scholarly journals Corepressor Rcor1 is essential for murine erythropoiesis

Blood ◽  
2014 ◽  
Vol 123 (20) ◽  
pp. 3175-3184 ◽  
Author(s):  
Huilan Yao ◽  
Devorah C. Goldman ◽  
Tamilla Nechiporuk ◽  
Sunita Kawane ◽  
Shannon K. McWeeney ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Key Points ◽  
Fetal Erythropoiesis

Key Points Rcor1 knockout mice show a block in fetal erythropoiesis at the proerythroblast stage. Rcor1 represses expression of HSCs and myeloid genes during erythropoiesis, including Csf2rb, which is important in myeloid function.

scholarly journals Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder

Blood ◽  
2013 ◽  
Vol 122 (6) ◽  
pp. 988-998 ◽  
Author(s):  
Yehudit Birger ◽  
Liat Goldberg ◽  
Timothy M. Chlon ◽  
Benjamin Goldenson ◽  
Inna Muler ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Myeloproliferative Disorder ◽  
Transient Myeloproliferative Disorder ◽  
Terminal Domain ◽  
Key Points ◽  
Fetal Hematopoiesis ◽  
Fetal Erythropoiesis

Key Points Transient expansion of fetal megaerythroid progenitors in ERG/Gata1s mouse is biologically similar to Down syndrome TMD. The N-terminal domain of GATA1 and the downregulation of ERG expression are essential for normal fetal erythropoiesis.

scholarly journals Critical requirement of VEGF-C in transition to fetal erythropoiesis

Blood ◽  
2016 ◽  
Vol 128 (5) ◽  
pp. 710-720 ◽  
Author(s):  
Shentong Fang ◽  
Harri Nurmi ◽  
Krista Heinolainen ◽  
Shuo Chen ◽  
Essi Salminen ◽  
...  
Keyword(s):  
Key Points ◽  
Critical Requirement ◽  
Fetal Erythropoiesis ◽  
Myeloid Progenitors

Key Points Vegfc is essential for mobilization, maturation, and enucleation of primitive erythroblasts. Vegfc deletion compromises liver colonization by erythro-myeloid progenitors and subsequent macrophage/erythroid expansion.

scholarly journals Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

Blood ◽  
2017 ◽  
Vol 129 (4) ◽  
pp. 405-414 ◽  
Author(s):  
Susanna Canali ◽  
Kimberly B. Zumbrennen-Bullough ◽  
Amanda B. Core ◽  
Chia-Yu Wang ◽  
Manfred Nairz ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Bone Morphogenetic Protein ◽  
Knockout Mice ◽  
Iron Homeostasis ◽  
Conditional Knockout ◽  
Conditional Knockout Mice ◽  
Morphogenetic Protein ◽  
Key Points ◽  
Paracrine Actions ◽  
Bone Morphogenetic Protein 6

Key Points Endothelial Bmp6 conditional knockout mice exhibit hemochromatosis, whereas hepatocyte and macrophage Bmp6 conditional knockout mice do not. Our data support a model in which EC Bmp6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin production.

scholarly journals Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Blood ◽  
2015 ◽  
Vol 125 (12) ◽  
pp. 1957-1967 ◽  
Author(s):  
Marjolein Meinders ◽  
Divine I. Kulu ◽  
Harmen J. G. van de Werken ◽  
Mark Hoogenboezem ◽  
Hans Janssen ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Platelet Aggregation ◽  
Knockout Mice ◽  
Platelet Dysfunction ◽  
Double Knockout ◽  
Key Points ◽  
Proplatelet Formation ◽  
And Function ◽  
Platelet Formation

Key Points Megakaryocyte-specific Sp1/Sp3 double-knockout mice display thrombocytopenia, platelet dysfunction, and defects in megakaryocyte maturation. Selective Mylk inhibition by ML7 affects proplatelet formation and stabilization and ITAM receptor–mediated platelet aggregation.

scholarly journals Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge

Blood ◽  
2017 ◽  
Vol 130 (21) ◽  
pp. 2339-2343 ◽  
Author(s):  
Chloé Latour ◽  
Céline Besson-Fournier ◽  
Ophélie Gourbeyre ◽  
Delphine Meynard ◽  
Marie-Paule Roth ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Hepcidin Expression ◽  
Lps Challenge ◽  
Key Points ◽  
Deficient Mice

Key Points Loss of Bmp6 further represses hepcidin expression in the liver of Hjv knockout mice and markedly worsens the iron phenotype of females. Induction of hepcidin by LPS is not prevented by lack of Bmp6 and/or Hjv but its level poststimulation is blunted compared with controls.

scholarly journals Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor

Blood ◽  
2016 ◽  
Vol 128 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Nur Hezrin Shahrin ◽  
Sonya Diakiw ◽  
Lindsay A. Dent ◽  
Anna L. Brown ◽  
Richard J. D’Andrea
Keyword(s):  
Bone Marrow ◽  
Transcription Factor ◽  
Knockout Mice ◽  
Conditional Knockout ◽  
Conditional Knockout Mice ◽  
Key Points

Key Points Klf5 functions in hematopoiesis to regulate HSC and progenitor proliferation and localization in the bone marrow. Klf5 is required in the granulocyte lineage and positively affects neutrophil output at the expense of eosinophil production.

scholarly journals Murine coagulation factor VIII is synthesized in endothelial cells

Blood ◽  
2014 ◽  
Vol 123 (24) ◽  
pp. 3697-3705 ◽  
Author(s):  
Lesley A. Everett ◽  
Audrey C. A. Cleuren ◽  
Rami N. Khoriaty ◽  
David Ginsburg
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Factor Viii ◽  
Knockout Mice ◽  
Coagulation Factor ◽  
Primary Source ◽  
Cell Populations ◽  
Key Points ◽  
Different Tissues

Key Points Lman1 tissue-specific knockout mice reveal that endothelial cells, not hepatocytes, are the primary source of FVIII biosynthesis. F8 gene expression is heterogeneous among endothelial cell populations in different tissues.

scholarly journals The actin-binding protein profilin 2 is a novel regulator of iron homeostasis

Blood ◽  
2017 ◽  
Vol 130 (17) ◽  
pp. 1934-1945 ◽  
Author(s):  
Sara Luscieti ◽  
Bruno Galy ◽  
Lucia Gutierrez ◽  
Michael Reinke ◽  
Jorge Couso ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Untranslated Region ◽  
Iron Homeostasis ◽  
Iron Accumulation ◽  
Actin Binding ◽  
Liver Iron ◽  
Iron Stores ◽  
Actin Binding Protein ◽  
Key Points ◽  
The Brain

Key Points Pfn2 mRNA has a functional and conserved IRE in the 3′ untranslated region. Pfn2 knockout mice display an iron phenotype with iron accumulation in specific areas of the brain and depletion of liver iron stores.

scholarly journals Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels

Blood ◽  
2013 ◽  
Vol 122 (8) ◽  
pp. 1478-1486 ◽  
Author(s):  
Somadri Ghosh ◽  
Dhananjay Shukla ◽  
Komjeti Suman ◽  
B. Jyothi Lakshmi ◽  
R. Manorama ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Pulmonary Thromboembolism ◽  
Clotting Time ◽  
Inorganic Polyphosphate ◽  
Inositol Hexakisphosphate ◽  
Key Points

Key Points Inositol hexakisphosphate kinase 1 (IP6K1) knockout mice display lower inorganic polyphosphate levels in platelets. Low platelet polyphosphate leads to lengthened clotting time, altered clot architecture, and protection against pulmonary thromboembolism.

scholarly journals p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency

Blood ◽  
2015 ◽  
Vol 125 (15) ◽  
pp. 2344-2348 ◽  
Author(s):  
Jad I. Belle ◽  
David Langlais ◽  
Jessica C. Petrov ◽  
Mercedes Pardo ◽  
Russell G. Jones ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Knockout Mice ◽  
Cell Function ◽  
Bone Marrow Failure ◽  
Developmental Defects ◽  
Hematopoietic Stem ◽  
Key Points ◽  
P53 Activation

Key Points Developmental defects and impairment in lymphopoiesis in Mysm1-knockout mice are the result of p53 activation. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 activation.

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