scholarly journals Contributors, risk associates, and complications of frailty in patients with chronic kidney disease: a scoping review

2019 ◽  
Vol 10 ◽  
pp. 204062231988038 ◽  
Author(s):  
Patrick Yihong Wu ◽  
Chia-Ter Chao ◽  
Ding-Cheng Chan ◽  
Jenq-Wen Huang ◽  
Kuan-Yu Hung
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sociodemographic Factors ◽  
Cross Sectional ◽  
Multifaceted Approach ◽  
Organ Specific ◽  
Health Related ◽  
Stage Renal Disease ◽  
End Stage

Frailty exhibits diverse influences on health-related outcomes and represents a surrogate of increased susceptibility to harmful injuries. Patients with chronic kidney disease (CKD) are at a higher risk of accelerated biologic aging, and, in this population, the concept of frailty emerges as an instrumental measurement of physiologic reserves. However, a comprehensive description of known independent contributors to, and risk associates of, frailty in these patients remain unavailable. In the present review, original studies up to 28 February 2019 that assessed frailty in patients with all stages of CKD were retrieved and reviewed, with results extracted and summarized. By pooling 62 original investigations, 58.1% and 49.1% used cohort and cross-sectional designs, respectively. Dialysis-dependent end-stage renal disease patients ( n = 39; 62.9%) were the most commonly examined population, followed by those with nondialysis CKD ( n = 12; 19.4%) and those receiving renal transplantation ( n = 11; 17.7%). Contributors to frailty in CKD patients included sociodemographic factors, smoking, CKD severity, organ-specific comorbidities, depression, hypoalbuminemia, and low testosterone levels. Conversely, the development of frailty was potentially associated with the emergence of cardiometabolic, musculoskeletal, and cerebral complications; mental distress; and a higher risk of subsequent functional and quality-of-life impairment. Moreover, frailty in CKD patients increased healthcare utilization and consistently elevated mortality among affected ones. Based on the multitude of contributors to frailty and its diverse health influences, a multifaceted approach to manage CKD patients with frailty is needed, and its potential influences on outcomes besides mortality need to be considered.

scholarly journals Effect of Exercise on Health-Related Quality of Life in Patients with End-Stage Renal Disease

2021 ◽  
Author(s):  
Dhanya Michael ◽  
Joseph S. Fidelis ◽  
Sijo Joseph Pakalomattom
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fitness Function ◽  
Well Being ◽  
Related Quality ◽  
Health Related ◽  
Stage Renal Disease ◽  
End Stage

Chronic kidney disease (CKD) is becoming more common around the world. Chronic kidney disease (CKD) is linked to a wide range of other health problems, such as diabetes, hypertension, stroke, and pulmonary illness. Patients with CKD tend to lead sedentary lives for a variety of reasons. Dialysis patients, on the other hand, are much less active than the general population. All of these factors raise the likelihood of future morbidity and mortality, while also lowering the overall quality of life for people who are ill (HRQoL). Regular physical activity (PE) has been shown to increase overall well-being and HRQoL. Here, we discuss several PEs and their effects on CKD patients\' physical fitness, function, and HRQoL, as well as the significance of haematocrit normalisation and the influence on their serum phosphorus levels. We have discussed the advantages of PE for this particular population of individuals as well as the side effects of intradialytic PE. There have also been discussions on factors that contribute to impaired physical function in CKD patients and the impact of PEs on different bodily systems.

scholarly journals An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost

Anemia ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Geoffrey Teehan ◽  
Robert L. Benz
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Randomized Trials ◽  
Lessons Learned ◽  
Patients With Diabetes ◽  
Anemia Management ◽  
Erythropoietin Deficiency ◽  
Stage Renal Disease ◽  
End Stage

Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial.Methods. We review three recent randomized trials in anemia in CKD: CHOIR, CREATE, and TREAT.Results. CHOIR (N=1432) was terminated early with more frequent death and cardiovascular outcomes in the higher Hb group (HR 1.34: 95% C.I. 1.03–1.74,P=.03). CREATE (N=603) showed no difference in primary cardiovascular endpoints. Stroke was more common in the higher Hb group (HR 1.92; 95% C.I. 1.38–2.68;P<.001) in TREAT (N=4038).Conclusions. There is no benefit to an Hb outside the 10–12 g/dL range in this population. To avoid transfusions and improve Quality of Life, ESAs should be used cautiously, especially in patients with Diabetes, CKD, risk factors for stroke, and ESA resistance.

scholarly journals Quality of Care in Chronic Kidney Disease and Incidence of End-Stage Renal Disease in Older Patients

Medical Care ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Shingo Fukuma ◽  
Tatsuyoshi Ikenoue ◽  
Sayaka Shimizu ◽  
Edward C. Norton ◽  
Rajiv Saran ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Quality Of Care ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Older Patients ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Quality of life predicts risks of end-stage renal disease and mortality in patients with chronic kidney disease

2010 ◽  
Vol 26 (1) ◽  
pp. 392-392
Author(s):  
Y.-C. Tsai ◽  
C.-C. Hung ◽  
S.-J. Hwang ◽  
S.-L. Wang ◽  
S.-M. Hsiao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Trends in the epidemiology of chronic kidney disease in Russian Federation according to the Federal Diabetes Register (2013–2016)

2018 ◽  
Vol 21 (3) ◽  
pp. 160-169 ◽  
Author(s):  
Minara S. Shamkhalova ◽  
Olga K. Vikulova ◽  
Anna V. Zheleznyakova ◽  
Michail A. Isakov ◽  
Marina V. Shestakova ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Russian Federation ◽  
Stage Renal Disease ◽  
End Stage ◽  
Increasing Trends ◽  
Diabetes Register ◽  
Epidemiological Characteristics

BACKGROUND: Chronic kidney disease (CKD) is one of the most severe complications of diabetes mellitus (DM), this determines the importance of the study of epidemiological characteristics of the disease. AIMS: To assess the epidemiological characteristics of CKD in adult DM patients with type 1 (T1), 2 (T2) in Russian Federation in 201316. METHODS: We have used the database of the Russian Federal Diabetes register, 81st regions included in online register. Indicators were estimated per 10,000 adult DM patients (18years). RESULTS: In 2016, the CKD frequency registration was T1 23%, T2 6.9% with marked interregional differences 1.5-49.9%, 0.623.5%, respectively. The CKD prevalence in dynamics 20132016 was 2171.42303.0 in T1 and 512.687.2 in T2. The incidence of new CKD cases increased 2 times in T1 (215.5 vs 104.2), and 3.7 times in T2 (190.4 vs 51.8). The analysis of distribution by CKD stages by KDIGO indicates the increase in the proportion of patients with low and moderate cardiovascular risk and end stage renal disease (ESRD) (with the initial stages of CKD, C1/2 A1) - 12.046.8% in T1; 10.050.4% in T2. The proportion of patients with a very high risk (stages C4/5 C3aA3 and C3bA2-3) progressively decreases: 13.46.7% in T1, 11.34.4% in T2. We observed relation between the CKD prevalence and DM duration. CKD develops in 5.1% patients if T15 years and in 48.0% if T130years; in T2 3.5% and 20.3%, respectively. The average age of CKD onset in T1 increased for 4,3yr (36,140,2), in T2 for 2,4yr (64,466,8), DM duration until CKD development increased in T1 11.814.2yr, in T2 7.68.2yr. CONCLUSIONS: There is a significant improvement in the quality of CKD diagnostics at the earlier stages, older age and a longer DM duration before CKD onset in both types while we observed the increasing trends in CKD prevalence in Russian Federation in the dynamics of 2013-2016. Advances in the management of patients with DM in recent years do not reduce the risk of CKD, but give us a delay in its development. The marked interregional differences frequency of registration of CKD might indicate some remaining problems in verification in a number of regions where the standard for mandatory assessment of albuminuria and glomerular filtration rate not implemented.

scholarly journals HUBUNGAN ANTARA DERAJAT PENYAKIT GINJAL KRONIK DENGAN NILAI AGREGASI TROMBOSIT DI RSUP PROF. DR. R. D. KANDOU MANADO

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Melti Tandi ◽  
Arthur Mongan ◽  
Firginia Manoppo
Keyword(s):  
Chronic Kidney Disease ◽  
Platelet Aggregation ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Long Life ◽  
End Stage ◽  
Hospital Clinic

Abstract: Chronic kidney disease has got a lot of attention and more widely studied despite reached end stage renal failure, patients still live a long life witha fairly good quality of life although the prevalence is increases throughout the year. one of the circumstances in chronic kidney disease is uremia which is a clinical and laboratory syndrome that occurs inorgans. In uremia interference with platelet function, the production ofprostacyclinin blood vesselswould increase, and excessurea levels in blood would be a potential vasodilator and platelet aggregation antagonist. Methods: An analytic observational cross-sectional study. Samples were patients that diagnosed with chronic kidney disease at the Hospital Clinic of Nephrology-Hypertension Prof. Dr.R. D.Kandou Manado in December toFebruary 2014. Criteria included were patients  <80 years old and has been diagnosed with chronic kidney disease in this case had done a physical examination and investigations by doctors, using medical record of urea-creatinine and also a complete blood countand platelet aggregation in Prokita Laboratory Manado. Forstatistical analysisusedShapiro-Wilk testalsoPearsonCorrelationstest. Result: There were 20 patients with chronic kidney disease sampled in this study. It was found that there is a relationship between of urea-creatinine and aggregation results in trace ADP5(P=0.004) while the value ADP10 no significant correlation(P =0.399). Conclusion: In chronic kidney disease patients, urea-creatininewiththe value of platelet aggregation intrace ADP5had a relation ship while intrace ADP10 had not a relationship. Keywords: Chronic kidney disease, platelet aggregation.

scholarly journals Chronic Kidney Disease-Associated Pruritus

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 527
Author(s):  
Puneet Agarwal ◽  
Vinita Garg ◽  
Priyanka Karagaiah ◽  
Jacek C. Szepietowski ◽  
Stephan Grabbe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
End Stage Renal Disease ◽  
English Language ◽  
Advanced Chronic Kidney Disease ◽  
Primary Care Doctors ◽  
Stage Renal Disease ◽  
End Stage ◽  
Distressing Condition

Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients. It has been reported to range from 20% to as high as 90%. The mechanism of CKD-associated pruritus (CKD-aP) has not been clearly identified, and many theories have been proposed to explain it. Many risk factors have been found to be associated with CKD-aP. The pruritus in CKD presents with diverse clinical features, and there are no set features to diagnose it.The patients with CKD-aP are mainly treated by nephrologists, primary care doctors, and dermatologists. Many treatments have been tried but nothing has been effective. The search of literature included peer-reviewed articles, including clinical trials and scientific reviews. Literature was identified through March 2021, and references of respective articles and only articles published in the English language were included.

scholarly journals Quality of life of elderly people with chronic kidney disease in conservative treatment

2017 ◽  
Vol 70 (4) ◽  
pp. 851-859 ◽  
Author(s):  
Roberta Maria de Pina Pereira ◽  
Marcelo Aparecido Batista ◽  
Aline de Sousa Meira ◽  
Marília Pilotto de Oliveira ◽  
Luciana Kusumota
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Conservative Treatment ◽  
Elderly People ◽  
Death And Dying ◽  
Inverse Correlation ◽  
Cross Sectional ◽  
Health Related

ABSTRACT Objective: To describe the quality of life (QOL) of elderly people with Chronic Kidney Disease (CKD) in conservative treatment, correlating it with sociodemographic and health-related aspects. Method: This is a quantitative, cross-sectional, and descriptive study that used: a previously validated instrument for data collection; the WHOQOL-BREF and WHOQOL-OLD QOL scales; and the Mini-Mental State Examination. Results: Thirty-five elderly people (54.30% females), with mean age of 68.26 years, took part in the study. They reported, on average, 3.70 comorbidities and 5.60 complications related to CKD. Regarding QOL, the "psychological" domain (54.40±16.29) and the "death and dying" facet (37.32±23.79) were considered the most damaged ones; the most strengthened were "social relationships" (70.36±18.32) and "intimacy" (66.61±16.80). A positive correlation was verified between comorbidities and complications (p = 0.015), and an inverse correlation between the number of complications and QOL (p = 0.004). Conclusion: These results, if considered during the care planning, may help improving the quality of the care provided for elderly people with CKD.

Chronic kidney disease care program improves quality of pre-end-stage renal disease care and reduces medical costs

Nephrology ◽  
2010 ◽  
Vol 15 (1) ◽  
pp. 108-115 ◽  
Author(s):  
SHU-YI WEI ◽  
YONG-YUAN CHANG ◽  
LIH-WEN MAU ◽  
MING-YEN LIN ◽  
HERNG-CHIA CHIU ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Care Program ◽  
Medical Costs ◽  
Chronic Kidney Disease Care ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Health Related Quality of Life Among Chronic Kidney Disease Patients Undergoing Hemodialysis in Pakistan.

2021 ◽  
Vol 5 (4) ◽  
pp. 100-104
Author(s):  
Raheel Ahmed ◽  
Tanveer Ahmed ◽  
Najm Ud Din ◽  
Syed Munib ◽  
Inayat Ur Rehman Inayat Ur Rehman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Maintenance Hemodialysis ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

Background: Hemodialysis is a well-established replacement therapy for patient with end stage kidney disease havin a great impact on the patient’s quality of life. Therefore, the purpose of this study is to identify the health-related quality of life of patients undergoing maintenance hemodialysis. Methods: A cross sectional single centere survey was carried out from March 2018 to June 2018 at Department of Nephrology, Institute of Kidney diseases, Peshawar in Pakistan. A 36 item KDQOL validated Urdu version was used to identify the quality of life of patients. Results: A total of n=184 patients having chronic kidney disease undergoing hemodialysis participated,of whom 63.6% were males and 57.1% patients were Pashtun. A multiple linear regression showed that patients having kidney disease caused due to hypertension had 45% higher kidney disease component summary (KDCS) score while 16% higher physical component summary (PCS) score and 60% higher mental component summary (MCS) score  and were statistically significant. Similarly; Peshawari patients had 22% lower PCS score as compared to other ethnic groups ; however, in MCS Peshawari patients had 16% higher score  and were statistically significant. Conclusion: The patients have poor quality of life receiving hemodialysis therapy in all three domains like PCS, MCS and KDCS.

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