A New Immunosuppressive Pregnane Glycoside and Two Known Analogues from Epigynum cochinchinensis
2018 ◽
Vol 13
(6)
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pp. 1934578X1801300
Keyword(s):
Con A
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Phytochemical investigation of the ethyl acetate soluble fraction from the leaves of Epigynum cochinchinensis led to the isolation of one new C21 pregnane glycoside, epigycoside C (1), along with two known analogues epigycoside A (2) and epigynoside G (3). Their structures were elucidated on the basis of extensive spectroscopic techniques. The in vitro immunosuppressive activity of compound 1 was evaluated against concanavalin A (Con A)- and lipopolysaccharides (LPS)-stimulated proliferation of mice splenocytes. Compound 1 displayed significant immunosuppressive activities in a dose-dependent manner.
2007 ◽
Vol 51
(9)
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pp. 3122-3130
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Keyword(s):
Keyword(s):
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2001 ◽
Vol 91
(6)
◽
pp. 2703-2712
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Keyword(s):