Non-primate Lentiviral Vector Administration in the TMJ

2004 ◽  
Vol 83 (1) ◽  
pp. 65-70 ◽  
Author(s):  
S. Kyrkanides ◽  
P. Kambylafkas ◽  
J.H. Miller ◽  
R.H. Tallents
Keyword(s):  
Temporomandibular Joint ◽  
Reporter Gene ◽  
Soft Tissues ◽  
Lentiviral Vector ◽  
Retrograde Transport ◽  
Lentiviral Vectors ◽  
Treatment Method ◽  
Joint Space ◽  
Nerve Fibers ◽  
Temporomandibular Joint Disorders

Gene therapy is emerging as a novel treatment method for the management of temporomandibular joint disorders. The aim of this investigation was to study the effects of lentiviral vectors on the temporomandibular joint. Consequently, we injected into the articular joint space a defective feline immunodeficiency virus capable of infecting dividing as well as terminally differentiated cells with the reporter gene lacZ, the expression of which was studied by means of PCR, X-gal histochemistry, and β-galactosidase immunocytochemistry. Our results showed successful transduction of hard and soft tissues of the temporomandibular joint. Interestingly, a subset of primary sensory neurons of the ipsilateral trigeminal ganglion also stained positive for the reporter gene, presumably following uptake of the lentiviral vector by peripheral nerve fibers and retrograde transport to the nucleus. These findings suggest that lentiviral vectors can potentially serve as a platform for the transfer of anti-nociceptive genes for the management of temporomandibular joint pain.

scholarly journals An additional lysis procedure during arthrocentesis of the temporomandibular joint

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Keon-Mo Lee ◽  
Wan-Hee Jang ◽  
Myoung-Sang You ◽  
Bu-Kyu Lee
Keyword(s):  
Temporomandibular Joint ◽  
Arthroscopic Surgery ◽  
Mouth Opening ◽  
Invasive Procedure ◽  
Joint Space ◽  
Temporomandibular Joint Disorders ◽  
Invasive Procedures ◽  
The Mean ◽  
Mechanical Lysis ◽  
Over Time

Abstract Background Arthrocentesis of the temporomandibular joint (TMJ) is an easy, highly efficient, minimally invasive procedure for treating temporomandibular joint disorders (TMDs). However, in some cases of mouth opening limitation (MOL), routine arthrocentesis is ineffective due to severe fibrotic adhesion in the superior joint space of the TMJ. In this condition, mechanical lysis of the adhesions might be needed to resolve the MOL, as well as other symptoms, such as chronic pain. Currently, this can be achieved by arthroscopic surgery or open TMJ surgery. The objective of this study was to introduce and evaluate our trial of the adhesion lysis procedure during arthrocentesis of the TMJ using normal 18-gauge needles. Results In this study, 40 patients with MOL due to disc derangement underwent conventional arthrocentesis at first and then physical detachment was conducted using the same needle. The change in maximum mouth opening (MMO) and the pain at the TMJ were recorded before, during, and after treatment according to our protocol. The mean increase in MMO after conventional arthrocentesis was 6.6 ± 4.2mm. The mean increase in MMO after the detachment procedure with the same needle was 4.2 ± 2.0 mm. The MMO in ten patients was significantly increased after the detachment procedure than after arthrocentesis alone. In all cases, the pain intensity in the TMJ significantly decreased over time, whereas the MMO increased over time. No adverse effect was observed in all joints during our observation periods. Conclusion We confirmed that our simple lysis procedure with the same needle of the arthrocentesis of the TMJ could not only improve the MMO more than after a conventional arthrocentesis but also resolve severe adhesion of the joint space that was ineffective by conventional arthrocentesis. Although this additional lysis procedure is simple, it might reduce the number of cases of more invasive procedures such as arthroscopic surgery or open TMJ surgery.

scholarly journals Posisi kondilus setelah perawatan ortodontik pada maloklusi kelas II divisi 1 dengan pencabutan premolarCondylar position after orthodontic treatment in class II division 1 malocclusion with premolar extraction

2021 ◽  
Vol 33 (1) ◽  
pp. 59
Author(s):  
Dhani Ayu Andini ◽  
Maria Purbiati ◽  
Nia Ayu Ismaniati Suria ◽  
Ira Tanti
Keyword(s):  
Temporomandibular Joint ◽  
Orthodontic Treatment ◽  
Joint Space ◽  
Class Ii ◽  
Temporomandibular Joint Disorders ◽  
Premolar Extraction ◽  
Division 1 ◽  
Before And After ◽  
The Right ◽  
Class Ii Division 1

Pendahuluan: Maloklusi kelas II divisi 1 dilaporkan seringkali memicu terjadinya gangguan sendi temporomandibula. Posisi kondilus mengalami perubahan pada akhir perawatan ortodontik dengan pencabutan premolar pada maloklusi kelas II divisi 1. Tujuan penelitian menganalisis posisi kondilus pada akhir perawatan ortodontik supaya dapat memberikan pelayanan yang efektif dan komprehensif kepada pasien. Metode: Jenis penelitian deskriptif observasional dengan desain kohort dilakukan pada Klinik Spesialis RSKGM FKG UI dari Maret sampai Mei 2019. Subjek sebanyak 30 orang mengalami maloklusi kelas II divisi 1 yang memiliki gejala gangguan temporomandibular yang memenuhi kriteria inklusi. Metode sampling yang digunakan adalah sampling konsekutif. Foto transkranial dibandingkan dan diukur ruang sendinya bagian anterior, posterior dan superior dan dianalisis menggunakan uji Mc Nemar. Hasil: Sebelum dan sesudah perawatan ortodontik, posisi kondilus kanan dan kiri tidak mengalami perubahan yang signifikan (p>0,05). Sebelum dan sesudah perawatan ortodontik, AJS (Anterior Joint Space), PJS (Posterior Joint Space), SS (Superior Space) kanan dan kiri tidak mengalami perubahan yang signifikan (p>0,05). Gejala gangguan sendi temporomandibula pada akhir perawatan ortodontik adalah kliking dan krepitasi dilaporkan masih ada sedangkan gejala tidak nyaman dan keterbatasan membuka mulut dilaporkan sudah hilang.  Simpulan: Tidak terdapat perbedaan posisi kondilus kanan dan kiri, sebelum dan sesudah perawatan ortodontik dengan pencabutan premolar pada maloklusi kelas II divisi 1. Keluhan gangguan sendi temporomandibular tidak ditemukan lagi pada akhir perawatan ortodontik.Kata kunci: Posisi kondilus, perawatan ortodontik, maloklusi kelas II divisi 1, pencabutan premolar. ABSTRACTIntroduction: Class II division 1 malocclusion is reported to trigger temporomandibular joint disorders often. The position of the condyles changed at the end of orthodontic treatment with premolar removal in class II division 1 malocclusion. This study aimed to analyse the position of the condyles at the end of orthodontic treatment to provide effective and comprehensive services to patients. Methods: This type of descriptive observational study with a cohort design was conducted at the Specialist Clinic of University of Indonesia Dental Hospital from March to May 2019. Thirty subjects experienced class II division 1 malocclusion who had temporomandibular disorders that met the inclusion criteria. The sampling method used was consecutive sampling. Transcranial radiographs were compared, and anterior, posterior and superior joint spaces were measured and analysed using the McNemar test. Results: Before and after orthodontic treatment, the position of the right and left condyles did not change significantly (p>0.05). Before and after orthodontic treatment, AJS (Anterior Joint Space), PJS (Posterior Joint Space), SS (Superior Space) right and left did not change significantly (p>0.05). Symptoms of temporomandibular joint disorder at the end of orthodontic treatment were clicking, and crepitus was reported to be present, while the symptoms of discomfort and limited opening of the mouth were reported to have disappeared. Conclusion: There is no difference in the position of the right and left condyles before and after orthodontic treatment with premolar extraction in class II division 1 malocclusion. Complaints of temporomandibular joint disorders were not found again at the end of orthodontic treatment. Keywords: Condyle position, orthodontic treatment, class II division 1 malocclusion, premolar extraction.

scholarly journals Evaluation of C-Reactive Protein Level in Patients with Pain Form of Temporomandibular Joint Dysfunction

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Malgorzata Pihut ◽  
Piotr Ceranowicz ◽  
Andrzej Gala
Keyword(s):  
Temporomandibular Joint ◽  
Soft Tissues ◽  
Temporomandibular Joint Disorders ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Level Of Evidence ◽  
Temporomandibular Joint Dysfunction ◽  
Mean Values ◽  
Reactive Protein

Temporomandibular joint dysfunction is a functional disorder concerned with the abnormal functioning of the muscles of the stomatognathic system and temporomandibular joints involved in the dynamic movements of the jaw and surrounding structures. The aim of the study was to compare the level of C-reactive protein in patients with pain and painless forms of temporomandibular joint dysfunction. Materials and methods. The study group consisted of 72 patients who reported to the prosthetic treatment because of temporomandibular joint dysfunction. The study group included 36 patients with pain form of dysfunction, and the control group included 36 patients with painless form of disorder. Each patient underwent specialized examination of functional disorders in order to diagnose the type of dysfunction and was commissioned to carry out a study of the blood test concerned with evaluation of the C-reactive protein (CRP) level in the same analytical laboratory. The results of the investigation were subjected to statistical analysis. The research obtained approval from the Ethics Committee of the Jagiellonian University (KBET/125/L/2013). Level of Evidence for primary research was established as type V. Results. The mean values of C-reactive protein levels in both groups were in the normal range and did not differ statistically significantly, which indicates the fact that the pain form of the temporomandibular joint disorders is not associated with inflammation of the soft tissues of the joint. Conclusion. Painful form of the temporomandibular joint dysfunctions is not connected with the inflammation of joints.

scholarly journals Evaluation of temporomandibular joint disorders using cone beam computed tomography

2017 ◽  
Vol 3 (4) ◽  
pp. 698
Author(s):  
Sonam Kohli ◽  
Rahul Krishan Sharma ◽  
Anchal Goel ◽  
M. K. Sunil
Keyword(s):  
Computed Tomography ◽  
Temporomandibular Joint ◽  
Cone Beam Computed Tomography ◽  
Joint Space ◽  
Temporomandibular Joint Disorders ◽  
Cone Beam ◽  
Glenoid Fossa ◽  
Significant Difference ◽  
Mandibular Fossa ◽  
Osseous Changes

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">The aim of this study was to evaluate efficacy of segmental cone beam computed tomography (CBCT) in detecting bony changes in condyle and thickness of roof of glenoid fossa in temporomandibular joint (TMJ) disorders.</span></p><p class="abstract"><strong>Methods:</strong> The study group comprised of 10 temporomandibular disorders (TMD) patients of either sex between the age group of 20-60 years diagnosed as TMDs by clinical evaluation using the research diagnostic criteria was considered. After the clinical examination, radiographic investigations were carried out which included digital OPG, transcranial radiograph and CBCT scan. TMJ Evaluation included: (a) bony changes of the condyle (flattening, erosion, sclerosis, osteophytes, resorption); (b) joint space (normal, increased, reduced, bony contact between the condyle and the mandibular fossa); and (c) bony changes of mandibular fossa (normal, sclerosis, erosion, resorption). The radiographic findings were statistically analysed.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Significant difference between OPG, transcranial and CBCT were found for the presence of erosion (P =0.000), thickness of roof of glenoid fossa (P =0.000), deformed contour (P =0.001), joint space (P =0.011), subchondral sclerosis (P =0.011), irregularity of articular surface and eminence (P =0.000), flattening (P =0.050). </span></p><p class="abstract"><strong>Conclusions:</strong> Using CBCT as imaging technique in our study to detect osseous changes in the TMJ was proved to be effective as compared to the conventional radiographic techniques, the results achieved with CBCT was 100%.The results obtained in our study prove to be a full proof one and it seems to promise to go one step closer to detect progression and severity of the osseous changes in the condylar head and mandibular fossa in patients with TMDs<span lang="EN-IN">.</span></p>

Distribution of substance P-like immunoreactive nerve fibers in temporomandibular joint soft tissues of monkey

1986 ◽  
Vol 94 (3) ◽  
pp. 225-230 ◽  
Author(s):  
ANN-SOFI JOHANSSON ◽  
GORAN ISACSSON ◽  
ANNIKA ISBERG ◽  
ANN-CHARLOTTE GRANHOLM
Keyword(s):  
Substance P ◽  
Temporomandibular Joint ◽  
Soft Tissues ◽  
Nerve Fibers

scholarly journals EVALUATION OF THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH TEMPOROMANDIBULAR JOINT DYSFUNCTION AFTER MANDIBULAR FRACTURES ACCORDING TO X-RAY EXAMINATION

2021 ◽  
Vol 74 (9) ◽  
pp. 2082-2086
Author(s):  
Olga L. Skrypa
Keyword(s):  
Temporomandibular Joint ◽  
Statistical Processing ◽  
Treatment Method ◽  
Joint Space ◽  
Main Group ◽  
Control Group ◽  
Mandibular Fractures ◽  
Temporomandibular Joint Dysfunction ◽  
Radiological Data ◽  
Post Traumatic

The aim: On the basis of radiological data to evaluate the effectiveness of our developed treatment complex of patients with temporomandibular joint dysfunction after mandibular fractures. Materials and methods: To achieve this goal, 92 patients hospitalized in the department of surgical dentistry of the Chernivtsi Regional Clinical Hospital were examined for traumatic fractures of the mandible with functional disorders of the TMJ. 46 patients (main group) were treated according to the treatment method developed by us, and 46 patients (control group) were treated with the traditional method. Patients underwent orthopanthography and radiography of the temporomandibular joint according to Schuller. Statistical processing of research results was carried out using commonly used methods of variation statistics. Results: After 12 months of studies in patients of the main group, unilateral narrowing of the joint space was determined in 6,52 ± 1,83% of persons p, p1 0.05.The number of persons with unilateral expansion of the joint space according to Rtg, in the main group decreased by 2,3 times relative to the data before treatment. Conclusions: Timely treatment of musculoskeletal disorders with the help of pharmacological and physiotherapeutic methods proposed by us, allowed, to a large extent, to eliminate clinical, radiological and ultrasound symptoms of temporomandibular joint dysfunction in patients with post-traumatic lesions of mandibule. This was confirmed by the improvement of the data of the conducted functional researches.

Reliability and Validity of Imaging Diagnosis of Temporomandibular Joint Disorder

1993 ◽  
Vol 7 (2) ◽  
pp. 137-151 ◽  
Author(s):  
P.-L. Westesson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Temporomandibular Joint ◽  
Soft Tissues ◽  
Imaging Techniques ◽  
Reliability And Validity ◽  
Plain Film ◽  
Temporomandibular Joint Disorders ◽  
Resonance Imaging ◽  
Imaging Diagnosis

The purpose of this article is to review reliability and validity of imaging diagnosis of temporomandibular joint disorders. Plain-film and tomography are basic imaging techniques for assessment of the temporomandibular joint. These can be used for evaluation of osseous disease and as a baseline for follow-up. In patients with symptoms from the joint, plain-film and tomography are rarely definitive, and evaluation of the soft tissues is frequently necessary. Arthrography, computed tomography, and magnetic resonance imaging have all been used for evaluation of the soft-tissue components of the joints. Accuracy studies of these techniques have demonstrated the highest diagnostic accuracy for magnetic resonance imaging. Arthrography is relatively insensitive for detection of medial and lateral displacements. Magnetic resonance imaging accurately depicts both hard and soft tissues, and this technique is emerging as the prime diagnostic imaging technique in patients presenting with clinical signs and symptoms of a disorder of the temporomandibular joint. The most frequent findings when patients with clinical symptoms of temporomandibular joint disorders are "imaged" are different forms of disc displacement and degenerative joint disease. Studies have demonstrated a high prevalence of different forms of disc displacement in patients, although these abnormalities are also seen in some asymptomatic volunteers. Future research should further refine imaging techniques to come closer to an understanding of the association between morphologic alterations and patient symptoms.

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