Associations between plasma levels of C-reactive protein and catecholamine metabolites in patients with major depression

Background:: Ursolic Acid (UA) is a pentacyclic triterpenoid carboxylic acid which is extracted from plants. UA may enhance the effect of Resistance Training (RT) in human. Objective: Current research was designed to show the effect of High-Intensity Resistance Training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6 and TNF-α in the low activity men. Method:: The study included twenty-two healthy male HIRT with placebo, supplementation, and HIRT in the presence of UA supplementation. The two groups received eight-week intervention including 2 sets of 8 exercises, with 8~10 repetitions at 70~75% of 1 repetition maximum and a 2 min rest interval between sets, performed 3 times/week. Placebo or UA orally was evaluated as 1 capsule 3 times/day during 8 weeks. The subsequent factors were measured post- and preintervention: C-Reactive Protein (CRP), Irisin, Tumor Necrotic Factor (TNF-α) and Interleukin-6 (IL-6). Results:: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p<0.05). UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-α in the HIRT+UA group versus the HIRT+P group (p<0.05). Conclusion:: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-α may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.

Download Full-text

Short term effect of atorvastatin on plasma levels of MCP-1, ICAM-1 and C-reactive protein in patients with coronary artery disease

Atherosclerosis ◽

10.1016/s0021-9150(00)80209-9 ◽

2000 ◽

Vol 151 (1) ◽

pp. 46

Author(s):

A Figueredo ◽

L Reinares ◽

A Rueda ◽

A Rodriguez ◽

M Ruiz-Yagüe ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Plasma Levels ◽

Term Effect ◽

C Reactive Protein ◽

Short Term ◽

Short Term Effect ◽

Reactive Protein ◽

Artery Disease

Download Full-text

Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study

Physiological Genomics ◽

10.1152/physiolgenomics.00054.2005 ◽

2006 ◽

Vol 27 (2) ◽

pp. 103-107 ◽

Cited By ~ 10

Author(s):

Timo A. Lakka ◽

Tuomo Rankinen ◽

Treva Rice ◽

Arthur S. Leon ◽

D. C. Rao ◽

...

Keyword(s):

Plasma Levels ◽

Family Study ◽

Inflammatory Diseases ◽

Low Grade ◽

C Reactive Protein ◽

Lod Score ◽

Chronic Inflammatory Diseases ◽

Reactive Protein ◽

A Genome ◽

Chromosome 20Q13

C-reactive protein (CRP) is a sensitive marker of systemic low-grade inflammation. Increased plasma levels of CRP predict the risk of cardiovascular and metabolic diseases. Although genetic factors account for 30–40% of individual differences in plasma CRP levels, genomic regions contributing to CRP levels remain unknown. We performed a genome-wide linkage scan for plasma CRP levels in healthy whites from the HERITAGE Family Study. CRP was measured with a high-sensitivity assay. Multipoint linkage analyses were performed in 280 sibling pairs with 654 markers using regression and variance components-based methods. Data were adjusted for independent correlates of plasma CRP. We showed the strongest evidence of linkage for plasma CRP levels on chromosome 20q13. Markers which gave suggestive linkages in this region were D20S52 [logarithm of odds (LOD) score 3.18, P = 0.00006], D20S857 (LOD score 2.87, P = 0.00014), D20S869 (LOD score 2.75, P = 0.0002), D20S480 (LOD score 2.59, P = 0.0003), D20S501 (LOD score 2.55, P = 0.0003), D20S840 (LOD score 2.18, P = 0.0008), and D20S876 (LOD score 2.07, P = 0.001). We also detected suggestive linkage on chromosome 5p13 for marker D5S1470 (LOD score 2.23, P = 0.0007). Chromosome 20q13 may contribute to plasma CRP levels in healthy whites. This region contains genes that are important in the inflammatory process and may play a role in the development of chronic inflammatory diseases. The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases.

Download Full-text

Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression

Brain Behavior and Immunity ◽

10.1016/j.bbi.2017.02.020 ◽

2017 ◽

Vol 62 ◽

pp. 344-350 ◽

Cited By ~ 64

Author(s):

Ole Köhler-Forsberg ◽

Henriette N. Buttenschøn ◽

Katherine E. Tansey ◽

Wolfgang Maier ◽

Joanna Hauser ◽

...

Keyword(s):

Depressive Symptoms ◽

Major Depression ◽

Symptom Severity ◽

Depression Symptom ◽

C Reactive Protein ◽

Reactive Protein

Download Full-text

Possible contribution of C-reactive protein within coronary plaque to increasing its own plasma levels across coronary circulation

The American Journal of Cardiology ◽

10.1016/j.amjcard.2003.11.030 ◽

2004 ◽

Vol 93 (5) ◽

pp. 611-614 ◽

Cited By ~ 28

Author(s):

Tetsunori Ishikawa ◽

Takuroh Imamura ◽

Kinta Hatakeyama ◽

Haruhiko Date ◽

Toshiro Nagoshi ◽

...

Keyword(s):

Plasma Levels ◽

Coronary Circulation ◽

Coronary Plaque ◽

C Reactive Protein ◽

Reactive Protein

Download Full-text

107 C-reactive protein (CRP) gene promoter (−286)C>T>A mutation is associated with protein plasma levels in sicilian population

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/s0939-4753(05)80107-3 ◽

2005 ◽

Vol 15 ◽

pp. S24

Keyword(s):

Plasma Levels ◽

Gene Promoter ◽

C Reactive Protein ◽

Reactive Protein ◽

Sicilian Population

Download Full-text

Evaluation of tumor necrosis factor-α, interleukin-6 and C-reactive protein plasma levels as predictors of bacteremia in patients presenting signs of sepsis without shock

Clinical Microbiology and Infection ◽

10.1111/j.1469-0691.1997.tb00618.x ◽

1997 ◽

Vol 3 (3) ◽

pp. 306-313 ◽

Cited By ~ 12

Author(s):

Baudouin Byl ◽

Jacques Devière ◽

Francis Saint-Hubert ◽

Francis Zech ◽

Béatrice Gulbis ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Interleukin 6 ◽

Plasma Levels ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

C Reactive Protein ◽

Reactive Protein ◽

Factor Α ◽

Necrosis Factor

Download Full-text

Immune Markers in Pregnancy A Study on Neopterin, β2-Microglobulin, Deoxythymidine Kinase and C-Reactive Protein

Pteridines ◽

10.1515/pteridines.1989.1.2.125 ◽

1989 ◽

Vol 1 (2) ◽

pp. 125-128

Author(s):

Margareta Norman ◽

Katarina Bremme ◽

Peter Eneroth

Keyword(s):

Immune System ◽

Plasma Levels ◽

Post Partum ◽

Maternal Serum ◽

C Reactive Protein ◽

Immune Markers ◽

Maternal Circulation ◽

Reactive Protein ◽

Increased Activity ◽

In Pregnancy

Summary Neopterin and β2-microglobulin but neither C-reactive protein nor deoxythymidine kinase increased in maternal serum from pregnancy week 20 to 40. Only maternal C-reactive protein concentrations changed during vaginal delivery and after 4 days post partum. Retroplacental plasma levels of neopterin, deoxythymidine kinase and β2-microglobulin were significantly higher than in maternal peripheral serum which was interpreted as an indication of increased activity of the immune system as influenced by the fetoplacental unit. The concentrations of neopterin, deoxythymidine kinase and β2-microglobulin were significantly higher in mixed artero-venous umbilical plasma than in the retroplacental plasma, possibly reflecting activation signals to immunocompetent cells in the neonates. The possibility of a transfer of these compounds from fetal to maternal circulation was also pointed out.

Download Full-text