scholarly journals Disappearance Curves for Tumor Markers after Resection of Intrathoracic Malignancies

1999 ◽  
Vol 14 (2) ◽  
pp. 99-105 ◽  
Author(s):  
T. Yoshimasu ◽  
S. Maebeya ◽  
T. Suzuma ◽  
T. Bessho ◽  
H. Tanino ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Tumor Markers ◽  
Residual Tumor ◽  
Serum Levels ◽  
Least Square ◽  
Serum Tumor Marker ◽  
Elimination Kinetics ◽  
Linear Least Square ◽  
Kinetics Of

Determination of the standard elimination kinetics of tumor markers will be helpful in the diagnosis of malignancies. We analyzed the disappearance curves for serum tumor marker levels after resection of intrathoracic malignancies. Serum levels of CEA, SLX, AFP, CA 19-9, SCC, TPA and CYFRA were measured several times after surgery in a total of 40 patients. To obtain precise biological half-lives, we applied non-linear least square analysis, taking into consideration the possibility of residual tumor cells. Disappearance curves were monophasic for CEA, SCC, TPA, CYFRA and SLX and biphasic for CA 19-9 and AFP. Temporary elevation of serum levels after surgery was observed for SCC, TPA and CYFRA. The average half-lives of CEA, SLX, SCC, TPA and CYFRA were 1.5 days, 2.7 days, 2.2 hours, 2.5 hours and 1.5 hours, respectively. The average half-life of CA 19-9 was 0.5 days in the first compartment and 4.3 days in the second compartment, while that of AFP was 1.0 days and 6.3 days, respectively. These values will be helpful in the interpretation of serum tumor marker levels after surgery.

scholarly journals Pre-Treatment Prediction of Chemoresistance in Second-Line Chemotherapy of Ovarian Carcinoma: Value of Serological Tumor Marker Determination (Tetranectin, YKL-40, CASA, CA 125)

2006 ◽  
Vol 21 (3) ◽  
pp. 141-148 ◽  
Author(s):  
B. Gronlund ◽  
E.V.S. Høgdall ◽  
I.J. Christensen ◽  
J.S. Johansen ◽  
B. Nørgaard-Pedersen ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Tumor Markers ◽  
Predictive Value ◽  
Serum Levels ◽  
Ca 125 ◽  
Second Line ◽  
Second Line Chemotherapy ◽  
Serological Tumor ◽  
Line Chemotherapy

Objective To examine if the determination of the levels of serological tumor markers at time of relapse had any predictive value for chemoresistance in the second-line treatment of ovarian cancer patients. Methods From a registry of consecutive single-institution patients with epithelial ovarian carcinoma pretreated with paclitaxel plus platinum, we selected 82 patients with (a) solid tumor recurrence, and (b) second-line chemotherapy consisting of topotecan (platinum-resistant disease) or paclitaxel plus carboplatin (platinum-sensitive disease). Stored serum samples were analyzed for the biochemical tumor markers tetranectin, YKL-40, CASA (cancer-associated serum antigen), and CA 125. The serum tumor marker levels at time of relapse were correlated with response status at landmark time after 4 cycles of second-line chemotherapy. Univariate and multivariate logistic regression analyses (chemoresistant vs non-chemoresistant disease) were performed. Results At landmark time, 26% of patients had progression according to the GCIG (Gynecologic Cancer Intergroup) progression criteria. In univariate logistic regression analysis, the tumor markers tetranectin (OR 0.4; 95% CI: 0.2–0.8; p=0.008), YKL-40 (OR 1.8; 95% CI: 1.0–3.3; p=0.045), and CASA (OR 1.8; 95% CI: 1.2–2.7; p=0.007) had predictive value for second-line chemoresistance, whereas serum CA 125 had no predictive value. In a multivariate logistic regression analysis, serum tetranectin and CASA both had independent predictive value for chemoresistance. The combined determination of tetranectin and CASA had a specificity of 90% with 33% sensitivity for the prediction of chemoresistance (area under the receiver operating characteristic curve = 0.78; 95% CI: 0.66–0.91; p=0.001). Conclusion Low serum levels of tetranectin, or high serum levels of CASA or YKL-40, are associated with increased risk of second-line chemoresistance in patients with ovarian cancer.

Experimental pancreatic adenocarcinoma: An immunohistochemical study for CA 19-9 and its correlation with serum levels

1989 ◽  
Vol 4 (4) ◽  
pp. 229-232
Author(s):  
M. Abad ◽  
J.I. Paz ◽  
M.J. Pedraz ◽  
E. Muñoz ◽  
A. Bullón
Keyword(s):  
Tumor Marker ◽  
Pancreatic Carcinoma ◽  
Pancreatic Adenocarcinoma ◽  
Immunohistochemical Study ◽  
Serum Levels ◽  
Subcutaneous Injections ◽  
Syrian Hamsters ◽  
Important Correlation ◽  
Papillary Lesions

Experimental pancreatic carcinoma induced in Golden Syrian Hamsters by subcutaneous injections of N-nitrosobis-(2-oxopropyl) amine (BOP) was studied during the different phases of its development by determination of serum CA 19-9 levels and tissue labeling with CA 19-9 TM. Significant differences were observed in the CA 19-9 values between the controls and animals with carcinoma (p < 0.01) and between the latter and animals with cystic or cystic papillary lesions (p < 0.01). Distribution of the deposits of CA 19-9 TM was different in the initial tumoral lesions and in the longer-developed tumors. An important correlation was observed between tissue deposits and serum levels of this tumor marker.

scholarly journals OVARIAN CANCER;

2013 ◽  
Vol 20 (06) ◽  
pp. 904-908
Author(s):  
NASEER AHMED SHAIKH ◽  
RUKHSANA PARVEEN SAMO ◽  
M. QASIM MEMON
Keyword(s):  
Tumor Marker ◽  
Malignant Tumors ◽  
Germ Cell Tumors ◽  
Specific Treatment ◽  
Serum Levels ◽  
Ca 125 ◽  
Serum Tumor Marker ◽  
Serous Cystadenocarcinoma ◽  
Appropriate Therapy ◽  
Sex Cord Stromal Tumors

Object: 1). To analyze of serum tumor marker CA-125 in patients with ovarian malignant tumors. 2). To correlate betweenthe serum levels of tumor marker with histological types of ovarian malignant tumors. Study Design: Institution based descriptive andprospective study. Place & Duration: Department of Pathology, Liaquat University of Medical & Health Sciences, Jamshoro from January2009 to June 2011. Material & Methods: One hundred cases, diagnosed as ovarian malignant tumor on H&E staining were selected forstudy & measure serum CA-125 preoperatively and postoperatively in each case. Results: Out of 100 cases diagnosed as on H&E stainwere 33 serous cystadenocarcinoma, 24 mucinous adenocarcinoma, 10 germ cell tumors and 08 sex-cord stromal tumors. On serumanalysis increased level of CA-125 was seen preoperatively in 33/33 cases of serous cystadenocarcinoma and 24/29 cases of mucinousadenocarcinoma. Serum tumor marker value was declined following appropriate therapy of the tumors. Conclusions: Serum tumormarkers CA-125 is useful and important for the detection of ovarian tumors. It is most significant for serous cystadenocarcinoma. It mayalso help in prognosis and specific treatment of ovarian malignancies relating to histological type.

scholarly journals Normalization of Elevated Tumor Marker CA27-29 After Bilateral Lung Transplantation in a Patient With Breast Cancer and Idiopathic Pulmonary Fibrosis

2018 ◽  
Vol 26 (3) ◽  
pp. 515-518
Author(s):  
Mehmet Sitki Copur ◽  
Julie Marie Wurdeman ◽  
Debra Nelson ◽  
Ryan Ramaekers ◽  
Dron Gauchan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Tumor Marker ◽  
Tumor Markers ◽  
Early Stage ◽  
Serum Tumor Marker ◽  
Normal Range ◽  
Bilateral Lung Transplantation ◽  
Bilateral Lung

Solid tumors involving glandular organs express mucin glycoprotein that is eventually shed into the circulation. As a result, these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA27-29 and CA15-3, which both measure the glycoprotein product of the mucin-1 (MUC1) gene. CA27-29 has been approved by the US Food and Drug Administration for monitoring disease activity in breast cancer patients. Most oncology clinical practice guidelines do not recommend the use of tumor markers for routine surveillance of early stage disease but recognize their utility in the metastatic setting. We present a patient with stage IIIA breast cancer and preexisting hypersensitivity pneumonitis who was found to have an elevated serum tumor marker CA27-29. After successful curative intent treatment of her early stage breast cancer, she developed gradual and progressive worsening of her lung disease with eventual development of severe pulmonary fibrosis requiring bilateral lung transplantation. As part of the pretransplant evaluation, she was found to have an elevation of serum tumor marker CA27-29. While the diagnostic evaluation, including imaging studies, was negative for the presence of recurrent disease, the serial serum tumor marker CA27-29 levels remained persistently elevated. The decision was made for her to undergo bilateral lung transplantation. Shortly after surgery, her CA27-29 tumor marker level returned to normal range, and it has continued to remain in the normal range with no evidence of breast cancer recurrence.

Comparison of CA 125 and Placental Alkaline Phosphatase as Ovarian Tumor Markers

1987 ◽  
Vol 73 (3) ◽  
pp. 301-302 ◽  
Author(s):  
Pentti K. Heinonen ◽  
Olli-Pekka Kallioniemi ◽  
Timo Koivula
Keyword(s):  
Ovarian Cancer ◽  
Alkaline Phosphatase ◽  
Tumor Marker ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Ovarian Tumor ◽  
Serum Levels ◽  
Ca 125 ◽  
Placental Alkaline Phosphatase ◽  
Serum Concentrations

The serum concentrations of CA 125 and placental alkaline phosphatase were analyzed in 16 patients with ovarian cancer. Increased serum levels of CA 125 and placental alkaline phosphatase were observed in 75% and 50% of the cancer patients, respectively. The serum levels of these tumor markers were not correlated, supporting their distinct antigenic nature. CA 125 seems to be a more promising tumor marker for ovarian cancer than placental alkaline phosphatase.

scholarly journals Uncertainty of nitrate and sulphate measured by ion chromatography in wastewater samples

2007 ◽  
Vol 5 (2) ◽  
pp. 557-569 ◽  
Author(s):  
Brigita Tepuš ◽  
Marjana Simonič
Keyword(s):  
Ion Chromatography ◽  
Storage Conditions ◽  
Least Square ◽  
Expanded Uncertainty ◽  
Determination Of Anions ◽  
The Difference ◽  
Wastewater Samples ◽  
Linear Least Square ◽  
Nitrate Anions

AbstractThis paper presents an evaluation of measurement uncertainty regarding the results of anion (nitrate and sulphate) concentrations in wastewater. Anions were determined by ion chromatography (EN ISO 10304-2, 1996). The major sources of uncertainty regarding the measurements’ results were identified as contributions to linear least — square or weighted regression lines, precision, trueness, storage conditions, and sampling. Determination of anions in wastewater is very important for the purification procedure, especially the amount of nitrate in waste and potable waters. The determined expanded uncertainty was 6.1 % for nitrate anions and 8.3 % for sulphate anions. The difference between measurement uncertainties determined by the two methods, the weighted and linear least — square methods, is negligible.

scholarly journals Determination of the kinematic viscosity by the liquid rise in a capillary tube

2013 ◽  
Vol 35 (3) ◽  
Author(s):  
J.L.G. Santander ◽  
G. Castellano
Keyword(s):  
Experimental Data ◽  
Kinematic Viscosity ◽  
Capillary Tube ◽  
Least Square ◽  
Theoretical Curve ◽  
Time Interval ◽  
Least Square Fitting ◽  
Linear Least Square ◽  
Valid Time

We discuss first the valid time interval of a formula found in the literature which gives the theoretical distance run by a liquid which rises along a capillary tube as a function of time. A non-linear least square fitting of experimental data to this theoretical curve allows the measurement of the kinematic viscosity of the liquid. The goodness of the fitting for three different sets of experimental data given in the literature is above 99%.

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