scholarly journals Myasthenia Gravis in a Patient with Chronic Myeloid Leukemia Treated by Busulfan

Blood ◽  
1968 ◽  
Vol 32 (2) ◽  
pp. 336-340 ◽  
Author(s):  
MEIR DJALDETTI ◽  
JACK PINKHAS ◽  
ANDRE DE VRIES ◽  
EDNA KOTT ◽  
HENRY JOSHUA ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myasthenia Gravis ◽  
Myeloid Leukemia ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Surgical Removal ◽  
Autoimmune Process ◽  
X Ray ◽  
Malignant Thymoma

Abstract Myasthenia gravis and roentgenologic evidence of a mass in the anterior mediastinum appeared in a patient with chronic myeloid leukemia following busulfan treatment. X-ray irradiation of the thymic area and subsequent surgical removal of the anterior mediastinal mass were followed by remission from the myasthenia gravis. Histologic examination of the mass showed involuted thymic remnants without evidence of leukemic infiltration or of malignant thymoma. The possible etiology of the myasthenia gravis in this patient, with special reference to a busulfan-induced autoimmune process, is discussed.

scholarly journals Thymoangiolipoma: A rare histologic variant of thymolipoma in a patient with myasthenia gravis

Rare Tumors ◽  
2020 ◽  
Vol 12 ◽  
pp. 203636132097921
Author(s):  
Mohammad Hossein Anbardar ◽  
Fatemeh Amirmoezi ◽  
Armin Amirian
Keyword(s):  
Myasthenia Gravis ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
High Serum ◽  
Anterior Mediastinal Mass ◽  
Spiral Computed ◽  
Thymic Tissue ◽  
Radiologic Evaluation ◽  
Thymic Neoplasm ◽  
Slow Growing

Thymoangiolipoma is a rare, slow-growing, benign thymic neoplasm that arises from the anterior mediastinum. A 61-year-old man with the chief complaint of right eye ptosis and high serum acetylcholine receptor antibody level is presented here. The spiral computed tomography of the chest revealed a hypodense mass in the anterior mediastinum. Microscopic examination showed admixture of adipose tissue, thymic tissue and blood vessels with the diagnosis of thymoangiolipoma. Thymoangiolipoma is a rare histologic variant of thymolipoma which can be associated with myasthenia gravis and must be considered as a differential diagnosis in anterior mediastinal mass with fat density in radiologic evaluation.

scholarly journals Discontinuation of imatinib mesylate could improve renal impairment in chronic myeloid leukemia

Open Medicine ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 22-24 ◽  
Author(s):  
Umit Y. Malkan ◽  
Ibrahim C. Haznedaroglu
Keyword(s):  
Pleural Effusion ◽  
Chronic Myeloid Leukemia ◽  
Serum Creatinine ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Laboratory Tests ◽  
Fluid Retention ◽  
X Ray ◽  
Cytogenetic Remission

AbstractWe aim to report a CML case that had fluid retention and serum creatinine increase under long-term imatinib mesylate (IM) treatment. A 68-year-old woman was diagnosed with chronic myeloid leukemia, and IM was started in 2002 with a dose of 400 mg/day. She had achieved complete hematological, molecular and cytogenetic remission under IM treatment. In September 2015, her creatinine level was 1.7 mg/dl. In May 2016, she was admitted to our hospital with dyspnea. Hypervolemia secondary to fluid retention was detected in our patient. Her laboratory tests results showed hemoglobin 9.7 gr/dl, white blood cell 7.6x103/μl, platelet 157x103/μl, creatinine 3.2 mg/dl, blood urea nitrogen (BUN) 88 mg/dl. In her X-ray chest film, bilateral pleural effusion was detected. The effusion was detected as transuda. The other reasons of pleural effusion were excluded and the development of pleural effusion was considered secondary to IM. IM was also considered responsible for the acute rise of serum creatinine levels of our patient. Therefore for these two reasons IM was stopped. After the discontinuation of IM, her creatinine levels decreased to 1.6 mg/dl and her pleural effusions disappeared. IM treatment was considered as the reason of serum creatinine elevation since serum creatinine levels decreased after the discontinuation of IM. All of the side-effects disappeared after discontinuation of IM.

Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy

1996 ◽  
Vol 32 (2) ◽  
pp. 111-117 ◽  
Author(s):  
MF Lainesse ◽  
SM Taylor ◽  
SL Myers ◽  
D Haines ◽  
JD Fowler
Keyword(s):  
Weight Loss ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Paraneoplastic Syndrome ◽  
Mediastinal Mass ◽  
Clinical Signs ◽  
Diagnostic Evaluation ◽  
Antibody Concentration ◽  
Surgical Removal ◽  
Clinically Normal

A 10-year-old, neutered male cocker spaniel-cross experienced regurgitation, dry retching, and weight loss. A large, mediastinal mass and dilatation of the esophagus were seen on thoracic radiographs. Cytological, histopathological, immunohistochemical, and serological findings were consistent with a lymphoepithelial thymoma and focal, esophageal myasthenia gravis. Surgical removal of the mass resulted in rapid resolution of the megaesophagus and a decrease in serum acetylcholine-receptor antibody concentration. The dog was clinically normal until the thymoma recurred six months postoperatively. Clinical signs, diagnostic evaluation, management, and treatment of a dog with thymoma and megaesophagus are described.

scholarly journals Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Mauricio A. Palau ◽  
Amanda Winters ◽  
Xiayuan Liang ◽  
Rachelle Nuss ◽  
Susan Niermeyer ◽  
...  
Keyword(s):  
Vitamin K ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
Medical Attention ◽  
Anterior Mediastinal Mass ◽  
Vitamin K Deficiency ◽  
K Deficiency ◽  
Chest X Ray ◽  
Work Up

We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Routine laboratory work-up revealed severe coagulopathy. Further questioning revealed the patient had not received prophylactic vitamin K at birth. The coagulopathy resolved with administration of vitamin K, and a biopsy confirmed the anterior mediastinal mass was due to spontaneous thymic hemorrhage.

Chronic Myeloid Leukemia in Myasthenia Gravis after Long-Term Treatment with 6-Mercaptopurine

2009 ◽  
Vol 210 (1-6) ◽  
pp. 235-238 ◽  
Author(s):  
J. Wanders ◽  
A. R. Wattendorff ◽  
L. J. Endtz ◽  
J. J. Nijs ◽  
C. H. W. Leeksma
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myasthenia Gravis ◽  
Myeloid Leukemia ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Development of myasthenia gravis in a patient with chronic myeloid leukemia during treatment with nilotinib

2014 ◽  
Vol 6 (2) ◽  
Author(s):  
David Sanford ◽  
Maria MacDonald ◽  
Michael Nicolle ◽  
Anargyros Xenocostas
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myasthenia Gravis ◽  
Myeloid Leukemia

scholarly journals Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review

2021 ◽  
pp. 101-106
Author(s):  
Akira Ishikawa ◽  
Kazuya Kuraoka ◽  
Junichi Zaitsu ◽  
Akihisa Saito ◽  
Atsushi Kamigaichi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Growth Pattern ◽  
Mediastinal Mass ◽  
Smooth Muscle Actin ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Muscle Actin

Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. Herein, we report a case of an 85-year-old female with an anterior mediastinal mass of 15 mm. Histological examination revealed spindle tumor cells showing a fascicular growth pattern. Immunohistochemically, the tumor cells were focal positive for desmin, calponin, and α-smooth muscle actin. The pathological diagnosis was leiomyosarcoma. In conclusion, we encountered a case of a very rare leiomyosarcoma that occurred in the anterior mediastinum, and our report may contribute to the understanding of this disease.

A Refractory Stage IVb Thymoma Responded Completely to a Combination of Dasatinib and Prednisone but Poorly to Either One Alone

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4925-4925
Author(s):  
Eric C. Y. Lian ◽  
Maria Matsangou ◽  
Diana Liu
Keyword(s):  
Partial Response ◽  
Myasthenia Gravis ◽  
Aplastic Anemia ◽  
Mediastinal Mass ◽  
White Male ◽  
Complete Response ◽  
Leukemic Cells ◽  
Phase Ii Trials ◽  
Malignant Thymoma ◽  
Stage Ivb

Abstract Abstract 4925 Introduction: Thymomas are rare tumors for which there is little randomized evidence to guide treatment and therefore, therapeutic options to cure advanced malignant thymomas are limited. We hereby report the first clinical outcome of combined dasatinib and prednisone therapy in a patient with heavily treated stage IVB malignant thymoma. Case Presentation: A 41 year old white male presented with fatigue, fever and granulocytopenia. He soon developed myasthenia gravis and aplastic anemia. Computer tomography showed a mediastinal mass, pleural thickening, splenomegaly and mesenteric nodes; biopsy of mediastinal mass revealed a malignant thymoma. Prednisone for 6 weeks along with antithymocyte globulin and cyclosporine were started for myasthenia gravis and aplastic anemia. Chemotherapy for unresectable thymoma was soon initiated with ADOC (Cisplatin, Doxorubicin, Vincristine, and Cyclophosphamide), but only small partial response was noted. After failing to show response to another three lines of therapy, we commenced therapy with dasatinib 75 mg twice daily. Thymoma showed partial response to dasatinib initially but soon became resistant and progressed. When prednisone 100 mg daily was added, a complete response was observed. Conclusion: A patient with stage IVB thymic carcinoma failed to respond well 3 lines of combination chemotherapy, and neither to prednisone or dasatinib alone. When dasatinib is combined with prednisone, it induced a complete response. Disclosures: Off Label Use: Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor. It is a potent inhibitor of Imatinib resistant KIT activation loop mutants and induces apoptosis in mast cells and leukemic cells. At higher concentrations, Dasatinib also inhibits c-Kit, PDGFR and EphedrinA2. it has currently FDA approval for treatment of adults in all phases of chronic myeloid leukemias with resistance or intolerance to prior therapy, including Gleevec. The second indication for Dasatinib, is for the treatment of Ph+ALL. A number of Phase II trials have shown activity of this agent to various solid tumors including breast and lung cancer. Imatinib showed activity in thymomas, thus the rationale for using Dasatinib in the treatment of our patient.

scholarly journals Serum Vitamin B12 in Leukemias and Malignant Lymphomas

Blood ◽  
1957 ◽  
Vol 12 (9) ◽  
pp. 804-813 ◽  
Author(s):  
M. RACHMILEWITZ ◽  
G. IZAK ◽  
A. HOCHMAN ◽  
J. ARONOVITCH ◽  
N. GROSSOWICZ
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Vitamin B12 ◽  
Myeloid Leukemia ◽  
Binding Capacity ◽  
Serum Vitamin ◽  
High Serum ◽  
Myeloid Differentiation ◽  
Malignant Lymphomas ◽  
X Ray ◽  
Lymphatic Leukemia

Abstract High serum vitamin B12 levels were found in chronic myeloid leukemia and in acute leukemia with myeloid differentiation. Following x-ray therapy and repeated blood transfusions, a drop of serum vitamin B12 was found. In chronic lymphatic leukemia, undifferentiated stem cell leukemia, Hodgkin’s disease, and multiple myeloma, the serum vitamin B12 concentrations were normal. In polycythemia with marked leukocytosis the serum B12 was normal. In myelosclerosis high B12 values may be found. The serum vitamin B12 in chronic myeloid leukemia is in a bound form and the binding capacity for added B12 is increased. Serum vitamin B12 determination may be of some value in differentiating various types of leukemia and other myelo-proliferative disorders.

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