scholarly journals Thymoangiolipoma: A rare histologic variant of thymolipoma in a patient with myasthenia gravis

Rare Tumors ◽  
2020 ◽  
Vol 12 ◽  
pp. 203636132097921
Author(s):  
Mohammad Hossein Anbardar ◽  
Fatemeh Amirmoezi ◽  
Armin Amirian
Keyword(s):  
Myasthenia Gravis ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
High Serum ◽  
Anterior Mediastinal Mass ◽  
Spiral Computed ◽  
Thymic Tissue ◽  
Radiologic Evaluation ◽  
Thymic Neoplasm ◽  
Slow Growing

Thymoangiolipoma is a rare, slow-growing, benign thymic neoplasm that arises from the anterior mediastinum. A 61-year-old man with the chief complaint of right eye ptosis and high serum acetylcholine receptor antibody level is presented here. The spiral computed tomography of the chest revealed a hypodense mass in the anterior mediastinum. Microscopic examination showed admixture of adipose tissue, thymic tissue and blood vessels with the diagnosis of thymoangiolipoma. Thymoangiolipoma is a rare histologic variant of thymolipoma which can be associated with myasthenia gravis and must be considered as a differential diagnosis in anterior mediastinal mass with fat density in radiologic evaluation.

scholarly journals Myasthenia Gravis in a Patient with Chronic Myeloid Leukemia Treated by Busulfan

Blood ◽  
1968 ◽  
Vol 32 (2) ◽  
pp. 336-340 ◽  
Author(s):  
MEIR DJALDETTI ◽  
JACK PINKHAS ◽  
ANDRE DE VRIES ◽  
EDNA KOTT ◽  
HENRY JOSHUA ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myasthenia Gravis ◽  
Myeloid Leukemia ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Surgical Removal ◽  
Autoimmune Process ◽  
X Ray ◽  
Malignant Thymoma

Abstract Myasthenia gravis and roentgenologic evidence of a mass in the anterior mediastinum appeared in a patient with chronic myeloid leukemia following busulfan treatment. X-ray irradiation of the thymic area and subsequent surgical removal of the anterior mediastinal mass were followed by remission from the myasthenia gravis. Histologic examination of the mass showed involuted thymic remnants without evidence of leukemic infiltration or of malignant thymoma. The possible etiology of the myasthenia gravis in this patient, with special reference to a busulfan-induced autoimmune process, is discussed.

Primary Mucinous Adenocarcinoma of the Thymus: A Case Report and Review of the Literature

2006 ◽  
Vol 130 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Payal Kapur ◽  
Dinesh Rakheja ◽  
Michael Bastasch ◽  
Kyle H. Molberg ◽  
Venetia R. Sarode
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Mucinous Adenocarcinoma ◽  
Mediastinal Mass ◽  
The Body ◽  
Anterior Mediastinal Mass ◽  
Review Of The Literature ◽  
Specific Identification ◽  
Biopsy Specimens ◽  
Thymic Neoplasm

Abstract Primary thymic mucinous adenocarcinoma is extremely rare; to our knowledge, only 2 cases have been reported to date. We describe a third case of primary mucinous adenocarcinoma of the thymus in a 41-year-old man who presented with an anterior mediastinal mass with subsequent metastasis to the lung. The initial diagnosis was of metastatic mucinous adenocarcinoma, but extensive clinical workup of the patient failed to reveal a primary tumor elsewhere in the body. The specific identification of mucinous adenocarcinoma as a primary thymic neoplasm can be difficult or impossible. Morphologic and immunophenotypic similarities to mucinous adenocarcinomas of the gastrointestinal tract can pose diagnostic challenges for surgical pathologists, especially in small biopsy specimens.

scholarly journals Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Mauricio A. Palau ◽  
Amanda Winters ◽  
Xiayuan Liang ◽  
Rachelle Nuss ◽  
Susan Niermeyer ◽  
...  
Keyword(s):  
Vitamin K ◽  
Mediastinal Mass ◽  
Anterior Mediastinum ◽  
Medical Attention ◽  
Anterior Mediastinal Mass ◽  
Vitamin K Deficiency ◽  
K Deficiency ◽  
Chest X Ray ◽  
Work Up

We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Routine laboratory work-up revealed severe coagulopathy. Further questioning revealed the patient had not received prophylactic vitamin K at birth. The coagulopathy resolved with administration of vitamin K, and a biopsy confirmed the anterior mediastinal mass was due to spontaneous thymic hemorrhage.

scholarly journals Case Report of An Unusual Mediastinal Mass - Thymolipoma

2020 ◽  
Vol 7 (11) ◽  
pp. C169-171
Author(s):  
Sreeja Raju ◽  
Divya S ◽  
M C Savithri ◽  
Ajaykumar KK ◽  
Gayathri G Nair
Keyword(s):  
Case Report ◽  
World Literature ◽  
Mediastinal Mass ◽  
Anterior Mediastinal Mass ◽  
Chest Discomfort ◽  
Mediastinal Neoplasms ◽  
Slow Growing

Thymolipomas are rare, slow-growing, benign anterior mediastinal neoplasms which are very often detected incidentally. Here we present a case of a 47 year old female who presented with chest discomfort and radiology revealed an anterior mediastinal mass. Total thymectomy was done and histopathology showed features consistent with thymolipoma. Very few cases of thymolipomas have been reported in Indian and world literature.

scholarly journals Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review

2021 ◽  
pp. 101-106
Author(s):  
Akira Ishikawa ◽  
Kazuya Kuraoka ◽  
Junichi Zaitsu ◽  
Akihisa Saito ◽  
Atsushi Kamigaichi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Growth Pattern ◽  
Mediastinal Mass ◽  
Smooth Muscle Actin ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Muscle Actin

Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. Herein, we report a case of an 85-year-old female with an anterior mediastinal mass of 15 mm. Histological examination revealed spindle tumor cells showing a fascicular growth pattern. Immunohistochemically, the tumor cells were focal positive for desmin, calponin, and α-smooth muscle actin. The pathological diagnosis was leiomyosarcoma. In conclusion, we encountered a case of a very rare leiomyosarcoma that occurred in the anterior mediastinum, and our report may contribute to the understanding of this disease.

scholarly journals Third distant recurrence of benign thymoma in a patient with myasthenia gravis

2019 ◽  
Vol 12 (4) ◽  
pp. e228529
Author(s):  
Justin Tyler Van Backer ◽  
Alex Cedeno-Rodriguez ◽  
John Nabagiez
Keyword(s):  
Autoimmune Disease ◽  
Neuromuscular Junction ◽  
Myasthenia Gravis ◽  
Mediastinal Mass ◽  
Distant Recurrence ◽  
Anterior Mediastinal Mass ◽  
Robotic Platform ◽  
Time Intervals ◽  
Robotic Assisted ◽  
Progressive Weakness

Myasthenia gravis (MG) is an autoimmune disease where antibodies attack the presynaptic terminals at the neuromuscular junction causing progressive weakness. Associated with thymomas, resection can improve symptoms. A 29-year-old woman with MG who underwent two previous thymectomies, at ages 11 and 15 presented 14 years later with recurrent MG symptoms and an anterior mediastinal mass. Robotic-assisted thoracoscopic excision of the mediastinal mass was performed without complications. She recovered well and had improvement of her MG symptoms. Thymectomy can significantly improve symptoms in MG even for patients who do not have a thymoma. Reports of distant benign thymoma recurrence are rare. MG patients require continued monitoring and vigilance, even after thymectomy. Benign thymomas can recur even after significant time intervals, and utilisation of the robotic platform for recurrent thymoma excision is safe, even following two sternotomies. Patient symptoms improve with redo thymectomy.

scholarly journals Thymic rebound hyperplasia post-chemotherapy mistaken as disease progression in a patient with lymphoma involving mediastinum: a case report and reflection

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lei Qiu ◽  
Yi Zhao ◽  
Yang Yang ◽  
He Huang ◽  
Zhen Cai ◽  
...  
Keyword(s):  
Young Adult ◽  
Disease Progression ◽  
Mediastinal Mass ◽  
Residual Disease ◽  
Anterior Mediastinum ◽  
Adult Patients ◽  
Thymic Hyperplasia ◽  
Anterior Mediastinal Mass ◽  
Hematopoietic Stem ◽  
Thymus Tissue

Abstract Background Chemotherapy can cause thymic atrophy and reduce T-cell output in cancer patients. However, the thymus in young adult patients has regenerative potential after chemotherapy, manifesting as thymic hyperplasia which can be easily mistaken as residual disease or recurrence in patients suffering lymphoma. Case presentation This study reports a case of lymphoma in a young female adult who was initially diagnosed with an anterior mediastinal mass, and was found to have soft tissue occupying the anterior mediastinum repeatedly after chemotherapy, suggesting a lymphoma residue or disease progression. From discussions by a multi-disciplinary team (MDT), the anterior mediastinal mass of the patient was considered unknown and might be thymus tissue or tumor tissue, and it was eventually identified as thymus tissue via histopathology. Conclusions The anterior mediastinal mass appearing after chemotherapy in patients with lymphoma can be considered as enlarged thymus, and such phenomenon is frequent in young adult patients who undergo chemotherapy or autologous hematopoietic stem cell transplantation. Additionally, detection of thymic output cells in peripheral blood might be a feasible approach to differentiate thymic hyperplasia from lymphoma.

Langerhans Cell Histiocytosis Involving the Thymus

2003 ◽  
Vol 127 (7) ◽  
pp. e294-e297 ◽  
Author(s):  
Benjamin H. Lee ◽  
Suzanne George ◽  
Jeffery L. Kutok
Keyword(s):  
Myasthenia Gravis ◽  
Langerhans Cell Histiocytosis ◽  
Mediastinal Mass ◽  
Langerhans Cell ◽  
Anterior Mediastinal Mass ◽  
Multisystem Disease ◽  
Computed Tomographic ◽  
Aged Woman ◽  
Middle Aged Woman ◽  
History Of

Abstract Langerhans cell histiocytosis (LCH) is a neoplastic proliferation of Langerhans cells that occurs in a range of nodal and extranodal sites. Scattered reports of LCH within the thymus exist, typically among children within the setting of multifocal, multisystem disease. Rare cases of isolated LCH involving the thymus have occurred in adult patients with myasthenia gravis. We report a case of unifocal LCH involving the thymus in a middle-aged woman with a history of a resected leiomyosarcoma but no evidence of myasthenia gravis. Computed tomographic scans revealed an anterior mediastinal mass, which was excised and measured 9.0 cm. Histologic and immunophenotypic findings (CD1a, S100, and Fascin positive and CD68 negative) were consistent with LCH. To our knowledge, this is the first example of LCH occurring in a patient with a history of soft tissue sarcoma and one of the rare reported examples of LCH presenting as a large isolated lesion in the thymus of a nonmyasthenic adult.

scholarly journals First Report ofNocardia asiaticaPresenting as an Anterior Mediastinal Mass in a Patient with Myasthenia Gravis: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Rima I. El-Herte ◽  
Souha S. Kanj ◽  
George F. Araj ◽  
Hassan Chami ◽  
Walid Gharzuddine
Keyword(s):  
Case Report ◽  
Myasthenia Gravis ◽  
Mediastinal Mass ◽  
Cystic Mass ◽  
Unusual Presentation ◽  
Anterior Mediastinal Mass ◽  
Skin Involvement ◽  
Review Of The Literature ◽  
Disseminated Infection ◽  
First Report

The spectrum of infections withNocardia spp. is heterogeneous. It has classically been associated with lung, brain, or skin involvement. We describe an unusual presentation ofNocardia asiatica (N. asiatica)in an Iraqi patient with myasthenia gravis suffering from a disseminated infection and presenting with an anterior mediastinal cystic mass.N. asiaticahas only been three times described outside Japan and Thailand, and the rarity of this entity deserves this communication.

scholarly journals A case report on incidental finding of thymoma as anterior mediastinal mass

2019 ◽  
Vol 8 (6) ◽  
pp. 1441
Author(s):  
Nithin K. T. ◽  
Vikas Kumar ◽  
P. Prasanth
Keyword(s):  
Mediastinal Mass ◽  
Incidental Finding ◽  
Primary Treatment ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Unknown Etiology ◽  
Mediastinal Tumors ◽  
Mediastinal Widening ◽  
Chest X Ray ◽  
Heterogeneous Solid

Thymomas are rare tumors in the anterior mediastinum, representing 50% of anterior mediastinal masses and about 20-30% of all mediastinal tumors. They are of unknown etiology; about 50% of patients with thymomas are diagnosed incidentally with chest radiography. Thymoma is classified into different stages, which determine the prognosis and type of management, the standard primary treatment for these tumors is Thymectomy. We present a case of 55-year female presented with shortness of breath, cough with expectoration and fever for past ten days. Chest x-ray revealed mediastinal widening. CECT chest showed a well-circumscribed heterogeneous solid enhancing mass lesion. FNAC was planned that showed features in favour of thymoma. Biopsy was done that confirmed lymphocyte rich type B thymoma.

Sign in / Sign up

Export Citation Format

Share Document