Non-melanoma Skin Cancer in Canada Chapter 2: Primary Prevention of Non-melanoma Skin Cancer

2015 ◽  
Vol 19 (3) ◽  
pp. 216-226 ◽  
Author(s):  
Kirk Barber ◽  
Gordon E. Searles ◽  
Ronald Vender ◽  
Hwee Teoh ◽  
John Ashkenas
Keyword(s):  
Public Health ◽  
Primary Prevention ◽  
Skin Cancer ◽  
Skin Cancer Prevention ◽  
Accurate Information ◽  
Non Melanoma Skin Cancer ◽  
Literature Searches ◽  
Canadian Health ◽  
Canadian Health Care ◽  
Melanoma Skin

Background Non-melanoma skin cancer (NMSC), including basal and squamous cell carcinoma (BCC and SCC), represents the most common malignancy. Objective To provide guidance to Canadian health care practitioners regarding primary prevention of NMSC. Methods Structured literature searches were conducted, using search terms including prevention, sunscreen, and sun prevention factor. All recommendations concern guidance that physicians should regularly discuss with their patients to help establish photoprotection habits. The GRADE system was used to assign strength to each recommendation. Results Ultraviolet exposure is the major modifiable risk factor for NMSC. Aspects of photoprotection, including effective sunscreen use and avoidance of both the midday sun and artificial tanning, are discussed. Several widespread misunderstandings that undermine responsible public health measures related to sun safety are addressed. Conclusions Photoprotection represents both an individual priority and a public health imperative. By providing accurate information during routine patient visits, physicians reinforce the need for ongoing skin cancer prevention.

Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma

2015 ◽  
Vol 19 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Mariusz Sapijaszko ◽  
David Zloty ◽  
Marc Bourcier ◽  
Yves Poulin ◽  
Peter Janiszewski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Excision ◽  
Non Melanoma Skin Cancer ◽  
Canadian Health ◽  
Canadian Health Care ◽  
Margin Control ◽  
Melanoma Skin

Background Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). Objective To provide guidance to Canadian health care practitioners regarding management of SCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results SCCs are sometimes confined to the epidermis, but they can also invade nearby tissues and, in some cases, metastasize to neighbouring lymph nodes or other organs. This chapter discusses the natural history, staging, prognosis, and management of SCC—a tumour type that is less common but typically more aggressive than BCC. For this reason, margin control is strongly preferred in treating SCCs. Conclusions Although approaches such as cryosurgery and radiation therapy may be considered for some patients, surgical excision—sometimes coupled with radiation—remains the cornerstone of SCC management. Patients with high-risk SCC may also be considered for referral to an appropriate multidisciplinary clinic.

A randomized trial of selenium and vitamin E for primary prevention of non-melanoma skin cancer: Trial results and experience from a low-resource setting.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1511-1511 ◽  
Author(s):  
Maria Argos ◽  
James J. Dignam ◽  
Faruque Parvez ◽  
Mahfuzar Rahman ◽  
Samar K Hore ◽  
...  
Keyword(s):  
Vitamin E ◽  
Primary Prevention ◽  
Skin Cancer ◽  
Beneficial Effect ◽  
Population Based ◽  
Cancer Trial ◽  
Low Resource ◽  
Non Melanoma Skin Cancer ◽  
Related Mortality ◽  
Melanoma Skin

1511 Background: Selenium and vitamin E supplementation previously have shown some evidence of a beneficial effect in the secondary prevention of non-melanoma skin cancer (NMSC). More than 100 million people worldwide are at increased risk of NMSC and other cancers due to arsenic exposure from drinking water and diet – a risk that persists for several decades even after the exposure has terminated. Here, we report on the design, methods and main results of the Bangladesh Vitamin E and Selenium Trial (BEST) – a population-based chemoprevention study conducted among 7,000 adults with visible arsenic toxicity. Methods: BEST is a 2 × 2 full factorial, double-blind, randomized placebo controlled trial of 7,000 adults having manifest arsenical skin lesions evaluating the efficacy of 6-year supplementation with alpha-tocopherol (100 mg daily) and L-selenomethionine (200 μg daily) for the prevention of NMSC incidence. Results: Excellent compliance was maintained through the course of the trial, based on data from pill counts, self-reported compliance, and bioadherence. Among participants on treatment through the end of the 6-year intervention period, > 85% were adherent to at least 80% of study supplements. More than 500 new NMSC cases were ascertained using a three-tiered biopsy protocol. No significant beneficial effects were observed on NMSC incidence during the study period for selenium or vitamin E. Among more than 500 observed deaths (including 182 cancer-related deaths), there were also no significant treatment effects on total mortality, cancer-related mortality or arsenical cancer-related mortality. Conclusions: This large population-based trial does not support any beneficial effect of vitamin E or selenium supplementation for the primary prevention of NMSC or mortality in an arsenic-exposed population. With the rapidly increasing burden of preventable cancers in low- and middle-income countries, efficient and feasible chemoprevention study designs and approaches, such as employed in Bangladesh, may prove impactful in conceiving large scale cancer chemoprevention trials in low-resource settings. Clinical trial information: NCT00392561.

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

2015 ◽  
Vol 19 (3) ◽  
pp. 239-248 ◽  
Author(s):  
David Zloty ◽  
Lyn C. Guenther ◽  
Mariusz Sapijaszko ◽  
Kirk Barber ◽  
Joël Claveau ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Recurrence Risk ◽  
Histologic Subtype ◽  
Non Melanoma Skin Cancer ◽  
Literature Searches ◽  
Canadian Health ◽  
Canadian Health Care ◽  
History Of

Background Basal cell carcinoma (BCC) is the most common malignancy. Growth of BCCs leads to local destruction of neighbouring healthy skin and underlying tissue and can result in significant functional and cosmetic morbidity. Objective To provide guidance to Canadian health care practitioners regarding management of BCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying Introduction. Results Although BCCs rarely metastasize“ they can be aggressive and disfiguring. This chapter describes the natural history and prognosis of BCCs. Risk stratification is based on clinical features” including the site and size of the tumour“ its histologic subtype (nodular vs sclerosing)” and its history of recurrence. Conclusions Various options should be considered for BCC treatment” including cryosurgery” curettage” and topical or photodynamic approaches, as well as fixed-margin surgery and Mohs micrographic surgery. Stratification of recurrence risk for individual BCCs determines the most appropriate therapeutic course.

Corrigendum

2015 ◽  
Vol 19 (6) ◽  
pp. 604-604
Keyword(s):  
Primary Prevention ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratoses ◽  
Non Melanoma Skin Cancer ◽  
Cancer Guidelines ◽  
Melanoma Skin

Guenther LC, Barber K, Searles GE, Lynde CW, Janiszewski P, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 1: Introduction to the Guidelines. J Cutan Med Surg. 2015;19(3):205-215. Original DOI: 10.1177/1203475415588652 Barber K, Searles GE, Vender R, Teoh H, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 2: Primary Prevention of Non-melanoma Skin Cancer. J Cutan Med Surg. 2015;19(3):216-226. Original DOI: 10.1177/1203475415576465 Poulin Y, Lynde CW, Barber K, Vender R, Claveau J, Bourcier M, Ashkenas J, for the Canadian non-Melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses. J Cutan Med Surg. 2015;19(3):227-238. Original DOI: 10.1177/1203475415583414 Zloty D, Guenther LC, Sapijaszko M, Barber K, Claveau J, Adamek T, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma. J Cutan Med Surg. 2015;19(3):239-248. Original DOI: 10.1177/1203475415586664 Sapijaszko M, Zloty D, Bourcier M, Poulin Y, Janiszewski P, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. J Cutan Med Surg. 2015;19(3):249-259. Original DOI: 10.1177/1203475415582318 In the above articles, the following disclaimer from the Canadian Dermatology Association should have been included: The Canadian Dermatology Association (CDA) recognizes the scientific merit of these guidelines. The CDA did not participate in their development or provide content.

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

2015 ◽  
Vol 19 (3) ◽  
pp. 227-238 ◽  
Author(s):  
Yves Poulin ◽  
Charles W. Lynde ◽  
Kirk Barber ◽  
Ronald Vender ◽  
Joël Claveau ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Treatment Options ◽  
Organ Transplant ◽  
Surgical Removal ◽  
Inadequate Response ◽  
Transplant Patients ◽  
Non Melanoma Skin Cancer ◽  
Photodamaged Skin ◽  
Canadian Health ◽  
Canadian Health Care

Background Actinic keratosis (AK) and cheilitis (AC) are lesions that develop on photodamaged skin and may progress to form invasive squamous cell carcinomas (SCCs). Objective To provide guidance to Canadian health care practitioners regarding management of AKs and ACs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results Treatment of AKs allows for secondary prevention of skin cancer in sun-damaged skin. Because it is impossible to predict whether a given AK will regress, persist, or progress, AKs should ideally be treated. This chapter discusses options for the management of AKs and ACs. Conclusions Treatment options include surgical removal, topical treatment, and photodynamic therapy. Combined modalities may be used in case of inadequate response. AKs are particularly common following the longterm immunosuppression in organ transplant patients, who should be monitored frequently to identify emerging lesions that require surgery.

scholarly journals The role of ultrasonography in head and neck Non-Melanoma Skin Cancer approach: an update with a review of the literature

2020 ◽  
Author(s):  
Tiberiu Tamas ◽  
Cristian Dinu ◽  
Manuela Lenghel ◽  
Grigore Băciuț ◽  
Simion Bran ◽  
...  
Keyword(s):  
Skin Cancer ◽  
New Technologies ◽  
Treatment Plan ◽  
Full Range ◽  
Excisional Biopsy ◽  
Skin Cancer Prevention ◽  
Depth Of Invasion ◽  
Non Melanoma Skin Cancer ◽  
The Face ◽  
Melanoma Skin

Non-Melanoma Skin Cancer is one of the most common cancer types and the face is the most affected region. The diagnosis of the skin cancer relies on clinical inspection, palpation, dermoscopy followed by incisional or excisional biopsy. When skin cancers are removed from the face, many factors are involved, including aesthetics. In addition, surgical planning with preoperative acknowledgement of the tumour margins is often the key to avoid incomplete excision, the need for reintervention, or in the prevention of functional and aesthetical defects in the treatment of skin tumours. In recent years, the development of new technologies in sonography, including high frequencies transducers can provide a full range of data. It can offer valuable information regarding the size of the tumour including the depth of invasion, the extent of the tumour, histology and subtypes of the lesions which are helpful for the treatment plan. It also may be efficient in detection of positive margins after surgery and it could play a role in the treatment of skin cancer, prevention of local recurrences and overall control of the disease. K

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