scholarly journals Clinical research nurses perspective on recruitment challenges and lessons learnt from a large multi-site observational study

2022 ◽  
pp. 174498712110437
Author(s):  
Ambreen Imran ◽  
Sithembinkosi Mpofu ◽  
Sharon Marie Weldon
Keyword(s):  
Observational Study ◽  
Clinical Research ◽  
Statistical Significance ◽  
Time Frame ◽  
Work And Family ◽  
Sample Collection ◽  
Lessons Learnt ◽  
Recruitment Challenges ◽  
Research Nurses ◽  
Time Required

Background Recruitment of large numbers of study participants within a designated time frame for multi-site clinical research studies is a significant challenge faced by researchers. If a study does not manage to recruit targeted number of participants, it could have a significant impact on the statistical significance of the research. Purpose This paper highlights the challenges of recruitment for a large multi-site UK-based tuberculosis observational study ‘PREDICT’. Methods It uses a case study analysis from the research nurses perspective, and descriptive information retrieved from non-recruitment log forms to understand reasons for potential recruits not participating. Results Some of the main challenges to recruitment included patients not attending their clinic appointments, time required to obtain site-specific permissions and courier timings for blood sample collection. This paper also outlines key reasons for potential recruits who did not participate. Some of the common barriers to participation for non-recruited participants were work and family commitments, additional blood tests and language barriers. Conclusion Successful strategies which were implemented to overcome some of the challenges during the study are presented. This paper, therefore, aims to present the challenges faced, lessons learnt and successful strategies implemented to inform the planning of similar longitudinal studies of this scale in future.

HUBUNGAN FAKTOR-FAKTOR INTERNAL PERAWAT DENGAN PENGETAHUAN PERAWAT TENTANG PENERAPAN STRATEGI PELAKSANAAN PADA PASIEN DENGAN GANGGUAN HALUSINASI

2018 ◽  
Vol 1 (1) ◽  
pp. 60
Author(s):  
Widya Arisandy
Keyword(s):  
Strategy Implementation ◽  
Analytic Approach ◽  
P Value ◽  
Sample Collection ◽  
Cross Sectional ◽  
Internal Factors ◽  
Is Research ◽  
Knowledge Strategy ◽  
Independent Variable ◽  
Research Nurses

Knowledge is the result of �know� and this is happening after they made a sensing towards an object certain .Sensing towards an object occur through panca human senses the sight , hearing , of smell , taste and touched with own .Knowledge about the implementation of the nurse strategy is obliged to understandable and in understand by a nurse soul .Many things can affect knowledge a nurse soul both internally and externally.Strategy the implementation of the act of nursing is a in made as a guide by a nurse if when interacting with disorder patients hallucinations.The purpose of research to know relations factors internal a nurse with knowledge nurse in the application of the implementation of the strategy in patients with disorder hallucinations in inpatient Rooms Hospital Ernaldi Bahar The Province Of South Sumatera 2017 . The kind of research done is research quantitative by using the method survey analytic approach in cross sectional .Technique the sample collection that is using a technique the sample collection total of sampling , the number of the sample are always 33 people .To research this independent variable consists of education , length of employment and the days of while dependent variable is knowledge nurse about strategy the implementation of the hallucinations . the results of this research was obtained one variable are associated than 3 variable internal factors researched namely working time with the results of p-value 0,011. Researchers hope from the results of this research , nurses can identify any factor that could affect the knowledge nurses and also can be used to understand the science of psychiatric Keywords : Nurses Knowledge, Strategy Implementation Hallucinations

scholarly journals Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert Markewitz ◽  
Antje Torge ◽  
Klaus-Peter Wandinger ◽  
Daniela Pauli ◽  
Andre Franke ◽  
...  
Keyword(s):  
Case Fatality ◽  
Time Frame ◽  
Epidemic Outbreak ◽  
Sample Collection ◽  
Rt Pcr ◽  
High Incidence ◽  
Duration Of Hospitalization ◽  
Reasonable Time Frame ◽  
Support Treatment ◽  
Diagnostic And Prognostic Value

AbstractLaboratory testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) consists of two pillars: the detection of viral RNA via rt-PCR as the diagnostic gold standard in acute cases, and the detection of antibodies against SARS-CoV-2. However, concerning the latter, questions remain about their diagnostic and prognostic value and it is not clear whether all patients develop detectable antibodies. We examined sera from 347 Spanish COVID-19 patients, collected during the peak of the epidemic outbreak in Spain, for the presence of IgA and IgG antibodies against SARS-CoV-2 and evaluated possible associations with age, sex and disease severity (as measured by duration of hospitalization, kind of respiratory support, treatment in ICU and death). The presence and to some degree the levels of anti-SARS-CoV-2 antibodies depended mainly on the amount of time between onset of symptoms and the collection of serum. A subgroup of patients did not develop antibodies at the time of sample collection. Compared to the patients that did, no differences were found. The presence and level of antibodies was not associated with age, sex, duration of hospitalization, treatment in the ICU or death. The case-fatality rate increased exponentially with older age. Neither the presence, nor the levels of anti-SARS-CoV-2 antibodies served as prognostic markers in our cohort. This is discussed as a possible consequence of the timing of the sample collection. Age is the most important risk factor for an adverse outcome in our cohort. Some patients appear not to develop antibodies within a reasonable time frame. It is unclear, however, why that is, as these patients differ in no respect examined by us from those who developed antibodies.

scholarly journals Impact of Observed and Controlled Water Intake on Reticulorumen Temperature in Lactating Dairy Cattle

Animals ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 194 ◽  
Author(s):  
Melissa Cantor ◽  
Joao Costa ◽  
Jeffrey Bewley
Keyword(s):  
Observational Study ◽  
Dairy Cattle ◽  
Water Temperature ◽  
Water Intake ◽  
Natural Water ◽  
Core Body Temperature ◽  
Latin Square ◽  
Water Quantity ◽  
Time Required ◽  
Water Meters

Dairy precision technologies helps producers monitor individual animals. Reticulorumen temperature boluses are a way to monitor core body temperature; however, factors such as water intake affects reticulorumen temperature. This research determined the effect of natural water intake and a controlled water drench on reticulorumen temperature (RT) in dairy cattle. In observational study part 1, tie- stall cows (n = 4) with RT transponders were observed for natural water intake (recorded by in line water meters) for 48 h. In experiment part 2, a randomized Latin square design with cows (n = 12) restricted on feed for 4 h, were drenched daily with a water quantity of 6.7 L, 11.4 L or 22.7 L, and at controlled water temperature of 1.7 °C, 7.2 °C, 15.5 °C, or 29.4 °C. Descriptively, observational study 1 had (Mean ± SD 0.27 ± 0.31 L ingested per drinking event (n = 84) and RT decline from baseline was 2.29 ± 1.82 °C. For the experiment, a 48-h specific rolling baseline temperature range (BTR) was calculated for each cow prior to the experiment to determine time required for RT to reach BTR, and time to return to BTR. In part 2 of the experiment, as water quantity increased, RT had a greater maximum degree drop from baseline. Water temperature and water quantity interaction influenced time required for BTR to reestablish. The coldest water temperature at the highest drench quantity affected time for BTR to reestablish the longest (103 min). Results from this study suggest that an algorithm could be designed to predict water intake events for producers using reticulorumen temperature.

The role and potential contribution of clinical research nurses to clinical trials

2007 ◽  
Vol 0 (0) ◽  
pp. 070621074500021-??? ◽  
Author(s):  
Karen Spilsbury ◽  
Emily Petherick ◽  
Nicky Cullum ◽  
Andrea Nelson ◽  
Jane Nixon ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Potential Contribution ◽  
Research Nurses

scholarly journals The Agile Approach with Doctoral Dissertation Supervision

2015 ◽  
Vol 8 (11) ◽  
pp. 139 ◽  
Author(s):  
Lars Göran Wallgren Tengberg
Keyword(s):  
Doctoral Students ◽  
Time Frame ◽  
Doctoral Dissertation ◽  
Doctoral Degrees ◽  
Practical Implementation ◽  
Doctoral Studies ◽  
Supervision Process ◽  
Agile Approach ◽  
Time Required ◽  
Teaching Learning

<p class="apa">Several research findings conclude that many doctoral students fail to complete their studies within the allowable time frame, in part because of problems related to the research and supervision process. Surveys show that most doctoral students are generally satisfied with their dissertation supervision. However, these surveys also reveal some students think their supervisors meet with them too infrequently, lack interest in their dissertation topics, and provide insufficient practical assistance. Furthermore, many countries will soon witness a large turnover in the labour market as people near retirement. Because this is also the case at many universities and colleges, the expectation is that there will be many teaching and research vacancies. Therefore, many new doctoral students who plan to enter academia after earning their doctoral degrees are needed. In responding to these complaints, this conceptual paper examines the use of the agile approach–which has achieved recognition and approval in software development–in the doctoral dissertation process. In the teaching/learning sphere, the agile approach can be used in iterative meetings between doctoral student and supervisor for dissertation planning, direction, and evaluation. The focus of the iterations, the so-called Sprints, is on communication and feedback throughout the entire process. The paper is based in theories on teaching/learning and on the author’s personal experience with the agile approach. Use of the agile approach, which can decrease the time required for doctoral studies, may thus increase the number of graduates with doctoral degrees. The paper makes suggestions for practical implementation of the agile approach.</p>

scholarly journals Efficiency of pharmacogenetic approach to anticoagulant therapy in patients with prosthetic heart valves

Kardiologiia ◽  
2019 ◽  
Vol 59 (9S) ◽  
pp. 25-30
Author(s):  
E. V. Gorbunova ◽  
V. V. Rozhnev ◽  
A. V. Ponasenko ◽  
Olga Leonidovna Barbarash
Keyword(s):  
Anticoagulant Therapy ◽  
Therapeutic Range ◽  
Heart Valves ◽  
Warfarin Therapy ◽  
Molecular Genetic ◽  
Time Frame ◽  
Prosthetic Heart Valves ◽  
Main Diagnosis ◽  
Mechanical Prostheses ◽  
Time Required

Background. This study examined clinical, demographic, anthropometric, and inheritance factors that influence individual sensitivity to warfarin therapy after heart valve surgery. The clinical significance of the pharmacogenetic approach was assessed using the individual time frame and time spent in the INR therapeutic range. Aims. We determined the clinical outcome of the pharmacogenetic approach at the start of warfarin therapy in patients with prosthetic heart valves. Materials and methods. The study included 915 patients, of which 512 women and 403 men (mean age 56±10 years), living in Western Siberia. Rheumatic heart disease was the main diagnosis that caused the acquired defect. Mechanical prostheses were used in 70% of cases of cardiac surgery. Real-time polymerase chain reaction used for molecular genetic testing. Results. The frequencies of the alleles and genotypes of CYP2C9 and VKORC1 in the study population of patients with heart valves prosthetic correspond to the distribution in Caucasoid populations. The use of pharmacogenetic testing results at the beginning of warfarin therapy reduced the time required for selecting a therapeutic dose of anticoagulant by 2 times and increased the duration of stay in the INR therapeutic range by 20.2%. Conclusion. The use of the pharmacogenetic approach at the begin‑ ning of warfarin therapy contributes to the effectiveness and safety of anticoagulant therapy in this category of patients.

scholarly journals Impact of Ethnicity and Underlying Comorbidity on COVID-19 Inhospital Mortality: An Observational Study in Abu Dhabi, UAE

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Asma Deeb ◽  
Khulood Khawaja ◽  
Nida Sakrani ◽  
Abdulla AlAkhras ◽  
Ahmed Al Mesabi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Observational Study ◽  
Older Patients ◽  
Statistical Significance ◽  
The Philippines ◽  
Abu Dhabi ◽  
Inhospital Mortality ◽  
Risk Of Death ◽  
Risk Of Mortality ◽  
The Impact

Background. The UAE reported its first cluster of COVID 2019 in a group of returned travellers from Wuhan in January 2020. Various comorbidities are associated with worse disease prognosis. Understanding the impact of ethnicity on the disease outcome is an important public health issue but data from our region is lacking. Aim. We aim to identify comorbidities among patients hospitalized for COVID-19 that are associated with inhospital death. Also, to assess if ethnicity is correlated with increased risk of death. Patients and Method. The study is a single-centre, observational study in Shaikh Shakhbout Medical City, Abu Dhabi. Patients admitted with COVID-19, between 1st of March and the end of May, were enrolled. Records were studied for demography, comorbidity, and ethnicity. Ethnicity was divided into Arabs (Gulf, North Africa, and the Levant), South Asia (India, Pakistan, Bangladesh, Nepal, and Afghanistan), Africans, the Philippines, and others. The study was approved by the Department of Health of Abu Dhabi. Results. 1075 patients (972 males) were enrolled. There were 24 nationalities under 5 ethnicity groups. Mean (average) age was 51 years (20–81). 101 (9.4%) died with deceased patients being significantly older. Death risk was not significantly influenced by sex. Duration of hospitalization among survivors was 6.2 days (0.2–40.4) with older patients and men staying longer ( P < 0.01 ). Comorbidities of diabetes, hypertension, cardiovascular disease, chronic renal disease, liver disease, and malignancy were associated with higher risk of mortality univariate, but only liver disease reached statistical significance after adjustment for age. The highest percentage of death was seen in Arab Levant (21.2) followed by the Asian Afghan (18.8); however, differences among ethnicities did not reach statistical significance ( P = 0.086 ). Conclusion. COVID-19 outcome was worse in older people and those with comorbidities. Men and older patients required longer hospitalization. Ethnicity is not seen to impact the risk of mortality.

Sign in / Sign up

Export Citation Format

Share Document