scholarly journals Radiation heart disease in a patient post treatment of Нodgkin’s lymphoma

2018 ◽  
pp. 45-47
Author(s):  
Е. S. Eniseeva ◽  
К. V. Protasov ◽  
N. L. Chernysheva ◽  
E. Yu. Bagadaeva ◽  
A. A. Stefanenkova
Keyword(s):  
Radiation Therapy ◽  
Heart Disease ◽  
Surgical Treatment ◽  
Female Patient ◽  
Constrictive Pericarditis ◽  
Clinical Case ◽  
Post Treatment ◽  
Hodgkin's Lymphoma ◽  
Radiation Induced ◽  
Post Radiation

A clinical case of radiation induced heart disease in 43 year old female patient after 15 years since radiation therapy of Hodgkin’s lymphoma. During clinical and instrumental investigation, a post-radiation constrictive pericarditis was found, comorbid with lesion of aortic, mitral and tricuspid valves. Surgical treatment of pericarditis was applied. Morphology confirmed the diagnosis.

scholarly journals Surgery for Patients with Radiation-Induced Constrictive Pericarditis

2019 ◽  
Vol 22 (6) ◽  
pp. E466-E469
Author(s):  
Shixiong Wei ◽  
Lin Zhang ◽  
Huimin Cui ◽  
Lianggang Li ◽  
Tong Ren ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Heart Disease ◽  
Effective Treatment ◽  
Constrictive Pericarditis ◽  
Side Effect ◽  
Treatment Method ◽  
Major Side Effect ◽  
Radiation Induced

Radiation-induced heart disease (RIHD) is a major side effect of chest radiation therapy (RT). Most changes of pericardium will occur within a few weeks after receiving chest RT, while most of them will take decades or more to become constrictive pericarditis. Pericardiectomy is an effective treatment method. Here, we report 2 cases of radiation pericarditis after chest RT at our center.

SURGICAL TREATMENT OF PSEUDOANEURYSM OF THE FREE LEFT VENTRICLE WALL: A CLINICAL CASE

2021 ◽  
Vol 5 (1) ◽  
pp. 1195-1201
Author(s):  
O. Kiziukevich ◽  
◽  
S. Spiridonov ◽  
A. Zhyhalkovich ◽  
D. Isachkin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Surgical Treatment ◽  
Left Ventricle ◽  
Ischemic Heart Disease ◽  
Clinical Case ◽  
Ischemic Heart ◽  
Free Wall ◽  
Heart Rupture ◽  
Myocardial Rupture

Today diseases of the cardiovascular system are the leading cause of death in many countries. The key role in this pathology is played by ischemic heart disease. An extreme manifestation of ischemic heart disease - myocardial infarction is one of the main causes of complications and mortality in patients with ischemic heart disease. One of the most formidable complications of acute myocardial infarction is heart rupture, which most often leads to death, more than 60% of cases occurring in the prehospital stage. Many studies of similar groups of patients show a wide spread in assessing the incidence and mortality of this pathology. The development of myocardial ruptures has two frequency peaks: the first day and 5-7 days from the onset of AMI. The most common case is acute rupture of the free wall of the left ventricle with extensive hemorrhage in the pericardium leading to a fulminant death. The development of a pseudoaneurysm of the left ventricle is a very rare outcome of the myocardial rupture. There are no convincing data on the incidence of pseudoaneurysms as a result of myocardial infarction (according to many authors, it is less than 0.5% of all cases of myocardial infarction). This type of rupture is most favorable in terms of the possibility of providing assistance. The complexity of providing care to patients with pseudoaneurysms of the left ventricle lies in their low frequency of occurrence and often asymptomatic nature of the course, which complicates the diagnosis of this pathology. Timely diagnosis plays a key role in avoiding a fatal outcome, since the vast majority of pseudoaneurysms are extremely unstable and, except occasional cases, require urgent surgical intervention. This article describes a clinical case of a patient who underwent surgical treatment for pseudoaneurysm of the free wall of the left ventricle as a result of myocardial infarction. The article also presents a brief literature review of the available isolated data on risk factors for myocardial rupture, methods of diagnosis and treatment of this pathology.

scholarly journals Radiation-Induced Heart Disease: A Clinical Update

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Syed Wamique Yusuf ◽  
Shehzad Sami ◽  
Iyad N. Daher
Keyword(s):  
Radiation Therapy ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Cancer Therapy ◽  
Cancer Survivors ◽  
Cardiovascular Effects ◽  
Cardiac Complication ◽  
Morbidity And Mortality ◽  
Radiation Induced ◽  
Effects Of Radiation

Cardiovascular diseases and cancer are the two leading causes of morbidity and mortality worldwide. Improvement in cancer therapy has led to increasing number of cancer survivors, some of whom may suffer from adverse cardiovascular effects of radiation therapy. Longterm followup is essential, as the cardiac complication may manifest years after completion of radiation therapy. In this paper, we have discussed the cardiovascular effects of radiation therapy.

scholarly journals SOMATO-PSYCHIC DISORDER CLINICAL CASE IN A FEMALE PATIENT WITH MULTINODULAR EUTHYROID GOITER

2016 ◽  
Vol 1 ◽  
pp. 3-8
Author(s):  
Oksana Tsyganenko
Keyword(s):  
Thyroid Cancer ◽  
Surgical Treatment ◽  
Female Patient ◽  
Multidisciplinary Team ◽  
Clinical Case ◽  
Outpatient Basis ◽  
Emotional Tension ◽  
Somatic Condition ◽  
Cancer Pathology ◽  
Combined Impact

The article presents a clinical case of somato-psychic disorder in a patient with multinodular euthyroid goiter. The patient was diagnosed with thyroid cancer on outpatient basis and was suggested urgent surgical treatment. After receiving information about cancer pathology the patient developed symptoms of hypernosognostic neurotic syndrome with manifestations of obsessions and hystero-hypohondriasis. The patient was focused on the rigid hypochondria with detailed statement of the slightest signs of bodily distress. Therefore, the above example demonstrates difficulty in selecting the tactics of management for such patients due to development of symptoms primarily determined by psycho-emotional tension. This category of patients should be followed not only by endocrinologists, surgeons, but the multidisciplinary team, including psychiatrists, and psychotherapists, since in case of combined impact of a number of adverse factors, the reaction to the disease can become so extreme that its management in the early stages of therapy seems no less important than the direct treatment of somatic condition.

scholarly journals Gender Disparity in Cardiovascular Mortality following Radiation Therapy for Hodgkin's Lymphoma: A Systematic Review

2020 ◽  
Author(s):  
Yaser Khalid ◽  
Michael Fradley ◽  
Neethi Dasu ◽  
Kirti Dasu ◽  
Ankit Shah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Radiation Therapy ◽  
Hodgkin’S Lymphoma ◽  
Background Radiation ◽  
Radiation Treatment ◽  
Hodgkin's Lymphoma ◽  
Secondary Outcome ◽  
All Cause Mortality ◽  
Radiation Induced ◽  
Meta Regression

Abstract Background Radiation-induced coronary artery disease (R-CAD) has become an increasingly recognized phenomenon. Although the clinical relationship between radiation therapy and CAD risk is well known, there has been very little investigation of the gender relationship to radiation-induced CAD events and resulting cardiovascular (CV) mortality. We study the gender variation in the incidence of CV events/mortality related to R-CAD in Hodgkin’s Lymphoma (HL) patients. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in this systematic review and network meta-analysis. PubMed, google scholar, and Cochrane databases were searched to identify prospective and retrospective observational studies comparing women and men following radiation treatment for Hodgkin's lymphoma. 10 studies were included (4 prospective, 6 retrospective). The primary outcome was incidence of cardiovascular events and mortality. The secondary outcome was all-cause mortality. Meta-regression for age was also performed. Results Of 13,975 patients including 41% females and 59% males, CV events/mortality was noted to be significantly higher in women compared to men (OR 3.74, 95% CI 2.44-5.72, p <0.001). All-cause mortality was also higher in women compared to men (OR 1.94, 95% CI 1.10-3.44, p <0.023). On meta-regression analysis, elderly populations have a higher rate of mortality which was even higher for women than men (coefficient = 0.0458, p=0.0374). Conclusions Women have a higher rate of CAD related CV events/mortality and all-cause mortality compared to men in radiation treated patients. These data highlight the need for increased surveillance to better monitor for CAD in female patients treated with mantle or mediastinal radiation.

Taste Loss and Recovery Following Radiation Therapy

2006 ◽  
Vol 85 (7) ◽  
pp. 608-611 ◽  
Author(s):  
P.L. Sandow ◽  
M. Hejrat-Yazdi ◽  
M.W. Heft
Keyword(s):  
Radiation Therapy ◽  
Parotid Glands ◽  
Time Intervals ◽  
Detection Thresholds ◽  
Primary Tumors ◽  
Hyperfractionated Radiotherapy ◽  
Radiation Induced ◽  
Post Radiation ◽  
Taste Detection ◽  
One Way Anova

Previous investigators have reported deficits in taste acuity in patients following radiation therapy for oropharyngeal cancer. In the present longitudinal study, 13 patients (mean age = 51.6 yrs) received conventional or hyperfractionated radiotherapy (63–76.8 Gy) for primary tumors of the oropharynx. One or both parotid glands and at least two-thirds of the tongue were included in the radiation field. Smell recognition and taste detection thresholds were determined at baseline, 1 month, 6 months, and 1 year post-radiation. Differences for smell recognition and the 4 taste qualities were assessed (independently) at the 4 time intervals, with a one-way ANOVA. Smell recognition was unaffected by radiation. There were significant elevations in thresholds for sweet (p < 0.005), salty (p < 0.005), bitter (p < 0.005), and sour (p< 0.001) during radiation therapy that were restored to baseline levels at 6 months and 1 year after radiation. This study demonstrated that radiation-induced taste deficits can be recovered by 6 months.

scholarly journals Gender Disparity in Cardiovascular Mortality following Radiation Therapy for Hodgkin's Lymphoma: A Systematic Review

2020 ◽  
Author(s):  
Yaser Khalid ◽  
Michael Fradley ◽  
Neethi Dasu ◽  
Kirti Dasu ◽  
Ankit Shah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Radiation Therapy ◽  
Hodgkin’S Lymphoma ◽  
Background Radiation ◽  
Hodgkin's Lymphoma ◽  
Secondary Outcome ◽  
Cochrane Central Register ◽  
All Cause Mortality ◽  
Radiation Induced ◽  
Meta Regression

Abstract Background Radiation-induced coronary artery disease (R-CAD) has become an increasingly recognized phenomenon. Although the clinical relationship between radiation therapy and CAD risk is well known, there is minimal investigation of the gender relationship to radiation-induced CAD events and resulting cardiovascular (CV) mortality. We study the gender variation in the incidence of CV events/mortality related to R-CAD in Hodgkin’s Lymphoma (HL) patients. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in this systematic review and network meta-analysis. OVID, Cochrane Central Register of Controlled Trials via the Wiley Interface, Web of Science Core Collection, MEDLINE, EMBASE, and Google Scholar were investigated to identify prospective and retrospective observational studies comparing women and men following radiation treatment for Hodgkin's lymphoma. 10 studies were included (4 prospective, 6 retrospective). The primary outcome was incidence of cardiovascular events and mortality. The secondary outcome was all-cause mortality. Meta-regression for age was also performed. Results Of 13,975 patients including 41% females and 59% males, CV events/mortality was noted to be significantly higher in women compared to men (OR 3.74, 95% CI 2.44-5.72, p <0.001). All-cause mortality was also higher in women compared to men (OR 1.94, 95% CI 1.10-3.44, p <0.023). On meta-regression analysis, elderly populations have a higher rate of mortality which was even higher for women than men (coefficient = 0.0458, p=0.0374). Conclusions Women have a higher rate of CAD related CV events/mortality and all-cause mortality compared to men in radiation treated patients. These data highlight the need for increased surveillance to better monitor for CAD in female patients treated with mantle or mediastinal radiation.

Laryngeal necrosis after combined chemotherapy and radiation therapy

1997 ◽  
Vol 111 (8) ◽  
pp. 763-765 ◽  
Author(s):  
Mamoru Miyaguchi ◽  
Hitoshi Takashima ◽  
Takeshi Kubo
Keyword(s):  
Radiation Therapy ◽  
Radiation Necrosis ◽  
Rare Complication ◽  
Late Complication ◽  
Major Complication ◽  
Combined Chemotherapy ◽  
Head And Neck Tumours ◽  
Radiation Induced ◽  
Node Metastases ◽  
Post Radiation

AbstractPost-radiation necrosis of the larynx is a major complication after irradiation and has become rare. Recently, combined chemotherapy and radiation therapy has been introduced for head and neck tumours. The authors report a case of laryngeal necrosis after combination therapy for a patient with cervical lymph node metastases of nasopharyngeal carcinoma and review the literature on late laryngeal necrosis. Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence. We should always consider it as a possible late complication and treat it appropriately.

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