Wide surgical excision was performed. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but patients should be carefully followed up.

scholarly journals An incidental finding of testicular seminoma in the context of acute pulmonary embolism: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Kaitlin J. Mayne ◽  
Emma Lewis ◽  
Lewis Vickers
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Clinical Guidelines ◽  
Acute Pulmonary Embolism ◽  
Incidental Finding ◽  
White Male ◽  
Vena Cava ◽  
Testicular Seminoma ◽  
Computed Tomography Scanning ◽  
The Right

Abstract Background Clinical guidelines do not recommend further investigation for occult malignancy in the scenario of unprovoked venous thromboembolism in the absence of additional clinical features suggestive of malignancy. We present the case of a young gentleman with pulmonary embolism who was diagnosed with testicular seminoma despite lack of symptoms or signs suggestive of malignancy. This is a unique case describing a scenario not well documented in existing literature where contravention of clinical guidelines had a potentially advantageous outcome for the patient. Case presentation A 37-year-old white male presented with seemingly unprovoked acute pulmonary embolism with right heart strain. He did not have any predisposing factors for venous thromboembolism and did not have any symptoms or signs suggestive of malignancy. Clinical guidelines do not recommend further investigation to screen for malignancy in this scenario. Despite this, our young, otherwise healthy patient proceeded to computed tomography scanning, resulting in the diagnosis of localized testicular seminoma. Testicular ultrasound described normal-sized testes (despite a discrete lesion in the right testis), suggesting this was not detectable by the patient or clinician on routine examination. The patient was anticoagulated and had an inferior vena cava filter inserted to facilitate orchidectomy followed by adjuvant radiotherapy. Conclusions This case highlights the importance of considering malignancy in seemingly unprovoked venous thromboembolism and the availability of guidelines to direct further investigation. Our patient’s treatment was not in line with clinical guidelines and was considered a “lucky find.”

scholarly journals Point-of-care Ultrasound Diagnosis of Pulmonary Embolism with Thrombus in Transit

2019 ◽  
Vol 3 (2) ◽  
pp. 11-12 ◽  
Author(s):  
Nicolas Kahl ◽  
Christopher Gabriel ◽  
Shadi Lahham ◽  
Maxwell Thompson ◽  
Wirachin Hoonpongsimanont
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Point Of Care ◽  
Skilled Nursing Facility ◽  
Point Of Care Ultrasound ◽  
Right Heart ◽  
Skilled Nursing ◽  
Chamber View ◽  
The Right ◽  
In Transit

A 95-year-old female with a history of dementia and atrial fibrillation (not on anticoagulation) presented to the emergency department (ED) by ambulance from her skilled nursing facility due to hypoxia. Point-of-care ultrasound was performed, and showed evidence of a large mobile thrombus in the right ventricle on apical four-chamber view. Further evidence of associated right heart strain was seen on the corresponding parasternal short-axis view. These ultrasound findings in combination with the patient’s clinical presentation are diagnostic of acute pulmonary embolism with right heart strain. Point-of-care transthoracic cardiac ultrasound in the ED is an effective tool to promptly diagnose acute pulmonary embolism with right heart strain and thrombus in transit and guide further treatment.

scholarly journals A Case of Verrucous Carcinoma of Larynx

2020 ◽  
Vol 23 (2) ◽  
pp. 208-211
Author(s):  
Mahmudul Hassan ◽  
Md Zahedul Alam ◽  
Mohammad Hanif ◽  
Md Rafiqul Islam ◽  
Saif Rahman Khan ◽  
...  
Keyword(s):  
Vocal Cord ◽  
Male Patient ◽  
Anterior Commissure ◽  
Verrucous Carcinoma ◽  
Fiberoptic Laryngoscope ◽  
Laser Excision ◽  
The Right ◽  
Carcinoma Of Larynx

A 50 years old male patient was admitted with complaints of change in voice for 2 years, dry cough 2 month and difficulty in breathing for 1 month. On examination with fiberoptic laryngoscope, an exophytic lesion covered with whitish plaque involving right vocal cord extending from anterior commissure to right arytenoid region, extending upto the right vestibular area and hanging in the subglottic area was seen. Patient was treated with Microlaryngeal Laser excision and the Histopathology report was suggestive of Verrucous Carcinoma of Larynx. Bangladesh J Otorhinolaryngol; October 2017; 23(2): 208-211

scholarly journals Case of COVID-19 infection and polycythaemia presenting with massive acute pulmonary embolism

2020 ◽  
Vol 13 (9) ◽  
pp. e237390
Author(s):  
Asadullah Nawazani ◽  
Mahmoud Ghanaim ◽  
Sadia Tariq
Keyword(s):  
Pulmonary Embolism ◽  
Oxygen Saturation ◽  
Male Patient ◽  
Acute Pulmonary Embolism ◽  
Polycythaemia Vera ◽  
Thromboembolic Events ◽  
Shortness Of Breath ◽  
Low Oxygen ◽  
High Index Of Suspicion ◽  
Predisposing Conditions

We are reporting a middle-aged male patient with polycythaemia vera comorbidity. The patient was exhibiting symptoms including fever, cough and shortness of breath and was found to have acute pulmonary embolism. He was diagnosed with SARS-CoV-2. This case suggests that a high index of suspicion should be taken into consideration for thromboembolic events, when treating patients with COVID-19 with breathing difficulty and low oxygen saturation levels, especially in those who have underlying predisposing conditions for coagulopathy.

scholarly journals Levosimendan in Acute Pulmonary Embolism

2007 ◽  
Vol 35 (5) ◽  
pp. 771-772 ◽  
Author(s):  
B. P. Powell ◽  
D. Simes
Keyword(s):  
Pulmonary Embolism ◽  
Right Ventricle ◽  
Cardiac Failure ◽  
Pulmonary Embolus ◽  
Myocardial Stunning ◽  
Acute Pulmonary Embolism ◽  
Animal Experiments ◽  
Life Threatening ◽  
The Right

Levosimendan has been used successfully in the treatment of ischaemic cardiac failure and myocardial stunning. There is growing evidence from both human and animal experiments that levosimendan has particularly favourable effects on the right ventricle. We describe a case of life-threatening pulmonary embolus supported by the use of levosimendan.

Pathophysiology of acute pulmonary embolism

ESC CardioMed ◽  
2018 ◽  
pp. 2756-2758
Author(s):  
Dieuwertje Ruigrok ◽  
Anton Vonk Noordegraaf
Keyword(s):  
Pulmonary Embolism ◽  
Patent Foramen Ovale ◽  
Acute Pulmonary Embolism ◽  
Vascular Occlusion ◽  
The Other ◽  
Mechanical Obstruction ◽  
Foramen Ovale ◽  
Compensatory Mechanisms ◽  
Acute Increase ◽  
The Right

Acute right ventricular (RV) failure and impaired gas exchange (mainly hypoxaemia) can be two important issues clinicians are confronted with in patients with acute pulmonary embolism. An acute increase in RV afterload due to mechanical obstruction and vasoconstriction is the crucial factor starting a cascade with compensatory mechanisms, RV dilatation, RV ischaemia, and inflammation ultimately leading to RV dysfunction/failure. On the other hand, vascular occlusion leads to redistribution of pulmonary perfusion to regions with relative overperfusion causing profound hypoxaemia. Less commonly, shunting occurs due to atelectasis or due to opening of a patent foramen ovale, causing refractory hypoxaemia. Understanding these mechanisms is crucial in making the right treatment decisions when faced with a patient with acute pulmonary embolism and haemodynamic or respiratory instability.

Computed tomography for the detection of free-floating thrombi in the right heart in acute pulmonary embolism

2010 ◽  
Vol 21 (2) ◽  
pp. 240-245 ◽  
Author(s):  
Nicolas Mansencal ◽  
David Attias ◽  
Vincent Caille ◽  
Julien Desperramons ◽  
Julie Guiader ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Right Heart ◽  
The Right

scholarly journals Acute pulmonary embolism in a patient with hepatitis C virus infection and hepatocellular carcinoma: a case report

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Mahmoud Abdelnabi ◽  
Yehia Saleh ◽  
Abdallah Almaghraby ◽  
Özge Özden Tok ◽  
Hoda Abdelgawad ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pulmonary Embolism ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Right Ventricular ◽  
Acute Pulmonary Embolism ◽  
Hepatitis C Virus Infection ◽  
Cardiac Metastases ◽  
The Right

Abstract Background Cardiac metastases in hepatocellular carcinoma patients are infrequently encountered and usually associated with a very poor prognosis. Case presentation Hereby, we report a case of an acute pulmonary embolism (PE) on top of HCC with direct cardiac invasion to the right atrium (RA) through the inferior vena cava with another metastasis to the right ventricular apex in the form of highly mobile cauliflower mass protruding through the tricuspid valve into RA and nearly obliterating right ventricular outflow tract in a multi-centric hepatocellular carcinoma patient. Conclusion Acute dyspnea in a patient with a long history of hepatitis C virus infection raises the suspicion of acute PE due to either hypercoagulable state induced by malignancy or by cardiac extension of the tumor which usually carries high mortality rates. To the best of our knowledge, this case is the first case in the literature to show cardiac metastases in HCC with two different pathological mechanisms.

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