Taste Loss and Recovery Following Radiation Therapy

2006 ◽  
Vol 85 (7) ◽  
pp. 608-611 ◽  
Author(s):  
P.L. Sandow ◽  
M. Hejrat-Yazdi ◽  
M.W. Heft
Keyword(s):  
Radiation Therapy ◽  
Parotid Glands ◽  
Time Intervals ◽  
Detection Thresholds ◽  
Primary Tumors ◽  
Hyperfractionated Radiotherapy ◽  
Radiation Induced ◽  
Post Radiation ◽  
Taste Detection ◽  
One Way Anova

Previous investigators have reported deficits in taste acuity in patients following radiation therapy for oropharyngeal cancer. In the present longitudinal study, 13 patients (mean age = 51.6 yrs) received conventional or hyperfractionated radiotherapy (63–76.8 Gy) for primary tumors of the oropharynx. One or both parotid glands and at least two-thirds of the tongue were included in the radiation field. Smell recognition and taste detection thresholds were determined at baseline, 1 month, 6 months, and 1 year post-radiation. Differences for smell recognition and the 4 taste qualities were assessed (independently) at the 4 time intervals, with a one-way ANOVA. Smell recognition was unaffected by radiation. There were significant elevations in thresholds for sweet (p < 0.005), salty (p < 0.005), bitter (p < 0.005), and sour (p< 0.001) during radiation therapy that were restored to baseline levels at 6 months and 1 year after radiation. This study demonstrated that radiation-induced taste deficits can be recovered by 6 months.

scholarly journals Radiation heart disease in a patient post treatment of Нodgkin’s lymphoma

2018 ◽  
pp. 45-47
Author(s):  
Е. S. Eniseeva ◽  
К. V. Protasov ◽  
N. L. Chernysheva ◽  
E. Yu. Bagadaeva ◽  
A. A. Stefanenkova
Keyword(s):  
Radiation Therapy ◽  
Heart Disease ◽  
Surgical Treatment ◽  
Female Patient ◽  
Constrictive Pericarditis ◽  
Clinical Case ◽  
Post Treatment ◽  
Hodgkin's Lymphoma ◽  
Radiation Induced ◽  
Post Radiation

A clinical case of radiation induced heart disease in 43 year old female patient after 15 years since radiation therapy of Hodgkin’s lymphoma. During clinical and instrumental investigation, a post-radiation constrictive pericarditis was found, comorbid with lesion of aortic, mitral and tricuspid valves. Surgical treatment of pericarditis was applied. Morphology confirmed the diagnosis.

scholarly journals Radiation-induced CT number changes in GTV and parotid glands during the course of radiation therapy for nasopharyngeal cancer

2016 ◽  
Vol 89 (1062) ◽  
pp. 20140819 ◽  
Author(s):  
Shouping Xu ◽  
Zhaoxia Wu ◽  
Cungeng Yang ◽  
Lin Ma ◽  
Baolin Qu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Nasopharyngeal Cancer ◽  
Parotid Glands ◽  
Ct Number ◽  
Radiation Induced

Laryngeal necrosis after combined chemotherapy and radiation therapy

1997 ◽  
Vol 111 (8) ◽  
pp. 763-765 ◽  
Author(s):  
Mamoru Miyaguchi ◽  
Hitoshi Takashima ◽  
Takeshi Kubo
Keyword(s):  
Radiation Therapy ◽  
Radiation Necrosis ◽  
Rare Complication ◽  
Late Complication ◽  
Major Complication ◽  
Combined Chemotherapy ◽  
Head And Neck Tumours ◽  
Radiation Induced ◽  
Node Metastases ◽  
Post Radiation

AbstractPost-radiation necrosis of the larynx is a major complication after irradiation and has become rare. Recently, combined chemotherapy and radiation therapy has been introduced for head and neck tumours. The authors report a case of laryngeal necrosis after combination therapy for a patient with cervical lymph node metastases of nasopharyngeal carcinoma and review the literature on late laryngeal necrosis. Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence. We should always consider it as a possible late complication and treat it appropriately.

scholarly journals Mechanistic modelling of prostate-specific antigen dynamics shows potential for personalized prediction of radiation therapy outcome

2019 ◽  
Vol 16 (157) ◽  
pp. 20190195 ◽  
Author(s):  
Guillermo Lorenzo ◽  
Víctor M. Pérez-García ◽  
Alfonso Mariño ◽  
Luis A. Pérez-Romasanta ◽  
Alessandro Reali ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Cancer Recurrence ◽  
Proliferation Rate ◽  
External Beam Radiation ◽  
Biochemical Relapse ◽  
Beam Radiation ◽  
Radiation Induced ◽  
Post Radiation

External beam radiation therapy is a widespread treatment for prostate cancer. The ensuing patient follow-up is based on the evolution of the prostate-specific antigen (PSA). Serum levels of PSA decay due to the radiation-induced death of tumour cells and cancer recurrence usually manifest as a rising PSA. The current definition of biochemical relapse requires that PSA reaches nadir and starts increasing, which delays the use of further treatments. Also, these methods do not account for the post-radiation tumour dynamics that may contain early information on cancer recurrence. Here, we develop three mechanistic models of post-radiation PSA evolution. Our models render superior fits of PSA data in a patient cohort and provide a biological justification for the most common empirical formulation of PSA dynamics. We also found three model-based prognostic variables: the proliferation rate of the survival fraction, the ratio of radiation-induced cell death rate to the survival proliferation rate, and the time to PSA nadir since treatment termination. We argue that these markers may enable the early identification of biochemical relapse, which would permit physicians to subsequently adapt patient monitoring to optimize the detection and treatment of cancer recurrence.

Radiation-induced sarcoma: A single center experience with 36 cases

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 20525-20525
Author(s):  
F. Mayer ◽  
H. G. Kopp ◽  
J. Classen ◽  
T. Kluba ◽  
A. Koenigsrainer ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Radiation Field ◽  
Background Radiation ◽  
Vascular Lesions ◽  
Surgical Removal ◽  
Time Interval ◽  
Term Survival ◽  
Primary Tumors ◽  
Radiation Induced

20525 Background: Radiation-induced sarcoma (RIS) is a rare complication of radiation therapy for any cause. With increasing numbers of patients receiving radiotherapy, data concerning the incidence and treatment outcome of RIS are urgently needed. Methods: We screened our local sarcoma registry for patients with RIS. 36 cases of RIS that had developed after radiation for malignant disease were identified and analyzed retrospectively over a 12 year period (1994–2006). Results: All patients had received radiation therapy between 1968 and 2002. The most frequent primary tumors were breast cancer (n = 19) and lymphoma (including Hodgkin`s and non-Hodgkin`s lymphoma, n = 9). The remainder received radiation therapy for tumors of the female reproductive organs (n = 2), head and neck cancer (n = 4), neuroblastoma (n = 1), and seminoma (n = 1).The median of delivered total radiation dose per patient was 50 Gy (35 to 72 Gray). Sources of irradiation were photons (n = 9), cobalt (n = 6), electrons (n = 2), and unknown in 19 cases. The median time interval from the start of irradiation the detection of the sarcoma was 11 years (1 - 35 years). The tumors arose within the radiation field in 29 cases, on the border of the field in 6 cases, and out of field in 1 case. The histology of RIS was angiosarcoma in most cases (n = 12), followed by pleomorphic sarcomas (n = 11), leiomyosarcoma (n = 4), fibrosarcoma (n = 2), osteosarcoma (n = 2), and others (n =5). Most cases were detected in a localized stage of disease (n = 33), and therefore, complete surgical removal was achieved in almost 50% (n = 17). However, this did not translate into long term survival within the overall study population. Only 11 patients remain free of disease during a mean follow-up period of 29 months (range, 0 - 51). Conclusions: Angiosarcomas within or on the border of the radiation field are the most common histological subentity of RIS. Therefore, follow-up of previously irradiated patients should include examination of irradiated regions with a high level of suspicion if cutaneous atypical vascular lesions are found. However, the clinician should be aware of the fact that RIS also occurs out of field and can be of non-angiogenic subtype as well. As far as treatment is concerned, RIS is treated the same as non-radiation induced sarcoma. No significant financial relationships to disclose.

Systemic and intravesical treatment of post-radiation cystitis: the role of hyaluronic acid

2020 ◽  
Vol 21 (3) ◽  
pp. 120-130
Author(s):  
E. I. Gutrova ◽  
◽  
D. I. Petrov ◽  
T. B. Grigorenko ◽  
A. A. Simonov ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Hyaluronic Acid ◽  
Malignant Tumors ◽  
Intravesical Instillation ◽  
Treatment Protocols ◽  
Radiation Cystitis ◽  
Radiation Induced ◽  
Post Radiation ◽  
Methods Of Treatment

The data presented in the review indicate that despite modern advances in chemotherapy, hormonal therapy, targeted therapy, and immunotherapy of neoplasms, radiation therapy is a common method of treating malignant tumors of various localization. The most compelling evidence of efficacy exists for systemic therapy with TCDO / WF10, cranberry capsules, hyperbaric oxygen therapy, and intravesical instillation of hyaluronic acid preparations. The presence of many methods of treatment of radiation-induced cystitis described in the literature: systemic, local with the use of physical methods, combinations of different methods – indicates the absence of a single concept for the prevention and treatment of this severe complication of radiation therapy justifies the relevance of further study of treatment protocols from the standpoint of evidence-based and personalized medicine.

scholarly journals Radiation-induced meningioma following radiation therapy for pituitary adenoma

1996 ◽  
Vol 1 (1) ◽  
pp. E12 ◽  
Author(s):  
Mark K. Lyons ◽  
Gilbert R. Gonzales ◽  
Steven E. Schild ◽  
Kent D. Nelson
Keyword(s):  
Radiation Therapy ◽  
Pituitary Adenoma ◽  
External Beam Radiation Therapy ◽  
External Beam Radiation ◽  
Term Result ◽  
Beam Radiation ◽  
Long Term Result ◽  
Radiation Induced ◽  
Post Radiation

The authors report the long-term result of treatment of a presumed pituitary adenoma with external-beam radiation therapy, which appears to be the development of a radiation-induced meningioma. Of the post radiation neoplasms that have been reported, meningiomas constitute a large proportion of these lesions.

scholarly journals TREATMENT OF RADIATION-INDUCED PELVIC DAMAGE AFTER RADIATION THERAPY FOR PROSTATE CANCER

2018 ◽  
Vol 17 (3) ◽  
pp. 64-71 ◽  
Author(s):  
I. V. Sycheva
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Conservative Treatment ◽  
Combination Treatment ◽  
External Beam Radiation ◽  
External Beam ◽  
Beam Radiation ◽  
Pelvic Organs ◽  
Radiation Induced ◽  
Post Radiation

Background. Radiation-induced damage to the pelvic organs (post-radiation proctitis, cystitis, urethritis) is a frequent complication after radiotherapy for prostate cancer. The reported frequency of late  radiation damage to the pelvic organs is up to 30 %.Material and methods. The paper presents treatment outcomes of 149 with radiation-induced pelvic injuries caused by brachitherapy  (15 patients) and combination treatment including brachitherapy and external beam radiation therapy (28 patients) for stage T1–3N0M0  prostate cancer. Radiationinduced rectitis (proctitis) was revealed in  149 patients and complications of the urinary tract after radiation treatment were noted in 107 (72 %) patients. Potency  failure was observed in 98 % of cases. All patients received  conservative treatment and 8 (5 %) of these patients underwent  surgery after inefficient conservative treatment. Results. Favorable effect of conservative therapy of radiation-induced rectitis was obtained in 141 (95 %) patients. Eight (5 %)  patients underwent colostomy due to the formation of vesicle-rectal  fistula. Chemical cauterization of the mucosa of the bladder and  rectum in patients with erosive hemorrhagic and hemorrhagic rectitis and cystitis was effective and safe. The frequency of post-radiation  complications was found to be less after brachitherapy than after  combination treatment using brachitherapy and external beam  radiation.

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