scholarly journals Implications of inflammation and insulin resistance in obese pregnant women with gestational diabetes: A case study

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984373
Author(s):  
Ebtisam Aziz Al-ofi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Polycystic Ovary ◽  
High Body Mass Index ◽  
C Reactive Protein ◽  
Ovary Syndrome ◽  
Reactive Protein

Background: Obesity is one of the leading pregnancy risks for both the mother and the neonate. The prevalence of gestational diabetes mellitus has been increasing, especially with the increase in obesity in reproductive-aged women. A high body mass index, a sedentary lifestyle, a previous macrosomic infant, polycystic ovary syndrome and hypothyroidism are the main risk factors for gestational diabetes mellitus. Early gestational diabetes mellitus detection in high-risk individuals is a useful method for preventing further complications and/or preventing this disease by improving the patient’s lifestyle. Case presentation: A morbidly obese woman with a high body mass index (>36) at 24 weeks gestational age presented with several gestational diabetes mellitus risk factors. Her glucose tolerance test verified gestational diabetes mellitus, and, incidentally, her C-reactive protein level was elevated without obvious reason. Her plasma levels of inflammatory cytokines had also been assessed and were exaggerated. After lifestyle intervention, including weight management, the patient’s inflammatory mediators, including her C-reactive protein level, dropped. Therefore, this study aimed to identify the relationship between the patient’s inflammation and obesity. Conclusion: Antenatal C-reactive protein screening could be used throughout pregnancy to predict inflammation from high-risk pregnant women. This case scenario describes the interrelationships between inflammation, insulin resistance and adipokines, as well as the contributions of hypothyroidism and polycystic ovary syndrome. Further research should emphasise the relationships between inflammation and obesity in pregnancy.

scholarly journals The risk factors of gestational diabetes mellitus in patients with polycystic ovary syndrome

Medicine ◽  
2021 ◽  
Vol 100 (31) ◽  
pp. e26521
Author(s):  
Xiaocui Li ◽  
Xinru Liu ◽  
Yan Zuo ◽  
Jiejun Gao ◽  
Yan Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Gestational Diabetes Mellitus ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes

2016 ◽  
Vol 13 (2) ◽  
pp. 366-374
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Control Group ◽  
Low Grade ◽  
C Reactive Protein ◽  
Cell Dysfunction ◽  
Reactive Protein

Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impaired glucose tolerance with first recognition during gestation. It develops when ?- cell of pancreas fail to compensate the diminished insulin sensitivity during gestation. This study aims to investigate the relationship between mother adiponectin level and ?- cell dysfunction with development gestational diabetes mellitus (GDM) and other parameters in the last trimester of pregnancy. This study includes (80) subjects ( pregnant women) in the third trimester of pregnancy, (40) healthy pregnant individuals as control group aged between (17 - 42) years and (40) gestational diabetes mellitus patients with aged between (20 - 42) years. The following biochemical investigation is studied: oral glucose tolerance test (OGTT), adiponectin , insulin, C-reactive protein (CRP),body mass index (BMI), and homeostasis model assessment- insulin resistance (HOMA – IR). The adiponectin levels are significantly lesser in females who develop GDM than the control group (P?0.01), while the insulin and OGTT concentrations were significantly higher in females with GDM than control group (P?0.01).The concentrations of CRP are non significantly different between the females who develop GDM and the control group.Conclusions: Lower adiponectin concentrations are associated with an increased risk of the development of gestational diabetes mellitus and females, who develop gestational diabetes mellitus, have higher levels of insulin resistance from normal females, Obesity is a shape of persistent low grade inflammation which causes elevated concentrations of C- reactive protein.

scholarly journals Risks for Gestational Diabetes Mellitus and Pregnancy-Induced Hypertension Are Increased in Polycystic Ovary Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Yunhui Wang ◽  
Xiaomiao Zhao ◽  
Huidan Zhao ◽  
Hong Ding ◽  
Jianping Tan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Gestational Diabetes Mellitus ◽  
Ovarian Stimulation ◽  
Polycystic Ovary ◽  
Pregnancy Induced Hypertension ◽  
Ovary Syndrome ◽  
Induced Hypertension ◽  
Ivf Et

Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS).Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined.Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0–4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0–5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%;P<0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1–4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1–6.2;P<0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI<24kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4–9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3–7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3–11.7).Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered withChiCTR-RCC-11001824.

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