Beyond the antioxidant properties: Pomegranate juice polyphenols increase hepatocyte paraoxonase 1 secretion

2010 ◽  
Vol 208 (1) ◽  
pp. 28-29 ◽  
Author(s):  
Alejandro Gugliucci
Keyword(s):  
Antioxidant Properties ◽  
Pomegranate Juice ◽  
Paraoxonase 1

Investigation of Antioxidant Activity of Pomegranate Juices by Means of Electron Paramagnetic Resonance and UV-Vis Spectroscopy

2015 ◽  
Vol 98 (4) ◽  
pp. 866-870 ◽  
Author(s):  
Violetta Kozik ◽  
Krystyna Jarzembek ◽  
Agnieszka Jędrzejowska ◽  
Andrzej Bąk ◽  
Justyna Polak ◽  
...  
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Free Radical ◽  
Epr Spectroscopy ◽  
Antioxidant Properties ◽  
Free Radical Scavenger ◽  
Pomegranate Juice ◽  
Radical Scavenger ◽  
Paramagnetic Resonance ◽  
Vis Spectroscopy ◽  
Electron Paramagnetic

Abstract Pomegranate fruit (Punica granatum L.) is a source of numerous phenolic compounds, and it contains flavonoids such as anthocyanins, anthocyanidins, cyanidins, catechins and other complexes of flavonoids, ellagitannins, and hydrolyzed tannins. Pomegranate juice shows antioxidant, antiproliferative, and anti-atherosclerotic properties. The antioxidant capacity (TEAC) of the pomegranate juices was measured using electron paramagnetic resonance (EPR) spectroscopy and 1,1-diphenyl-2-picrylhydrazyl (DPPH•) as a source of free radicals, and the total phenolic (TP) content was measured using UV-Vis spectroscopy. All the examined pomegranate juices exhibited relatively high antioxidant properties. The TEAC values determined by means of EPR spectroscopy using Trolox (TE) as a free radical scavenger were in the range of 463.12 to 1911.91 μmol TE/100 mL juice. The TP content measured by the Folin-Ciocalteu method, using gallic acid (GA) as a free radical scavenger, widely varied in the investigated pomegranate juice samples and ranged from 1673.62 to 5263.87 mg GA/1 L juice. The strongest antioxidant properties were observed with the fresh pomegranate juices obtained from the fruits originating from Israel, Lebanon, and Azerbaijan. Correlation analysis of numerical data obtained by means of EPR spectroscopy (TEAC) and UV-Vis spectroscopy (TP) gave correlation coefficient (r) = 0.90 and determination coefficient (r2) = 0.81 (P <0.05).

scholarly journals Sitagliptin-Dependent Differences in the Intensity of Oxidative Stress in Rat Livers Subjected to Ischemia and Reperfusion

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Małgorzata Trocha ◽  
Małgorzata Krzystek-Korpacka ◽  
Anna Merwid-Ląd ◽  
Beata Nowak ◽  
Małgorzata Pieśniewska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Ischemia Reperfusion ◽  
Antioxidant Properties ◽  
Thiobarbituric Acid ◽  
Treated Group ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Tbars Level ◽  
Rat Livers

Purpose. Ischemia/reperfusion (IR) is the main cause of liver damage after transplantation. We evaluated the effect of sitagliptin (STG) on oxidative stress parameters in the rat liver under IR. Methods. Rats were treated with STG (5 mg/kg) (S and SIR) or saline solution (C and CIR). Livers from CIR and SIR were subjected to ischemia (60 min) and reperfusion (24 h). During reperfusion, aminotransferases (ALT and AST) were determined in blood samples. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), paraoxonase-1 (PON1), glutathione peroxidase (GPx), and the mRNA expression of SOD1 were determined in liver homogenates after reperfusion. Different regions of livers were also histologically evaluated. Results. The PON1 activity was higher, and the TBARS level was lower in SIR than in CIR. There was an inverse relationship between TBARS and PON1 levels in the whole cohort. The GPx activity was lower in ischemic than in nonischemic groups regardless of the STG treatment. In SIR, the SOD1 activity was higher compared to that in CIR. In S, the expression of SOD1 mRNA was the highest of all examined groups and positively correlated with the SOD1 activity in the whole animal cohort. During IR aminotransferases, the activity in the drug-treated group was lower in all examined points of time. In drug-treated groups, the percentage of steatosis was higher than that in nontreated groups regardless of IR. Conclusions. The protective effect of STG on the rat liver, especially its antioxidant properties, was revealed under IR conditions.

scholarly journals Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients

2008 ◽  
Vol 50 (4) ◽  
pp. 223-227 ◽  
Author(s):  
Elaine Nunes Daminelli ◽  
Celso Spada ◽  
Arício Treitinger ◽  
Tatiane Vanessa Oliveira ◽  
Maria da Conceição Latrilha ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Antioxidant Properties ◽  
Density Lipoprotein ◽  
High Density ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Premature Coronary Artery Disease ◽  
Cholesteryl Esters ◽  
Hiv Patients ◽  
Hdl Function

HIV+ patients often develop alterations of the plasma lipids that may implicate in development of premature coronary artery disease. High-density lipoprotein (HDL) has an important role in preventing atherogenesis and the aim of this study was to investigate aspects of HDL function in HIV+ patients. HIV+ patients (n = 48) and healthy control subjects (n = 45) of both sexes with similar age were studied. Twenty-five were not being treated with antiretroviral agents, 13 were under reverse transcriptase inhibitor nucleosidic and non-nucleosidic (NRTI+NNRTI) and 10 were under NRTI + protease inhibitors (NRTI+PI) treatment. Paraoxonase 1 (PON1) activity and the transfer of free and esterified cholesterol, tryglicerides and phospholipids from a lipidic nanoemulsion to HDL were analyzed. In comparison with healthy controls, HIV+ patients presented low PON-1 activity and diminished transfer of free cholesterol and tryglicerides. In contrast, phospholipid transfer was increased in those patients, whereas the transfer of cholesteryl esters was unchanged. NRTI+NNRTI increases the transfer of cholesteryl esters and triglycerides but in NRTI+PI there was no difference in respect to non-treated HIV+ patients. HDL from HIV+ patients has smaller antioxidant properties, as shown by lower PON-1 activity, and the transfer of lipids to this lipoprotein fraction is also altered, suggesting that HDL function is defective in those patients.

scholarly journals Quality Parameters and Consumer Acceptance of Jelly Candies Based on Pomegranate Juice “Mollar de Elche”

Foods ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 516 ◽  
Author(s):  
Marina Cano-Lamadrid ◽  
Ángel Calín-Sánchez ◽  
Jesús Clemente-Villalba ◽  
Francisca Hernández ◽  
Ángel A. Carbonell-Barrachina ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Quality Parameters ◽  
Quality Parameter ◽  
Pomegranate Juice ◽  
High Brightness ◽  
Red Color ◽  
Pomegranate Fruit ◽  
Derivative Products ◽  
Natural Way

There is an upward trend towards reducing or suppressing additives in foods, as well as reducing the use of E-numbers in labels providing clean label foods. Therefore, the development of confectionary products based exclusively on natural ingredients with antioxidant properties may offer valuable solutions to the confectionery industry. Fruit juices and purées may provide functional and organoleptic properties in jelly candies in a natural way. The consumption of pomegranate fruit and derivative products has increased due to their association with health benefits. The aim of this study was to determine consumer insights about pomegranate-based jellies, cultivar “Mollar de Elche”, as affected by formulation (100% pomegranate juice or 50%–50% pomegranate juice–apple purée) and type of sweetener (sugar or honey), and to link affective and descriptive data from sensory studies. The most valued quality parameter of pomegranate products, red color (measured by the green–red coordinate, a*), was not negatively affected by jelly preparation. It was determined that the main liking drivers for pomegranate jellies were intense red color and high brightness. The results might be used by pomegranate processing companies to improve their manufacturing protocols and to develop successful products meeting consumer demands and needs. The formulation containing 20% gelatin, pure “Mollar de Elche” pomegranate juice, 1% citric acid, and sucrose as sweetener provided the best quality of jellies in terms of color, texture, antioxidant capacity, and sensory attributes.

ROLE OF BILIRUBIN AS A POTENTIALANTIOXIDANT IN SMOKERS

2021 ◽  
pp. 43-45
Author(s):  
Varshini. S ◽  
A. Preethi ◽  
G. Udayakumari
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Properties ◽  
Antioxidant Property ◽  
Mean Value ◽  
Paraoxonase 1 ◽  
P Value ◽  
College Hospital ◽  
Chronic Respiratory Diseases ◽  
The Mean

Introduction: Globally, smoking causes about 71% of lung cancer, 42% of chronic respiratory diseases and about 10% of cardiovascular disease. Smokers are exposed to potential oxidative damage. This leads to depletion of the body's defense against oxidative stress, like decrease in the levels of Paraoxanase -1. This study aimed to assess the antioxidant property of Bilirubin in comparison to Paraoxonase-1 in smokers. Materials & methods: This case control study was carried out at Govt. Kilpauk Medical College Hospital after obtaining ethical committee approval and informed consent. This study involves 2 groups with 90 chronic smokers and 90 apparently healthy individuals who are not smokers. Serum Bilirubin and Paraoxanase -1 levels were estimated and compared between these two groups. Correlation between Bilirubin and Paraoxanase-1 was analyzed. Statistical analysis was done using SPSS package version 20. Results: The mean value for Bilirubin is 0.566 +/- 0.03 mg/dL in smokers and 0.620 +/- 0.05 mg/dL in non-smokers. There is signicant difference in bilirubin levels between smokers and non smokers (p value - 0.049). The mean value for Paraoxonase-1 is 3.291+/- 0.75 ng/dL in smokers and 4.513+/- 0.96 ng/dL in non-smokers. There is signicant difference in Paraoxanase -1 levels between smokers and non smokers (p value - 0.025). The scatter plot between Paraoxanase -1 and Bilirubin shows no signicant correlation. Conclusion: The Paraoxanase -1 and Bilirubin values in smokers are considerably reduced in comparison to that of non-smokers. This shows that Paraoxanase -1 and Bilirubin exhibits potential antioxidant properties. Bilirubin estimation is inexpensive and can be easily measured rather than measuring other known antioxidants such as PON-1. Role of Bilirubin as a marker to detect the oxidative stress levels in smokers is established in this study

Quality and antioxidant properties of a reduced-sugar pomegranate juice jelly with an aqueous extract of pomegranate peels

2013 ◽  
Vol 136 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Janeth Ventura ◽  
Francisco Alarcón-Aguilar ◽  
Rubén Roman-Ramos ◽  
Efraín Campos-Sepulveda ◽  
Maria L. Reyes-Vega ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antioxidant Properties ◽  
Pomegranate Juice

scholarly journals Antioxidant Properties of Synthesized Bicyclic Thiazolopyrimidine Derivatives as Possible Therapeutic Agents

2018 ◽  
Vol 9 (1) ◽  
pp. 113 ◽  
Author(s):  
Darinka Gjorgieva Ackova ◽  
Jelena Kotur-Stevuljevic ◽  
Chandra Bhushan Mishra ◽  
Pratibha Mehta Luthra ◽  
Luciano Saso
Keyword(s):  
Antioxidant Activity ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Redox Status ◽  
The Body ◽  
Paraoxonase 1 ◽  
Lipid Hydroperoxides ◽  
Frap Assay ◽  
Antioxidant Power ◽  
Antioxidative Status

Oxidant/antioxidant imbalance in the body has been implicated as one of the pathophysiological mechanisms leading to disease development. Therefore, we searched for a good antioxidant candidate that can be used as a therapeutic agent alone or in combination with other reported drugs. Earlier, we reported the A2A receptor antagonist properties of 7-Imino-3-substituted-2-thioxo-3,7-dihydro-2H-thiazolo[4,5-d]pyrimidin-6-yl)-urea derivatives (compounds 1–12) and the neuroprotective effect of compound 2. Therefore, in the present work, the antioxidant potential of compounds 1–12 was studied. Compounds 1–12 were screened using different (red/ox) tests, such as the Ferric Reducing Antioxidant Power (FRAP) assay, to determine total antioxidant activity, redox status tests (with and without prooxidants) such as Advanced Oxidation Protein Products (AOPP) and Total Oxidative Status (TOS) which measures H2O2 and lipid hydroperoxides, Paraoxonase-1 Enzyme Activity (PON1), Total SH-groups content, and Total Antioxidative Status (TAS) for antioxidant determination. The Prooxidative Score, Antioxidative Score, and Oxy Score were also calculated. From the obtained results, compounds 6 (8720 FRAP value and 39.31 Oxy Score) and 12 (7866 FRAP value and 36.41 Oxy Score) were found to possess significant antioxidant activity with reasonable potential for therapeutic activity.

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