Investigation of relation between visceral and subcutaneous abdominal fat volumes and calcified aortic plaques via multislice computed tomography

Vascular ◽  
2014 ◽  
Vol 23 (4) ◽  
pp. 396-402 ◽  
Author(s):  
Duran Efe ◽  
Fatih Aygün ◽  
Türker Acar ◽  
Melda Yildiz ◽  
Kazım Gemici
Keyword(s):  
Computed Tomography ◽  
Visceral Fat ◽  
Multislice Computed Tomography ◽  
Subcutaneous Fat ◽  
Volume Group ◽  
Group 3 ◽  
Group 2 ◽  
Aortic Plaques ◽  
Fat Volume ◽  
Group 1

Objective The present study investigated effect of subcutaneous fat volume and abdominal visceral fat volume on aortic atherosclerosis via multislice computed tomography. Materials and methods The present study comprised 424 subjects who underwent non-contrast-enhanced abdominal CT in our clinic between June 2012 and June 2013. Using dedicated software visceral fat volume was calculated for each individual and then subcutaneous fat volume was calculated by subtracting visceral fat volume from total fat volume. By dividing visceral fat volume/subcutaneous fat volume participants were assigned to three groups according to their mean visceral fat volume/subcutaneous fat volume: Group 1 consisted of subjects with visceral fat volume/subcutaneous fat volume lower than 0.48 (Group 1 < 0.48); Group 2 consisted of subjects with visceral fat volume/subcutaneous fat volume equal to or higher than 0.48 and lower than 0.69 (0.48 ≤ Group 2 < 0.69); and Group 3 consisted of subjects with visceral fat volume/subcutaneous fat volume equal to or higher than 0.69 (Group 3 ≥ 0.69). Results The mean abdominal aortic calcium scores according to Agatston scoring (au) were 136.8 ± 418.7 au in Group 1, 179.9 ± 463 au in Group 2 and 212.2 ± 486.9 in Group 3, respectively. Conclusions We have demonstrated a significant correlation between visceral fat volume and abdominal aorta atherosclerosis, while there was absence of significant correlation between subcutaneous fat volume and abdominal atherosclerosis.

scholarly journals A tissue-engineered urinary conduit in a porcine urinary diversion model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Arkadiusz Jundziłł ◽  
Piotr Kwieciński ◽  
Daria Balcerczyk ◽  
Tomasz Kloskowski ◽  
Dariusz Grzanka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Urinary Diversion ◽  
Porcine Model ◽  
Histological Evaluation ◽  
Metabolic Complications ◽  
Group 3 ◽  
Group 2 ◽  
The Right ◽  
Group 1

AbstractThe use of an ileal segment is a standard method for urinary diversion after radical cystectomy. Unfortunately, utilization of this method can lead to numerous surgical and metabolic complications. This study aimed to assess the tissue-engineered artificial conduit for urinary diversion in a porcine model. Tissue-engineered tubular polypropylene mesh scaffolds were used for the right ureter incontinent urostomy model. Eighteen male pigs were divided into three equal groups: Group 1 (control ureterocutaneostomy), Group 2 (the right ureter-artificial conduit-skin anastomoses), and Group 3 (4 weeks before urostomy reconstruction, the artificial conduit was implanted between abdomen muscles). Follow-up was 6 months. Computed tomography, ultrasound examination, and pyelogram were used to confirm the patency of created diversions. Morphological and histological analyses were used to evaluate the tissue-engineered urinary diversion. All animals survived the experimental procedures and follow-up. The longest average patency was observed in the 3rd Group (15.8 weeks) compared to the 2nd Group (10 weeks) and the 1st Group (5.8 weeks). The implant’s remnants created a retroperitoneal post-inflammation tunnel confirmed by computed tomography and histological evaluation, which constitutes urostomy. The simultaneous urinary diversion using a tissue-engineered scaffold connected directly with the skin is inappropriate for clinical application.

scholarly journals The Important Role of Tumor Volume In Surgical Approach Choice, Surgical Complexity, and Post-Operative Complications In Renal Cell Carcinoma With Venous Tumor Thrombus From A Large Chinese Center Experience

2021 ◽  
Author(s):  
Qais A. Baheen ◽  
Zhuo Liu ◽  
Yichang Hao ◽  
Rejean R.R. Sawh ◽  
Yuxuan Li ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tumor Volume ◽  
Operative Blood Loss ◽  
Operative Complications ◽  
Surgical Complexity ◽  
Volume Group ◽  
Group 3 ◽  
Group 2 ◽  
Group 1 ◽  
Post Operative Complications

Abstract Background: To evaluate the significance of interactions between tumor volume (TV) and surgical approach choice, surgical complexity, intra-operative blood loss, post-operative complications, as well as overall survival (OS) for patients with inferior vena cava tumor thrombus (IVCT-T) in locally advanced renal cell carcinoma (RCC). Method: From Jan 2014 to Jan 2020, we identified 132 patients who underwent radical nephrectomy with inferior vena cava thrombectomy (RN-IVCT) in Peking University Third Hospital (PKUTH) and had available imaging for review. TV for RCC, renal vein (RV) and IVCT were separately measured through the well-known and commonly used application by medical professions，3D slicer. The significance of differences between groups was evaluated using linear regression. Prognostic factors were identified by univariate and multivariate analyses using the Cox proportional hazards model, and hazard ratios (HRs) with 95% confidence intervals were calculated. Results: Patients were divided into three groups based on the inferior vena caval tumor thrombus volume (IVCT-TV); group 1 comprised of all patients with IVCT-TV between 0-15 cubic centimeter (cm3), group 2 comprised of all patients with IVCT-TV between 15-30 cm3, and group 3 comprised of all patients with IVCT-TV greater than 30 cm3. Using these criteria, there were 48 patients in group 1, 38 in group 2, and 46 in group 3, representing 36.6%, 28%, and 35% of the total number of patients, respectively. There were 24 patients with Mayo grade I, 74 patients with Mayo grade II, 19 patients with Mayo grade III, and 18 patients with Mayo grade IV. Fifty-nine patients (44.7%) underwent complete laparoscopic surgery, and 73 patients (55%) underwent open surgery. The median surgery time was 334 minutes for group 1, 341 minutes for group 2, and 374 minutes for group 3 (p <0.044). The median intra-operative blood loss was 650 ml for group 1, 600 ml for group 2, and 2350 ml for Group 3 (p <0.001). Post-operative complications occurred in 13 (27.1%) patients from group 1, 15 (39.5%) patients from group 2, and 35 (76.1%) patients from group 3 (p < 0.001). Open approach surgery was the more desirable choice for caval tumor group (p< 0.001) and total thrombi volume group (P<0.001). Overall surgery time was significantly longer, and operation was more difficult for renal venous thrombus volume group (P < 0.014), caval tumor volume group (P <0.033), and total thrombi volume group (P <0.005). Intra-operative blood loss was more and statistical difference was seen for caval tumor volume (p<0.001) and total tumor volume (p<0.001). No significant difference was noted for a demographic characteristic such as age, gender, side, size, BMI index, tumor type. Operative time, intra-operative blood loss, depth of IVC vascular wall invasion, surgical approach, and Mayo level were identified as the independent factors in this study. Conclusion: Results of this present study indicate that a larger TV necessitates open surgery approach, and is associated with a prolonged operative time, increased intra-operative blood loss, increased surgical complexity, and a higher incidence of post-operative complications. However, TV does not affect the overall patient survival and hospitalization time.

scholarly journals Visceral Fat Area Evaluation by Computed Tomography Correlates with Visceral Fat Volume

2017 ◽  
Vol 9 (10) ◽  
pp. 78
Author(s):  
Masato Mizui ◽  
Yuji Mizoguchi ◽  
Yutaka Senda ◽  
Masayuki Yokoi ◽  
Takao Tashiro
Keyword(s):  
Computed Tomography ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Area Measurement ◽  
Abdominal Circumference ◽  
Ct Scans ◽  
Visceral Fat Area ◽  
Visceral Fat Accumulation ◽  
Fat Volume ◽  
Very High

In Japan, the measurement of abdominal circumference is commonly used in diagnosis of visceral fat accumulation. It is also recommended that visceral fat at the umbilical level be measured using CT scans. If CT is used to measure the visceral fat area, we do not have to consider the possibility of measurement error due to subcutaneous fat. However, it is unknown whether the visceral fat area measurement by CT reflects the visceral fat volume of the entire abdomen.We examined the correlation between the visceral fat area at the umbilical level and the visceral fat volume of the entire abdomen using CT images taken from the diaphragm to the pubic bone.The results showed that there was a very high correlation between the visceral fat area and the visceral fat volume. The correlation was not affected by gender differences, old age or whether visceral fat was accumulated or not.Therefore, we concluded that it is possible to estimate the visceral fat volume of the entire abdomen by measuring the visceral fat area at the umbilical level.

scholarly journals The clinical implications of incidental coronary artery calcification in routine, non-triggered high-resolution thoracic computed tomography: a retrospective study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Saluja ◽  
J Sobolewska ◽  
K Khan ◽  
H Contractor ◽  
L.J Mitchell ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Risk Factor ◽  
Coronary Artery ◽  
High Resolution ◽  
Independent Risk Factor ◽  
Incidental Finding ◽  
Agatston Score ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Background Coronary artery calcium (CAC) is a marker of atherosclerosis and an independent risk factor for cardiac-related mortality. The measurement of this score has traditionally been based on using ECG triggered computed tomography (CT). However, CAC, identified on non-contrast high resolution chest computed tomography (HRCT), should be considered diagnostic for coronary artery disease (CAD). We aimed to evaluate the incidental prevalence and burden of CAC on non-gated HRCT thorax used for patients undergoing lung cancer screening or follow-up for interstitial lung disease. We also assessed how often Radiologists reported CAC as an incidental finding on these scans. Methods Computerised Radiology Information Service (CRIS) was manually searched to determine all HRCT scans performed in our Trust from 01/05/2018 to 01/05/2019. The reports issued by Radiologists and images of selected studies were reviewed. Results 2185 HRCT scans were performed over this period. Patients were divided into three groups of age &lt;50 (Group 1); 50-&lt;60 (Group 2) and 60 (Group 3). 100 scans were randomly selected from each group using a random number generator to give a total of 300 patients. The mean ages of patients in Group 1, 2 and 3 were 48.3±2.3, 54.8±2.4 and 65±3.2 respectively. There was, approximately, the same number of males as females in each group. CAC was noted in 15% of scans in Group 1, 82% of scans in Group 2 and 94% scans in Group 3. CAC was only noted in 1/15 (6.7%) of scan reports in Group 1, 41/82 (50%) in Group 2 and 37/94 (39.4%) in Group 3. Among the 79 patients with radiologist-reported incidental CAC, statin and aspirin prescriptions increased by approximately 7 percentage points each. A diagnosis of CAD was eventually made in 9 (11.4%) patients through functional imaging or coronary angiogram. Two authors independently calculated the Agatston scores of HRCT scans whose reports did not comment on the degree of calcification. We excluded 15/112 (13.4%) scans as they were uninterpretable due to motion artefacts. Of the remaining 97 scans analysed 58/97 (59.8%) had severe CAC with an Agatston score of &gt;400 with the remaining showing moderate calcification (101–400). Cohen κ agreement between the two authors rating was 0.90 (95% confidence interval [CI] 0.87–0.96). Group 2 and 3 had significantly more patients with severe CAC then group 1 (p&lt;0.001). Left anterior descending artery was most commonly affected. Conclusion This study shows that CAC is under reported on non-gated HRCT scans which represents a missed opportunity to implement strategies for primary and secondary prevention. Given that respiratory disease is an independent risk factor for developing cardiac disease, it is incumbent upon the interpreting clinician to report all findings and ensure that critical findings are highlighted. The images of calcified coronary arteries may also potentially have a role in convincing people to make correct lifestyle choices. Funding Acknowledgement Type of funding source: None

scholarly journals AB1022 PANNICULITIS IN RHEUMATOLOGICAL PRACTICE: THE RESULTS OF LONG-TERM FOLLOW-UP

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1803.1-1804
Author(s):  
O. Egorova ◽  
B. Belov
Keyword(s):  
Bacterial Infections ◽  
Inflammatory Diseases ◽  
Subcutaneous Fat ◽  
Weight Lifting ◽  
Group 4 ◽  
Group 3 ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Group 1

Background:Panniculitis is a group of heterogeneous inflammatory diseases that occur with damage to the subcutaneous fat (SCF), musculoskeletal system, and often internal organsObjectives:to evaluate the course and outcome in patients with panniculitisMethods:the course of the disease was monitored in 193 patients treated at the V.A. Nasonova Research Institute of Rheumatology for 3-5 years (142 women, 51 men) aged 19 to 77 with the referral diagnosis of erythema nodosum (EN) and undifferentiated panniculitis and with the disease duration of 1 week to 13 years. In addition to general clinical study, serum concentrations of α-1 antitrypsin, amylase, lipase, ferritin, creatinephosphokinase were determined, computed tomography of the chest organs, immunological, ultrasound scanning of the skin and SCF of the node area, tuberculosis tests and pathomorphological study of skin biopsy from the node area were performed.Results:: as a result of laboratory and instrumental examination, the following diagnoses were made: EN associated with infection (72 people – group 1), lipodermatosclerosis (LDS) (40 –group 2), idiopathic lobular panniculitis (ILP) (32 – group 3), Löfgren’s syndrome (SL) (49 –group 4). During the follow-up period, 6 deaths occurred (3.1%): in a patient with LDS due to acute heart failure and in 5 patients with ILP due to the activity of the disease which led to the development of cardiopulmonary pathology and disseminated intravascular coagulation (DIC) syndrome. In group 1, during the observation period, UE recurred in 18 people (25%), the probable causes were: hypothermia (6), exacerbation of chronic tonsillitis (6), acute respiratory viral infections (ARVI) (4), stress (1), a rapid decrease in the dose of glucocorticoids (GC) (1), the cause is unknown (2). In group 2, recurrence occurred in 19 patients (47.5%) due to the lack of anti-inflammatory therapy (plaquenil) (10), trauma (4), stress (3), and weight lifting (2). There was no recurrence in 7 patients in this group, however, nodes would not disappear completely, which is obviously due to the absence of plaquenil. In group 3, recurrence was registered in 24 cases (75%) and it was associated with insufficient effect of the ongoing anti-inflammatory therapy (9), a decrease in blood glucose to minimal doses (6), hypothermia (6) and the absence/cancellation of anti-inflammatory therapy (3). In group 4, recurrence of nodes was registered in 14 cases (28.5%), possible causes: cancellation of GC (9) and cooling/ARVI(5).Conclusion:in the observed group of patients with panniculitis mortality was 3.1%. The main causes of recurrence in EN were viral-bacterial infections, and in case of ILP, LDS and SL it was insufficient effect/absence of anti-inflammatory therapy.Disclosure of Interests:None declared

scholarly journals Quantification of Epicardial Fat Volume as a Novel Cardiovascular Risk Marker in Asymptomatic Subjects for Early Detection of Cardiovascular Disease

2020 ◽  
Author(s):  
Mahfouz El Shahawy ◽  
Lillee Izadi ◽  
Antonella Sabatini ◽  
Susan Tucker ◽  
Jessica Patella ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Visceral Obesity ◽  
Asymptomatic Patients ◽  
Epicardial Fat Volume ◽  
Group 3 ◽  
Group 2 ◽  
Asymptomatic Subjects ◽  
Fat Volume ◽  
Cardiovascular Risk Marker ◽  
Group 1

AbstractEpicardial fat volume (EFV), also known as epicardial adipose tissue (EAT), sometimes acts as a protector against heart problems; however, in excess volume was found to be associated with cardiovascular structural and functional abnormalities. This study aims to establish a threshold between normal and abnormal values for EFV/EAT in asymptomatic subjects, as well as to assess whether excess EFV/EAT is associated with significant structural and functional abnormalities, including coronary artery calcium score (CACS). A total of 220 asymptomatic patients, were screened utilizing Early Cardiovascular Disease Risk Score (ECVDRS), and CT for CACS and EFV/EAT quantification. Out of the 220 subjects, 69 had a 0 CACS and were included in this analysis. These 69 were then further categorized into 3 groups: Group 1 (Normal subjects; n=20) with ECVDRS < 3, and ACC/AHA risk score < 5%; Group 2 (n= 16) with elevated EFV/EAT and no abdominal visceral obesity; Group 3 (n=33) with elevated EFV/EAT and abdominal visceral obesity. The average EFV/EAT was identified to be 69 cm3 ± 20 in females and 68 cm3 ± 15 in males among Group 1, which indicate the normal values for EFV/EAT. It was also found that elevated EFV/EAT without (Group 2) or with (Group 3) abdominal visceral adiposity was associated with significant vascular abnormalities, as compared to the normal group among these populations of asymptomatic patients with 0 CACS. Elevated EFV/EAT is a novel cardiovascular risk marker regardless of gender, which might be the culprit for major cardiovascular risk factors.

Effect of age on the performance of single detector helical computed tomography in suspected pulmonary embolism

2004 ◽  
Vol 91 (02) ◽  
pp. 296-299 ◽  
Author(s):  
Henri Bounameaux ◽  
Arnaud Perrier ◽  
Marc Righini
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Diagnostic Yield ◽  
Helical Ct ◽  
Helical Computed Tomography ◽  
Suspected Pulmonary Embolism ◽  
Predictive Values ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

SummaryThe prevalence of pulmonary embolism increases with age, but reduces the diagnostic yield of ventilation-perfusion lung scan age. Helical computed tomography (hCT) is widely used to diagnose pulmonary embolism, and should be less susceptible to the influence of age. We studied the influence of age on the performance of hCT to verify that hypothesis. We analyzed a database of 299 consecutive outpatients suspected of pulmonary embolism, in whom pulmonary embolism was diagnosed according to accepted criteria, and who were all submitted to a helical CT. We divided the patient population into tertiles, corresponding to the following age categories: less than 59 years (group 1), 60 to 75 years (group 2), and over 75 years (group 3). Sensitivity and specificity of hCT were calculated in each age category. Overall sensitivity was 70% (95% CI: 62 to 78) and specificity was 91% (95% CI: 86 to 95). Sensitivity was 81% (95% CI: 64 to 93) in group 1, 63% (95% CI: 46 to 78) in group 2, and 67 % (95% CI: 52 to 80) in group 3.The corresponding values for specificity were 92% (95% CI: 82 to 97) in group 1, 86% (95% CI: 75 to 94) in group 2 and 96% (95% CI: 87 to 100) in group 3. Positive predictive values ranged from 75% to 94% and negative predictive values from 77% to 94%. Our data suggest that age does not have a marked influence on the diagnostic performances of hCT in clinically suspected pulmonary embolism.

scholarly journals Buccolingual inclination of molars in untreated children and adults: A cone beam computed tomography study

2018 ◽  
Vol 89 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Brianna Yang ◽  
Chun-Hsi Chung
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Maxillary Molars ◽  
Computed Tomography Images ◽  
Group 3 ◽  
Left And Right ◽  
Group 2 ◽  
Mandibular First Molar ◽  
Group 1

ABSTRACT Objectives: To evaluate and compare the buccolingual inclinations of maxillary and mandibular first molars in untreated children and adults. Materials and Methods: One hundred and thirty-eight subjects were selected and divided into three groups, as follows: (1) age 6–9 years, N = 46; (2) age 10–19 years, N = 56; and (3) age 25–35 years, N = 36. For each subject, existing cone beam computed tomography images were used, and the long axis for each maxillary and mandibular first molar was determined. The converge angles formed by the long axis of left and right maxillary first molars and by the long axis of left and right mandibular first molars were measured. Results: The maxillary molars exhibited buccal inclination, with the converge angle of 21.1° ± 9.5° in group 1, 17.3° ± 8.6° in group 2, and 9.3° ± 7.3° in group 3. Statistically significant differences were found between groups 1 and 3 and groups 2 and 3, but not between groups 1 and 2. The mandibular molars exhibited lingual inclination, with the converge angle of 34.9° ± 11° for group 1, 26.6° ± 9.2° for group 2, and 26.1° ± 7.7° for group 3. Statistically significant differences were found between groups 1 and 2 and groups 1 and 3, but not between groups 2 and 3. Conclusions: Maxillary first molars exhibited buccal inclination. Adults displayed less inclination than did children. Mandibular first molars exhibited lingual inclination. Adults displayed less inclination than did children. Some degree of curve of Wilson should be maintained at the end of orthodontic treatment to fulfill physiologic needs and stability.

scholarly journals The Effect of Periplaque Fat on Coronary Plaque Vulnerability in Patients with Stable Coronary Artery Disease – a 128-multislice CT-based Study

2018 ◽  
Vol 3 (2) ◽  
pp. 69-76
Author(s):  
Nóra Raț ◽  
Diana Opincariu ◽  
Emese Márton ◽  
Ramona Zavate ◽  
Mirela Pintican ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Stable Coronary Artery Disease ◽  
Coronary Plaque ◽  
Plaque Vulnerability ◽  
Pericardial Fat ◽  
Group 2 ◽  
Artery Disease ◽  
Fat Volume ◽  
Group 1

Abstract Background: The role of periplaque fat (PPF), as a fragment of the total epicardial adipose tissue, measured in the vicinity of a target coronary lesion, more specifically within the close proximity of a vulnerable plaque, has yet to be evaluated. The study aimed to evaluate the interrelation between PPF and coronary plaque vulnerability in patients with stable coronary artery disease (CAD). Secondary objective: evaluation of the relationship between the total pericardial fat and markers for plaque vulnerability. Materials and methods: We prospectively enrolled 77 patients with stable CAD, who underwent 128-multislice computed tomography coronary angiography (CTCA), and who presented minimum one lesion with >50% stenosis. CTCA analysis included measurements of: total pericardial fat and PPF volumes, coronary plaque characteristics, markers for plaque vulnerability – positive remodeling (PR), low attenuation plaque (LAP), spotty calcifications (SC,) napkin ring sign (NRS). Study subjects were divided into two categories: Group 1 – 1 marker of plaque vulnerability (n = 36, 46.75%) and Group 2 – ≥1 marker of vulnerability (n = 41, 53.25%). Results: The mean age of the population was 61.77 ± 11.28 years, and 41 (53.24%) were males. The analysis of plaque characteristics showed that Group 2 presented significantly longer plaques (16.26 ± 4.605 mm vs. 19.09 ± 5.227 mm, p = 0.02), remodeling index (0.96 ± 0.20 vs. 1.18 ± 0.33, p = 0.0009), and vessel volume (p = 0.027), and more voluminous plaques (147.5 ± 71.74 mm3 vs. 207.7 ± 108.9 mm3, p = 0.006) compared to Group 1. Group 2 presented larger volumes of PPF (512.2 ± 289.9 mm3 vs. 710.9 ± 361.9 mm3, p = 0.01) and of thoracic fat volume (1,616 ± 614.8 mm3 vs. 2,000 ± 850.9 mm3, p = 0.02), compared to Group 1, but no differences were found regarding the total pericardial fat (p = 0.49). Patients with 3 or 4 vulnerability markers (VM) presented significantly larges PPF volumes compared to those with 1 or 2 VM, respectively (p = 0.008). There was a significant positive correlation between PPF volume and the non-calcified (r = 0.474, 95% CI 0.2797–0.6311, p <0.0001), lipid-rich (r = 0.316, 95% CI 0.099–0.504, p = 0.005), and fibro-fatty (r = 0.452, 95% CI 0.2541–0.6142, p <0.0001) volumes. The total pericardial fat was significantly correlated only with the volume of lipid-rich plaques (p = 0.02). Conclusions: Periplaque fat volume was associated with a higher degree of coronary plaque vulnerability. PPF was correlated with lipid-rich, fibro-fatty, and non-calcified plaque-related volumes, as markers for enhanced plaque vulnerability. PPF volume, assessed with native cardiac computed tomography, could become a novel marker for coronary plaque vulnerability.

Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease.

1986 ◽  
Vol 4 (4) ◽  
pp. 576-583 ◽  
Author(s):  
T O'Rourke ◽  
C B George ◽  
J Redmond ◽  
H Davidson ◽  
P Cornett ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Metastatic Disease ◽  
Compression Fracture ◽  
Benign Disease ◽  
Plain Radiographs ◽  
Spinal Ct ◽  
Epidural Compression ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

New lesions were shown by Tc99m bone scans to have developed in sixty patients with known metastatic cancer or high-risk primary cancer and normal neurologic examinations; they were further evaluated with plain radiographs, spinal computed tomography (CT), and CT myelography (CT-M) according to an algorithm. Three groups were identified based on plain radiographs: group 1 (normal radiograph), group 2 (compression fracture as indicated by radiograph), group 3 (evidence of metastasis as indicated by radiograph). In group 1 (n = 18), spinal CT revealed that 33% of the patients had benign disease and 67%, metastases; epidural compression was seen in 25% of the patients with metastasis as indicated by CT-M. In group 2 (n = 26), CT-M disclosed that 38% had a benign compression fracture and 62% had metastases and that 63% of the patients with metastases had an epidural compression. In group 3 (n = 16), spinal CT revealed that 15 patients had metastases (one patient had benign disease). Epidural cord compression was seen in 47% of the patients with metastatic disease. In all groups, the presence of cortical bone discontinuity around the neural canal (seen in 31 patients) was highly associated with epidural compression (seen in 20 patients). Our approach allowed the early and accurate diagnosis of spinal metastasis and epidural tumor as well as the diagnosis of benign disease and was useful in planning optimal local therapy.

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