Kidney Graft Survival in Italy and Factors Influencing it

2005 ◽  
Vol 15 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Orsola Pugliese ◽  
Francesca Quintieri ◽  
Dino Alberto Mattucci ◽  
Sante Venettoni ◽  
Emanuela Taioli ◽  
...  
Keyword(s):  
Graft Survival ◽  
Developed Countries ◽  
National Registry ◽  
Kidney Graft ◽  
Allograft Function ◽  
Recipient Age ◽  
Transplant Registry ◽  
Using Data ◽  
National Registry Data

Purpose National registry data are often a suitable basis for examination of transplant outcomes. Using data supplied by the Italian National Transplant Registry, established in 1995, we performed the first nationwide analysis of this kind. Methods A retrospective analysis of 4893 recipients of cadaveric kidneys transplanted in all Italian centers from 1995 through 2000 was done to study 5-year graft survival. The association between some donor and recipient variables and outcomes in renal transplantation was analyzed. Graft survival was 93% at 3 months, 89% at 1 year, 82% at 3 years, and 80% at 5 years after transplantation. Results A significant association between graft survival and donor age (old vs young, relative risk [RR] = 1.62, 95% CI 1.27–2.06) and recipient age (old vs young, RR = 1.25, 95% CI 1.02–1.53). Graft survival was also associated with cold ischemia time (24–36 hours, RR=1.39, 95% CI 1.05–1.85 and >36 hours, RR=1.94, 95% CI 1.32–2.86 vs 0–24 hours) and donor/recipient sex mismatch (female/male vs male/male, RR=1.50, 95% CI 1.17–1.93). Conclusion The quality of kidney transplantation in Italy is satisfactory and is comparable to that in other developed countries. Furthermore, our experience confirms that both donor and recipient factors are major determinants of renal allograft function.

The impact of HLA-DR compatibility on cadaver kidney graft survival in a prospective study with special emphasis on the quality of typing

2008 ◽  
Vol 23 (2) ◽  
pp. 94-104 ◽  
Author(s):  
BODIL K. JAKOBSEN ◽  
ERIK LANGHOFF ◽  
PER PLATZ ◽  
LARS P. RYDER ◽  
JØRN HESS THAYSEN ◽  
...  
Keyword(s):  
Prospective Study ◽  
Graft Survival ◽  
Kidney Graft ◽  
Hla Dr ◽  
Cadaver Kidney ◽  
A Prospective Study ◽  
The Impact

Home and facility haemodialysis patients: a comparison of outcomes in a matched cohort

2020 ◽  
Author(s):  
Emily K Yeung ◽  
Kevan R Polkinghorne ◽  
Peter G Kerr
Keyword(s):  
Graft Survival ◽  
Smoking Status ◽  
Ageing Population ◽  
Matched Cohort ◽  
Home Haemodialysis ◽  
Risk Of Death ◽  
Competing Risks Analysis ◽  
Transplant Registry ◽  
End Stage

Abstract Background Home haemodialysis (HHD) is utilised significantly less often than facility haemodialysis globally with few exceptions despite being associated with improved survival, and better quality of life. Previously, HHD was exclusively offered to younger patients with few comorbidities. However, with the increasing burden of end-stage kidney disease (ESKD) alongside an ageing population, increasing numbers of older patients are being treated with HHD. This study aims to re-evaluate survival and related outcomes in the context of this epidemiological shift. Methods A matched cohort design was used to compare all-cause mortality, transplantation, average biochemical values and graft survival 6 months post-transplant between HHD and facility haemodialysis patients. 181 HHD patients from a major hospital network were included, with 413 facility haemodialysis patients from the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) matched by age, gender, and cause of ESKD. Survival analysis and competing risks analysis (for transplantation) were performed. Results After adjusting for BMI, smoking status, racial group, and comorbidities, HHD was associated with significantly reduced risk of death compared to facility HD patients (HR = 0.47, 95% CI 0.30-0.74). Transplantation rates were comparable, with high rates of graft survival at 6 months in both groups. Haemoglobin, calcium, and parathyroid hormone levels did not vary significantly. However, home HD patients had significantly lower phosphate levels. Conclusions In this study, improved survival outcomes were observed in patients on home compared to facility dialysis, with comparable rates of transplantation, graft survival and biochemical control.

scholarly journals Transplantation outcomes in patients with primary hyperoxaluria: a systematic review

2021 ◽  
Author(s):  
Elisabeth L. Metry ◽  
Liza M. M. van Dijk ◽  
Hessel Peters-Sengers ◽  
Michiel J.S. Oosterveld ◽  
Jaap W. Groothoff ◽  
...  
Keyword(s):  
Graft Survival ◽  
Data Extraction ◽  
Meta Analysis ◽  
Survival Rates ◽  
Primary Hyperoxaluria ◽  
Kidney Graft ◽  
High Quality ◽  
Liver Transplantations ◽  
Using Data ◽  
Patient And Graft Survival

Abstract Background Primary hyperoxaluria type 1 (PH1) is characterized by hepatic overproduction of oxalate and often results in kidney failure. Liver-kidney transplantation is recommended, either combined (CLKT) or sequentially performed (SLKT). The merits of SLKT and the place of an isolated kidney transplant (KT) in selected patients are unsettled. We systematically reviewed the literature focusing on patient and graft survival rates in relation to the chosen transplant strategy. Methods We searched MEDLINE and Embase using a broad search string, consisting of the terms ‘transplantation’ and ‘hyperoxaluria’. Studies reporting on at least four transplanted patients were selected for quality assessment and data extraction. Results We found 51 observational studies from 1975 to 2020, covering 756 CLKT, 405 KT and 89 SLKT, and 51 pre-emptive liver transplantations (PLT). Meta-analysis was impossible due to reported survival probabilities with varying follow-up. Two individual high-quality studies showed an evident kidney graft survival advantage for CLKT versus KT (87% vs. 14% at 15 years, p<0.05) with adjusted HR for graft failure of 0.14 (95% confidence interval: 0.05–0.41), while patient survival was similar. Three other high-quality studies reported 5-year kidney graft survival rates of 48–89% for CLKT and 14–45% for KT. PLT and SLKT yielded 1-year patient and graft survival rates up to 100% in small cohorts. Conclusions Our study suggests that CLKT leads to superior kidney graft survival compared to KT. However, evidence for merits of SLKT or for KT in pyridoxine-responsive patients was scarce, which warrants further studies, ideally using data from a large international registry.

scholarly journals Pengalaman pemberian ASI ekslusif pada Ibu bekerja: scoping review

2021 ◽  
Vol 3 (2) ◽  
pp. 61
Author(s):  
Dinar Agustin ◽  
Andari Wuri Astuti
Keyword(s):  
Scoping Review ◽  
Working Mothers ◽  
Literature Search ◽  
Grey Literature ◽  
Developed Countries ◽  
Population Exposure ◽  
Exclusion Criteria ◽  
Quantitative Studies ◽  
Using Data

Working mothers faced many challenges and constraints. Despite legislations mandating workplaces to give support, including breastfeeding areas for their employees, a number of hurdles remained, preventing them from achieving exclusive breastfeeding (EBF). Therefore, this review intended to review evidence on the experience of EBF practices among working mothers. This study employed scoping review by using four stages. Firstly, develop the focus of the study through the framework of PEOS (Population, Exposure, Outcome and study design). Secondly, conducted literature search using three relevant databases (PubMed, Science Direct, Wiley Online) and grey literature (Google scholar). Thirdly, selected relevant studies using inclusion and exclusion criteria. Fourthly, conducted critical appraisals using data charting to assess the quality of included articles, followed by analyzing and reporting the results. PRISMA flowchart was used to describe the literature search plot. Based on 12 included articles, twothirds of the included articles were qualitative studies categorized as grade A. The other four articles had grade B where three out of four were non-randomized quantitative studies and one mixed-method study. Some factors identified to be the cause to prevent continued EBF were insufficiency support and facilities from family, husband, coworkers in the workplaces (paid leave, availability of daycare, lactation room, breast milk pumping tools). Two other identified factors were previous breastfeeding experience and knowledge. The implementation of EBF practices were challenging in some developed countries. However, having good knowledge was necessary to reduce the gap between maternal perception and belief in which was occurred in Italy study. In contrary, low knowledge was found as an important obstacle in the developing world such as Bangladesh. Overall, perception and belief related to EBF of working mothers contributed to the practice of EBF.

scholarly journals Matching Older Kidneys with Older Patients Does Not Improve Allograft Survival

2002 ◽  
Vol 13 (4) ◽  
pp. 1067-1072
Author(s):  
Bertram L. Kasiske ◽  
Jon Snyder
Keyword(s):  
Confidence Interval ◽  
Graft Survival ◽  
Graft Failure ◽  
The United States ◽  
Independent Effect ◽  
Donor Age ◽  
Recipient Age ◽  
Kidney Transplantations ◽  
Using Data ◽  
Older Recipients

ABSTRACT. Centers may restrict the use of some donor kidneys on the belief that overall graft survival is improved by giving older kidneys to older recipients andvice versa. The prevalence and the effect on graft survival (determined by death, return to dialysis, or retransplantation) of this practice among 74,297 first cadaver kidney transplantations in 1988 to 1998 was examined by using data from the United States Renal Data System. Giving older kidneys to older recipients is common; recipients ≥55 yr old received donor kidneys that were ≥55 yr old 46.2% more often than expected, but they received kidneys that were 18 to 29 yr old 33.6% less often than expected (χ2P< 0.0001). Both recipient and donor age have important effects on graft survival, although the effects of donor age are much stronger than those of recipient age. Compared with recipients 18 to 29 yr old, recipients ≥55 yr old were 25% (95% confidence interval, 15 to 35%,P< 0.0001) more likely to have graft failure (adjusted for donor age and other risk factors). On the other hand, donor kidneys ≥55 yr old were 78% (95% confidence interval, 58 to 99%,P< 0.0001) more likely to fail compared with kidneys 18 to 29 yr old. However, giving older kidneys to older recipients had little independent effect on graft survival, once the intrinsic effects of recipient and donor age were taken into account. For example, transplanting donor kidneys ≥55 yr old into recipients ≥55 yr old reduced the risk of graft failure only −6% (95% confidence interval, −18 to 8%,P= 0.3923) after the independent effects of donor and recipient ageper sewere taken into account. Thus, giving older kidneys to older recipients is a common practice that does not improve overall graft survival.

scholarly journals Quality of haemophilia treatment in Serbia: National haemophilia registry report

2010 ◽  
Vol 138 (suppl. 1) ◽  
pp. 23-27 ◽  
Author(s):  
Danijela Mikovic ◽  
Ljiljana Rakic ◽  
Gordana Jankovic-Trsnjak ◽  
Radmila Baklaja ◽  
Ivo Elezovic
Keyword(s):  
National Registry ◽  
Bleeding Disorders ◽  
Organization Of Care ◽  
Antifibrinolytic Drugs ◽  
Novi Sad ◽  
Von Willebrand ◽  
Registry Report ◽  
National Registry Data ◽  
Significant Support

Introduction. The National Registry of patients with inherited bleeding disorders was established in 1963 and ever since it has been in charge of the Haemophilia Centre, Blood Transfusion Institute of Serbia, Belgrade. Objective. Purpose was to assess the quality of haemophilia treatment in Serbia from 2000 to 2008 based on the National Registry data related with the organization of care and quantities, and the choice of products. Methods. Analysis of data collected by the National Registry from January 2000 to December 2008. Results. The National Registry of patients with hereditary coagulopathy encompasses a database of 392 patients with haemophilia A (HA), 64 haemophilia B (HB), 217 von Willebrand?s disease and 19 with rare bleeding disorders. Treatment can be obtained in seven haemophilia treatment centres; haematological and paediatric institutes and hospitals in Belgrade, Nis and Novi Sad, as well as in other twenty local hospitals. From 2000 to 2003 about three million units of FVIII concentrate were administered annually, e.g. 0.25 IU/capita/year. Besides, national cryoprecipitate was available for the treatment. In 2003, National Haemophilia Committee was founded and centralized products supply was introduced. During 2004 and 2005, about five million units of FVIII concentrate were provided: annually, i.e. 0.65 IU/capita/ year. The choice of products was also improved. Namely, until 2004 the availability of DDAVP, antifibrinolytic drugs and rFVIIa concentrate was limited, while from 2004 these products became available for haemophilia treatment in Serbia. In order to improve haemophilia care we established international cooperation; education, training, consulting and participation in clinical and research projects. As the result, FVIII concentrate consumption in 2008 was 10.5 million units, e.g. 1.35 IU/capita/year. Conclusion. The considerable improvement of treatment is the result of efforts made by health care and regulatory institutions in Serbia. Significant support has been provided by cooperation within twinning programmes between Stockholm and Belgrade Haemophilia Centres in 2003-2004 and Hamilton and Belgrade Haemophilia Centres in 2005-2008.

Recipient Sex Differences in Kidney Graft Survival Are Influenced by Donor Sex and Recipient Age

2021 ◽  
Vol 19 (3) ◽  
pp. 190-203
Author(s):  
Georgia Morgan ◽  
Zahrah Goolam-Mahomed ◽  
James Hodson ◽  
Jay Nath ◽  
Adnan Sharif
Keyword(s):  
Sex Differences ◽  
Graft Survival ◽  
Kidney Graft ◽  
Recipient Age

Physical capital stock, technological upgrading and modernisation in Hungary

2005 ◽  
Vol 55 (2) ◽  
pp. 201-221 ◽  
Author(s):  
Andrea Szalavetz
Keyword(s):  
Capital Accumulation ◽  
Physical Capital ◽  
Developed Countries ◽  
Point Of View ◽  
Technology Generation ◽  
Development Policies ◽  
Specific Factors ◽  
Physical Capital Accumulation

This paper discusses the relation between the quality and quantity indicators of physical capital and modernisation. While international academic literature emphasises the role of intangible factors enabling technology generation and absorption rather than that of physical capital accumulation, this paper argues that the quantity and quality of physical capital are important modernisation factors, particularly in the case of small, undercapitalised countries that recently integrated into the world economy. The paper shows that in Hungary, as opposed to developed countries, the technological upgrading of capital assets was not necessarily accompanied by the upgrading of human capital i.e. the thesis of capital skill complementarity did not apply to the first decade of transformation and capital accumulation in Hungary. Finally, the paper shows that there are large differences between the average technological levels of individual industries. The dualism of the Hungarian economy, which is also manifest in terms of differences in the size of individual industries' technological gaps, is a disadvantage from the point of view of competitiveness. The increasing differences in the size of the technological gaps can be explained not only with industry-specific factors, but also with the weakness of technology and regional development policies, as well as with institutional deficiencies.

Effect of networks on product innovation: empirical evidence from Indonesian SMEs

2013 ◽  
Vol 1 (2) ◽  
pp. 140-158 ◽  
Author(s):  
Nurul Indarti ◽  
Theo Postma
Keyword(s):  
Empirical Evidence ◽  
Product Innovation ◽  
Dynamic Effects ◽  
Depth Of Knowledge ◽  
External Knowledge ◽  
Software Firms ◽  
Using Data

Innovative companies generally establish linkages with other actors and access external knowledge in order to benefit from the dynamic effects of interactive processes. Using data from 198 furniture and software firms in Indonesia, this study shows that the quality of interaction (i.e. multiplexity) as indicated by the depth of knowledge absorbed from various external parties and intensity of interaction (i.e., tie intensity) are better predictors of product innovation than the diversity of interaction.

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