scholarly journals Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines

Blood ◽  
2017 ◽  
Vol 129 (16) ◽  
pp. 2257-2265 ◽  
Author(s):  
Frederika A. van Nimwegen ◽  
Georgios Ntentas ◽  
Sarah C. Darby ◽  
Michael Schaapveld ◽  
Michael Hauptmann ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hodgkin Lymphoma ◽  
Radiation Doses ◽  
Key Points

Key Points Risk of HF increases following cardiac radiation doses above 20 Gy. Anthracyclines increase HF rate by threefold independently of radiation.

Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma

Blood ◽  
2013 ◽  
Vol 121 (17) ◽  
pp. 3431-3433 ◽  
Author(s):  
Jing Ouyang ◽  
Annette Plütschow ◽  
Elke Pogge von Strandmann ◽  
Katrin S. Reiners ◽  
Sabine Ponader ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Clinical Features ◽  
Serum Levels ◽  
Tumor Burden ◽  
Clinical Parameters ◽  
Classical Hodgkin Lymphoma ◽  
Key Points ◽  
Normal Controls

Key Points Serum levels of galectin-1 are significantly higher in patients with cHL than in normal controls. Galectin-1 serum levels are associated with clinical parameters of tumor burden in patients with cHL.

scholarly journals Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Blood ◽  
2017 ◽  
Vol 130 (22) ◽  
pp. 2420-2430 ◽  
Author(s):  
Christopher D. Carey ◽  
Daniel Gusenleitner ◽  
Mikel Lipschitz ◽  
Margaretha G. M. Roemer ◽  
Edward C. Stack ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Topological Analysis ◽  
Key Points

Key Points Regionally localized PD-L1+ macrophages form a specialized microenvironmental niche for Hodgkin Reed-Sternberg cells in cHL.

scholarly journals Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3547-3553 ◽  
Author(s):  
Jennifer A. Kanakry ◽  
Hailun Li ◽  
Lan L. Gellert ◽  
M. Victor Lemas ◽  
Wen-son Hsieh ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Epstein Barr Virus ◽  
Prognostic Significance ◽  
Barr Virus ◽  
Correlative Analysis ◽  
Key Points ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Group Trial

Key Points Plasma EBV-DNA is highly concordant with EBV tumor status in Hodgkin lymphoma. Plasma EBV-DNA has prognostic significance in Hodgkin lymphoma, both before therapy and at month 6 of follow-up.

scholarly journals Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma

Blood ◽  
2018 ◽  
Vol 131 (21) ◽  
pp. 2345-2356 ◽  
Author(s):  
Elena Battistello ◽  
Natalya Katanayeva ◽  
Elie Dheilly ◽  
Daniele Tavernari ◽  
Maria C. Donaldson ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Molecular Subtypes ◽  
Src Kinase ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Oncogenic Signaling ◽  
Kinase Inhibition ◽  
Non Hodgkin Lymphoma ◽  
Key Points

Key Points Inhibition of BTK in patients who are resistant to ibrutinib changes signaling tumor dependencies and promotes MYC upregulation. Multitarget inhibition of LYN, FYN, and BLK is therapeutically effective in patients with DLBCL independent of their molecular subtypes.

scholarly journals Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell–rich and exhausted T-effector microenvironment

Blood ◽  
2018 ◽  
Vol 132 (8) ◽  
pp. 825-836 ◽  
Author(s):  
Fathima Zumla Cader ◽  
Ron C. J. Schackmann ◽  
Xihao Hu ◽  
Kirsty Wienand ◽  
Robert Redd ◽  
...  
Keyword(s):  
T Cell ◽  
Hodgkin Lymphoma ◽  
Regulatory T Cell ◽  
Newly Diagnosed ◽  
Mass Cytometry ◽  
Concomitant Increase ◽  
Key Points

Key Points Newly diagnosed primary cHLs have a concomitant increase in CD4+ Th1-polarized Tregs and differentiated Teffs. Primary cHLs exhibit 2 major complementary bases of immunosuppression: likely exhausted PD-1+ Th1 Teffs and active PD-1− Th1 Tregs.

scholarly journals Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older

Blood ◽  
2015 ◽  
Vol 126 (26) ◽  
pp. 2798-2804 ◽  
Author(s):  
Andres Forero-Torres ◽  
Beata Holkova ◽  
Jerome Goldschmidt ◽  
Robert Chen ◽  
Gregg Olsen ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Brentuximab Vedotin ◽  
Phase 2 ◽  
Phase 2 Study ◽  
Key Points

Key Points Frontline brentuximab vedotin monotherapy provided a 92% ORR and was generally well tolerated in elderly HL patients.

scholarly journals Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma

Blood ◽  
2018 ◽  
Vol 131 (22) ◽  
pp. 2413-2425 ◽  
Author(s):  
Valeria Spina ◽  
Alessio Bruscaggin ◽  
Annarosa Cuccaro ◽  
Maurizio Martini ◽  
Martina Di Trani ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Residual Disease ◽  
Clonal Evolution ◽  
Circulating Tumor Dna ◽  
Classical Hodgkin Lymphoma ◽  
Key Points ◽  
Tumor Dna

Key Points ctDNA is as an easily accessible source of tumor DNA for cHL genotyping. ctDNA is a radiation-free tool to track residual disease in cHL.

scholarly journals Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma

2018 ◽  
Vol 2 (23) ◽  
pp. 3479-3482 ◽  
Author(s):  
Chia-Ching Wang ◽  
Cassandra Thanh ◽  
Erica A. Gibson ◽  
Maya Ball-Burack ◽  
Louise E. Hogan ◽  
...  
Keyword(s):  
T Cell ◽  
Hodgkin Lymphoma ◽  
Brentuximab Vedotin ◽  
Cd4 T Cell ◽  
Plasma Viremia ◽  
Hiv Rna ◽  
Key Points ◽  
Transient Loss ◽  
Hiv 1 ◽  
Residual Plasma Viremia

Key Points Anti-CD30 therapy for Hodgkin lymphoma led to transient loss of detectable CD4+ T-cell HIV RNA and a decrease in residual plasma viremia. Targeting nonviral markers expressed on HIV-1 transcriptionally active cells may lead to reduced measures of HIV-1 persistence.

scholarly journals Producing an effective care plan in advanced heart failure

2019 ◽  
Vol 21 (Supplement_M) ◽  
pp. M61-M63 ◽  
Author(s):  
Loreena Hill
Keyword(s):  
Heart Failure ◽  
Advanced Heart Failure ◽  
Care Plan ◽  
Effective Discharge ◽  
Discharge Plan ◽  
Effective Care ◽  
Key Points ◽  
Management Plans ◽  
Association Meeting

Abstract An effective discharge plan is associated with better outcomes in advanced heart failure (HF) patients. Furthermore, a patient-centred care planning can improve patients’ satisfaction, quality of life, and enhance self-care. Telemedicine may allow optimized monitoring of advanced HF patients. Nevertheless, its implementation into clinical practice across European countries is still limited. This document reflects the key points discussed concerning effective management plans in advanced HF by a panel of experts during a Heart Failure Association meeting on physiological monitoring of the complex multimorbid HF patient.

scholarly journals Targetable subsets of non-Hodgkin lymphoma in Malawi define therapeutic opportunities

2016 ◽  
Vol 1 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Elizabeth A. Morgan ◽  
M. Patrick Sweeney ◽  
Tamiwe Tomoka ◽  
Nadja Kopp ◽  
Daniel Gusenleitner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Hodgkin Lymphoma ◽  
Expression Profiling ◽  
Resource Constraints ◽  
Objective Assessment ◽  
Non Hodgkin Lymphoma ◽  
Key Points ◽  
Targeted Gene Expression

Key Points NHL subclassification is lacking in Malawi due to resource constraints yet is critical for directing therapy. Targeted gene expression profiling facilitates objective assessment and segregation of biologically defined subsets of NHL from Malawi.

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