Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

2015 ◽  
Vol 19 (3) ◽  
pp. 227-238 ◽  
Author(s):  
Yves Poulin ◽  
Charles W. Lynde ◽  
Kirk Barber ◽  
Ronald Vender ◽  
Joël Claveau ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Treatment Options ◽  
Organ Transplant ◽  
Surgical Removal ◽  
Inadequate Response ◽  
Transplant Patients ◽  
Non Melanoma Skin Cancer ◽  
Photodamaged Skin ◽  
Canadian Health ◽  
Canadian Health Care

Background Actinic keratosis (AK) and cheilitis (AC) are lesions that develop on photodamaged skin and may progress to form invasive squamous cell carcinomas (SCCs). Objective To provide guidance to Canadian health care practitioners regarding management of AKs and ACs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results Treatment of AKs allows for secondary prevention of skin cancer in sun-damaged skin. Because it is impossible to predict whether a given AK will regress, persist, or progress, AKs should ideally be treated. This chapter discusses options for the management of AKs and ACs. Conclusions Treatment options include surgical removal, topical treatment, and photodynamic therapy. Combined modalities may be used in case of inadequate response. AKs are particularly common following the longterm immunosuppression in organ transplant patients, who should be monitored frequently to identify emerging lesions that require surgery.

Non-melanoma Skin Cancer in Canada Chapter 2: Primary Prevention of Non-melanoma Skin Cancer

2015 ◽  
Vol 19 (3) ◽  
pp. 216-226 ◽  
Author(s):  
Kirk Barber ◽  
Gordon E. Searles ◽  
Ronald Vender ◽  
Hwee Teoh ◽  
John Ashkenas
Keyword(s):  
Public Health ◽  
Primary Prevention ◽  
Skin Cancer ◽  
Skin Cancer Prevention ◽  
Accurate Information ◽  
Non Melanoma Skin Cancer ◽  
Literature Searches ◽  
Canadian Health ◽  
Canadian Health Care ◽  
Melanoma Skin

Background Non-melanoma skin cancer (NMSC), including basal and squamous cell carcinoma (BCC and SCC), represents the most common malignancy. Objective To provide guidance to Canadian health care practitioners regarding primary prevention of NMSC. Methods Structured literature searches were conducted, using search terms including prevention, sunscreen, and sun prevention factor. All recommendations concern guidance that physicians should regularly discuss with their patients to help establish photoprotection habits. The GRADE system was used to assign strength to each recommendation. Results Ultraviolet exposure is the major modifiable risk factor for NMSC. Aspects of photoprotection, including effective sunscreen use and avoidance of both the midday sun and artificial tanning, are discussed. Several widespread misunderstandings that undermine responsible public health measures related to sun safety are addressed. Conclusions Photoprotection represents both an individual priority and a public health imperative. By providing accurate information during routine patient visits, physicians reinforce the need for ongoing skin cancer prevention.

Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma

2015 ◽  
Vol 19 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Mariusz Sapijaszko ◽  
David Zloty ◽  
Marc Bourcier ◽  
Yves Poulin ◽  
Peter Janiszewski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Excision ◽  
Non Melanoma Skin Cancer ◽  
Canadian Health ◽  
Canadian Health Care ◽  
Margin Control ◽  
Melanoma Skin

Background Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). Objective To provide guidance to Canadian health care practitioners regarding management of SCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results SCCs are sometimes confined to the epidermis, but they can also invade nearby tissues and, in some cases, metastasize to neighbouring lymph nodes or other organs. This chapter discusses the natural history, staging, prognosis, and management of SCC—a tumour type that is less common but typically more aggressive than BCC. For this reason, margin control is strongly preferred in treating SCCs. Conclusions Although approaches such as cryosurgery and radiation therapy may be considered for some patients, surgical excision—sometimes coupled with radiation—remains the cornerstone of SCC management. Patients with high-risk SCC may also be considered for referral to an appropriate multidisciplinary clinic.

CONTEMPORARY TREATMENT APPROACH OF SQUAMOUS CELL SKIN CANCER: REVIEW

2019 ◽  
Vol 65 (1) ◽  
pp. 7-15
Author(s):  
Aleksey Belyaev ◽  
Georgiy Prokhorov ◽  
Zamira Radzhabova ◽  
Olga Baykalova
Keyword(s):  
Skin Cancer ◽  
Squamous Cell ◽  
New Technologies ◽  
Treatment Options ◽  
Epidermoid Carcinoma ◽  
Surgical Removal ◽  
Cochrane Central Register ◽  
Epithelial Tumor ◽  
Randomized Controlled Studies ◽  
Skin Malignancy

The incidence of skin cancer is a steady increasing around the world. Tumors of epithelial origin occupy the first place in the structure of all skin malignancy. Epidermoid carcinoma is the most malignant epithelial tumor of the skin and mucous membranes with squamous differentiation. Generally, squamous cell carcinoma is successfully treated by surgical and radiological methods. Often a different kind of plastic defect reconstructions are required after surgical removal. The incidence of epidermoid carcinoma increases with age (average age of patients falls on 65 years) therefore variants of treatment options is limited by comorbidities. However, surgical oncologist do not have enough date and randomized controlled studies on this theme. Minimally invasive methods, especially cryothechnology are increasingly used, but unfortunately their advantage requires additional evidence. We suppose Inclusion in the conventional treatment of new technologies may possibly improve the results of treatment. We reviewed the literature, summarizing data on various methods of treating squamous cell skin cancer. Comprehensive and systematic search was based on MedLine, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus and PubMed among original articles for the period from January 1974 to October 2018.

Transplant-Associated Skin Cancer: Role of Reducing Immunosuppression

2007 ◽  
Vol 5 (5) ◽  
pp. 541-549 ◽  
Author(s):  
Marcy Neuburg
Keyword(s):  
Skin Cancer ◽  
Therapeutic Strategy ◽  
Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Cutaneous Malignancy ◽  
Transplant Patients ◽  
Historic Review ◽  
Solid Organ Transplant Recipients

This article explores the role of reducing immunosuppression as a therapeutic strategy for the problem of transplant-associated skin cancer. The specific issue of immunosuppression reduction is based on a brief historic review of the epidemiology of skin cancer in transplant patients, followed by a description of the role of immunosuppression as a cause of skin cancer. Finally, the literature pertaining to the hypothesis that reducing immunosuppression in solid organ transplant recipients favorably impacts both the incidence of cutaneous malignancy and outcomes relating to individual aggressive malignancies is presented.

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