scholarly journals Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

Blood ◽  
2014 ◽  
Vol 124 (6) ◽  
pp. 913-923 ◽  
Author(s):  
Cathy X. Wang ◽  
Blythe D. Sather ◽  
Xuefeng Wang ◽  
Jennifer Adair ◽  
Iram Khan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Delivery ◽  
Hematopoietic Stem Cells ◽  
Lentiviral Vector ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Lentiviral Integration ◽  
Human And Mouse ◽  
Vector Transduction

Key PointsRapamycin significantly enhances lentiviral vector gene delivery to hematopoietic stem cells while preserving engraftment potential. Rapamycin-mediated transduction enhancement is not accompanied by alterations in lentiviral integration profile.

scholarly journals Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy

Gene Therapy ◽  
2020 ◽  
Vol 27 (12) ◽  
pp. 545-556
Author(s):  
Yoonjeong Jang ◽  
Yoon-Sang Kim ◽  
Matthew M. Wielgosz ◽  
Francesca Ferrara ◽  
Zhijun Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Hematopoietic Stem Cells ◽  
Lentiviral Vector ◽  
Hematopoietic Stem ◽  
Vector Transduction

scholarly journals Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes

Blood ◽  
2019 ◽  
Vol 134 (16) ◽  
pp. 1298-1311 ◽  
Author(s):  
Stosh Ozog ◽  
Nina D. Timberlake ◽  
Kip Hermann ◽  
Olivia Garijo ◽  
Kevin G. Haworth ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Delivery ◽  
Progenitor Cells ◽  
Lentiviral Vector ◽  
Transmembrane Protein ◽  
Endosomal Trafficking ◽  
Dependent Manner ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Stem And Progenitor Cells

Key Points The cyclic resveratrol trimer caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A decreases interferon-induced transmembrane protein-mediated restriction in an endosomal trafficking-dependent manner.

Lentiviral Vector Transduction of Hematopoietic Stem Cells that Mediate Long-Term Reconstitution of Lethally Irradiated Mice

Stem Cells ◽  
2000 ◽  
Vol 18 (5) ◽  
pp. 352-359 ◽  
Author(s):  
WenYong Chen ◽  
Xiaoyun Wu ◽  
Dana N. Levasseur ◽  
Hongmei Liu ◽  
Lilin Lai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Lentiviral Vector ◽  
Hematopoietic Stem ◽  
Vector Transduction

Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells

Blood ◽  
2013 ◽  
Vol 122 (10) ◽  
pp. 1730-1740 ◽  
Author(s):  
Francois Lassailly ◽  
Katie Foster ◽  
Lourdes Lopez-Onieva ◽  
Erin Currie ◽  
Dominique Bonnet
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Comparative Analysis ◽  
Hematopoietic Stem Cells ◽  
Multimodal Imaging ◽  
Intravital Imaging ◽  
Functional Heterogeneity ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Functional Implications

Key Points Comparative analysis of epiphyses, diaphyses, and calvaria in terms of homeostatic HSC content, homing, and early reconstitution is described. Noninvasive intravital imaging of intact bones and assessment of BVF, BRA, and hypoxia are reported.

scholarly journals Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis

2018 ◽  
Vol 2 (11) ◽  
pp. 1220-1228 ◽  
Author(s):  
Richard H. Chapple ◽  
Yu-Jung Tseng ◽  
Tianyuan Hu ◽  
Ayumi Kitano ◽  
Makiko Takeichi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Steady State ◽  
Hematopoietic Stem Cells ◽  
Lineage Tracing ◽  
Lymphoid Cells ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Active Contribution

Key Points HSCs contribute robustly to steady-state hematopoiesis. Platelets receive extensive influx from HSCs compared with other myeloid or lymphoid cells.

scholarly journals Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency

Blood ◽  
2014 ◽  
Vol 124 (10) ◽  
pp. 1622-1625 ◽  
Author(s):  
Serine Avagyan ◽  
Michael Churchill ◽  
Kenta Yamamoto ◽  
Jennifer L. Crowe ◽  
Chen Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem Cell ◽  
Premature Aging ◽  
Hematopoietic Stem ◽  
Cell Dysfunction ◽  
Key Points ◽  
Deficient Mice

Key Points XLF-deficient mice recapitulate the lymphocytopenia of XLF-deficient patients. Premature aging of hematopoietic stem cells underlies the severe and progressive lymphocytopenia in XLF-deficient mice.

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