scholarly journals Air quality in the clinical embryology laboratory: a mini-review

2021 ◽  
Vol 15 ◽  
pp. 263349412199068
Author(s):  
Romualdo Sciorio ◽  
Erika Rapalini ◽  
Sandro C. Esteves
Keyword(s):  
Quality Control ◽  
Air Quality ◽  
Critical Role ◽  
Ambient Air ◽  
Chemical Pollution ◽  
Future Research ◽  
Preimplantation Genetic Testing ◽  
Vitro Fertilization ◽  
Air Quality Control

The scope of the clinical embryology laboratory has expanded over recent years. It now includes conventional in vitro fertilization (IVF) techniques and complex and time-demanding procedures like blastocyst culture, processing of surgically retrieved sperm, and trophectoderm biopsy for preimplantation genetic testing. These procedures require a stable culture environment in which ambient air quality might play a critical role. The existing data indicate that both particulate matter and chemical pollution adversely affect IVF results, with low levels for better outcomes. As a result, IVF clinics have invested in air cleaning technologies with variable efficiency to remove particulates and volatile organic compounds. However, specific regulatory frameworks mandating air quality control are limited, as are evidence-based guidelines for the best air quality control practices in the embryology laboratory. In this review, we describe the principles and existing solutions for improving air quality and summarize the clinical evidence concerning air quality control in the embryology laboratory. In addition, we discuss the gaps in knowledge that could guide future research to improve clinical outcomes.

scholarly journals Association between ambient air pollution and in vitro fertilization pregnancy outcomes in Taiyuan: A retrospective study in a heavy polluted city in northern China

2020 ◽  
Author(s):  
Suming Xu ◽  
Chunqing Sun ◽  
Xingyu Bi ◽  
Dan Feng ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Air Pollution ◽  
Air Quality ◽  
Pregnancy Outcomes ◽  
Northern China ◽  
Ambient Air ◽  
Clinical Pregnancy ◽  
Ambient Air Pollution ◽  
Vitro Fertilization ◽  
Biochemical Pregnancy

Abstract BackgroundGlobally, air pollution has a significant impact on human health. However, the effects of air pollution on pregnancy outcomes in patients undergoing in vitro fertilization (IVF) have not been fully understood. In this study, we analyzed the effects of air pollution on IVF pregnancy outcomes in Taiyuan, which is a heavy polluted city in northern China.Methods516 patients who underwent first fresh IVF cycle were enrolled in the retrospective study from January 1, 2015 to May 31, 2020. We collected medical record data from the electronic medical record system and daily average air pollution data from air quality monitoring station. Logistic regression was used to analyze the relationship between six atmospheric pollutants (PM2.5, PM10, O3, NO2, SO2, CO) and air quality index (AQI) and IVF pregnancy outcomes (biochemical pregnancy and clinical pregnancy) in different exposure periods. ResultsThe results indicated that exposure to NO2 was negatively associated with the odds of biochemical pregnancy and clinical pregnancy, whereas exposure to O3 presented positive association. Furthermore, we also found that AQI was negatively associated with IVF pregnancy outcomes. ConclusionsOur findings suggested that exposure to ambient air pollution during any period may have an impact on IVF pregnancy outcomes, and poor air quality is more likely to reduce clinical pregnancy rates.

Progress and Challenges in Laboratory-Based Diagnostic and Screening Approaches for Aneuploidy Detection during Pregnancy

2021 ◽  
pp. 247263032110217
Author(s):  
Lindsay Schneider ◽  
Anubhav Tripathi
Keyword(s):  
Sample Collection ◽  
Aneuploidy Screening ◽  
Preimplantation Genetic Testing ◽  
Cellular Division ◽  
Vitro Fertilization ◽  
Genetic Abnormalities ◽  
The Social ◽  
Diagnostic Technologies ◽  
Screening Approaches

Aneuploidy is caused by problems during cellular division and segregation errors during meiosis that lead to an abnormal number of chromosomes and initiate significant genetic abnormalities during pregnancy or the loss of a fetus due to miscarriage. Screening and diagnostic technologies have been developed to detect this genetic condition and provide parents with critical information about their unborn child. In this review, we highlight the complexities of aneuploidy as a disease as well as multiple technological advancements in testing that help to identify aneuploidy at various time points throughout pregnancy. We focus on aneuploidy diagnosis during preimplantation genetic testing that is performed during in vitro fertilization as well as prenatal screening and diagnosis during pregnancy. This review focuses on DNA-based analysis and laboratory techniques for aneuploidy detection through reviewing molecular- and engineering-based technical advancements. We also present key challenges in aneuploidy detection during pregnancy, including sample collection, mosaic embryos, economic factors, and the social implications of this testing. The goal of this review is to synthesize broad information about aneuploidy screening and diagnostic sample collection and analysis during pregnancy and discuss major challenges the field is still facing despite decades of advancements.

scholarly journals Ambient air pollutant exposure and in vitro fertilization treatment outcomes in Zhengzhou, China

2021 ◽  
Vol 214 ◽  
pp. 112060
Author(s):  
Wei Dai ◽  
Hao Shi ◽  
Zhiqin Bu ◽  
Yiping Yu ◽  
Zhimin Sun ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Treatment Outcomes ◽  
Ambient Air ◽  
Air Pollutant ◽  
Vitro Fertilization

scholarly journals Preimplantation genetic testing for aneuploidy in uterus transplant patients

2021 ◽  
Vol 15 ◽  
pp. 263349412110098
Author(s):  
Rhea Chattopadhyay ◽  
Elliott Richards ◽  
Valerie Libby ◽  
Rebecca Flyckt
Keyword(s):  
Genetic Testing ◽  
In Vitro Fertilization ◽  
Immunosuppressive Agents ◽  
Live Birth Rate ◽  
Preimplantation Genetic Testing ◽  
Vitro Fertilization ◽  
Uterus Transplantation ◽  
Advantages And Disadvantages ◽  
Dilation And Curettage

Uterus transplantation is an emerging treatment for uterine factor infertility. In vitro fertilization with cryopreservation of embryos prior is required before a patient can be listed for transplant. Whether or not to perform universal preimplantation genetic testing for aneuploidy should be addressed by centers considering a uterus transplant program. The advantages and disadvantages of preimplantation genetic testing for aneuploidy in this unique population are presented. The available literature is reviewed to determine the utility of preimplantation genetic testing for aneuploidy in uterus transplantation protocols. Theoretical benefits of preimplantation genetic testing for aneuploidy include decreased time to pregnancy in a population that benefits from minimization of exposure to immunosuppressive agents and decreased chance of spontaneous abortion requiring a dilation and curettage. Drawbacks include increased cost per in vitro fertilization cycle, increased number of required in vitro fertilization cycles to achieve a suitable number of embryos prior to listing for transplant, and a questionable benefit to live birth rate in younger patients. Thoughtful consideration of whether or not to use preimplantation genetic testing for aneuploidy is necessary in uterus transplant trials. Age is likely a primary factor that can be useful in determining which uterus transplant recipients benefit from preimplantation genetic testing for aneuploidy.

Air quality and synergistic health effects of ozone and nitrogen oxides in response to China’s integrated air quality control policies during 2015–2019

Chemosphere ◽  
2021 ◽  
Vol 268 ◽  
pp. 129385
Author(s):  
Xuguo Zhang ◽  
Jimmy C.H. Fung ◽  
Alexis K.H. Lau ◽  
Md Shakhaoat Hossain ◽  
Peter K.K. Louie ◽  
...  
Keyword(s):  
Quality Control ◽  
Air Quality ◽  
Nitrogen Oxides ◽  
Health Effects ◽  
Control Policies ◽  
Air Quality Control
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