scholarly journals Evaluation of short-term safety of COVID-19 vaccines in patients with multiple sclerosis from Latin America

2021 ◽  
Vol 7 (4) ◽  
pp. 205521732110615
Author(s):  
Ricardo Alonso ◽  
Aníbal Chertcoff ◽  
Felisa del V Leguizamón ◽  
Lorna Galleguillos Goiry ◽  
Maria B Eizaguirre ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Adverse Events ◽  
Latin American ◽  
Adenovirus Vector ◽  
Cross Sectional Study ◽  
Serious Adverse Events ◽  
Cross Sectional ◽  
Web Based ◽  
Patient Organizations ◽  
Latin American Countries

Background To date, there are no data available on the safety of COVID-19 vaccines in Latin American patients with Multiple Sclerosis (MS). Objective Characterize safety of COVID-19 vaccines in Latin American (LATAM) patients with Multiple Sclerosis (pwMS). Methods A cross-sectional study between February 1, 2021, and April 30, 2021. Individuals with MS from LATAM countries were invited to participate in a self-administered web-based survey, through MS patient organizations from the region. Results 393 vaccinated pwMS from 10 different Latin American countries were included. The vaccines administered were: inactivated virus vaccines (IVV) in 38.2% of patients, adenovirus vector vaccines (AdV) in 48.8% and mRNA vaccines 13%. All patients received at least one dose of any of the COVID-19 vaccines and 123 (31.3%) declared receiving a second dose. Mean (SD) age 41.5 (11.8) years, 82.4% female, MS disease duration: 8.4 (8.2) years. No serious adverse events were reported with any of the COVID-19 vaccines after either the first or second dose. A lower frequency of adverse events was found with IVV (22%) in comparison with AdV (46.4%) and mRNA (35.3%) ( p < 0.01). Five participants reported having an MS relapse after IVV first dose. Conclusion COVID-19 vaccines applied in LATAM proved safe for MS patients.

scholarly journals Predictors of COVID-19 Fatality: A Worldwide Analysis of the Pandemic over Time and in Latin America

2022 ◽  
Author(s):  
Dayana Rojas ◽  
Jorge Saavedra ◽  
Mariya Petrova ◽  
Yue Pan ◽  
José Szapocznik
Keyword(s):  
Latin America ◽  
Latin American ◽  
Strong Association ◽  
Case Fatality ◽  
Cross Sectional Study ◽  
Fatality Rate ◽  
Cross Sectional ◽  
The Difference ◽  
Latin American Countries ◽  
Risk Ratios

AbstractSARS-CoV-2 has infected over one hundred million people worldwide and has affected Latin America particularly severely in terms of both cases and deaths. This study aims to determine the association between SARS-CoV-2 testing and COVID-19 fatality rate worldwide over 8 months and to examine how this relationship differs between Latin America and all other countries. This cross-sectional study used March 2021 data from 169 countries. Multivariate regressions predicted COVID-19 fatality (outcome) from the number of SARS-CoV-2 tests (exposure), while controlling for other predictors. Results for March 2021 were compared to results from June 2020. Additionally, results for Latin America were also compared to all other countries except Latin American for March 2021. SARS-CoV-2 testing was associated with a significant decrease in COVID-19 fatality rate in both June 2020 and March 2021 (RR = 0.92; 95% CI 0.87–0.96 and RR = 0.86; 95% CI 0.74–1.00, respectively). SARS-CoV-2 testing was associated with a significant decrease in COVID-19 fatality rate in Latin American countries but not in all other countries (RR = 0.45; 95% CI 0.23–0.89 and RR = 0.95; 95% CI 0.82–1.11, respectively). However, the difference between the risk ratios for June 2020 and March 2021 and between the risk ratios for Latin America and all other countries were not statistically significant. Increased SARS-CoV-2 testing may be a significant predictor of lower COVID-19 case fatality rate, specifically in Latin American countries, due to the existence of a strong association, which may have driven the worldwide results.

scholarly journals Risk Analysis for Patient Safety in Surgical Departments: Cross-Sectional Design Usefulness

2020 ◽  
Vol 17 (7) ◽  
pp. 2516
Author(s):  
Verónica Aranaz Ostáriz ◽  
María Teresa Gea Velázquez de Castro ◽  
Francisco López Rodríguez-Arias ◽  
José Lorenzo Valencia Martín ◽  
Carlos Aibar Remón ◽  
...  
Keyword(s):  
Patient Safety ◽  
Adverse Events ◽  
Latin American ◽  
Health Care Quality ◽  
Health Impact ◽  
Cross Sectional Study ◽  
Care Quality ◽  
Cross Sectional ◽  
Improve Health Care Quality ◽  
Health Organization

(1) Background: Identifying and measuring adverse events (AE) is a priority for patient safety, which allows us to define and prioritise areas for improvement and evaluate and develop solutions to improve health care quality. The aim of this work was to determine the prevalence of AEs in surgical and medical-surgical departments and to know the health impact of these AEs. (2) Methods: A cross-sectional study determining the prevalence of AEs in surgical and medical-surgical departments was conducted and a comparison was made among both clinical areas. A total of 5228 patients were admitted in 58 hospitals in Argentina, Colombia, Costa Rica, Mexico, and Peru, within the Latin American Study of Adverse Events (IBEAS), led by the Spanish Ministry of Health, the Pan American Health Organization, and the WHO Patient Safety programme. (3) Results: The global prevalence of AEs was 10.7%. However, the prevalence of AEs in surgical departments was 11.9%, while in medical-surgical departments it was 8.9%. The causes of these AEs were associated with surgical procedures (38.6%) and nosocomial infections (35.4%). About 60.6% of the AEs extended hospital stays by 30.7 days on average and 25.8% led to readmission with an average hospitalisation of 15 days. About 22.4% resulted in death, disability, or surgical reintervention. (4) Conclusions: Surgical departments were associated with a higher risk of experiencing AEs.

A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis

2011 ◽  
Vol 17 (6) ◽  
pp. 708-719 ◽  
Author(s):  
Carolina Holmén ◽  
Fredrik Piehl ◽  
Jan Hillert ◽  
Anna Fogdell-Hahn ◽  
Malin Lundkvist ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Adverse Events ◽  
Drug Effects ◽  
Surveillance Study ◽  
Serious Adverse Events ◽  
Web Based ◽  
Quality Registry ◽  
Post Marketing Surveillance ◽  
Natalizumab Treatment ◽  
Post Marketing

Background: A post marketing surveillance study was conducted to evaluate safety and efficacy of natalizumab in Swedish multiple sclerosis (MS) patients since its introduction in August 2006 until March 2010. Methods: Patients were registered in the web-based Swedish MS-registry at 40 locations and evaluated every 6 months. Adverse events and clinical outcomes were recorded. Results: One thousand one hundred and fifty-two patients were included (71.4% female) and 149 patients stopped treatment; the main reason was planned pregnancy. Anti-natalizumab antibodies were found in 4.5% (52 patients) of which 1.6% displayed persistent antibodies. Serious adverse events were rare, but included three cases with progressive multifocal leukoencephalopathy (PML). There were seven fatal cases, probably unrelated to the natalizumab treatment. For relapsing–remitting MS patients ( n = 901), mean Expanded Disability Status Scale (EDSS, −10.7%), Multiple Sclerosis Severity Scale (MSSS, −20.4%), Multiple Sclerosis Impact Scale (MSIS-29, physical −9.9%, psychological −13.3%) and Symbol Digit Modalities Test (SDMT, +10.7%) all showed significant improvements during 24 months of treatment with natalizumab. The Swedish web-based MS quality registry proved to function as a platform for post-marketing MS drug surveillance, providing long-term data regarding drug effects and adverse events beyond clinical trials. Conclusions: Our results indicate that natalizumab is generally well tolerated and has sustained efficacy for patients with active MS, though the risk of PML is still an important concern.

scholarly journals Profile of simultaneous poly-substance users of undergraduate students at one university, Kingston - Jamaica

2012 ◽  
Vol 21 (spe) ◽  
pp. 63-67
Author(s):  
Joy Harrison ◽  
Laura Simich ◽  
Carol Strike ◽  
Bruna Brands ◽  
Norman Giesbrecht ◽  
...  
Keyword(s):  
Undergraduate Students ◽  
Latin American ◽  
Cross Sectional Study ◽  
Health Science ◽  
Caribbean Island ◽  
Cross Sectional ◽  
University Level ◽  
Second Year ◽  
The University ◽  
Latin American Countries

This study is part of a multicentric research project involving seven universities in five Latin American countries and one Caribbean island (Jamaica). This cross-sectional study examines the profile of a sample of first and second year undergraduate students in the Medical/Health Science Department of one university in Kingston, Jamaica. The sample size was 295 students. Our results revealed that this pattern of drug use is occurring in this specific university. Alcohol was the most frequently reported substance 27.5%, followed by cannabis 6.1% and tobacco 4.7%. Report of polydrug consumption was low for all categories studied. Our findings may inform interventions at the university level.

scholarly journals Adverse events following immunization with Covi-shield tm vaccine: a descriptive cross-sectional study at a tertiary center, Nepal

2021 ◽  
pp. 163-163
Author(s):  
Gopal Lama ◽  
Runa Jha ◽  
Sagar K Rajbhandari ◽  
Jenish Neupane ◽  
Anup Bastola
Keyword(s):  
Adverse Events ◽  
Injection Site ◽  
Cross Sectional Study ◽  
Injection Site Pain ◽  
Sectional Study ◽  
Serious Adverse Events ◽  
Cross Sectional ◽  
Tertiary Center ◽  
National Public Health ◽  
Site Pain

Introduction: As the COVID-19 pandemic continues to unfold, rapid global efforts to develop and test vaccines against SARS-CoV-2 have started. Adverse events after immunization are a common issue seen in many vaccines. This study aims at finding the adverse events following the first dose of CovishieldTM vaccine administered to the staffs at two health institutions in Kathmandu. Methods: This was a descriptive cross sectional study conducted among the staffs at National Public Health Laboratory and Sukraraj Tropical and Infectious Disease Hospital, Kathmandu between February to April, 2021. It included 162 participants who had taken the first dose of CovishieldTM vaccine. Ethical approval was taken from Nepal Health Research Council. Statistical Package for the Social Sciences were used for analysis. Results: Various adverse events were seen in 139 (85.8%) participants which were all minor events. None of the participants developed serious adverse events. Very common adverse events experienced were Injection site pain 116 (71.6%), myalgia 76 (46.9%), chills 68 (42%), headache 65 (40.1%), fever 54 (33.3%), dizziness 43 (26.5%) and nausea 20 (12.4%). Similarly, the range of time period from onset to recovery of adverse event was different for different adverse reactions. Conclusions: The adverse events following first dose of CovishieldTM vaccine were all minor reactions with commonest being injection site pain followed by myalgia, chills, headache and fever.

Analysis of prevalence and sociodemographic conditions among women in labor with and without COVID-19 in public hospitals in Chile

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Helga Vera von Bargen ◽  
María Espinosa Serrano ◽  
Daniel Martin Navarrete ◽  
Paz Ahumada Droguett ◽  
Carolina Méndez B. ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Latin American ◽  
Cross Sectional Study ◽  
Public Hospitals ◽  
Premature Births ◽  
Cross Sectional ◽  
Homogeneous Population ◽  
Significant Difference ◽  
Term Delivery ◽  
Latin American Countries

Abstract Objectives The SARS-CoV-2 virus continues wreaking worldwide havoc on health and between March and August 2020, the first outbreak of COVID-19 hit Chile. The pregnant population is especially vulnerable to infection. Studies have been published that associate socioeconomic status, overcrowding, and poverty with a higher prevalence of SARS-CoV-2 infection. There are few studies about the development of this pandemic in Latin American countries so far. This study seeks to show the prevalence and sociodemographic and perinatal characteristics in pregnant women at the time of delivery, comparing both groups with positive and negative COVID-19 PCR results. Methods A prospective, cross-sectional study of pregnant women who delivered at the San Juan de Dios Hospital in Santiago between April 15, 2020 and June 15, 2020. Analysis of epidemiological, sociodemographic, obstetric, perinatal and sociodemographic data of patients with positive and negative COVID-19 PCR results. Results There were 701 patients included in the study. The prevalence of those with a positive COVID-19 PCR was 9.7% and 67.7% being asymptomatic. Pre-term delivery was significantly higher in the group of positive patients (23.5%) vs. negative patients (8.7%), which was not the same rate as with cesarean sections (C-sections). A 13.2% of patients required management of the pathology in the Critical Care Unit (CCU) and there were no cases of maternal or fetal deaths. We found no significant difference between both groups when analyzing socioeconomic variables, though we noted a trend of greater overcrowding among the group of patients with infection. Conclusions The majority of pregnant patients with SARS-CoV-2 infection are asymptomatic. COVID-19 increases the rate of premature births, but this rate is not same with C-sections. Sociodemographic conditions and overcrowding do not show a higher infection rate in a homogeneous population in relation to the economic, social and demographic level.

scholarly journals Association between Perceived Neighborhood Built Environment and Walking and Cycling for Transport among Inhabitants from Latin America: The ELANS Study

2020 ◽  
Vol 17 (18) ◽  
pp. 6858
Author(s):  
Gerson Ferrari ◽  
André Oliveira Werneck ◽  
Danilo Rodrigues da Silva ◽  
Irina Kovalskys ◽  
Georgina Gómez ◽  
...  
Keyword(s):  
Latin America ◽  
Built Environment ◽  
Latin American ◽  
Cross Sectional Study ◽  
Neighborhood Environment ◽  
Cross Sectional ◽  
Nationally Representative ◽  
Alternative Routes ◽  
Neighborhood Built Environment ◽  
Latin American Countries

Purpose: This study aimed to examine the associations of the perceived neighborhood built environment with walking and cycling for transport in inhabitants from Latin American countries. Methods: This cross-sectional study involved 9218 participants (15–65 years) from the Latin American Study of Nutrition and Health, which included a nationally representative sample of eight countries. All participants completed the International Physical Activity Questionnaire-Long Form for measure walking and cycling for transport and the Neighborhood Environment Walkability Scale-Abbreviated. Furthermore, perceived proximity from home to public open spaces and shopping centers was assessed. Results: Perceived land use mix-access (OR: 1.32; 95%CI: 1.16,1.50) and the existence of many alternative routes in the neighbourhood (1.09 1.01,1.17) were associated with higher odds of reporting any walking for transport (≥10 min/week). Perceived slow speed of traffic (1.88 1.82,1.93) and few drivers exceeding the speed limits (1.92; 1.86,1.98) were also related to higher odds of reporting any walking for transport. The odds of reporting any cycling for transport (≥10 min/week) were higher in participants perceiving more walking/cycling facilities (1.87 1.76,1.99), and better aesthetics (1.22 1.09,1.38). Conclusions: Dissimilar perceived neighborhood built environment characteristics were associated with walking and cycling for transport among inhabitants from Latin America.

scholarly journals Evaluation of teamwork and its associated factors in the emergency rooms of Sousse - Tunisia

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
H Lamine ◽  
M Tyss ◽  
M A Tlili ◽  
E Taghouti ◽  
W Aouicha ◽  
...  
Keyword(s):  
Patient Safety ◽  
Adverse Events ◽  
Work Experience ◽  
Participation Rate ◽  
Cross Sectional Study ◽  
Measurement Tool ◽  
Affecting Factors ◽  
Emergency Rooms ◽  
Serious Adverse Events ◽  
Cross Sectional

Abstract Background In recent years, patient safety has become a priority and a major target for improvement especially in the emergency rooms. According to the French National Authority for Health, 1/3 of serious adverse events could be avoided thanks to better coordination and better communication between the teams. Thus, this study aimed to describe the perceptions of healthcare professionals in the emergency rooms of Sousse-Tunisia regarding teamwork, and to determine the factors influencing it. Methods It is a descriptive cross-sectional study, conducted between December 2018 and April 2019. It included all the caregivers working in all the emergency rooms of Sousse-Tunisia. The measurement tool used in this study was “Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS)” Teamwork Perception Questionnaire. Data were coded and analyzed by The Statistical Package for Social Sciences (SPSS 20.0). Results A total of 110 participants were recruited with a participation rate of 72.36%. Nurses represent more than half of the respondents (56.4%). Average work experience was 7.27 years. The Teamwork overall score was 2.5±0.5. The most developed dimension was leadership (2.7±0.8) and the less developed dimension was communication (2.3±0.7). Women had a significantly higher overall score than men (2.6±0.5, 2.4±0.3, p = 0.017). Results also showed that emergency technicians have significantly higher overall score than doctors and nurses (p = 1 × 10-5). The overall score also varied significantly across the hospitals (p = 0.016). Conclusions Our results showed that the level of teamwork still needs to be improved. Furthermore, various factors are associated with teamwork, and that should be taken into consideration to guide the future interventions. Key messages There is a direct relationship between the quality of care and the effectiveness of teamwork. It is necessary to focus on the affecting factors of teamwork, in order to prevent adverse events.

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