scholarly journals How prolonged mechanical ventilation is a neglected disease in chest medicine: a study of prolonged mechanical ventilation based on 6 years of experience in Taiwan

2019 ◽  
Vol 13 ◽  
pp. 175346661987855
Author(s):  
Chienhsiu Huang

Background: An increasing number of patients require prolonged mechanical ventilation (PMV) to survive recovery from critical care. It should be emphasized that PMV is a neglected disease in chest medicine. We investigated 6 years of clinical outcomes and long-term survival rates of patients who required PMV. Methods: We analyzed retrospectively data from patients in respiratory care center (RCC) to investigate the main causes of respiratory failure leading patients to require PMV. We also studied the factors that influence the ventilator weaned rate, factors that influence the long-term ventilator dependence of patients who require PMV, as well as patients’ hospital mortality and long-term survival rates. Results: A total of 574 patients were admitted to RCC during the 6 years. Of these, 428 patients (74.6%) were older than 65 years. A total of 391 patients (68.1%) were successfully weaned from the ventilator while 83 patients (14.4%) were unsuccessfully weaned. A total of 95 patients (16.6%) died during RCC hospitalization. The most common cause of acute respiratory failure leading to patients requiring PMV was pneumonia. The factor that affected whether patients were successfully weaned from the ventilator was the cause of the respiratory failure that lead patients to require PMV. Our hospital mortality rate was 32.4%; the 1-year survival rate was 24.3%. There was a strong correlation between higher patient age and higher hospital mortality rate and poor 1-year survival rate. Patients with no comorbidity demonstrated good 1-year survival rates. Patients with four comorbidities and patients with end-stage renal disease requiring hemodialysis comorbidity showed poor 1-year survival rates. Conclusions: The factor that affected whether patients were successfully weaned from the ventilator was the cause of the respiratory failure that lead patients to require PMV. Older patients, patients with renal failure requiring hemodialysis, and those with numerous comorbidities demonstrated poor long-term survival. The reviews of this paper are available via the supplemental material section.

2020 ◽  
Author(s):  
Chienhsiu Huang

Abstract Background The 1-year survival rate of patients on prolonged mechanical ventilation was 29-42% before 2000. By 2012, Carson reported the 1-year survival rate of prolonged mechanical ventilation patients was 52%, an unsatisfactory improvement in survival time. We explored the long-term survival rate of prolonged mechanical ventilation patients at our hospital, 2012-2017. Methods We analyzed retrospectively data from our respiratory care center patients to investigate the discharge status, long-term survival rate, and cause of death. We also compared the 5-year survival rates of prolonged mechanical ventilation patients and our hospital lung cancer patients. Results Five hundred seventy-four patients were admitted to respiratory care center during the study period. The long-term follow-up data of 403 prolonged mechanical ventilation, including 186 patients died in the hospital, 157 discharged prolonged mechanical ventilation patients, and 60 respiratory care ward patients until October 30, 2018. The 1-year survival rate of all prolonged mechanical ventilation patients, discharged prolonged mechanical ventilation patients, and respiratory care ward patients were 24.3%, 50.3%, and 31.7%, respectively. The 5-year survival rates of all prolonged mechanical ventilation patients, discharged prolonged mechanical ventilation patients, and respiratory care ward patients were 18.1%, 40.05%, and 11.7%, respectively. Successful weaning from mechanical ventilation was a key factor in the long-term survival of prolonged mechanical ventilation patients. The 5-year survival rate of discharged prolonged mechanical ventilation patients was better than that of all lung cancer patients. The 5-year survival rates of all prolonged mechanical ventilation patients and respiratory care ward patients were similar to that of stage IV lung cancer patients. Conclusions Prolonged mechanical ventilation patients had the worst long-term survival rate of all patients with chest diseases in our hospital. Successful weaning from the mechanical ventilator was most important factors for improving long-term outcomes in prolonged mechanical ventilation patients.


2019 ◽  
Vol 47 (3) ◽  
pp. 1221-1231 ◽  
Author(s):  
Zhixiang Bian ◽  
Huiyi Gu ◽  
Peihua Chen ◽  
Shijian Zhu

Background The survival rate of patients undergoing hemodialysis and other renal replacement therapies has been extensively studied, but comparative studies of emergency and scheduled hemodialysis are limited. Methods This study included 312 patients who underwent emergency hemodialysis and 274 who received scheduled hemodialysis. We investigated the prognostic differences between these two groups of patients, including the short-term and long-term survival rates. Results The overall survival rate was significantly better among the patients in the scheduled hemodialysis group than emergency hemodialysis group. The mortality rate within 3 months of emergency hemodialysis was 4.8%, while that within 3 months of scheduled hemodialysis was 1.1%. Conclusions Significant differences were present between emergency and scheduled hemodialysis, especially the levels of serum creatinine and hemoglobin.


2019 ◽  
Vol 48 ◽  
Author(s):  
Rafael Coutinho Mello MACHADO ◽  
Geninho THOMÉ ◽  
Sergio Rocha BERNARDES ◽  
Ana Claudia Moreira MELO

Abstract Introduction The long-term implant-supported prosthetic rehabilitation monitoring is extremely important in evaluating parameters that could interfere in the success of the treatment. Objective To evaluate the influence of macrodesign (shape of the body and apex), length and diameter, insertion torque, site of installation as well as the loading protocol, on long-term survival rates. Material and method The data obtained was from the medical records of rehabilitated patients who had had at least one Morse taper implant surgery done at ILAPEO School between 2006 -2012. Incomplete medical records, from which it would have been impossible to extract all data essential to complete the study, were excluded. Result A total of 1,142 patient’s medical records comprised the sample; documenting the progress of 5,601 implants, done in both jaws and mandibles. The final survival rate was 98.31%, over an average time of 37.54 months. The type of implant most used was cylindrical (70.33%). The mean installation torque most evidenced in the study was between 41 and 50 Ncm. A logistical regression analysis showed that none of the following variables, site of installation, body and apex shape designs and length, had any significant statistical influence on implant loss. Torque increase and diameter influenced implant loss while immediate loading favored implant maintenance. Conclusion It can be concluded that Morse taper implants present a long-term survival rate that can be lowered by excessive torque, as well as by the diameter of the implant.


2020 ◽  
Author(s):  
Chienhsiu Huang

Abstract Background Over six years, five hundred and seventy-four patients were admitted to the respiratory care center. Three hundred and ninety-one patients were successfully weaned from the ventilator. How is the long term outcome of these successfully weaned prolonged mechanical ventilation patients? Very few articles were discussing the long term outcome of successfully weaned prolonged mechanical ventilation patients. We will explore this issue in-depth in this article. Methods We analyzed retrospective data from successfully weaned prolonged mechanical ventilation patients to investigate the clinical variables, discharged status, long term survival, the cause of death, end-of-life decisions. Results We can further gather long term follow-up data on 243 patients. The factors between patients who died in the ward and those who survived ≥1 year revealed the poorer survival of patients who died in the ward was due to a higher percentage of end-stage renal disease comorbidity, a higher percentage of malignant comorbidity, higher percentage of ≥ four comorbidities and a higher percentage of signed do-not-resuscitate / do-not-intubate orders. The factors between patients who survived <1 year and those who survived ≥1 year revealed the poorer survival of patients who survived <1 year was due to older age, a higher percentage of signed do-not-resuscitate / do-not-intubate orders. That 81 patients (33.3%) who signed a do-not-resuscitate / do-not-intubate orders, indicates that, at most, 66.7% of survivors were willing to receive mechanical ventilation again. Conclusion The end-of-life decision (signed do-not-resuscitate / do-not-intubate orders) is one of the major influence factors of long term survival of successfully weaned prolonged mechanical ventilation patients. In all, 81 patients (33.3%) in our study signed do-not-resuscitate / do-not-intubate orders, meaning that, at most, 66.7% of survivors were willing to receive mechanical ventilation again.


2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
R. Vibo ◽  
S. Schneider ◽  
J. Kõrv

The aim of this paper was to evaluate the long-term survival of young stroke patients in Estonia, analyse time trends of survival, and compare the results with other studies. We have used 2 population-based first-ever stroke registry data (1991–1993 and 2001–2003) to analyse the 1-, 5-, and 7-year outcome of young stroke patients by the Kaplan-Meier method of analysis. From the group of 1206 patients, 129 (11%) were aged under 55 years. The overall survival rate at 1, 5, and 7 years was 0.70 (95% CI 0.62–0.78), 0.63 (95% CI 0.55–0.72), and 0.61 (95% CI 0.53–0.70), respectively. The survival was significantly worse for patients with intracerebral haemorrhage (P<0.01) and for those aged from 45 to 54 years compared to the younger age group from 0 to 44 years (P=0.03). For patients with ischemic stroke, aged from 15 to 44 years, the 1-, 5-, and 7-year survival rate was 0.89 (95% CI 0.79–1.00), 0.75 (95% CI 0.61–0.93), and 0.75 (0.61–0.93), respectively. There was no difference in overall survival between the two studied periods. We report a low long-term survival rate among young stroke patients in Estonia. Increasing age and hemorrhagic stroke subtype were associated with lower survival. We have previously shown a worse outcome for 1-year survival compared to other studies and currently this trend continues for 5- and 7-year survival rates. In fact, these are the lowest survival rates for the combined and separate stroke subtypes reported so far.


1992 ◽  
Vol 43 (4) ◽  
pp. 737 ◽  
Author(s):  
JH Primavera ◽  
RM Caballero

The effects of streamer tags and initial prawn size on survival and growth in 2-month- and 7-monthold pond-reared juveniles of Penaeus monodon Fabricius ( 1 1-30 mm carapace length, CL) were assessed under laboratory conditions. Tagging did not cause immediate mortality in juveniles of 11-21 mm CL within a one-week period but led to a significantly lower survival rate after 6 to 8 weeks in 1-m3 tanks. However, tagged prawns of 21-30 mm CL showed high long-term survival rates up to 90% in a 12-m3 tank. The 2-month-old juveniles had lower survival rates than 7-month-old prawns. Specific growth rate was not affected by tagging but was significantly higher in smaller prawns. In general, there was no interaction between the effects of tagging and prawn size in terms of growth and survival rates. The lower long-term survival rate associated with tags may be due to the attractiveness of tags to predators, or to trauma or stress caused by the weight of the tags. These factors are discussed in relation to findings for other penaeid species.


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