scholarly journals Cytotoxic Compounds from Endemic Arnebia purpurea

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Merve Yuzbasioglu ◽  
Ayse Kuruuzum-Uz ◽  
Zuhal Guvenalp ◽  
András Simon ◽  
Gábor Tóth ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Flavonoid Glycosides ◽  
Cytotoxic Activities ◽  
Aerial Parts ◽  
Isolation And Characterization ◽  
Cytotoxic Compounds ◽  
Standard Doxorubicin ◽  
Murine Fibrosarcoma ◽  
Phytochemical Studies ◽  
First Time

Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl- n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3- O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3- O-rutinoside (7), kaempferol-3- O-rutinoside (8), kaempferol 3- O-(5″-acetyl) apiofuranoside 7- O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3- O-Acetyl-oleanolic acid, isorhamnetin-3- O-rutinoside, kaempferol-3- O-rutinoside, and kaempferol 3- O-(5″-acetyl) apiofuranoside 7- O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1–4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

scholarly journals Phytochemical studies on the aerial parts of Sarcococca hookeriana (Baillon) of Nepalese origin

1970 ◽  
Vol 21 ◽  
pp. 8-15
Author(s):  
Narayan P. Rai ◽  
Bimala Lama ◽  
Shiva P. Subedi ◽  
W. C. Taylor ◽  
M. D. Manandhar
Keyword(s):  
Spectral Analysis ◽  
Oleanolic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Chemical Society ◽  
Chloroform Extract ◽  
Hmbc Spectrum ◽  
Aerial Parts ◽  
Phytochemical Studies ◽  
First Time

Two known pregnane type of alkaloids, axillaridine A and spiropachysine, and an unidentified pregane alkaloid along with oleanolic acid and stigmasteryl glucoside have been isolated from chloroform extract of the aerial parts of Sarcococca hookeriana. The structures of the alkaloids are established on the basis of spectral analysis of 1H-NMR, 13C-NMR, HMQC, COSY and HMBC spectrum. All compounds were isolated for the first time from S. hookeriana. So far, species of Sarcococca was not reported to contain spiropachysine which was initially reported as a novel alkaloid from Pachysandra terminalis SIEB. et ZUCC.(Buxaceae).DOI: 10.3126/jncs.v21i0.215Journal of Nepal Chemical Society Vol.21 2006 pp.8-15

scholarly journals Cytotoxic Activities of Flavonoids fromCentaurea scoparia

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sayed A. Ahmed ◽  
Emadeldin M. Kamel
Keyword(s):  
Hepatocellular Carcinoma ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Oroxylin A ◽  
Aerial Parts ◽  
Phytochemical Studies ◽  
First Time ◽  
Mcf 7

Phytochemical studies on the ethanolic extract of the aerial parts ofCentaurea scoparialed to the isolation of two new flavonoids, 3′,4′-dihydroxy-(3′′,4′′-dihydro-3′′-hydroxy-4′′-acetoxy)-2′′,2′′-dimethylpyrano-(5′′,6′′:7,8)-flavone-3-O-β-D-glucopyranoside (1) and 3,3′,4′-trihydroxy-(3′′,4′′-dihydro-3′′,4′′-dihydroxy)-2′′,2′′-dimethylpyrano-(5′′,6′′:7,8)-flavone (2), along with eight known flavonoids isolated for the first time from this plant, cynaroside (3), Apigetrin (4), centaureidin (5), oroxylin A (6), 5,7-dihydroxy-3′,4′,5′-trimethoxyflavone (7), atalantoflavone (8), 5-hydroxy-3′,4′,8-trimethoxy-2′′,2′′-dimethylpyrano (5′′,6′′:6,7)-flavone (9), and 3′,4′,5,8-tetramethoxy-2′′,2′′-dimethylpyrano (5′′,6′′:6,7)-flavone (10). The structures of the isolated compounds were elucidated by means of spectroscopic tools including 1D and 2D NMR, UV, IR, and mass spectroscopy. Cytotoxic activities of the isolated compounds were evaluated against human cervical carcinoma HeLa, human hepatocellular carcinoma HepG2, and human breast carcinoma MCF-7. Compound2was the most potent cytotoxic agent against HeLa cells with an IC500.079 μM.

Flavon- and Flavonolglycosides from Achillea pannonica Scheele

2001 ◽  
Vol 56 (7-8) ◽  
pp. 521-525 ◽  
Author(s):  
Denata Kasaj ◽  
Liselotte Krenn ◽  
Sonja Prinz ◽  
Antje Hüfner ◽  
Shi Shan Yuc ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Spectroscopic Methods ◽  
Esi Ms ◽  
Aerial Parts ◽  
Nmr Techniques ◽  
Chemotaxonomic Study ◽  
First Time ◽  
C Nmr

The detailed investigation of a methanolic extract of aerial parts of Achillea pannonica SCHEELE. within a chemotaxonomic study led to the isolation of 6 flavonoid glycosides. Besides rutin, apigenin-7-O-glucopyranoside, luteolin-7-O-glucopyranoside, apigenin-7-O-rutinoside and acacetin-7-O-rutinoside, an unusual flavondiglucoside was isolated. Its structure was established by UV, 1HNMR and 13C NMR spectroscopic methods including 2D-NMR techniques and ESI-MS as luteolin-7,4′-O-β-diglucoside. This substance is reported for the first time in the genus Achillea. Chemotaxonomic aspects are discussed briefly

scholarly journals Bioactive Phenolics from Carthamus lanatus L.

2003 ◽  
Vol 58 (9-10) ◽  
pp. 704-707 ◽  
Author(s):  
Rilka Taskova ◽  
Maya Mitova ◽  
Bozhanka Mikhova ◽  
Helmut Duddeck
Keyword(s):  
Chlorogenic Acid ◽  
Methanol Extract ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Ethyl Acetate Fraction ◽  
Free Radical Scavenging ◽  
Flavonoid Glycosides ◽  
Aerial Parts ◽  
Free Radical Scavenging Assay ◽  
First Time

AbstractTwo flavonoid aglycons, eight flavonoid glycosides, chlorogenic acid and syringin were isolated from aerial parts of Carthamus lanatus. Isorhamnetin 3-O-β-ᴅ-glucoside and chlorogenic acid were found for the first time in the genus Carthamus and respectively, quercimeritrin, astragalin, kaempferol 3-O-β-ᴅ-sophoroside and syringin in the species. The ethyl acetate fraction of the methanol extract exhibited a higher antioxidant activity than the butanol fraction measured by the α,α-diphenyl-β-picrazylhydrazyl (DPPH) free radical scavenging assay. Cytotoxicity and antioxidant activities of the main constituent, luteolin 7-O-β-D-glucoside, were evaluated.

scholarly journals Chemical Constituents of the Aerial Parts of Euphorbia Nematocypha

2016 ◽  
Vol 11 (2) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Chen Xu ◽  
Hai-Yang Jia ◽  
Bo Zuo ◽  
Zhi-Xin Liao ◽  
Lan-Ju Ji ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Ellagic Acid ◽  
Betulinic Acid ◽  
Methylene Chloride ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Aerial Parts ◽  
Methylene Chloride Extract ◽  
Oleanane Triterpenoid

Chemical constituents of the dried aerial parts of Euphorbia nematocypha were investigated. A new oleanane triterpenoid, trans, trans-2′,4′-hexadienedioicacid-1′-β-amyrin ester (1), together with, β-amyrin (2), β-amyrin acetate (3), betulinic acid (4), ellagic acid (5), oleanolic acid (6), β-sitosterol (7), kaempferol (8), quercetin (9), lupeol (10) and pseudo-taraxasterol (11) were isolated from the methylene chloride extract. Their structures were elucidated on the basis of extensive spectroscopic (1D- & 2D-NMR) and ESI-MS analysis and comparison with data reported in the literature. The new isolated triterpenoid showed moderate cytotoxic activities against HeLa and MCF-7cell lines.

Cytotoxic Constituents of Viscum coloratum

2012 ◽  
Vol 67 (3-4) ◽  
pp. 129-134 ◽  
Author(s):  
Yun L. Zhao ◽  
Xin Y. Wang ◽  
Li X. Sun ◽  
Rong H. Fan ◽  
Kai S. Bi ◽  
...  
Keyword(s):  
2D Nmr ◽  
Cytotoxic Activities ◽  
Human Tumour ◽  
The Family ◽  
Tumour Cell Lines ◽  
Phytochemical Studies ◽  
First Time ◽  
Human Tumour Cell Lines ◽  
Tof Ms ◽  
Mcf 7

4Phytochemical studies on Viscum coloratum have resulted in the isolation of nineteen compounds. The structures of the isolated compounds were identified on the basis of 1D, 2D NMR and HR-ESI-Q-TOF-MS. Pachypodol () and ombuine (6) were characterized in the family Loranthaceae for the first time. 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (8) and 5-hydroxy-3,7,3’-trimethoxyfl avone-4’-O-β-D-glucoside (13) were two new natural compounds, which exhibited cytotoxic activities against four human tumour cell lines (HeLa, SGC-7901, MCF-7, and U251)

scholarly journals Phytochemical Characterization, In Vitro Anti-Inflammatory, Anti-Diabetic, and Cytotoxic Activities of the Edible Aromatic Plant; Pulicaria jaubertii

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 203
Author(s):  
Hamdoon A. Mohammed ◽  
Mohammed F. Abdelwahab ◽  
El-Sayed M. El-Ghaly ◽  
Ehab A. Ragab
Keyword(s):  
Biological Activities ◽  
Hexane Extract ◽  
Hexane Fraction ◽  
Antidiabetic Activity ◽  
Cytotoxic Activities ◽  
Alcoholic Extract ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
First Time

Pulicaria jaubertii is a medicinal herb that alleviates inflammations and fever. Chromatographic separation, phytochemical characterization, and in vitro biological activities of the plant n-hexane extract were conducted for the first time in this study. Six compounds were isolated for the first time from the n-hexane fraction of Pulicaria jaubertii aerial parts and were identified on the bases of NMR and MS analyses as pseudo-taraxaterol (1), pseudo-taraxasterol acetate (2), 3β-acetoxytaraxaster-20-en-30-aldehyde (3), calenduladiol-3-O-palmitate (4), stigmasterol (5), and α-tocospiro B (6). Compound (6) was a rare tocopherol-related compound and was isolated for the first time from family Asteraceae, while compound (3) was isolated for the first time from genus Pulicaria. The total alcoholic extract and n-hexane fraction were tested for their anti-inflammatory, antidiabetic, and cytotoxic activities. The n-hexane fraction has dose dependent red blood cells (RBCs) membrane stabilization and inhibition of histamine release activities with IC50: 60.8 and 72.9 µg/mL, respectively. As antidiabetic activity, the alcoholic extract exerted the most inhibition on the activity of yeast α-glucosidase, with an IC50: 76.8 µg/mL. The n-hexane fraction showed cytotoxic activity against hepatocarcinoma (HepG-2), breast carcinoma (MCF-7), and prostate carcinoma (PC-3) cell lines with IC50: 51.8, 90.8 and 62.2 µg/mL, respectively. In conclusion, the anti-inflammatory effect of Pulicaria jaubertii might be attributed to the triterpenoid constituents of the n-hexane extract of the plant.

Isolation and Characterization of Two Verrucarins from Myrothecium roridum

2006 ◽  
Vol 61 (5-6) ◽  
pp. 309-314 ◽  
Author(s):  
Sylvia Schoettler ◽  
Marcelo Bascope ◽  
Olov Sterner ◽  
Timm Anke
Keyword(s):  
Breast Cancer Cells ◽  
Protein Biosynthesis ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Isolation And Characterization ◽  
Cytotoxic Compounds ◽  
Myrothecium Roridum ◽  
First Time

In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.

scholarly journals Phytochemical and Molluscicidal Investigations of Fagonia arabica

2007 ◽  
Vol 62 (9-10) ◽  
pp. 661-667 ◽  
Author(s):  
Eman A. El-Wakil
Keyword(s):  
Ethyl Acetate ◽  
Intermediate Host ◽  
Oleanolic Acid ◽  
Methanolic Extract ◽  
Ethyl Acetate Fraction ◽  
The Other ◽  
Flavonoid Glycosides ◽  
Biomphalaria Alexandrina ◽  
Aerial Parts ◽  
Molluscicidal Activity

The aqueous methanolic extract of the aerial parts of Fagonia arabica L. (family Zygophyllaceae) was successively fractionated using certain organic solvents. From the ethyl acetate fraction, two flavonoid glycosides were isolated and identified as kaempferol-7-O-rhamnoside and acacetin-7-O-rhamnoside. Four triterpenoidal glycosides were isolated from the butanolic layer. Their structures were elucidated on the basis of the spectral and chemical data as 3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranoside oleanolic acid (1), 3-O-α-L-arabinopyranosyl quinovic acid 28-O-β-D-glucopyranoside (2), 3-O-β-D-glucopyranosyl- (1→2)]-β-D-glucopyranosyl-(1→3)-α-L-arabinosyl oleanolic acid (3) and 3-O-β-D-glucopyranosyl-( 1→3)-α-L-arabino-pyranosyl quinovic acid 28-O-β-D-glucopyranoside (4). The two monodesmosidic saponins 1 and 3 were found to possess strong molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni in Egypt (LC90 = 13.33 and 16.44 μM), whereas the other two bidesmosidic saponins 2 and 4 as well as the two flavonoid glycosides were inactive up to 50 μM.

scholarly journals Flavonoid Constituents of Pistacia integerrima

2012 ◽  
Vol 7 (8) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Zia Ullah ◽  
Rashad Mehmood ◽  
Muhammad Imran ◽  
Abdul Malik ◽  
Rehana A. Afzal
Keyword(s):  
Spectroscopic Analysis ◽  
Methanolic Extract ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Acidic Hydrolysis ◽  
Aerial Parts ◽  
First Time

Pistacides A and B (1–2), two new flavonoid glycosides, have been isolated from the methanolic extract of the aerial parts of Pistacia integerrima, along with 2′-hydroxyisoorientin (3), echioidinin 2′- O-β-D-(6″- O-acetyl) glucopyranoside (4), chrysoeriol (5), and diandraflavone A (6), reported for the first time from this species. Their structures were elucidated by spectroscopic analysis including 2D NMR, FAB-MS, and acidic hydrolysis.

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