scholarly journals Chemical and Biological Investigation of Some Secondary Metabolites in Atriplex Halimus Growing in Egypt

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Amal Kabbash ◽  
Nagwa Shoeib
Keyword(s):  
Multidrug Resistance ◽  
Soluble Fraction ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Dpph Radical ◽  
Biological Investigation ◽  
Atriplex Halimus ◽  
Aerial Parts ◽  
Dpph Radical Scavenging

The n-BuOH-soluble fraction of the MeOH-CH2Cl2 (1:1) extract of the aerial parts of Egyptian Atriplex halimus L. yielded two new flavonol glycosides, designated as atriplexoside A (1) [3′- O-methylquercetin-4′- O-β-apiofuranoside-3- O-(6″- O-α-rhamnopyranosyl-β-glucopyranoside)] and atriplexoside B (2) [3′- O-methylquercetin-4′- O-(5″″- O-β-xylopyranosyl-β-apiofuranoside)-3- O-(6″- O-α-rhamnopyranosyl-β-glucopyranoside)], together with six known compounds: two phenolic glucosides (3, 4), one ecdysteroid (5), one megastigmane (6) and two methoxylated flavonoid glycosides (7, 8). The structures of the compounds were elucidated by detailed spectroscopic analysis, including HR-ESI-MS and 2D-NMR spectroscopic data. DPPH radical scavenging, antileishmanial and anti-multidrug resistance activities were investigated using the n-BuOH-soluble fraction as well as the isolated compounds. Compound 8 (5- O-methylquercetin-3- O-(6″- O-α-rhamnopyranosyl-β-glucopyranoside) presented marked DPPH radical scavenging, weak antileishmanial and anti-multidrug resistance activity while the other tested compounds showed weaker activities.

scholarly journals New Flavonoids from Baeckea Frutescens and their Antioxidant Activity

2008 ◽  
Vol 3 (5) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Tran Hong Quang ◽  
Nguyen Xuan Cuong ◽  
Chau Van Minh ◽  
Phan Van Kiem
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate Extract ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Dpph Radical ◽  
Aerial Parts ◽  
Baeckea Frutescens ◽  
New Compounds ◽  
Dpph Radical Scavenging

From the ethyl acetate extract of the aerial parts of Baeckea frutescens, a new flavonoid, 6,8-di- C-methylkaempferol (1), and three new flavonoid glycosides, 6,8-di- C-methylkaempferol 3- O-α-L-rhamnopyranoside (2), 6- C-methylquercetin 3- O-α-L-rhamnopyranoside (3), and 6- C-methylquercetin 4′- O-β-D-glucopyranoside (4), along with four known flavonoids were isolated. Their structures were elucidated by extensive spectroscopic methods including 1D and 2D NMR experiments, as well as ESI-MS analysis. All the new compounds were tested for their antioxidant activity in the 1,1-diphenyl-2-pecrylhydrazyl (DPPH) radical scavenging assay system. Compounds 3 and 4 showed potent activity with IC50 values of 12.1 ± 0.5 and 13.5 ± 0.9 (μM), respectively.

scholarly journals Antibacterial, Antiviral, Antioxidant and Antiproliferative Activities of Thymus guyonii Essential Oil

2017 ◽  
Vol 12 (10) ◽  
pp. 1934578X1701201 ◽  
Author(s):  
Assia Zeghib ◽  
Ahmed Kabouche ◽  
Souheila Laggoune ◽  
Claude-Alain Calliste ◽  
Alain Simon ◽  
...  
Keyword(s):  
Essential Oil ◽  
Pathogenic Bacteria ◽  
Radical Scavenging ◽  
Bactericidal Effect ◽  
Dpph Radical ◽  
Aerial Parts ◽  
Colorectal Cell ◽  
Test Concentration ◽  
Dpph Radical Scavenging ◽  
Ht 29

The aerial parts of Thymus guyonii were hydrodistilled in a Clevenger type apparatus and analyzed by GC and GC-MS. 26 components were identified representing 99.8%, with carvacrol (55.6%), thymol (21.2%), o-cymene (9.7%) and δ-terpinene (5.7%) as the major components. T. guyonii essential oil exhibited a good bactericidal effect (MBC/MIC ratio = 2) against all the tested pathogenic bacteria. The essential oil lacks antiviral activity towards coxsackievirus B3 however it showed a good DPPH radical scavenging at 0.5 and 5 mg/mL test-concentrations (15.5±1.2% and 44.3±1.95%, respectively). The essential oil exhibited a proliferation inhibition of Human colorectal cell line HT-29 (30.4±3.4%) at 50 μg/mL test-concentration.

DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla

2007 ◽  
Vol 62 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Masateru Ono ◽  
Eriko Oda ◽  
Takemi Tanaka ◽  
Yoshihiko Iida ◽  
Toru Yamasaki ◽  
...  
Keyword(s):  
Radical Scavenging ◽  
Dpph Radical ◽  
Scavenging Effect ◽  
Aerial Parts ◽  
Radical Scavenging Effect ◽  
Dpph Radical Scavenging ◽  
Lippia Triphylla

scholarly journals Phenolic Glucosides from Flacourtia Indica

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Swati Madan ◽  
Steve T. Pannakal ◽  
Seru Ganapaty ◽  
Gyanendra N. Singh ◽  
Yatendra Kumar
Keyword(s):  
Benzyl Alcohol ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Positive Control ◽  
Dpph Radical ◽  
Dpph Radical Scavenging Activity ◽  
Phenolic Glucosides ◽  
Phenolic Glucoside ◽  
Dpph Radical Scavenging

A new phenolic glucoside, ( rel)-2-(4′,6′-dibenzoyl-β-glucopyranosyloxy)-7-(1α-hydroxy-2α-ethoxy-6α-acetyloxy-3-oxocyclohex-4-enoyl)-benzyl alcohol (Flacourticin) (1) and the known, 2-(4′,6′-dibenzoyl-β-glucopyranosyl)-5-hydroxy benzyl alcohol (4′-benzoylpoliothrysoside) (2) together with the new, (2E)-heptyl-3-(3,4-dihydroxyphenyl) acrylate (3), (+)-catechin (4) and sitosterol-β-D-glucoside were isolated from Flacourtia indica. Their structures were assigned on the basis of 1D, 2D-NMR and as well by analysis of the LC-ESIMS data. The isolated compounds (1-4) were evaluated for α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging activity, and 3 was found to be two-fold less potent, with an IC50 =12.01 μg/mL, compared to the positive control, Rutin, (IC50 = 5.83 μg/mL).

Antioxidative Principals of Extracts from the Fruit of Viburnum awabuki

2013 ◽  
Vol 709 ◽  
pp. 875-878
Author(s):  
Hai Lan Huang ◽  
Shu Mei Qiu ◽  
Hai Yuan Wang ◽  
Zong Hua Wang
Keyword(s):  
Hydroxyl Radical ◽  
Ethyl Acetate ◽  
Crude Extract ◽  
Soluble Fraction ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Dpph Radical ◽  
Dpph Radical Scavenging

The fruit of Viburnum awabuki is an elliptical berry.The crude extract and its four fractions derived from the peel of the fruit Viburnum awabuki were evaluated for the DPPH radical scavenging ability(DRSA), hydroxyl radical scavenging capacity(HRSA) and reducing power(RP), and the content of some antioxidative compounds and the relationships between these antioxidative compounds and antioxidant activities of the crude extract (CE) and its four fractions were investigated. The results showed that the ethyl acetate-soluble fraction (EAF) was the richest fraction in total flavonoids, ascorbic acid content (45.34 and 8.92 mg/g, respectively). The ethyl acetate-soluble fraction showed good DPPH radical-scavenging activity and reducing power, while the crude extract (CE) possessed better hydroxyl radical-scavenging than other fractions. There were statistically significant correlations between some antioxidants and antioxidant activities.

scholarly journals A new Butenolide Derivative from the Brown Alga Sargassum micracanthum

2022 ◽  
Vol 17 (1) ◽  
pp. 1934578X2110686
Author(s):  
Ji-Yul Kim ◽  
Jeong Min Lee ◽  
Hyun-Soo Kim ◽  
Dae-Won Ki ◽  
Mi-Jin Yim ◽  
...  
Keyword(s):  
Brown Alga ◽  
Sulfonic Acid ◽  
Spectroscopic Data ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Dpph Radical ◽  
Meoh Extract ◽  
Dpph Radical Scavenging

A new butenolide derivative (1), along with three known compounds (2-4) were isolated from the MeOH extract of brown alga Sargassum micracanthum. The structures of 1 to 4 were determined by the analyses of 1D and 2D NMR and mass spectroscopic data. The known compounds (2-4) were identified as (5 E,10 Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione (2), (5 E,9 E)-6,10,14-trimethylpentadeca-5,9-dien-2,12-dione (3), and (-)-loliolide (4) by comparing with their published spectroscopic data. The antioxidant activities of compounds 1 to 4 were evaluated based on using 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Compounds 1 to 4 were inactive at the concentration of 200 μM.

scholarly journals New Flavonol Glycoside from the Leaves of Ventilago africana

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001
Author(s):  
Diane Patricia Apie Gossan ◽  
Abdulmagid Alabdul Magid ◽  
Philomène Akoua Yao-Kouassi ◽  
Damien Le Faucheur ◽  
Antoine Ahibo Coffy ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Positive Control ◽  
Flavonol Glycoside ◽  
Spectroscopic Methods ◽  
Dpph Radical ◽  
Dpph Radical Scavenging ◽  
Radical Scavenging Assay

A new flavonol diglycoside, rhamnocitrin-3- O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside, was isolated from the leaves of Ventilago Africana. in addition to 11 known flavonoids. Their structures were determined by spectroscopic methods including 1D- and 2D-NMR, and HR-ESI-MS analysis. The isolated compounds were evaluated for their antioxidant activity by using DPPH radical-scavenging assay. Compounds 4, 7–9 have discrete to good antioxidant potential with EC50 values ranging from 20.9 to 40.4 μM. compared with ascorbic acid (EC50 60 μM) used as positive control.

scholarly journals Chemical Composition and Biological Activity of the Essential Oil and Solvent Extracts of Scaligeria Nodosa

2017 ◽  
Vol 5 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Amir Reza Jassbi ◽  
Mehdi Zare ◽  
Fatemeh Heidary Jamebozorgi
Keyword(s):  
Essential Oil ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenol ◽  
Gas Chromatography Mass Spectrometry ◽  
Total Phenolic ◽  
Dilution Method ◽  
Dpph Radical ◽  
Aerial Parts ◽  
Dpph Radical Scavenging

Background:The essential oil and three solvent extracts of the aerial parts ofScaligeria nodosa(Boiss.) that were collected in Bamu Mountains (Iran), were screened for their antioxidant, antimicrobial properties and total phenolic contents for the first time.Methods:The essential oil was extracted by hydrodistillation and analyzed by capillary gas chromatography-mass spectrometry (GC-MS) and GC flame ionization detector (GC-FID).Results:Forty five components were identified in the oil, among them, germacrene D (18.1±0.1%), bicyclogermacrene (1.4±0.0%), and spathunelnol (2.7±0.0%) were the major sesquiterpenoids,n-tetradecanol (4.9±0.0%) was the most abundant fatty alcohol and diisobuthyl phthalate (43.9±0.2%) was the most abundant constituent. The extracts of aerial parts ofSc. nodosawere prepared using different solvents; dichloromethane (DCM), methanol (MeOH) and MeOH: H2O (80:20). Antibacterial activity of the oil and each solvent extract was tested against three Gram-positive and three Gram-negative bacteria by nutrient broth micro dilution method. Among the tested microorganisms,Staphylococcus epidermidis(IC501.25-5mg/ml),Bacillus subtilis(IC501.25mg/ml) andEscherichia coli(IC501.25mg/ml) were the most susceptible to the applied oils and the extracts. The antioxidant potential and total phenol contents of the extracts were assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and Folin- Ciocalteu reagent, respectively. Methanol and 80% methanol extracts of the plant showed relatively weak DPPH radical scavenging activity and low amounts of total phenol contents.

scholarly journals BIOACTIVITIES AND CHEMICAL CONSTITUENTS OF A VIETNAMESE MEDICINAL PLANT VANG SE JASMINUM SUBTRIPLINERVE BLUME

2012 ◽  
Vol 15 (3) ◽  
pp. 37-44
Author(s):  
Huong Thi Diem Nguyen ◽  
Son Hong Phan ◽  
Huong Dang Thien Bui ◽  
Hoai Thi Cam Ho ◽  
Mai Thi Thanh Nguyen
Keyword(s):  
Medicinal Plant ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Antioxidative Activity ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Dpph Radical ◽  
Dpph Radical Scavenging

From the total crude ethanol extract of Jasminum subtriplinerve Blume.’s leaves and stems, (Vang se in Vietnamese), four extracts were obtained by partitioning with petroleum ether, cloroform, ethyl acetate and n-butanol solvents. These four extracts were tested for antioxydative activity, determined using the DPPH●.radical scavenging and nitric oxyde-inhibitory assay. All the extracts showed antioxidative activity except the petroleum ether extracts. Among the crude extracts, the acetate ethyl extract was the most potent extract in both assays with the SC50 values of 8.2 μg/mL and 80.7 μg/mL, respectively. From the VS3 substract, three compounds were isolated, including two acids namely 3,4- dihidroxybenzoic acid (1), 3,4,5-trihidroxybenzoic acid (2) and a glycoside, verbascoside (3). The structure of those compounds was elucidated by spectrometric methods IR, MS, LC-MS, 1D-NMR, and 2D-NMR.

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