scholarly journals Immunoenzymatic localization of prolactin-like immunoreactivity in decidual cells of the endometrium from pregnant and nonpregnant women.

1980 ◽  
Vol 28 (12) ◽  
pp. 1347-1350 ◽  
Author(s):  
S Meuris ◽  
G Soumenkoff ◽  
A Malengreau ◽  
C Robyn
Keyword(s):  
Normal Pregnancy ◽  
Tubal Pregnancy ◽  
Molar Pregnancy ◽  
Nonpregnant Woman ◽  
Immunoenzymatic Method ◽  
Decidual Cells ◽  
Endocrine Influence ◽  
Trophoblastic Tissue

Prolactin-like immunoreactivity has been localized by an immunoenzymatic method in the decidual cells of the endometrium in cases of early (10 weeks) normal pregnancy, (12 weeks) molar pregnancy, (8--10 weeks) tubal pregnancy, and of a nonpregnant woman under progestogen (lynestrenol) treatment. A specific endocrine influence, predominantly progestogenic, rather than the implantation of trophoblastic tissue seems to be required for the appearance of prolactin-like immunoreactivity in the decidual cells of the endometrium.

Immune cell profiling in normal pregnancy, partial and complete molar pregnancy

2007 ◽  
Vol 107 (2) ◽  
pp. 292-297 ◽  
Author(s):  
Z NAGYMANYOKI ◽  
M CALLAHAN ◽  
M PARAST ◽  
V FULOP ◽  
S MOK ◽  
...  
Keyword(s):  
Immune Cell ◽  
Normal Pregnancy ◽  
Molar Pregnancy

scholarly journals A case of complete cure of tubal pregnancy by galvanism. Subsequent normal pregnancy

2020 ◽  
Vol 6 (12) ◽  
pp. 1241-1242
Author(s):  
D. Ruzi
Keyword(s):  
Normal Pregnancy ◽  
Tubal Pregnancy ◽  
Complete Cure

Citing a case of curing an ectopic tubal pregnancy with electrification, the author expresses himself in the sense that this method should be considered one of the best at present. Where there are no life indications for gluttony, electricity must be tried first.

scholarly journals Immunohistochemistry Study of P53 and C-erbB-2 Expression in Trophoblastic Tissue and Their Predictive Values in Diagnosing Malignant Progression of Simple Molar Pregnancy

2016 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Malihe Hasanzadeh ◽  
Norrie Sharifi ◽  
Marjaneh Farazestanian ◽  
Seyed Saman Nazemian ◽  
Faezeh Madani Sani
Keyword(s):  
Malignant Progression ◽  
Molar Pregnancy ◽  
Predictive Values ◽  
Trophoblastic Tissue

scholarly journals Intramural ectopic pregnancy

2010 ◽  
Vol 18 (1-2) ◽  
pp. 30-31
Author(s):  
Biljana Lazovic ◽  
Vera Milenkovic
Keyword(s):  
Ectopic Pregnancy ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Elevated Serum ◽  
Normal Pregnancy ◽  
Primiparous Woman ◽  
Histopathological Analysis ◽  
Molar Pregnancy ◽  
Gestational Trophoblastic Neoplasia ◽  
History Of

Gestational trophoblastic neoplasia refers to a subset of gestational trophoblastic conditions characterized with persistently elevated serum ?-human chorionic gonadotropin, absence of a normal pregnancy, and a history of normal or abnormal pregnancies. We described a case of suspected ectopic molar pregnancy in a primiparous woman who had elevated ?-human chorionic gonadotropin and required chemotherapy to achieve remission. Final histopathological finding was ectopic pregnancy; no gestational trophoblastic neoplasia was found. This case stresses the importance of histopathological analysis in diagnosis of gestational trophoblastic neoplasia when ectopic pregnancy is present, considering that histopathological analysis is less sensitive for gestational trophoblastic neoplasia than for ectopic pregnancy.

scholarly journals Term Delivery of a Complete Molar Pregnancy with a Coexistent Normal Pregnancy

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Manisha Chhetry ◽  
Aruna Pokharel ◽  
Amar Nath Chaudhary
Keyword(s):  
Breech Presentation ◽  
Normal Pregnancy ◽  
Molar Pregnancy ◽  
Healthy Male ◽  
Singleton Pregnancy ◽  
Complete Mole ◽  
Beta Hcg ◽  
Term Delivery ◽  
Normal Placenta

Twin pregnancy with a complete mole and a coexistent normal fetus reaching term is a rare occurrence. We report a case of a 21-yrs G2P1L0 un-booked patient at 39 weeks who was referred for the same condition diagnosed incidentally on ultrasound scan which showed a singleton pregnancy in breech presentation with a normal placenta and a heterogeneous cystic lesion seen anteriorly, suggesting a coexistent molar pregnancy. Cesarean section was done, and a healthy male baby was delivered with a grossly normal placenta and a second placenta with grape like vesicles. Histopathology confirmed the diagnosis of complete mole and normal placenta. Postoperative period was uneventful, and the patient was kept on beta hcg follow-up to monitor progression to gestational trophoblastic neoplasia, but it normalized by 12 weeks.

scholarly journals Soluble Endoglin Serum Level is Higher in Preeclampsia Compared to Molar and Normal Pregnancy

2014 ◽  
pp. 76-81
Author(s):  
Maya K. Puspitasari ◽  
Anita D. Anwar ◽  
Firman F. Wirakusumah
Keyword(s):  
Serum Level ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
Analytic Study ◽  
P Value ◽  
Molar Pregnancy ◽  
Soluble Endoglin ◽  
Significant Difference ◽  
The Mean

Abstract Objective: To analyze th e differences of maternal serum soluble endoglin level in pr eeclampsia, molar pregnan cy, and normal pregnancy, and to analyze th e correlation between maternal serum soluble endoglin level with gestational age. Method: This is a cros s-sectional compara tive analytic study involving 18 preeclamps ia cases, 18 molar pr egnan cies, and 18 normal pregnancies. The sample were obtained from Dr. Hasan Sad ikin hospital and six satellite hospitals from January until Mar ch 2013. The comparison of mean seng se rum level of th e preeclampsia,molar pregnancy, and normal pregnancy gro up was calculated using Kruskal Wallis, and the corr elation we re calculated using Rank Spearman. Result: The mean level of seng se rum in pr eeclamp sia gro up was higher (168.79 ngjml) than in molar pr egnan cy (43.47 ngjml) and normal pregnancy (32.38 ngjml). Ther e is no significant difference of se rum seng level be tween molar and norm al pregnan cy, with p value of 0.393 (p>0.05). There is significant differ ences of seng serum level between pr eeclampsia gro up and molar pr egnancy (p=O.OOO), but no significant differ ences between molar and normal pregnancy, p value=0.393 (p >0.05). Ther e is positive correlati on between seng se rum level of norm al pregnancy with gestational age (rs=0 .647 ; p<0.001). Conclusion: Mat ern al se rum seng level in preeclampsia is higher than th e level of which in molar pre gnan cy and norm al pregnancy. Keywords: molar pregnancy, norm al pr egnancy, pr eeclamp sia, soluble endoglin level

Neuroendocrine regulation of anterior pituitary function in patients during and after molar pregnancy

1987 ◽  
Vol 116 (3) ◽  
pp. 373-380 ◽  
Author(s):  
G. Forsbach ◽  
J. Contreras ◽  
R. de Hoyos ◽  
A. Martinez-Campos
Keyword(s):  
Anterior Pituitary ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Placental Lactogen ◽  
Endocrine Regulation ◽  
Molar Pregnancy ◽  
Normal Range ◽  
Significant Difference ◽  
Before And After ◽  
Β Hcg

Abstract. Only partial studies evaluating the endocrine profile in molar pregnancy have been performed. In order to characterize the neuro-endocrine pattern during and after molar pregnancy, we studied the basal hormonal levels of hCG, human placental lactogen (hPL), FSH, GH, TSH, free thyroxine index (FTI), oestradiol-17β (E2), and progesterone (PG), as well as the anterior pituitary response to TRH, GnRH, and hypoglycaemia induced by insulin in 7 patients during molar pregnancy and one week after molar abortion. hCG showed significantly higher serum levels during rather than after molar pregnancy and hPL was detectable in only 4 patients during, but in none after molar pregnancy. FSH values were in the follicular phase range before and after molar abortion (12.7 ± 0.8 and 12.7 ± 3.5 IU/l). PRL had elevated basal levels before and after molar abortion; 103.0 ± 16.5 and 43 ± 10.6 μg/l, respectively (P < 0.05). GH levels were distinctly elevated in 3 patients during molar pregnancy; after molar abortion, the basal GH values were normal in all patients < 10 μg/l. Basal cortisol and TSH levels were in the normal range before and after molar abortion. The FTI was above the normal range in 3 patients during molar pregnancy, whereas after molar abortion the values were normalized. E2 levels were elevated before and after molar abortion, 1881 ± 477 and 96.5 ± 39.2 ng/l, respectively (P < 0.01). PG levels before and after molar abortion were 30.9 ± 5.4 and 10 ± 6.7 μg/l, respectively (P < 0.05). Comparison of women with molar pregnancy vs women with normal pregnancy showed a significant difference only as to β hCG (P < 0.05), whereas comparison of women in molar puerperium vs women in normal puerperium after term pregnancy showed a significant difference in β hCG (P < 0.01), PRL (P < 0.01), and PG (P < 0.01). Six of the 7 patients had a PRL increase of over 100% of the basal level in the first 15 min after TRH administration; one week after molar abortion, all patients had a normal PRL response to TRH. During molar pregnancy, only 3 patients showed a normal TSH response to TRH, 4 patients did not respond; 3 of them had an FTI above normal range. During the second challenge one week after molar abortion, 5 patients showed a normal TSH response to TRH. The hypoglycaemia stimulus induced a normal cortisol and GH response in 6 and in 5 patients, respectively, during molar pregnancy; after molar abortion, all patients had a normal cortisol and GH response to hypoglycaemia. FSH had no response to GnRH during or after molar pregnancy. These results establish the neuro-endocrine pattern in patients with molar pregnancy showing a clear disturbance in the neuro-endocrine regulation of the thyroid axis as well as in the GH release.

scholarly journals Possible Roles of Calreticulin in Uterine Decidualization and Receptivity in Rats and Humans

2021 ◽  
Vol 22 (19) ◽  
pp. 10505
Author(s):  
Mikihiro Yoshie ◽  
Kazuya Kusama ◽  
Risaka Tanaka ◽  
Takanori Okubo ◽  
Junya Kojima ◽  
...  
Keyword(s):  
Connexin 43 ◽  
Normal Pregnancy ◽  
Related Factor ◽  
Pregnant Rat ◽  
Expression Levels ◽  
Artificial Induction ◽  
Decidual Cells ◽  
High Level

Previous in vitro studies have suggested that calreticulin (CALR), which is responsible for the folding and quality control of glycoproteins, may be associated with decidualization. However, its precise role in regulating decidualization has not been explored in vivo. Here, we used pregnant rat models to examine endometrial CALR expression during the peri-implantation period. We also examined whether polypectomy, a procedure that could ameliorate infertility, alters the endometrial expression levels of CALR and several implantation factors in women diagnosed as infertile. In rats, uterine CALR was expressed at a high level at the implantation site, and a marked increase in CALR expression was observed in decidual cells of normal pregnancy. In addition, endometrial CALR expression was enhanced by either administration of estradiol-17β in the delayed implantation rat model or the artificial induction of decidualization in the pseudopregnant rat. In cultured stromal cells, siRNA-mediated silencing of CALR inhibited the decidual stimulus-induced expression of prolactin, decidual/trophoblast prolactin-related protein, and connexin 43. In humans, the endometrial expression levels of the mRNAs encoding CALR and the implantation-related factor insulin-like growth factor binding protein (IGFBP)-7 tended to increase after polypectomy. The strongest positive correlation between expression levels before polypectomy was observed for IGFBP-7 and CALR, and the strength of this correlation increased after the surgery. Thus, endometrial CALR may play a role in the formation of decidua, and the polypectomy of infertile patients may result in the co-operative expression of endometrial factors, including CALR, that could enhance endometrial receptivity.

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