scholarly journals Evidence-Based Minireview: Molecular precision and clinical uncertainty: should molecular profiling be routinely used to guide risk stratification in MDS?

Hematology ◽  
2021 ◽  
Vol 2021 (1) ◽  
pp. 435-438
Author(s):  
Daniel R. Richardson ◽  
Amy E. DeZern
Keyword(s):  
Risk Stratification ◽  
Molecular Profiling ◽  
Clinical Vignette ◽  
Evidence Based ◽  
Review Of The Literature ◽  
Patient Case ◽  
Clinical Uncertainty ◽  
Advantages And Disadvantages ◽  
Molecular Sequencing

Abstract This is a focused clinical vignette and review of the literature in MDS to discuss the application of molecular sequencing for risk stratification in MDS. The authors utilize an exemplar patient case and explain the advantages and disadvantages, based on available data, of routine use of this testing for MDS patients.

Dexmedetomidine in Adult Patients in Cardiac Surgery Critical Care: An Evidence-Based Review

2019 ◽  
Vol 30 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Lyndsay Brock
Keyword(s):  
Intensive Care Unit ◽  
Critical Care ◽  
Cardiac Surgery ◽  
Intensive Care ◽  
Drug Cost ◽  
Patient Population ◽  
Evidence Based ◽  
Review Of The Literature ◽  
Advantages And Disadvantages ◽  
Adrenoceptor Agonist

Although several options are available for postoperative sedation in the intensive care unit, the selective α2-adrenoceptor agonist dexmedetomidine may offer advantages for patients after cardiac surgery. The author conducted a review of the literature on the use of dexmedetomidine in the cardiac surgery population to determine possible advantages and disadvantages in this patient population. Although the use of dexmedetomidine has not been conclusively shown to change overall morbidity and mortality and may be associated with higher drug cost, its other demonstrated effects offer advantages for postoperative cardiac surgery patients that other forms of sedation cannot match.

scholarly journals How Can Scientific Literature Support Decision-Making in the Renovation of Historic Buildings? An Evidence-Based Approach for Improving the Performance of Walls

2021 ◽  
Vol 13 (4) ◽  
pp. 2266
Author(s):  
Valentina Marincioni ◽  
Virginia Gori ◽  
Ernst Jan de Place Hansen ◽  
Daniel Herrera-Avellanosa ◽  
Sara Mauri ◽  
...  
Keyword(s):  
Energy Performance ◽  
Decision Makers ◽  
Cultural Value ◽  
Correct Selection ◽  
Evidence Based ◽  
Historic Buildings ◽  
Indoor Environmental Quality ◽  
Building Stock ◽  
Advantages And Disadvantages ◽  
Assessment Design

Buildings of heritage significance due to their historical, architectural, or cultural value, here called historic buildings, constitute a large proportion of the building stock in many countries around the world. Improving the performance of such buildings is necessary to lower the carbon emissions of the stock, which generates around 40% of the overall emissions worldwide. In historic buildings, it is estimated that heat loss through external walls contributes significantly to the overall energy consumption, and is associated with poor thermal comfort and indoor air quality. Measures to improve the performance of walls of historic buildings require a balance between energy performance, indoor environmental quality, heritage significance, and technical compatibility. Appropriate wall measures are available, but the correct selection and implementation require an integrated process throughout assessment (planning), design, construction, and use. Despite the available knowledge, decision-makers often have limited access to robust information on tested retrofit measures, hindering the implementation of deep renovation. This paper provides an evidence-based approach on the steps required during assessment, design, and construction, and after retrofitting through a literature review. Moreover, it provides a review of possible measures for wall retrofit within the deep renovation of historic buildings, including their advantages and disadvantages and the required considerations based on context.

scholarly journals Evidence-Based Management of the Anzali Wetland System (Northern Iran) Based on Innovative Monitoring and Modeling Methods

2021 ◽  
Vol 13 (10) ◽  
pp. 5503
Author(s):  
Roghayeh Sadeghi Pasvisheh ◽  
Marie Anne Eurie Forio ◽  
Long Tuan Ho ◽  
Peter L. M. Goethals
Keyword(s):  
Sustainable Development ◽  
Environmental Modeling ◽  
Evidence Based ◽  
Anzali Wetland ◽  
Northern Iran ◽  
The Sustainable Development ◽  
Advantages And Disadvantages ◽  
Modeling Techniques ◽  
State Changes ◽  
Wetland System

As an “international aquatic ecosystem” in Northern Iran, the Anzali wetland is a nursery for fish and a breeding and wintering area for a wide variety of waterfowl. The wetland is threatened by human activities (deforestation, hunting, tourism, and urbanization), leading to habitat destruction, eutrophication, and sediment accumulation. To stop the degradation and to set up effective protection and restoration in line with the Sustainable Development Goals, scientific insights must be integrated into a practical framework for evidence-based support for policymakers and managers of the Anzali wetland. In this study, the Drivers–Pressure–State–Impact–Response (DPSIR) framework is used as a suitable tool to link human pressures and state changes to derive an overview of the potential impacts. Population growth, intensive agriculture, increased urbanization, and industrialization are the major driving forces that have led to a complex cascade of state changes. For instance, during recent years, water quality deterioration, habitat degradation, and the overgrowth of invasive species in the Anzali wetland watershed have caused negative socio-economic and human health impacts. Integrated and innovative monitoring programs combined with socio-environmental modeling techniques are needed for a more evidence-based management approach as part of a multiresponse strategy for the sustainable development of the wetland system. In this respect, there is a critical gap in useful information concerning biological composition and innovative monitoring methods. Moreover, the relation of biota with human activity and environmental conditions needs to be better quantified. Therefore, ecological modeling techniques based on machine learning and statistics were reviewed for their advantages and disadvantages. The overview of approaches presented here can serve as the basis for scientists, practitioners, and decision-makers to develop and implement evidence-based management programs for the Anzali wetland.

scholarly journals Contrasting Public and Scientific Assessments of Fracking

2021 ◽  
Vol 13 (12) ◽  
pp. 6650
Author(s):  
Yu Zhang ◽  
John A. Rupp ◽  
John D. Graham
Keyword(s):  
New York ◽  
Public Perceptions ◽  
Evidence Based ◽  
Opinion Survey ◽  
Think Tank ◽  
Advantages And Disadvantages ◽  
Local Media

This paper examines whether public perceptions of the claimed advantages and disadvantages of fracking are consistent with an evidence-based assessment of the claimed advantages and disadvantages. Public assessments are obtained from an internet-based opinion survey in 2014 in six states: California, Illinois, New York, Ohio, Pennsylvania, and Texas. The survey presented eleven advantages and eleven disadvantages of fracking derived from local media stories, from advocacy claims made by pro- or anti-fracking groups, and from think tank pieces. Then the respondents were asked to indicate their feelings about how important each claimed advantage and disadvantage was to their support of/opposition to fracking. Scientific assessments regarding the same claims are compiled from available peer-reviewed literature and evidence-based reviews. We classify each claim as either (a) supported by the weight of the available evidence, (b) not supported by the weight of the available evidence, or (c) there is inadequate evidence to assess it. We find less consistency with respect to the disadvantages than advantages. Respondents perceive four disadvantages out of eleven as extremely important while there is inadequate evidence to assess them or the available evidence does not support them. Our comparison has interesting implications for understanding the controversy about fracking.

scholarly journals Intra-Abdominal Localisation of a Buschke-Lowenstein Tumour: Case Presentation and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
N. E. Wester ◽  
E. M. Hutten ◽  
C. Krikke ◽  
Robert A. Pol
Keyword(s):  
Interferon Therapy ◽  
Verrucous Carcinoma ◽  
Treatment Options ◽  
Condyloma Acuminata ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Advantages And Disadvantages ◽  
Literature Overview ◽  
Mucosal Surfaces ◽  
Tumour Reduction

Giant condyloma acuminatum or Buschke-Lowenstein tumour is a very rare disease which usually is located in the genital, anorectal, and perianal regions. It is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces where it is locally invasive but displays a benign cytology. We describe a case of a 24-year-old woman with persisting condyloma acuminata progressing to a large intra-abdominal Buschke-Lowenstein tumour. To our knowledge such an advanced stage has only been reported once before. The severity and extent of the tumour both determine the treatment and patient outcome. Treatment was impeded by cachexia, an immunosuppressive state after kidney transplantation and difficulties in establishing a reliable diagnose. Interferon treatment was started which initially led to tumour reduction but was complicated by an interferon-induced pancreatitis, pneumonia, and fasciitis necroticans resulting in death. We present a literature overview on the treatment options for a Buschke-Lowenstein tumour, with emphasis on interferon therapy, with all the advantages and disadvantages.

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