Long-Term Survival of Young Stroke Patients: A Population-Based Study of Two Stroke Registries from Tartu, Estonia

The aim of this paper was to evaluate the long-term survival of young stroke patients in Estonia, analyse time trends of survival, and compare the results with other studies. We have used 2 population-based first-ever stroke registry data (1991–1993 and 2001–2003) to analyse the 1-, 5-, and 7-year outcome of young stroke patients by the Kaplan-Meier method of analysis. From the group of 1206 patients, 129 (11%) were aged under 55 years. The overall survival rate at 1, 5, and 7 years was 0.70 (95% CI 0.62–0.78), 0.63 (95% CI 0.55–0.72), and 0.61 (95% CI 0.53–0.70), respectively. The survival was significantly worse for patients with intracerebral haemorrhage (P<0.01) and for those aged from 45 to 54 years compared to the younger age group from 0 to 44 years (P=0.03). For patients with ischemic stroke, aged from 15 to 44 years, the 1-, 5-, and 7-year survival rate was 0.89 (95% CI 0.79–1.00), 0.75 (95% CI 0.61–0.93), and 0.75 (0.61–0.93), respectively. There was no difference in overall survival between the two studied periods. We report a low long-term survival rate among young stroke patients in Estonia. Increasing age and hemorrhagic stroke subtype were associated with lower survival. We have previously shown a worse outcome for 1-year survival compared to other studies and currently this trend continues for 5- and 7-year survival rates. In fact, these are the lowest survival rates for the combined and separate stroke subtypes reported so far.

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The Anti-PD-1/PD-L1 Immunotherapy for Gastric Esophageal Cancer: A Systematic Review and Meta-Analysis and Literature Review

Cancer Control ◽

10.1177/1073274821997430 ◽

2021 ◽

Vol 28 ◽

pp. 107327482199743

Author(s):

Ke Chen ◽

Xiao Wang ◽

Liu Yang ◽

Zheling Chen

Keyword(s):

Overall Survival ◽

Esophageal Cancer ◽

Survival Rate ◽

Meta Analysis ◽

Response Rates ◽

Control Group ◽

Term Survival ◽

Long Term Survival ◽

And Control

Background: Treatment options for advanced gastric esophageal cancer are quite limited. Chemotherapy is unavoidable at certain stages, and research on targeted therapies has mostly failed. The advent of immunotherapy has brought hope for the treatment of advanced gastric esophageal cancer. The aim of the study was to analyze the safety of anti-PD-1/PD-L1 immunotherapy and the long-term survival of patients who were diagnosed as gastric esophageal cancer and received anti-PD-1/PD-L1 immunotherapy. Method: Studies on anti-PD-1/PD-L1 immunotherapy of advanced gastric esophageal cancer published before February 1, 2020 were searched online. The survival (e.g. 6-month overall survival, 12-month overall survival (OS), progression-free survival (PFS), objective response rates (ORR)) and adverse effects of immunotherapy were compared to that of control therapy (physician’s choice of therapy). Results: After screening 185 studies, 4 comparative cohort studies which reported the long-term survival of patients receiving immunotherapy were included. Compared to control group, the 12-month survival (OR = 1.67, 95% CI: 1.31 to 2.12, P < 0.0001) and 18-month survival (OR = 1.98, 95% CI: 1.39 to 2.81, P = 0.0001) were significantly longer in immunotherapy group. The 3-month survival rate (OR = 1.05, 95% CI: 0.36 to 3.06, P = 0.92) and 18-month survival rate (OR = 1.44, 95% CI: 0.98 to 2.12, P = 0.07) were not significantly different between immunotherapy group and control group. The ORR were not significantly different between immunotherapy group and control group (OR = 1.54, 95% CI: 0.65 to 3.66, P = 0.01). Meta-analysis pointed out that in the PD-L1 CPS ≥10 sub group population, the immunotherapy could obviously benefit the patients in tumor response rates (OR = 3.80, 95% CI: 1.89 to 7.61, P = 0.0002). Conclusion: For the treatment of advanced gastric esophageal cancer, the therapeutic efficacy of anti-PD-1/PD-L1 immunotherapy was superior to that of chemotherapy or palliative care.

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Comparison of prognosis between emergency and scheduled hemodialysis

Journal of International Medical Research ◽

10.1177/0300060518807092 ◽

2019 ◽

Vol 47 (3) ◽

pp. 1221-1231 ◽

Cited By ~ 2

Author(s):

Zhixiang Bian ◽

Huiyi Gu ◽

Peihua Chen ◽

Shijian Zhu

Keyword(s):

Overall Survival ◽

Survival Rate ◽

Mortality Rate ◽

Serum Creatinine ◽

Survival Rates ◽

Overall Survival Rate ◽

Short Term ◽

Term Survival ◽

Renal Replacement Therapies

Background The survival rate of patients undergoing hemodialysis and other renal replacement therapies has been extensively studied, but comparative studies of emergency and scheduled hemodialysis are limited. Methods This study included 312 patients who underwent emergency hemodialysis and 274 who received scheduled hemodialysis. We investigated the prognostic differences between these two groups of patients, including the short-term and long-term survival rates. Results The overall survival rate was significantly better among the patients in the scheduled hemodialysis group than emergency hemodialysis group. The mortality rate within 3 months of emergency hemodialysis was 4.8%, while that within 3 months of scheduled hemodialysis was 1.1%. Conclusions Significant differences were present between emergency and scheduled hemodialysis, especially the levels of serum creatinine and hemoglobin.

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Long-term survival rates of older breast cancer patients: Population-based estimates over three decades.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.9051 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 9051-9051

Author(s):

B. Kanapuru ◽

A. Jemal ◽

C. S. Hesdorffer ◽

W. B. Ershler ◽

J. W. Yates

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Survival Rates ◽

Population Based ◽

Breast Cancer Patients ◽

Term Survival ◽

Long Term Survival

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Long-term survival rates of patients undergoing vitrectomy for diabetic retinopathy in an Australian population: a population-based audit

Clinical and Experimental Ophthalmology ◽

10.1111/ceo.13466 ◽

2019 ◽

Vol 47 (5) ◽

pp. 598-604 ◽

Cited By ~ 4

Author(s):

Ebony Liu ◽

Jose Estevez ◽

Georgia Kaidonis ◽

Mark Hassall ◽

Russell Phillips ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Survival Rates ◽

Population Based ◽

Australian Population ◽

Term Survival ◽

Long Term Survival

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Can local treatment prolong the sensitivity of metastatic prostate cancer to androgen deprivation or even prevent castration resistance?

World Journal of Urology ◽

10.1007/s00345-020-03568-3 ◽

2021 ◽

Author(s):

Christina Niklas ◽

Matthias Saar ◽

Alessandro Nini ◽

Johannes Linxweiler ◽

Stefan Siemer ◽

...

Keyword(s):

Prostate Cancer ◽

Overall Survival ◽

Biochemical Recurrence ◽

Metastatic Prostate Cancer ◽

Locally Advanced ◽

Survival Rates ◽

Term Survival ◽

Long Term Survival ◽

Hormonal Manipulation

Abstract Purpose A number of observational clinical studies suggest that prior primary tumor treatment favorably influences the course of metastatic prostate cancer (PCa), but its mechanisms of action are still speculative. Here, we describe the long-lasting sensitivity to various forms of androgen deprivation in patients after radical prostatectomy (RP) for locally advanced PCa as one potential mechanism. Methods A consecutive series of 115 radical prostatectomies after inductive therapy for T4 prostate cancer was re-analyzed, and long-term survival, as well as recurrence patterns and responses to different forms of hormonal manipulation, were assessed. Results The estimated biochemical response-free, PCa-specific, and overall survival rates after 200 months were 20%, 65%, and 47% with a median overall survival of 156 months. The majority of patients, although not cured of locally advanced PCa (84/115), showed long-term survival after RP. PCa-specific and overall survival rates of these 84 patients with biochemical recurrence were 61% and 44% at 150 months. Long-term sensitivity to ADT was found to be the main reason for the favorable tumor-specific survival in spite of biochemical recurrence. Conclusions Sensitivity to primary or secondary hormonal manipulation was the main reason for the long-term survival of patients who had not been cured by surgery only. The results suggest that treatment of the primary tumor-bearing prostate delays castration-resistant PCa and enhances the effect of hormonal therapies in a previously unknown manner. The underlying cellular and molecular mechanisms need to be explored in more detailed analyses, which could profoundly impact treatment concepts of locally advanced and metastatic PCa.

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How prolonged mechanical ventilation is a neglected disease in chest medicine: a study of prolonged mechanical ventilation based on 6 years of experience in Taiwan

Therapeutic Advances in Respiratory Disease ◽

10.1177/1753466619878552 ◽

2019 ◽

Vol 13 ◽

pp. 175346661987855

Author(s):

Chienhsiu Huang

Keyword(s):

Mechanical Ventilation ◽

Respiratory Failure ◽

Survival Rate ◽

Mortality Rate ◽

Hospital Mortality ◽

Prolonged Mechanical Ventilation ◽

Survival Rates ◽

Term Survival ◽

Long Term Survival

Background: An increasing number of patients require prolonged mechanical ventilation (PMV) to survive recovery from critical care. It should be emphasized that PMV is a neglected disease in chest medicine. We investigated 6 years of clinical outcomes and long-term survival rates of patients who required PMV. Methods: We analyzed retrospectively data from patients in respiratory care center (RCC) to investigate the main causes of respiratory failure leading patients to require PMV. We also studied the factors that influence the ventilator weaned rate, factors that influence the long-term ventilator dependence of patients who require PMV, as well as patients’ hospital mortality and long-term survival rates. Results: A total of 574 patients were admitted to RCC during the 6 years. Of these, 428 patients (74.6%) were older than 65 years. A total of 391 patients (68.1%) were successfully weaned from the ventilator while 83 patients (14.4%) were unsuccessfully weaned. A total of 95 patients (16.6%) died during RCC hospitalization. The most common cause of acute respiratory failure leading to patients requiring PMV was pneumonia. The factor that affected whether patients were successfully weaned from the ventilator was the cause of the respiratory failure that lead patients to require PMV. Our hospital mortality rate was 32.4%; the 1-year survival rate was 24.3%. There was a strong correlation between higher patient age and higher hospital mortality rate and poor 1-year survival rate. Patients with no comorbidity demonstrated good 1-year survival rates. Patients with four comorbidities and patients with end-stage renal disease requiring hemodialysis comorbidity showed poor 1-year survival rates. Conclusions: The factor that affected whether patients were successfully weaned from the ventilator was the cause of the respiratory failure that lead patients to require PMV. Older patients, patients with renal failure requiring hemodialysis, and those with numerous comorbidities demonstrated poor long-term survival. The reviews of this paper are available via the supplemental material section.

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Morse taper implant macrodesign, loading protocol and site of installation – retrospective study of 5,601 implants

Revista de Odontologia da UNESP ◽

10.1590/1807-2577.06919 ◽

2019 ◽

Vol 48 ◽

Author(s):

Rafael Coutinho Mello MACHADO ◽

Geninho THOMÉ ◽

Sergio Rocha BERNARDES ◽

Ana Claudia Moreira MELO

Keyword(s):

Survival Rate ◽

Medical Records ◽

Survival Rates ◽

The Body ◽

Insertion Torque ◽

Term Survival ◽

Long Term Survival ◽

Treatment Objective ◽

Final Survival

Abstract Introduction The long-term implant-supported prosthetic rehabilitation monitoring is extremely important in evaluating parameters that could interfere in the success of the treatment. Objective To evaluate the influence of macrodesign (shape of the body and apex), length and diameter, insertion torque, site of installation as well as the loading protocol, on long-term survival rates. Material and method The data obtained was from the medical records of rehabilitated patients who had had at least one Morse taper implant surgery done at ILAPEO School between 2006 -2012. Incomplete medical records, from which it would have been impossible to extract all data essential to complete the study, were excluded. Result A total of 1,142 patient’s medical records comprised the sample; documenting the progress of 5,601 implants, done in both jaws and mandibles. The final survival rate was 98.31%, over an average time of 37.54 months. The type of implant most used was cylindrical (70.33%). The mean installation torque most evidenced in the study was between 41 and 50 Ncm. A logistical regression analysis showed that none of the following variables, site of installation, body and apex shape designs and length, had any significant statistical influence on implant loss. Torque increase and diameter influenced implant loss while immediate loading favored implant maintenance. Conclusion It can be concluded that Morse taper implants present a long-term survival rate that can be lowered by excessive torque, as well as by the diameter of the implant.

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A retrospective clinical observation of long-term survival in patients after prolonged mechanical ventilation

10.21203/rs.2.21403/v1 ◽

2020 ◽

Author(s):

Chienhsiu Huang

Keyword(s):

Mechanical Ventilation ◽

Survival Rate ◽

Prolonged Mechanical Ventilation ◽

Survival Rates ◽

Respiratory Care ◽

Term Survival ◽

Long Term Survival ◽

Lung Cancer Patients ◽

Care Ward

Abstract Background The 1-year survival rate of patients on prolonged mechanical ventilation was 29-42% before 2000. By 2012, Carson reported the 1-year survival rate of prolonged mechanical ventilation patients was 52%, an unsatisfactory improvement in survival time. We explored the long-term survival rate of prolonged mechanical ventilation patients at our hospital, 2012-2017. Methods We analyzed retrospectively data from our respiratory care center patients to investigate the discharge status, long-term survival rate, and cause of death. We also compared the 5-year survival rates of prolonged mechanical ventilation patients and our hospital lung cancer patients. Results Five hundred seventy-four patients were admitted to respiratory care center during the study period. The long-term follow-up data of 403 prolonged mechanical ventilation, including 186 patients died in the hospital, 157 discharged prolonged mechanical ventilation patients, and 60 respiratory care ward patients until October 30, 2018. The 1-year survival rate of all prolonged mechanical ventilation patients, discharged prolonged mechanical ventilation patients, and respiratory care ward patients were 24.3%, 50.3%, and 31.7%, respectively. The 5-year survival rates of all prolonged mechanical ventilation patients, discharged prolonged mechanical ventilation patients, and respiratory care ward patients were 18.1%, 40.05%, and 11.7%, respectively. Successful weaning from mechanical ventilation was a key factor in the long-term survival of prolonged mechanical ventilation patients. The 5-year survival rate of discharged prolonged mechanical ventilation patients was better than that of all lung cancer patients. The 5-year survival rates of all prolonged mechanical ventilation patients and respiratory care ward patients were similar to that of stage IV lung cancer patients. Conclusions Prolonged mechanical ventilation patients had the worst long-term survival rate of all patients with chest diseases in our hospital. Successful weaning from the mechanical ventilator was most important factors for improving long-term outcomes in prolonged mechanical ventilation patients.

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