scholarly journals Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes

2016 ◽  
Vol 13 (4) ◽  
pp. 299-302 ◽  
Author(s):  
Panagiota Veloudi ◽  
Leigh Blizzard ◽  
Velandai K Srikanth ◽  
Paul McCartney ◽  
Elena V Lukoshkova ◽  
...  

Blood pressure variability is associated with macrovascular complications and stroke, but its association with the microcirculation in type II diabetes has not been assessed. This study aimed to determine the relationship between blood pressure variability indices and retinal arteriolar diameter in non-diabetic and type II diabetes participants. Digitized retinal images were analysed to quantify arteriolar diameters in 35 non-diabetic (aged 52 ± 11 years; 49% male) and 28 type II diabetes (aged 61 ± 9 years; 50% male) participants. Blood pressure variability was derived from 24-h ambulatory blood pressure. Arteriolar diameter was positively associated with daytime rate of systolic blood pressure variation ( p = 0.04) among type II diabetes participants and negatively among non-diabetics ( p = 0.008; interaction p = 0.001). This finding was maintained after adjusting for age, sex, body mass index and mean daytime systolic blood pressure. These findings suggest that the blood pressure variability–related mechanisms underlying retinal vascular disease may differ between people with and without type II diabetes.

2021 ◽  
Vol 1 (3) ◽  
pp. 230-236
Author(s):  
Toni Prasetia ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Mohamad Imam Istawa

ABSTRACT: CORRELATION OF SYSTOLIC BLOOD PRESSURE WITH TRIGLYCERIDE LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNGBackground: Hypertension is the main risk factor for DM. Hypertension can make cells insensitive to insulin. Even though insulin plays a role in increasing glucose uptake in many cells and in this way also regulates carbohydrate metabolism, so that if insulin resistance occurs by cells, the blood sugar levels can also be disrupted. Dyslipidemia is a change in blood lipid profile, one of which is an increase in triglyceride levels. High triglyceride levels can cause thickening of the blood vessels and cause narrowing of the arteries.Objective: To determine the relationship between systolic blood pressure and triglyceride levels in patients with type 2 diabetes mellitus in Klniki Arafah Tengah Lampung.Methodology: This research uses a descriptive-analytic research method with a cross-sectional approach. The sampling technique is Total Sampling. . Respondents in this study were patients with Type 2 Diabetes Mellitus at the Arafah Clinic in Central Lampung in 2020.Results: It is known that in the sex frequency distribution, there were 16 men with 34.8% and 30 women with 65.2%. Distribution of frequency based on age, it was found that the age group 24-45 years numbered 7 patients (15.2%), the age group 46-65 years amounted to 32 patients (69.6%), and the group> 65 years amounted to 7 patients (15.2 %). It is known that the frequency distribution of systolic blood pressure in type II diabetes mellitus patients, it was found that type II diabetes mellitus patients with normal systolic blood pressure levels were 34 patients with 73.9%, while high systolic blood pressure levels were 12 patients with 26.1%. It is known that the frequency distribution of triglyceride levels in patients with type II diabetes mellitus, it was found that 8 patients with normal triglycerides had normal triglyceride levels, and 38 patients (82.6%) had high triglyceride levels. The results of the chi-square statistical test found no relationship with the results of p = 898 (p> 0.05).Conclusion: There is no correlation between systolic blood pressure and cholesterol triglycerides in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung in 2020.                 Keywords: Type 2 Diabetes Mellitus, Systolic Blood Pressure Triglierida INTISARI: HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN KADAR TRIGLISERIDA PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAHLatar Belakang: Hipertensi merupakan faktor risiko untama untuk terjadinya DM. Hipertensi dapat membuat sel tidak sensitif terhadap insulin. Padahal insulin berperan meningkatkan ambilan glukosa di banyak sel dan dengan cara ini juga mengatur metabolisme karbohidrat, sehingga jika terjadi resistensi insulin oleh sel, maka kadar gula di dalam darah juga dapat mengalami gangguan. Dislipidemia adalah perubahan dari profil lipid darah salah satunya adalah peningkatan kadar trigliserida. Kadar trigliserida yang tinggi dapat menyebabkan penebalan pembuluh darah dan menyebabkan penyempitan pembuluh darahTujuan : Untuk mengetahui hubungan tekanan darah sistolik dengan kadar trigliserida pada pasien diabetes melitus tipe 2 di klniki arafah lampung tengahMetode : Jenis penelitian ini menggunakan metode penelitian deskriptif analitik dengan pendekatan cross – sectional. Teknik pengambilan sampel berupa Total Sampling. . Responden dalam penelitian ini adalah pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020.Hasil : pada variabel trigliserida dan tekanan darah sistolik diperoleh nilai p Vale = 898 (p>0,05)Kesimpulan: Tidak terdapat Hubungan Antara Tekanan Darah Sistolik dengan Trigliserida Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020.Kata Kunci     : Diabetes Melitus tipe 2, Tekanan Darah Sistolil Triglierid


2004 ◽  
Vol 22 (8) ◽  
pp. 1543-1549 ◽  
Author(s):  
Harry Leung ◽  
Jie Jin Wang ◽  
Elena Rochtchina ◽  
Tien Y Wong ◽  
Ronald Klein ◽  
...  

2016 ◽  
Vol 9 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Valencia Foo ◽  
Joanne Quah ◽  
Gemmy Cheung ◽  
Ngiap Chun Tan ◽  
Kyi Lin Ma Zar ◽  
...  

2012 ◽  
Vol 130 (8) ◽  
pp. 1019 ◽  
Author(s):  
Ronald Klein ◽  
Chelsea E. Myers ◽  
Michael D. Knudtson ◽  
Kristine E. Lee ◽  
Ronald Gangnon ◽  
...  

JMS SKIMS ◽  
2011 ◽  
Vol 14 (2) ◽  
pp. 56-60
Author(s):  
Arvind Mishra ◽  
Anupam Mehrotra ◽  
Reshu Tewari

BACKGROUND: Ghrelin is a multi-functional gut-derived peptide hormone. Administered ghrelin has shown an increase in appetite and food intake and also stimulate the secretion of the growth hormone in rodents as well as in humans. Ghrelin is the strongest orexigenic hormone. OBJECTIVE: The aim of the study was to estimate plasma active Ghrelin levels in type – II diabetes mellitus patients and establish its relation to Insulin Resistance, Hypertension, Dyslipidemia and Obesity. MATERIALS & METHODS: A total of 81 patients were enrolled in the study out of then 50 were the cases and 31 were controls. RESULTS: A significant negative correlation was found between Fasting plasma active ghrelin levels and systolic blood pressure (r = -0.71, p <0.02), diastolic blood pressure (r = -0.64, p <0.02) , obesity (r = -0.71, p <0.001), fasting insulin levels (r = -0.40, p <0.01), insulin resistance (r = -0.32, p <0.01).A deeper understanding on this interesting pleiotropic hormone could be anticipated to open new insights into the metabolic pathways causing a predisposition for obesity and its co-morbidities. JMS 2011;14(2):56-60


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