The Norsjö-Cooperstown healthy heart project: A case study combining data from different studies without the use of meta-analysis

2001 ◽  
Vol 29 (56_suppl) ◽  
pp. 40-45 ◽  
Author(s):  
P.L. Jenkins ◽  
L. Weinehall ◽  
T.A. Erb ◽  
C. Lewis ◽  
A.N. Nafziger ◽  
...  

Objectives: This paper aims to develop and describe a method for combining, comparing, and maximizing the statistical power of two longitudinal studies of risk factors for cardiovascular disease that did not have identical data collection methodologies. Methods: Subjects from a 1986 cross-sectional study (n= 180) were pair-matched with subjects of corresponding gender and age (+ 5 years) from a 1990 cross-sectional study. The methodology is described and results are calculated for various measures of cardiovascular risk or risk factors (e.g. cholesterol, Finnish Risk Score). Results: Box's test of equality and symmetry of covariance matrices gave chi-square values of 223.8 and 710.0 for two cardiovascular risk factors (cholesterol and cardiac risk score, respectively); these values were highly significant (p=0.0001). For the North Karelia Risk Score, repeated measures ANOVA revealed a borderline significant interaction for treatment by time (p=0.054) and a significant interaction for treatment by time by country (p=0.035). These probabilities compared favorably with a randomized blocks model. Conclusions: Creation of a synthetic longitudinal control group resulted in a statistically valid ANOVA model that increased the statistical power of the study.

2012 ◽  
Vol 3 (3) ◽  
pp. 1-11 ◽  
Author(s):  
Macide Artac ◽  
Andrew R H Dalton ◽  
Azeem Majeed ◽  
Kit Huckvale ◽  
Josip Car ◽  
...  

2014 ◽  
Vol 132 (3) ◽  
pp. 152-157 ◽  
Author(s):  
Cristiane Moço Canhetti Oliveira ◽  
Paula Roberta Nogueira

CONTEXT AND OBJECTIVE:There have been few studies on the risk factors for subgroups of stuttering. The aim of this study was to characterize the risk factors for developmental familial stuttering among boys who stutter and who do not stutter, such as disfluency types, associated quality and communication factors, emotional and physical stress, familial attitudes and personal reactions.DESIGN AND SETTING:Analytical cross-sectional study with a control group, performed at the Fluency Studies Laboratory of the Department of Speech and Hearing Disorders of a public university.METHODS: The parents of 40 age-matched stuttering and non-stuttering boys took part in this study. The participants were divided into two groups: stuttering children (SC) and non-stuttering children (NSC), with ages between 6 years 0 months and 11 years 11 months. Initially, all of the participants underwent a fluency assessment and then data were gathered using the Protocol for the Risk of Developmental Stuttering.RESULTS:There were no differences in the physical stress distribution factors and personal reactions between the groups. Inappropriate familial attitudes were presented by 95% of the SC and 30% of the NSC. Four risk factors analyzed were not shown by the NSC, namely stuttering-like disfluency, quality factors, physical stress and emotional stresses.CONCLUSIONS:The findings suggest that the presence of stuttering-like disfluency, associated quality and communication factors, emotional stress and inappropriate family attitudes are important risk factors for familial developmental stuttering among boys.


Thorax ◽  
2014 ◽  
Vol 69 (Suppl 2) ◽  
pp. A11-A12 ◽  
Author(s):  
V. Navaratnam ◽  
E. Millett ◽  
J. Hurst ◽  
S. Thomas ◽  
L. Smeeth ◽  
...  

2020 ◽  
Author(s):  
Maryam Sabbari ◽  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Khadijeh Mirzaei

Abstract Objective: No studies have examined the relationship between recommended food score (RFS), none recommended food score (NRFS) and cardiovascular risk factors. This study was conducted to evaluate the association of RFS and NRFS with cardiovascular risk factors in overweight and obese women.Methods: This cross-sectional study was performed on 379 overweight and obese (BMI ≥25 kg/m2) women aged 18-48 years. Anthropometric measurements and body composition analysis were assessed in all participants. Dietary intake was assessed by a valid and reliable food frequency questionnaire (FFQ) containing 147 items and RFS and NRFS calculated. Biochemical assessments including TC, HDL, LDL, TG, FBS, insulin, HOMA-IR and hs-CRP were quantified by ELISA.Results: The mean age and BMI of participants were 36.73±9.21 (y) and 31.17±4.22 (kg/m²) respectively. Binary logistic analysis showed that participants in the highest quartile of the RFS compared to the lowest quartile had 82% lower risk for Hypertriglyceridemia [OR=0.18, 95%CI=0.06-0.53, P=0.002] and 91% lower risk for abdominal obesity [OR=0.09, 95%CI=0.008-1.04, P=0.05]. in addition, Participants who were in the highest quartile of the RFS compared to the lowest quartile had lower HOMA-IR [OR=0.29, 95%CI=0.08-1.00, P=0.05]. subjects with high adherence to the NRFS had lower HDL [OR=2.11, 95%CI=1.08-4.12, P=0.02] and higher risk for Hypertriglyceridemia [OR=2.95, 95%CI=1.47-5.94, P=0.002] compared to low adherence. Conclusions: There was an inverse significant association between adherence to RFS and risk of Hypertriglyceridemia, insulin resistance, and abdominal obesity. There was a significant association between NRFS and Hypertriglyceridemia, and also we found an inverse relationship between NRFS and HDL.


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