Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35–0.77 for ≥12 versus <6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20–0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43–0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61–1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction <0.01).Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

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Anthropometry at birth and at age of routine vaccination to predict mortality in the first year of life: A birth cohort study in BukinaFaso

PLoS ONE ◽

10.1371/journal.pone.0213523 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0213523 ◽

Cited By ~ 8

Author(s):

Martha Mwangome ◽

Moses Ngari ◽

Paluku Bwahere ◽

Patrick Kabore ◽

Marie McGrath ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Routine Vaccination ◽

Birth Cohort Study ◽

First Year ◽

First Year Of Life

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Breastfeeding and Infant Eczema in the First Year of Life in the KOALA Birth Cohort Study: A Risk Period-Specific Analysis

PEDIATRICS ◽

10.1542/peds.2006-0772 ◽

2007 ◽

Vol 119 (1) ◽

pp. e137-e141 ◽

Cited By ~ 22

Author(s):

B. E. P. Snijders ◽

C. Thijs ◽

I. Kummeling ◽

J. Penders ◽

P. A. van den Brandt

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Birth Cohort Study ◽

First Year ◽

Specific Analysis ◽

Risk Period ◽

First Year Of Life ◽

Infant Eczema

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Acid-suppressive medications in the first year of life and risk of childhood asthma: a population-based birth cohort study

European Respiratory Journal ◽

10.1183/13993003.00197-2020 ◽

2020 ◽

Vol 56 (5) ◽

pp. 2000197 ◽

Cited By ~ 1

Author(s):

Claudio Barbiellini Amidei ◽

Rosanna Comoretto ◽

Loris Zanier ◽

Daniele Donà ◽

Anna Cantarutti ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Childhood Asthma ◽

Population Based ◽

Birth Cohort Study ◽

First Year ◽

First Year Of Life

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Clinical Features of Food Allergy During the First Year of Life: The ADAPAR Birth Cohort Study

PEDIATRICS ◽

10.1542/peds.2017-2475pp ◽

2017 ◽

Vol 140 (Supplement 3) ◽

pp. S196.1-S196

Author(s):

Angela Tsuang ◽

Julie Wang

Keyword(s):

Cohort Study ◽

Food Allergy ◽

Birth Cohort ◽

Clinical Features ◽

Birth Cohort Study ◽

First Year ◽

First Year Of Life

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Increased Burden of Respiratory Disease in the First Year of Life Due to Prenatal Ambient Air to Polycyclic Aromatic Hydrocarbons, Krakow Birth Cohort Study

Epidemiology ◽

10.1097/00001648-200611001-00208 ◽

2006 ◽

Vol 17 (Suppl) ◽

pp. S88

Author(s):

Wieslaw Jedrychowski

Keyword(s):

Cohort Study ◽

Polycyclic Aromatic Hydrocarbons ◽

Birth Cohort ◽

Respiratory Disease ◽

Aromatic Hydrocarbons ◽

Ambient Air ◽

Birth Cohort Study ◽

First Year ◽

Polycyclic Aromatic ◽

First Year Of Life

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Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa310 ◽

2020 ◽

Vol 222 (Supplement_7) ◽

pp. S606-S612 ◽

Cited By ~ 1

Author(s):

Joanne G Wildenbeest ◽

Roy P Zuurbier ◽

Koos Korsten ◽

Marlies A van Houten ◽

Marie N Billard ◽

...

Keyword(s):

Respiratory Syncytial Virus ◽

Birth Cohort ◽

Primary Outcome ◽

Virus Disease ◽

Severe Disease ◽

Birth Cohort Study ◽

First Year ◽

Healthy Infants ◽

Syncytial Virus ◽

First Year Of Life

Abstract Background Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity and cardiopulmonary disease are risk factors for severe disease, the majority of infants hospitalized with RSV are previously healthy. Various vaccines and therapeutics are under development and expected to be available in the near future. To inform the use of these new vaccines and therapeutics, it is necessary to determine the burden of RSV disease in Europe. We will prospectively follow-up a birth cohort to obtain incidence data on RSV acute respiratory tract infection (ARTI). Methods Multicenter prospective study of a birth cohort consisting of 10 000 healthy infants, recruited during 3 consecutive years. RSV associated hospitalization in the first year of life will be determined by questionnaires and hospital chart reviews. A nested cohort of 1000 infants will be actively followed. In case of ARTI, a respiratory sample will be collected for RSV molecular diagnosis. Results The primary outcome is the incidence rate of RSV-associated hospitalization in the first year of life. In the active cohort the primary outcome is RSV associated ARTI and MA-ARTI. Conclusions We will provide key information to fill the gaps in knowledge about the burden of RSV disease in healthy infants. Clinical Trials Registration NCT03627572.

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