scholarly journals Citriquinones A and B, New Benzoquinones from Penicillium Citrinum

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
P. K. Vinitha Ranji ◽  
S. Chandrani Wijeyaratne ◽  
K. Hector Jayawardana ◽  
G. M. Kamal B. Gunaherath
Keyword(s):  
Antibacterial Activity ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Soil Fungus ◽  
Penicillium Citrinum ◽  
Bacillus Sp ◽  
Human Cancer Cell ◽  
New Compounds

Two new benzoquinones, citriquinone A (1) and B (2), were isolated from the methanol extract of a soil fungus, Penicillium citrinum. The structures of the new compounds were determined on the basis of detailed spectroscopic analysis. Citriquinone A (1) exhibited antibacterial activity against Bacillus sp. and cell migration inhibitory activity (CMIA) against human cancer cell line HEp 2.

scholarly journals A New Benzofuran Derivative From the Stems of Helicteres hirsuta

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985881
Author(s):  
Nguyen Thanh Tra ◽  
Nguyen Thi Thu Ha ◽  
Ba Thi Cham ◽  
Le Thi Tu Anh ◽  
Le Thi Hai Yen ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Mass Spectroscopy ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC50 values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta.

scholarly journals Universal attenuators and their interactions with feedback loops in gene regulatory networks

2016 ◽  
Author(s):  
Dianbo Liu ◽  
Luca Albergante ◽  
Timothy J Newman
Keyword(s):  
Gene Expression ◽  
Gene Regulatory Networks ◽  
Gene Networks ◽  
Regulatory Networks ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Feedback Loops ◽  
Human Cancer Cell ◽  
E Coli ◽  
Gene Regulatory

AbstractUsing a combination of mathematical modelling, statistical simulation and large-scale data analysis we study the properties of linear regulatory chains (LRCs) within gene regulatory networks (GRNs). Our modelling indicates that downstream genes embedded within LRCs are highly insulated from the variation in expression of upstream genes, and thus LRCs act as attenuators. This observation implies a progressively weaker functionality of LRCs as their length increases. When analysing the preponderance of LRCs in the GRNs of E. coli K12 and several other organisms, we find that very long LRCs are essentially absent. In both E. coli and M. tuberculosis we find that four-gene LRCs are intimately linked to identical feedback loops that are involved in potentially chaotic stress response, indicating that the dynamics of these potentially destabilising motifs are strongly restrained under homeostatic conditions. The same relationship is observed in a human cancer cell line (K562), and we postulate that four-gene LRCs act as “universal attenuators”. These findings suggest a role for long LRCs in dampening variation in gene expression, thereby protecting cell identity, and in controlling dramatic shifts in cell-wide gene expression through inhibiting chaos-generating motifs.In briefWe present a general principle that linear regulatory chains exponentially attenuate the range of expression in gene regulatory networks. The discovery of a universal interplay between linear regulatory chains and genetic feedback loops in microorganisms and a human cancer cell line is analysed and discussed.HighlightsWithin gene networks, linear regulatory chains act as exponentially strong attenuators of upstream variationBecause of their exponential behaviour, linear regulatory chains beyond a few genes provide no additional functionality and are rarely observed in gene networks across a range of different organismsNovel interactions between four-gene linear regulatory chains and feedback loops were discovered in E. coli, M. tuberculosis and human cancer cells, suggesting a universal mechanism of control.

scholarly journals Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line

DNA Repair ◽  
2009 ◽  
Vol 8 (8) ◽  
pp. 886-900 ◽  
Author(s):  
Oliver Zschenker ◽  
Avanti Kulkarni ◽  
Douglas Miller ◽  
Gloria. E. Reynolds ◽  
Marine Granger-Locatelli ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Double Strand Breaks ◽  
Human Cancer Cell ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Increased Sensitivity ◽  
Subtelomeric Regions

scholarly journals Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (5) ◽  
pp. 900-905 ◽  
Author(s):  
Reji N. Nair ◽  
Jitendra K. Mishra ◽  
Fangzheng Li ◽  
Mariola Tortosa ◽  
Chunying Yang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Line ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Human Cancer Cell Line ◽  
Human Cancer Cell

Gln and Tyr conjugates of MCT inhibitors were designed and shown to be highly cytotoxic to a human cancer cell line expressing the transporters Asct2, LAT1, and MCT1/2.

Diterpenoids from Leaves of Cultivated Plectranthus ornatus

Planta Medica ◽  
2020 ◽  
Author(s):  
Lidivânia Silva Freitas Mesquita ◽  
Taynara Simão Matos ◽  
Fábio do Nascimento Ávila ◽  
Alison da Silva Batista ◽  
Andréa Felinto Moura ◽  
...  
Keyword(s):  
Guinea Pig ◽  
13C Nmr ◽  
Intestinal Motility ◽  
Spectroscopic Analysis ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Guinea Pig Ileum ◽  
Atomic Orbitals ◽  
Human Cancer Cell Lines ◽  
Hct 116

AbstractTwo new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3–13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.

scholarly journals A New Cycloartane Glucoside from Rhizophora stylosa

2014 ◽  
Vol 9 (9) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Phan Thi Thanh Huong ◽  
Chau Ngoc Diep ◽  
Nguyen Van Thanh ◽  
Vu Anh Tu ◽  
Tran Hong Hanh ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Lung Adenocarcinoma ◽  
Cell Lines ◽  
Caspase 3 ◽  
Methanol Extract ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Rhizophora Stylosa ◽  
Human Cancer Cell Lines ◽  
C Nmr

Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.

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