scholarly journals Reversible Encepahlopathy Induced by Ifosfamide with Brain Imaging

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110304
Author(s):  
Daoud Ali Mohamed ◽  
Arthur Semedo ◽  
Boris Adeyemi ◽  
Leila Hessissen ◽  
Maria El Kababri ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Brain Damage ◽  
Neurological Complications ◽  
Late Complications ◽  
Acute Encephalopathy ◽  
Peripheral Neurotoxicity ◽  
Reversible Encephalopathy

Chemotherapy may be responsible for central and/or peripheral neurotoxicity. These neurological complications are frequent but little known. Some molecules are more providers, responsible for acute or late complications, sometimes not reversible. Some manifestations such as acute encephalopathy and acute reversible encephalopathy are increasingly understood. We report here a case of acute ifosfamide-induced encephalopathy (EII) with brain damage resolved after discontinuation of this treatment in a 13-years-old child.

scholarly journals An Unusual Case of Campylobacter jejuni Gastroenteritis Presenting with Acute Reversible Encephalopathy in an Immunocompetent Host

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Irma Huayanay ◽  
Leonardo Pozo ◽  
Salman Bangash ◽  
Denisse Ramirez ◽  
Luis Rosas ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Neurological Complications ◽  
Immunocompetent Patient ◽  
Cross Reactivity ◽  
Acute Encephalopathy ◽  
Guillain Barré ◽  
Reversible Encephalopathy ◽  
The Brain

Campylobacter jejuni gastroenteritis is the most frequent organism associated with acute infectious diarrhea worldwide. The clinical presentation involves fever, diarrhea, rigors, and myalgias. Other extraintestinal symptoms that have been described involve delirium and other neurological complications, and the most well-known is Guillain-Barré, where there is cross-reactivity between the gastrointestinal tract and the brain. Despite previously described multiple neurological complications, there is a lack of clinical data on the association of Campylobacter-related gastroenteritis with acute encephalopathy in immunocompetent patients. The type of population, immunocompetent stage, and unfamiliarity with the clinical presentation makes this a challenging diagnosis for clinicians. We report a case of Campylobacter gastroenteritis associated with acute encephalopathy in an immunocompetent patient.

Posterior Reversible Encephalopathy (PRES) in a Child with Severe Dengue

2019 ◽  
Vol 66 (3) ◽  
pp. 322-326
Author(s):  
Yogini Sawant ◽  
Suresh Birajdar ◽  
Hiren Doshi ◽  
Pooja Soni ◽  
Deepak Patkar ◽  
...  
Keyword(s):  
Pediatric Population ◽  
White Blood Cells ◽  
Neurological Complications ◽  
Severe Dengue ◽  
Mri Findings ◽  
Posterior Reversible Encephalopathy ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Changes ◽  
Reversible Encephalopathy ◽  
Csf Examination

Abstract Among neurological complications associated with dengue, posterior reversible encephalopathy syndrome (PRES) has not been reported in pediatric population. We report a 10-year-old girl with severe dengue who developed PRES. The patient presented with hemorrhagic shock that required fluid resuscitation and inotropic support. She developed seizures with encephalopathy 2 days after recovering from the shock. Cerebrospinal fluid (CSF) examination was negative for dengue (no white blood cells in CSF with negative polymerase chain reaction for dengue). Her clinical features and magnetic resonance imaging (MRI) findings showed typical changes associated with posterior encephalopathy that reverted after resolution of hypertension. Repeat MRI after a month was normal. PRES should be considered as a possible differential diagnoses of dengue associated encephalopathy, especially in cases with normal CSF examination and characteristic MRI changes.

Hypertension and Confusion

2016 ◽  
Author(s):  
Ji Y. Chong ◽  
Michael P. Lerario
Keyword(s):  
White Matter ◽  
Brain Imaging ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Clinical Course ◽  
Severe Hypertension ◽  
Vasogenic Edema ◽  
Blurred Vision ◽  
Posterior Reversible Encephalopathy ◽  
Immunosuppressive Medications ◽  
Reversible Encephalopathy

Posterior reversible encephalopathy syndrome is a clinical–radiographic syndrome of progressive headaches, blurred vision, confusion, and seizures in the setting of vasogenic edema on brain imaging, which is often localized to the posterior white matter. The symptoms are classically triggered by severe hypertension, pregnancy and the puerperium, or exposure to immunosuppressive medications. The symptoms can be reversible if the offending etiology is quickly removed, but permanent deficits can remain if strokes or hemorrhage complicate the clinical course.

scholarly journals Spectrum of neuroimaging findings in COVID-19

2021 ◽  
Vol 94 (1117) ◽  
pp. 20200812
Author(s):  
Ahmed H El Beltagi ◽  
Surjith Vattoth ◽  
Mohamed Abdelhady ◽  
Islam Ahmed ◽  
Yahya Paksoy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Critical Illness ◽  
Cerebral Venous Thrombosis ◽  
Virus Disease ◽  
Acute Disseminated Encephalomyelitis ◽  
Neurological Complications ◽  
Posterior Reversible Encephalopathy ◽  
Cerebrovascular Stroke ◽  
Reversible Encephalopathy ◽  
Ischemic Encephalopathy

An outbreak of corona virus disease 2019 (COVID-19) began in China in December 2019, and rapidly spread to become a worldwide pandemic. Neurological complications encountered in hospitalized patients include acute arterial ischemic cerebrovascular stroke, cerebral venous thrombosis, critical illness-associated cerebral microbleeds, hypertensive hemorrhagic posterior reversible encephalopathy, meningoencephalitis/flare up of infections, flare up of multiple sclerosis, acute disseminated encephalomyelitis, cerebral hemodynamic/hypoxic changes such as watershed ischemic changes and hypoxic ischemic encephalopathy, and spine manifestations of Guillain Barre syndrome and viral myelitis. The purpose of our study is to illustrate the different neuroimaging features in critically ill hospitalized COVID-19 positive patients in the State of Qatar.

scholarly journals CNS imaging studies in cystic fibrosis patients presenting with sudden neurological events

2019 ◽  
Vol 6 (1) ◽  
pp. e000456
Author(s):  
Samantha Ellis ◽  
Catherine Rang ◽  
Tom Kotsimbos ◽  
Dominic Keating ◽  
Felicity Finlayson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Brain Imaging ◽  
Medical Records ◽  
Seizure Activity ◽  
Neurological Complications ◽  
Neurological Symptoms ◽  
Imaging Studies ◽  
Vascular Events ◽  
Mri Brain ◽  
Large Teaching Hospital

BackgroundAcute neurological events may present as an extrapulmonary complication in patients with cystic fibrosis (CF). These events can be secondary to a range of different aetiologies.MethodsA retrospective analysis of 476 medical records of CF patients attending a large teaching hospital between 2000 and 2018 was performed. Patients presenting with acute neurological events who had MRI brain imaging were evaluated. Patients who had headaches without associated neurological symptoms were excluded from this analysis.ResultsAcute neurological presentations, excluding headaches without associated neurological symptoms, were reported in 27 index patients out of the 476 patients. Of these, 16 patients had MRI brain imaging for review. Three patients suffered pathology secondary to vascular events, both ischaemic and haemorrhagic; four patients had evidence of ischaemia or infarction not consistent with a vascular territory stroke and the remaining patients experienced a range of different neurological events. The most common presentation among these patients was seizure activity, followed by a transient motor or sensory deficit.ConclusionsNeurological complications are recognised among individuals with CF. Although rare, they can be secondary to a range of different aetiologies, including dysfunctional cell energetics. Additional studies are required to further evaluate this association.

scholarly journals Posterior Reversible Encephalopathy Syndrome following Ustekinumab Induction for Crohn’s Disease

2018 ◽  
Vol 12 (2) ◽  
pp. 521-527 ◽  
Author(s):  
Avantika Mishra ◽  
Darren N. Seril
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Human Monoclonal Antibody ◽  
Interleukin 12 ◽  
Cytokine Signaling ◽  
Acute Encephalopathy ◽  
Posterior Reversible Encephalopathy ◽  
Inflammatory Bowel ◽  
Reversible Encephalopathy

Biological agents are frequently used in the management of inflammatory bowel disease, and it is important to understand the potential adverse effects of these therapies. Ustekinumab is a human monoclonal antibody that interferes with interleukin-12 and -23 cytokine signaling and is approved for the treatment of moderate to severe Crohn’s disease. We report 2 cases of neurological adverse events, one of which is consistent with posterior reversible encephalopathy syndrome (PRES), in the setting of ustekinumab therapy for Crohn’s disease. The first patient had a seizure and classic neuroimaging features of PRES following induction with ustekinumab. The second patient presented with acute encephalopathy and atypical imaging findings concerning for PRES after ustekinumab induction. Both patients recovered fully following cessation of ustekinumab therapy. PRES associated with ustekinumab is uncommon, but must be a consideration in Crohn’s disease patients receiving this therapy who present with focal neurological symptoms or change in mentation.

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