scholarly journals Sensitivity of the Wound Edge Gene Signature “WD14” in Responding to Clinical Change: A Longitudinal Cohort Study

2021 ◽  
pp. 153473462110567
Author(s):  
David C. Bosanquet ◽  
Ryan Laloo ◽  
Andrew J. Sanders ◽  
Fiona Ruge ◽  
Jane Lane ◽  
...  
Keyword(s):  
Wound Healing ◽  
Predictive Value ◽  
Clinical Status ◽  
Gene Signature ◽  
Leg Ulcers ◽  
Wound Edge ◽  
Venous Leg Ulcers ◽  
Clinical Healing ◽  
Genotype A ◽  
Over Time

Introduction: WounD14 (WD14) gene signature is a recently developed tool derived from genetic interrogation of wound edge biopsies of chronic venous leg ulcers to identify heard-to-heal wounds and enable clinicians to target aggressive therapies to promote wound healing. This study aimed to evaluate if changes in wound clinical healing status were detected by the WD14 gene signature over time as this is currently poorly understood. Material and methods: WD14 was developed through gene screening and subsequent validation in 3 patient cohorts involving 85 consecutive patients with chronic venous leg ulcers referred to a tertiary wound healing unit. Patients underwent a wound edge biopsy to interrogate for a “healing” or “non-healing” genotype. A smaller cohort (18%) underwent a second biopsy, which comprised this pilot cohort reported herein. Twelve weeks following biopsy, wounds were clinically assessed for healing status based on reduction in size and compared to WD14 genotype. Results: Sequential biopsies and WD14 scores were derived from 16 patients. WD14 signature predicted wound healing status among this cohort at either visit (32 wound edge biopsies) with a positive predictive value (PPV) of 85.2% (95% CI 74.1%-92.0%) and negative predictive value (NPV) of 80.0% (95% CI 34.2%-96.9%). A total of 6 wounds underwent altered clinical status between the 2 visits. In this cohort, WD14 has a PPV of 66.7% (95% CI 47.3%-81.7%) and NPV of 100%. Conclusion: Although the WD14 gene signature did change with wound healing status, larger studies are required to precisely clarify its role and ability to prognosticate wounds of differing clinical status over time.

Neurovascular changes after four-layer compression bandaging in people with chronic venous leg ulcers

2007 ◽  
Vol 22 (2) ◽  
pp. 49-55 ◽  
Author(s):  
R Ogrin ◽  
P Darzins ◽  
Z Khalil
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Statistical Significance ◽  
Sensory Nerve ◽  
Compression Therapy ◽  
Clinical Problem ◽  
Leg Ulcers ◽  
Venous Leg Ulcers ◽  
Perfusion Measurement ◽  
Compression Bandaging

Objectives: Venous leg ulcers represent a major clinical problem, with poor rates of healing. Ideal treatment is compression bandaging. The effect of compression on neurovascular tissues involved in wound repair is unclear. This study aims to assess the effect of four-layer compression therapy (40 mmHg) on neurovascular function and wound healing in people with chronic venous leg ulcers – 15 people (55 years or older) with venous leg ulcers for more than six weeks. Methods: Basal microvascular perfusion measurement (MPM), oxygen tension (tc pO2) measured at sensor temperatures of 39°C and 44°C and sensory nerve function using electrical cutaneous perception thresholds (ECPT) at 5, 250 and 2000 Hz (corresponding to C, A δ and A β fibres) were assessed adjacent to the ulcer site, and at a mirror location on the non-ulcerated limb. Testing was undertaken before and after therapy for 5–12 weeks of four-layer compression bandaging. Results: There was significant improvement in tc pO2 at 44°C and ECPT at 2000 Hz ( P<0.05) compared with pre-intervention. Changes in basal MPM, tc pO2 at 39°C and ECPT at 5 and 250 Hz after compression therapy did not reach statistical significance. Conclusion: Four-layer compression bandaging in people with venous leg ulcers improved some components of neurovascularture in people with chronic venous leg ulcers. Whether this improvement has contributed to wound healing in this study requires further investigation.

scholarly journals Treatment of venous leg ulcers with an ointment containing yarrow (Achillea millefolium) extract / Primena preparata sa ekstraktom hajdučke trave (Achillea millefolium) u lečenju venskih ulkusa potkolenice

2009 ◽  
Vol 1 (3) ◽  
pp. 101-106 ◽  
Author(s):  
Milan Matić ◽  
Verica Đuran ◽  
Marina Jovanović ◽  
Zorica Gajinov ◽  
Aleksandra Matić ◽  
...  
Keyword(s):  
Wound Healing ◽  
Saline Solution ◽  
Achillea Millefolium ◽  
Control Group ◽  
Leg Ulcers ◽  
Herbal Preparations ◽  
Venous Leg Ulcers ◽  
Accelerate Wound Healing ◽  
Venous Ulcers ◽  
Experimental Group

Abstract Traditional medicine credits yarrow (Achillea millefolium) with the ability to accelerate wound healing. The purpose of this research was to determine the effects of yarrow on the epithelization of the lower leg venous ulcers. The study included 39 patients with venous leg ulcers. They were divided into two groups: the first (experimental) group of patients were treated with an ointment containing 7.5% of yarrow extract. In the second (control) group, saline solution dressings were applied to ulcers, within the period of three weeks. In the experimental group, at the beginning of the therapy, the total surface of all the ulcers was 44736 mm2. After three weeks, the total surface of all the ulcers was 27000 mm2 (a decrease of 39.64%). In the control group, at the beginning of the therapy, the total surface of all the ulcers was 46116 mm2. At the end of the study (21 days) the total surface of all the ulcers was 39153 mm2 (a decrease of 15.1%). Herbal preparations are suitable for application in the therapy of venous ulcers, but their efficiency in wound healing is still to be investigated.

scholarly journals What is the effect of exercise on wound healing in patients with venous leg ulcers? A systematic review

2018 ◽  
Vol 15 (3) ◽  
pp. 441-453 ◽  
Author(s):  
Daisy Smith ◽  
Rebecca Lane ◽  
Rosemary McGinnes ◽  
Jane O'Brien ◽  
Renea Johnston ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Leg Ulcers ◽  
Venous Leg Ulcers

Does the use of low-level laser influence wound healing in chronic venous leg ulcers?

2005 ◽  
Vol 14 (8) ◽  
pp. 391-394 ◽  
Author(s):  
D. Kopera ◽  
R. Kokol ◽  
C. Berger ◽  
J. Haas
Keyword(s):  
Wound Healing ◽  
Leg Ulcers ◽  
Low Level ◽  
Venous Leg Ulcers ◽  
Low Level Laser ◽  
Level Laser

A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs

2007 ◽  
Vol 15 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Charlotte E. Davies ◽  
Katja E. Hill ◽  
Robert G. Newcombe ◽  
Phil Stephens ◽  
Melanie J. Wilson ◽  
...  
Keyword(s):  
Prospective Study ◽  
Predictive Value ◽  
Leg Ulcers ◽  
Venous Leg Ulcers ◽  
A Prospective Study

Some Effects of a Topical Collagen-Based Matrix on the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations

2005 ◽  
Vol 4 (4) ◽  
pp. 214-224 ◽  
Author(s):  
Uwe Wollina ◽  
Wolf-Dieter Schmidt ◽  
Claudia Krönert ◽  
Cornelia Nelskamp ◽  
Armin Scheibe ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leg Ulcers ◽  
Venous Leg Ulcers

scholarly journals Hyperbaric Oxygen Therapy for Venous Leg Ulcers: A 6 Year Retrospective Study of Results of a Single Center

2021 ◽  
Vol 8 ◽  
Author(s):  
Rutger C. Lalieu ◽  
Ida Akkerman ◽  
Rob A. van Hulst
Keyword(s):  
Wound Healing ◽  
Pain Score ◽  
Outcome Measures ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Leg Ulcers ◽  
Single Center ◽  
Venous Leg Ulcers ◽  
Number Of Patients

Background: Venous leg ulcers (VLUs) are common and have a large impact on healthcare budgets worldwide. Hyperbaric oxygen therapy (HBOT) may improve healing of these ulcers.Methods: Retrospective, single-center cohort study between 2013 and 2019. All patients with a VLU from an outpatient clinic providing HBOT and wound care were included. The primary outcome measure was wound healing, determined at discharge from the center. Other outcome measures were improvement in patient related outcome measures (PROMs), as assessed by the EQ-5D-3L questionnaire and including quality of life (QoL) and pain score.Results: Fifty patients were included, 53% female, with a mean age of 73.4 (±12.2). Most wounds (83%) had existed longer than 3 months before starting treatment. Patients received an average of 43 (±20) sessions of HBOT. After treatment, 37 patients (63%) achieved complete or near-complete wound healing. Wound size decreased from a median of 14 cm2 [interquartile range (IQR) 32 cm2] to 0.5 cm2 (IQR 5.3 cm2), a median decrease of 7.5 (IQR 16.2 cm2) in cm2 (94%). Patients mostly reported improvement for all health aspects on the questionnaire. Pain score decreased from 5.7 (±2.5) to 2.1 (±2.2) (p &lt; 0.0001) and health score increased from 57.2 (±15.6) to 69.9 (±18.9) (p = 0.02).Conclusions: Patients with non-healing VLUs may benefit from HBOT to achieve complete or substantial wound healing. We recommend a well-designed randomized clinical trial with a number of patients allowing enough statistical power, and of a reasonable duration, to establish the potential of additional HBOT on hard-to-heal venous ulcers.

Effect of Physical Therapy on Wound Healing and Quality of Life in Patients With Venous Leg Ulcers

2015 ◽  
Vol 151 (3) ◽  
pp. 320 ◽  
Author(s):  
Elizabeth Yim ◽  
Robert S. Kirsner ◽  
Robert S. Gailey ◽  
David W. Mandel ◽  
Suephy C. Chen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Wound Healing ◽  
Physical Therapy ◽  
Leg Ulcers ◽  
Venous Leg Ulcers

Comparison of Efficacy of Unna’s boot and Ozone therapy on Chronic Venous Leg Ulcers: a series of case

2020 ◽  
Vol 9 (9) ◽  
pp. e44996967
Author(s):  
Denise Viviane Ferreira Del Castilo ◽  
Marcello Magri Amaral ◽  
Carla Roberta Tim ◽  
Cintia Cristina Santi Martignago ◽  
Daniela Bezerra Macedo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Chronic Wounds ◽  
Healing Time ◽  
Ozone Treatment ◽  
Leg Ulcers ◽  
Ozone Therapy ◽  
Venous Leg Ulcers ◽  
Wound Healing Time ◽  
Tissue Reduction

The aim of this study was to evaluate and compare the effectiveness of Unna’s boot and ozone therapy on chronic venous leg ulcers. Seven patients with chronic venous leg ulcers were taken into the study and were randomly divided into two groups: Unna’s boot treatment group (BU); Ozone treatment group (OZ). The therapies were performed weekly until wound closure. The morphological descriptive results demonstrated that during the treatments, it was possible to observe the presence of semi-planar borders, granulation tissue, reduction of edema, fibrin and exudate and absence of odor. These morphological modifications were more pronounced in the OZ when compared to the BU. Furthermore, both treatments promoted the same wound healing time, never the less the ozone therapy produced a higher percentage of weekly wound reduction compared to Unna's boot. Unna's boot and ozone therapy treatments appeared to positively impact the course of wound healing in chronic wounds, however the ozone therapy may improve the healing of chronic venous leg ulcers in a higher weekly percentage.

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