scholarly journals Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation

2019 ◽  
Vol 8 ◽  
pp. 204800401984304 ◽  
Author(s):  
Sofia Giannitsi ◽  
Bougiakli Maria ◽  
Aris Bechlioulis ◽  
Katerina Naka
Keyword(s):  
Heart Failure ◽  
Endothelial Dysfunction ◽  
Wide Spectrum ◽  
Mortality Rates ◽  
Targeted Treatment ◽  
Flow Mediated Dilation ◽  
Potential Target ◽  
Therapeutic Development ◽  
Underlying Pathophysiology

Heart failure affects 1–2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30–50%, mortality rates remain high. A complex blend of structural and functional alterations accounts for the genesis and progression of heart failure, but the exact underlying pathophysiology remains poorly understood. The aim of this review is to summarize endothelial dysfunction and its role in the pathogenesis and progression of heart failure. Moreover, it sums up all the appropriate methods of assessing endothelial dysfunction emphasizing on flow-mediated dilation and introduces endothelium as a potential target for new therapeutic development and research in the wide spectrum of the syndrome called heart failure.

scholarly journals Many faces of acute bowel ischemia: overview of radiologic staging

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Amir H. Davarpanah ◽  
Afshar Ghamari Khameneh ◽  
Bardia Khosravi ◽  
Ali Mir ◽  
Hiva Saffar ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Bowel Ischemia ◽  
Management Approach ◽  
Final Decision ◽  
Imaging Findings ◽  
Life Threatening ◽  
Imaging Signs ◽  
Late Stages ◽  
Underlying Pathophysiology ◽  
Made In

AbstractAcute bowel ischemia (ABI) can be life threatening with high mortality rate. In spite of the advances made in diagnosis and treatment of ABI, no significant change has occurred in the mortality over the past decade. ABI is potentially reversible with prompt diagnosis. The radiologist plays a central role in the initial diagnosis and preventing progression to irreversible intestinal ischemic injury or bowel necrosis. The most single imaging findings described in the literature are either non-specific or only present in the late stages of ABI, urging the use of a constellation of features to reach a more confident diagnosis. While ABI has been traditionally categorized based on the etiology with a wide spectrum of imaging findings overlapped with each other, the final decision for patient’s management is usually made on the stage of the ABI with respect to the underlying pathophysiology. In this review, we first discuss the pathologic stages of ischemia and then summarize the various imaging signs and causes of ABI. We also emphasize on the correlation of imaging findings and pathological staging of the disease. Finally, a management approach is proposed using combined clinical and radiological findings to determine whether the patient may benefit from surgery or not.

scholarly journals Healthcare-related impact of gout in hospitalized patients in Spain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Diego Benavent ◽  
Diana Peiteado ◽  
María Ángeles Martinez-Huedo ◽  
María Hernandez-Hurtado ◽  
Alejandro Balsa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Kidney Disease ◽  
Mortality Rates ◽  
Progressive Increase ◽  
Cerebrovascular Diseases ◽  
Hospitalized Patients ◽  
Data Set ◽  
Private Hospitals ◽  
Risk Of Mortality ◽  
General Mortality

AbstractTo analyze the epidemiology, clinical features and costs of hospitalized patients with gout during the last decade in Spain. Retrospective observational study based on data from the Minimum Basic Data Set (MBDS) from the Spanish National Health Service database. Patients ≥ 18 years with any gout diagnosis at discharge who had been admitted to public or private hospitals between 2005 and 2015 were included. Patients were divided in two periods: p1 (2005–2010) and p2 (2011–2015) to compare the number of hospitalizations, mean costs and mortality rates. Data from 192,037 patients with gout was analyzed. There was an increase in the number of hospitalized patients with gout (p < 0.001). The more frequent comorbidities were diabetes (27.6% of patients), kidney disease (26.6%) and heart failure (19.3%). Liver disease (OR 2.61), dementia (OR 2.13), cerebrovascular diseases (OR 1.57), heart failure (OR 1.41), and kidney disease (OR 1.34) were associated with a higher mortality risk. Women had a lower risk of mortality than men (OR 0.85). General mortality rates in these hospitalized patients progressively increased over the years (p < 0.001). In addition, costs gradually rose, presenting a significant increase in p2 even after adjusting for inflation (p = 0.001). A progressive increase in hospitalizations, mortality rates and cost in hospitalized patients with gout was observed. This harmful trend in a preventable illness highlights the need for change and the search for new healthcare strategies.

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